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Q8BKX6

- SMG1_MOUSE

UniProt

Q8BKX6 - SMG1_MOUSE

Protein

Serine/threonine-protein kinase SMG1

Gene

Smg1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Manganese.By similarity

    Enzyme regulationi

    Inhibited by caffeine, LY294002 and wortmannin.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. DNA repair Source: UniProtKB-KW
    2. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB-KW
    3. peptidyl-serine phosphorylation Source: Ensembl
    4. phosphatidylinositol phosphorylation Source: Ensembl
    5. protein autophosphorylation Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    DNA damage, DNA repair, Nonsense-mediated mRNA decay

    Keywords - Ligandi

    ATP-binding, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase SMG1 (EC:2.7.11.1)
    Short name:
    SMG-1
    Gene namesi
    Name:Smg1
    Synonyms:Kiaa0421
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1919742. Smg1.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 36583658Serine/threonine-protein kinase SMG1PRO_0000229792Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei171 – 1711N6-acetyllysine1 Publication
    Modified residuei3547 – 35471PhosphothreonineBy similarity
    Modified residuei3553 – 35531PhosphoserineBy similarity
    Modified residuei3567 – 35671PhosphoserineBy similarity
    Modified residuei3570 – 35701PhosphothreonineBy similarity

    Post-translational modificationi

    Autophosphorylated.

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8BKX6.
    PaxDbiQ8BKX6.
    PRIDEiQ8BKX6.

    PTM databases

    PhosphoSiteiQ8BKX6.

    Expressioni

    Gene expression databases

    BgeeiQ8BKX6.
    CleanExiMM_2610207I05RIK.
    GenevestigatoriQ8BKX6.

    Interactioni

    Subunit structurei

    Component of the SMG1C complex composed of SMG1, SMG8 and SMG9; the recruitment of SMG8 to SMG1 N-terminus induces a large conformational change in the SMG1 C-terminal head domain containing the catalytic domain. Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. Interacts with PRKCI. Interacts with TELO2 and TTI1. Interacts with RUVBL1 and RUVBL2.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1129 – 1864736FATPROSITE-ProRule annotationAdd
    BLAST
    Repeati1815 – 185036HEATAdd
    BLAST
    Domaini2148 – 2476329PI3K/PI4KPROSITE-ProRule annotationAdd
    BLAST
    Domaini3626 – 365833FATCPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PI3/PI4-kinase family.Curated
    Contains 1 FAT domain.PROSITE-ProRule annotation
    Contains 1 FATC domain.PROSITE-ProRule annotation
    Contains 1 HEAT repeat.Curated
    Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5032.
    GeneTreeiENSGT00720000108744.
    HOVERGENiHBG093965.
    InParanoidiQ8BKX6.
    KOiK08873.
    OMAiLMIVHGD.
    OrthoDBiEOG7RV9F7.
    TreeFamiTF352560.

