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Q8BKX6

- SMG1_MOUSE

UniProt

Q8BKX6 - SMG1_MOUSE

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Protein
Serine/threonine-protein kinase SMG1
Gene
Smg1, Kiaa0421
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Manganese By similarity.

Enzyme regulationi

Inhibited by caffeine, LY294002 and wortmannin.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. DNA repair Source: UniProtKB-KW
  2. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB-KW
  3. peptidyl-serine phosphorylation Source: Ensembl
  4. phosphatidylinositol phosphorylation Source: Ensembl
  5. protein autophosphorylation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

DNA damage, DNA repair, Nonsense-mediated mRNA decay

Keywords - Ligandi

ATP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SMG1 (EC:2.7.11.1)
Short name:
SMG-1
Gene namesi
Name:Smg1
Synonyms:Kiaa0421
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1919742. Smg1.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 36583658Serine/threonine-protein kinase SMG1
PRO_0000229792Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei171 – 1711N6-acetyllysine1 Publication
Modified residuei3547 – 35471Phosphothreonine By similarity
Modified residuei3553 – 35531Phosphoserine By similarity
Modified residuei3567 – 35671Phosphoserine By similarity
Modified residuei3570 – 35701Phosphothreonine By similarity

Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8BKX6.
PaxDbiQ8BKX6.
PRIDEiQ8BKX6.

PTM databases

PhosphoSiteiQ8BKX6.

Expressioni

Gene expression databases

BgeeiQ8BKX6.
CleanExiMM_2610207I05RIK.
GenevestigatoriQ8BKX6.

Interactioni

Subunit structurei

Component of the SMG1C complex composed of SMG1, SMG8 and SMG9; the recruitment of SMG8 to SMG1 N-terminus induces a large conformational change in the SMG1 C-terminal head domain containing the catalytic domain. Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. Interacts with PRKCI. Interacts with TELO2 and TTI1. Interacts with RUVBL1 and RUVBL2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1129 – 1864736FAT
Add
BLAST
Repeati1815 – 185036HEAT
Add
BLAST
Domaini2148 – 2476329PI3K/PI4K
Add
BLAST
Domaini3626 – 365833FATC
Add
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.
Contains 1 FAT domain.
Contains 1 FATC domain.
Contains 1 HEAT repeat.
Contains 1 PI3K/PI4K domain.

Phylogenomic databases

eggNOGiCOG5032.
GeneTreeiENSGT00720000108744.
HOVERGENiHBG093965.
InParanoidiQ8BKX6.
KOiK08873.
OMAiLMIVHGD.
OrthoDBiEOG7RV9F7.
TreeFamiTF352560.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
InterProiIPR016024. ARM-type_fold.
IPR003152. FATC.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR014009. PIK_FAT.
[Graphical view]
PfamiPF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8BKX6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSRRAPGSRL SSGGGGTKYP RSWNDWQPRT DSASADPDTL KYSSSRDRGV     50
SSSYGLQPSN SAVVSRQRHD DTRGHADIQN DEKGGYSVNG GSGENTYGRK 100
SLGQELRINN VTSPEFTSVQ HGSRALATKD MRKSQERSMS YSDESRLSNL 150
LRRITREDDR DRRLATVKQL KEFIQQPENK LVLVKQLDNI LAAVHDVLNE 200
SSKLLQELRQ EGACCLGLLC ASLSYEAEKI FKWIFSKFSS SAKDEVKLLY 250
LCATYRALET VGEKKAFSSV MQLVMTSLQS ILENVDTPEL LCKCVKCILL 300
VARCYPHIFS TNFRDTVDIL VGWHIDHTQK PSLTQQVSGW LQSLEPFWVA 350
DLAFSTTLLG QFLEDMEAYA EDLSHVASGE SVDEDVPPPS VSLPKLAALL 400
RVFSTVVRSI GERFSPIRGP PITEAYVTDV LYRVMRCVTA ANQVFFSEAV 450
LTAANECVGV LLGSLDPSMT IHCDMVITYG LDQLENCQTC GTDYIISVLN 500
LLTLIVEQIN TKLPSSFVEK LFIPSSKLLF LRYHKEKEVV AVAHAVYQAV 550
LSLKNIPVLE TAYKLILGEM TCALNNLLHS LQLPDACSEI KHEAFQNHVF 600
NIDNANFVVI FDLSALTTIG NAKNSLIGMW ALSPTVFALL SKNLMIVHSD 650
LAVHFPAIQY AVLYTLYSHC TRHDHFISSS LSSSSPSLFD GAVISTVTTA 700
TKKHFSIILN LLGILLKKDN LNQDTRKLLM TWALEVAVLM KKSETYAPLF 750
SLPSFHKFSK GLLANTLVED VNICLQACSS LHALSSSLPD DLLQRCVDVC 800
RVQLVHSGTR IRQAFGKLLK SIPLDVVLSN NNHTEIQEIS LALRSHMSKA 850
PSNTFHPQDF SDVISFILYG NSHRTGKDNW LERLFYSCQR LDKRDQSTIP 900
RNLLKTDAVL WQWAIWEAAQ FTVLSKLRTP LGRAQDTFQT IEGIIRSLAA 950
HTLNPDQDVS QWTTADNDEG HGSNQLRLVL LLQYLENLEK LMYNAYEGCA 1000
NALTSPPKVI RTFFYTNRQT CQDWLTRIRL SIMRVGLLAG QPAVTVRHGF 1050
DLLTEMKTNS LTQGSELEVT IMMVVEALCE LHCPEAIQGI AVWSSSAVGK 1100
NLLWINSVAQ QAEGRFEKAS VEYQEHLCAM TGVDCCISSF DKSVLTLANA 1150
GRNSASPKHS LNGESRKTVL SKSIDSSPEV ISYLGNKACE CYISIADWAA 1200
VQEWQNAVHD LKKNSSSTSL NLKADFNYIK SLSSFESGEF VECTEQLELL 1250
PGENINLLAG GSKEKIDMKK LLPNMLSPDP RELQKSIEVQ LLRSSVFLAT 1300
ALNHMEQDQK WQSLTENVVK YLKQTSRIAI GPLRLSTLTV SQSLPVLSTL 1350
QLYCSSALEN TVSNRLSTED CLIPLFSDAL RSCKQHDVRP WMQALRYTMY 1400
QNQLLEKIKE QTVPIRSHLM ELGLTAAKFA RKRGNVSLAT RLLAQCSEVQ 1450
LGKTTTAQDL VQHFKKLSTQ GQVDEKWGPE LDIEKTKLLY TAGQSTHAME 1500
MLSSCAISFC KSAKAEYAVA KSILTLAKWV QAEWKEISGQ LRQVYRAQQQ 1550
QNLSGLSTLS RNILALIELP SANTVGEEHP RIESESTVHI GVGEPDFILG 1600
QLYHLSSVQA PEVAKSWAAL ASWAYRWGRK VVDNASQGEG VRLLPREKSE 1650
VQNLLPDTIT EEEKERIYGI LGQAVCRPAG IQDEDITLQI TESEDNEDDD 1700
MVDVIWRQLI SSCPWLSELD ENATEGVIKV WRKVVDRIFS LYKLSCSAYF 1750
TFLKLNAGQV LLDEDDPRLH LSHRAEQSTD DVIVMATLRL LRLLVKHAGE 1800
LRQYLEHGLE TTPTAPWRGI IPQLFSRLNH PEVYVRQSIC NLLCRVAQDS 1850
PHLILYPAIV GTISLSSESQ ASGNKYSSAI PTLLGNIQGE ELLVSECEGG 1900
SPPASQDSNK DEPKSGLNED QAMMQDCYSK IVDKLSSANP TMVLQVQMLV 1950
AELRRVTVLW DELWLGVLLQ QHMYVLRRIQ QLEDEVKRVQ NNNTLRKEEK 2000
IAIMREKHTA LMKPIVFALE HVRSITAAPA ETPHEKWFQD NYGDAIDNAL 2050
EKLKTPSNPA KPGSSWIPFK EIMLSLQQRA QKRASYILRL DEISPWLAAM 2100
TNTEIALPGE VSARDTVTIH SVGGTITILP TKTKPKKLLF LGSDGKSYPY 2150
LFKGLEDLHL DERIMQFLSI VNTMFATINR QETPRFHARH YSVTPLGTRS 2200
GLIQWVDGAT PLFGLYKRWQ QREAALQAQK AQDSYQTPQN PSIVPRPSEL 2250
YYSKIGPALK TVGLSLDVSR RDWPLHVMKA VLEELMEATP PNLLAKELWS 2300
SCTTPDEWWR VTQSYARSTA VMSMVGYIIG LGDRHLDNVL IDMTTGEVVH 2350
IDYNVCFEKG KSLRVPEKVP FRMTQNIETA LGVTGVEGVF RLSCEQVLHI 2400
MRRGRETLLT LLEAFVYDPL VDWTAGGEAG FAGAVYGGGG QQAESKQSKR 2450
EMEREITRSL FSSRVAEIKV NWFKNRDEML VVLPKLDSSL DEYLSLQEQL 2500
TDVEKLQGKL LEEIEFLEGA EGVDHPSHTL QHRYSEHTQL QTQQRAVQEA 2550
IQVKLNEFEQ WITHYQAAFN NLEATQLASL LQEISTQMDL GPPSYVPATA 2600
FLQNAGQAHL ISQCEQLEGE VGALLQQRRS VLRGCLEQLH HYATVALQYP 2650
KAIFQKHRIE QWKAWMEELI CNTTVERCQE LYRKYEMQYA PQPPPTVCQF 2700
ITATEMTLQR YAADINSRLI RQVERLKQEA VTVPVCEDQL KEIERCIKVF 2750
LHENGEEGSL SLASVIISAL CTLTRRNLMM EGAASSAGEQ LVDLTSRDGA 2800
WFLEELCSMS GNVTCLVQLL KQCHLVPQDL DIPNPVEASE AVHLANGVYT 2850
SLQELNSNFR QIIFPEALRC LMKGECTLES MLHELDSLIE QTTDGVPLQT 2900
LVESLQAYLR NTAMGLEEET HAHYIDVARM LHAQYGELIQ PRNGSVDETP 2950
KMSAGQMLLV AFDGMFAQVE TAFGLLVEKL NKMEIPVAWR KIDIIREARS 3000
TQVNFFDDDN HRQVLEEIFF LKRLQTIKEF FRLCGTFSKT LSGSSSLEDQ 3050
NTVNGPVQIV NVKTLFRNSC FSEDQMAKPI KAFTADFVRQ LLIGLPNQAL 3100
GLTLCSFISA LGVDIIAQVE AKDFGAESKV SVDDLCKKAV EHNIQVGKFS 3150
QLVMNRATVL ASSYDTAWKK HDLVRRLETS ISSCKTSLQR VQLHIAMFQW 3200
QHEDLLISRP QAMSVTPPRS AILTSMKKKL HALSQIETSI GTVQEKLAAL 3250
EASIEQRLKW AGGANPALAP VLQDFEATIA ERRNLVLKES QRANQVTFLC 3300
SNIIHFESLR TRTAEALSLD AALFELIKRC QQMCSFASQF NSSVSELELR 3350
LLQRVDTTLE HPIGSSEWLL SAHKQLTQDM STQRAVQTEK EQQIETVCET 3400
IQSLVDSVKT VLTGHNRQLG DVKHLLKAMA KDEEAALADA EDIPYESSVR 3450
QFLAEYKSWQ DNIQTVLFTL VQAMGQVRSQ EHVEMLQEIT PTLKELKTQS 3500
QSIYNNLVSF ASPLVTDAAN ECSSPTSSAT YQPSFAAAVR SNTGQKTQPD 3550
VMSQNAKKLI QKNLATSADT PPSTIPGTGK SIACSPKKAV RDPKTGKAVQ 3600
ERNSYAVSVW KRVKAKLEGR DVDPNRRMSV AEQVDYVIKE ATNLDNLAQL 3650
YEGWTAWV 3658
Length:3,658
Mass (Da):409,769
Last modified:July 27, 2011 - v3
Checksum:i8C13F45BE0D35042
GO
Isoform 2 (identifier: Q8BKX6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     273-284: LVMTSLQSILEN → VRARDPQCSAVR
     285-3658: Missing.