    Family and domain databases

    Gene3Di1.10.1070.11. 3 hits.
    InterProiIPR016024. ARM-type_fold.
    IPR003152. FATC.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR014009. PIK_FAT.
    [Graphical view]
    PfamiPF02260. FATC. 1 hit.
    PF00454. PI3_PI4_kinase. 1 hit.
    [Graphical view]
    SMARTiSM00146. PI3Kc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 4 hits.
    SSF56112. SSF56112. 2 hits.
    PROSITEiPS51189. FAT. 1 hit.
    PS51190. FATC. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8BKX6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSRRAPGSRL SSGGGGTKYP RSWNDWQPRT DSASADPDTL KYSSSRDRGV     50
    SSSYGLQPSN SAVVSRQRHD DTRGHADIQN DEKGGYSVNG GSGENTYGRK 100
    SLGQELRINN VTSPEFTSVQ HGSRALATKD MRKSQERSMS YSDESRLSNL 150
    LRRITREDDR DRRLATVKQL KEFIQQPENK LVLVKQLDNI LAAVHDVLNE 200
    SSKLLQELRQ EGACCLGLLC ASLSYEAEKI FKWIFSKFSS SAKDEVKLLY 250
    LCATYRALET VGEKKAFSSV MQLVMTSLQS ILENVDTPEL LCKCVKCILL 300
    VARCYPHIFS TNFRDTVDIL VGWHIDHTQK PSLTQQVSGW LQSLEPFWVA 350
    DLAFSTTLLG QFLEDMEAYA EDLSHVASGE SVDEDVPPPS VSLPKLAALL 400
    RVFSTVVRSI GERFSPIRGP PITEAYVTDV LYRVMRCVTA ANQVFFSEAV 450
    LTAANECVGV LLGSLDPSMT IHCDMVITYG LDQLENCQTC GTDYIISVLN 500
    LLTLIVEQIN TKLPSSFVEK LFIPSSKLLF LRYHKEKEVV AVAHAVYQAV 550
    LSLKNIPVLE TAYKLILGEM TCALNNLLHS LQLPDACSEI KHEAFQNHVF 600
    NIDNANFVVI FDLSALTTIG NAKNSLIGMW ALSPTVFALL SKNLMIVHSD 650
    LAVHFPAIQY AVLYTLYSHC TRHDHFISSS LSSSSPSLFD GAVISTVTTA 700
    TKKHFSIILN LLGILLKKDN LNQDTRKLLM TWALEVAVLM KKSETYAPLF 750
    SLPSFHKFSK GLLANTLVED VNICLQACSS LHALSSSLPD DLLQRCVDVC 800
    RVQLVHSGTR IRQAFGKLLK SIPLDVVLSN NNHTEIQEIS LALRSHMSKA 850
    PSNTFHPQDF SDVISFILYG NSHRTGKDNW LERLFYSCQR LDKRDQSTIP 900
    RNLLKTDAVL WQWAIWEAAQ FTVLSKLRTP LGRAQDTFQT IEGIIRSLAA 950
    HTLNPDQDVS QWTTADNDEG HGSNQLRLVL LLQYLENLEK LMYNAYEGCA 1000
    NALTSPPKVI RTFFYTNRQT CQDWLTRIRL SIMRVGLLAG QPAVTVRHGF 1050
    DLLTEMKTNS LTQGSELEVT IMMVVEALCE LHCPEAIQGI AVWSSSAVGK 1100
    NLLWINSVAQ QAEGRFEKAS VEYQEHLCAM TGVDCCISSF DKSVLTLANA 1150
    GRNSASPKHS LNGESRKTVL SKSIDSSPEV ISYLGNKACE CYISIADWAA 1200
    VQEWQNAVHD LKKNSSSTSL NLKADFNYIK SLSSFESGEF VECTEQLELL 1250
    PGENINLLAG GSKEKIDMKK LLPNMLSPDP RELQKSIEVQ LLRSSVFLAT 1300
    ALNHMEQDQK WQSLTENVVK YLKQTSRIAI GPLRLSTLTV SQSLPVLSTL 1350
    QLYCSSALEN TVSNRLSTED CLIPLFSDAL RSCKQHDVRP WMQALRYTMY 1400
    QNQLLEKIKE QTVPIRSHLM ELGLTAAKFA RKRGNVSLAT RLLAQCSEVQ 1450
    LGKTTTAQDL VQHFKKLSTQ GQVDEKWGPE LDIEKTKLLY TAGQSTHAME 1500
    MLSSCAISFC KSAKAEYAVA KSILTLAKWV QAEWKEISGQ LRQVYRAQQQ 1550
    QNLSGLSTLS RNILALIELP SANTVGEEHP RIESESTVHI GVGEPDFILG 1600
    QLYHLSSVQA PEVAKSWAAL ASWAYRWGRK VVDNASQGEG VRLLPREKSE 1650
    VQNLLPDTIT EEEKERIYGI LGQAVCRPAG IQDEDITLQI TESEDNEDDD 1700
    MVDVIWRQLI SSCPWLSELD ENATEGVIKV WRKVVDRIFS LYKLSCSAYF 1750
    TFLKLNAGQV LLDEDDPRLH LSHRAEQSTD DVIVMATLRL LRLLVKHAGE 1800
    LRQYLEHGLE TTPTAPWRGI IPQLFSRLNH PEVYVRQSIC NLLCRVAQDS 1850
    PHLILYPAIV GTISLSSESQ ASGNKYSSAI PTLLGNIQGE ELLVSECEGG 1900
    SPPASQDSNK DEPKSGLNED QAMMQDCYSK IVDKLSSANP TMVLQVQMLV 1950
    AELRRVTVLW DELWLGVLLQ QHMYVLRRIQ QLEDEVKRVQ NNNTLRKEEK 2000
    IAIMREKHTA LMKPIVFALE HVRSITAAPA ETPHEKWFQD NYGDAIDNAL 2050
    EKLKTPSNPA KPGSSWIPFK EIMLSLQQRA QKRASYILRL DEISPWLAAM 2100
    TNTEIALPGE VSARDTVTIH SVGGTITILP TKTKPKKLLF LGSDGKSYPY 2150
    LFKGLEDLHL DERIMQFLSI VNTMFATINR QETPRFHARH YSVTPLGTRS 2200
    GLIQWVDGAT PLFGLYKRWQ QREAALQAQK AQDSYQTPQN PSIVPRPSEL 2250
    YYSKIGPALK TVGLSLDVSR RDWPLHVMKA VLEELMEATP PNLLAKELWS 2300
    SCTTPDEWWR VTQSYARSTA VMSMVGYIIG LGDRHLDNVL IDMTTGEVVH 2350
    IDYNVCFEKG KSLRVPEKVP FRMTQNIETA LGVTGVEGVF RLSCEQVLHI 2400
    MRRGRETLLT LLEAFVYDPL VDWTAGGEAG FAGAVYGGGG QQAESKQSKR 2450
    EMEREITRSL FSSRVAEIKV NWFKNRDEML VVLPKLDSSL DEYLSLQEQL 2500
    TDVEKLQGKL LEEIEFLEGA EGVDHPSHTL QHRYSEHTQL QTQQRAVQEA 2550
    IQVKLNEFEQ WITHYQAAFN NLEATQLASL LQEISTQMDL GPPSYVPATA 2600
    FLQNAGQAHL ISQCEQLEGE VGALLQQRRS VLRGCLEQLH HYATVALQYP 2650
    KAIFQKHRIE QWKAWMEELI CNTTVERCQE LYRKYEMQYA PQPPPTVCQF 2700
    ITATEMTLQR YAADINSRLI RQVERLKQEA VTVPVCEDQL KEIERCIKVF 2750
    LHENGEEGSL SLASVIISAL CTLTRRNLMM EGAASSAGEQ LVDLTSRDGA 2800
    WFLEELCSMS GNVTCLVQLL KQCHLVPQDL DIPNPVEASE AVHLANGVYT 2850
    SLQELNSNFR QIIFPEALRC LMKGECTLES MLHELDSLIE QTTDGVPLQT 2900
    LVESLQAYLR NTAMGLEEET HAHYIDVARM LHAQYGELIQ PRNGSVDETP 2950
    KMSAGQMLLV AFDGMFAQVE TAFGLLVEKL NKMEIPVAWR KIDIIREARS 3000
    TQVNFFDDDN HRQVLEEIFF LKRLQTIKEF FRLCGTFSKT LSGSSSLEDQ 3050
    NTVNGPVQIV NVKTLFRNSC FSEDQMAKPI KAFTADFVRQ LLIGLPNQAL 3100
    GLTLCSFISA LGVDIIAQVE AKDFGAESKV SVDDLCKKAV EHNIQVGKFS 3150
    QLVMNRATVL ASSYDTAWKK HDLVRRLETS ISSCKTSLQR VQLHIAMFQW 3200
    QHEDLLISRP QAMSVTPPRS AILTSMKKKL HALSQIETSI GTVQEKLAAL 3250
    EASIEQRLKW AGGANPALAP VLQDFEATIA ERRNLVLKES QRANQVTFLC 3300
    SNIIHFESLR TRTAEALSLD AALFELIKRC QQMCSFASQF NSSVSELELR 3350
    LLQRVDTTLE HPIGSSEWLL SAHKQLTQDM STQRAVQTEK EQQIETVCET 3400
    IQSLVDSVKT VLTGHNRQLG DVKHLLKAMA KDEEAALADA EDIPYESSVR 3450
    QFLAEYKSWQ DNIQTVLFTL VQAMGQVRSQ EHVEMLQEIT PTLKELKTQS 3500
    QSIYNNLVSF ASPLVTDAAN ECSSPTSSAT YQPSFAAAVR SNTGQKTQPD 3550
    VMSQNAKKLI QKNLATSADT PPSTIPGTGK SIACSPKKAV RDPKTGKAVQ 3600
    ERNSYAVSVW KRVKAKLEGR DVDPNRRMSV AEQVDYVIKE ATNLDNLAQL 3650
    YEGWTAWV 3658
    Length:3,658
    Mass (Da):409,769
    Last modified:July 27, 2011 - v3
    Checksum:i8C13F45BE0D35042
    GO
    Isoform 2 (identifier: Q8BKX6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         273-284: LVMTSLQSILEN → VRARDPQCSAVR
         285-3658: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:284
    Mass (Da):31,739
    Checksum:i8B0693F8E27FF13D
    GO
    Isoform 3 (identifier: Q8BKX6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         431-433: LYR → SVF
         434-3658: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:433
    Mass (Da):48,246
    Checksum:i4A48D537C9327637
    GO

    Sequence cautioni

    The sequence BAD90238.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti566 – 5661I → V in BAC33168. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei273 – 28412LVMTS…SILEN → VRARDPQCSAVR in isoform 2. 1 PublicationVSP_017749Add
    BLAST
    Alternative sequencei285 – 36583374Missing in isoform 2. 1 PublicationVSP_017750Add
    BLAST
    Alternative sequencei431 – 4333LYR → SVF in isoform 3. 1 PublicationVSP_017751
    Alternative sequencei434 – 36583225Missing in isoform 3. 1 PublicationVSP_017752Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC131788 Genomic DNA. No translation available.
    AC132432 Genomic DNA. No translation available.
    AK129136 mRNA. Translation: BAC97946.1.
    AK220328 mRNA. Translation: BAD90238.1. Different initiation.
    AK041264 mRNA. Translation: BAC30884.2.
    AK047829 mRNA. Translation: BAC33168.2.
    AK049391 mRNA. Translation: BAC33729.1.
    AK052331 mRNA. Translation: BAC34941.1.
    CCDSiCCDS40102.1. [Q8BKX6-1]
    RefSeqiNP_001026984.1. NM_001031814.1. [Q8BKX6-1]
    UniGeneiMm.309053.

    Genome annotation databases

    EnsembliENSMUST00000032891; ENSMUSP00000032891; ENSMUSG00000030655. [Q8BKX6-1]
    GeneIDi233789.
    KEGGimmu:233789.
    UCSCiuc009jjp.1. mouse. [Q8BKX6-1]
    uc009jjq.1. mouse. [Q8BKX6-3]
    uc009jjr.1. mouse. [Q8BKX6-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC131788 Genomic DNA. No translation available.
    AC132432 Genomic DNA. No translation available.
    AK129136 mRNA. Translation: BAC97946.1 .
    AK220328 mRNA. Translation: BAD90238.1 . Different initiation.
    AK041264 mRNA. Translation: BAC30884.2 .
    AK047829 mRNA. Translation: BAC33168.2 .
    AK049391 mRNA. Translation: BAC33729.1 .
    AK052331 mRNA. Translation: BAC34941.1 .
    CCDSi CCDS40102.1. [Q8BKX6-1 ]
    RefSeqi NP_001026984.1. NM_001031814.1. [Q8BKX6-1 ]
    UniGenei Mm.309053.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BKX6.

    Proteomic databases

    MaxQBi Q8BKX6.
    PaxDbi Q8BKX6.
    PRIDEi Q8BKX6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032891 ; ENSMUSP00000032891 ; ENSMUSG00000030655 . [Q8BKX6-1 ]
    GeneIDi 233789.
    KEGGi mmu:233789.
    UCSCi uc009jjp.1. mouse. [Q8BKX6-1 ]
    uc009jjq.1. mouse. [Q8BKX6-3 ]
    uc009jjr.1. mouse. [Q8BKX6-2 ]

    Organism-specific databases

    CTDi 23049.
    MGIi MGI:1919742. Smg1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG5032.
    GeneTreei ENSGT00720000108744.
    HOVERGENi HBG093965.
    InParanoidi Q8BKX6.
    KOi K08873.
    OMAi LMIVHGD.
    OrthoDBi EOG7RV9F7.
    TreeFami TF352560.

    Enzyme and pathway databases

    Reactomei REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Miscellaneous databases

    ChiTaRSi SMG1. mouse.
    NextBioi 381825.
    PROi Q8BKX6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BKX6.
    CleanExi MM_2610207I05RIK.
    Genevestigatori Q8BKX6.

    Family and domain databases

    Gene3Di 1.10.1070.11. 3 hits.
    InterProi IPR016024. ARM-type_fold.
    IPR003152. FATC.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR014009. PIK_FAT.
    [Graphical view ]
    Pfami PF02260. FATC. 1 hit.
    PF00454. PI3_PI4_kinase. 1 hit.
    [Graphical view ]
    SMARTi SM00146. PI3Kc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 4 hits.
    SSF56112. SSF56112. 2 hits.
    PROSITEi PS51189. FAT. 1 hit.
    PS51190. FATC. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2976-3658.
      Tissue: Fetal brain.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1996 (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Aorta, Head, Heart and Vein.
    4. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 67-73, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-171, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiSMG1_MOUSE
    AccessioniPrimary (citable) accession number: Q8BKX6
    Secondary accession number(s): E9QLR6
    , Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 101 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3