Note: No experimental confirmation available.

Show »
Length:284
Mass (Da):31,739
Checksum:i8B0693F8E27FF13D
GO
Isoform 3 (identifier: Q8BKX6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     431-433: LYR → SVF
     434-3658: Missing.

Note: No experimental confirmation available.

Show »
Length:433
Mass (Da):48,246
Checksum:i4A48D537C9327637
GO

Sequence cautioni

The sequence BAD90238.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei273 – 28412LVMTS…SILEN → VRARDPQCSAVR in isoform 2.
VSP_017749Add
BLAST
Alternative sequencei285 – 36583374Missing in isoform 2.
VSP_017750Add
BLAST
Alternative sequencei431 – 4333LYR → SVF in isoform 3.
VSP_017751
Alternative sequencei434 – 36583225Missing in isoform 3.
VSP_017752Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti566 – 5661I → V in BAC33168. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC131788 Genomic DNA. No translation available.
AC132432 Genomic DNA. No translation available.
AK129136 mRNA. Translation: BAC97946.1.
AK220328 mRNA. Translation: BAD90238.1. Different initiation.
AK041264 mRNA. Translation: BAC30884.2.
AK047829 mRNA. Translation: BAC33168.2.
AK049391 mRNA. Translation: BAC33729.1.
AK052331 mRNA. Translation: BAC34941.1.
CCDSiCCDS40102.1. [Q8BKX6-1]
RefSeqiNP_001026984.1. NM_001031814.1. [Q8BKX6-1]
UniGeneiMm.309053.

Genome annotation databases

EnsembliENSMUST00000032891; ENSMUSP00000032891; ENSMUSG00000030655. [Q8BKX6-1]
GeneIDi233789.
KEGGimmu:233789.
UCSCiuc009jjp.1. mouse. [Q8BKX6-1]
uc009jjq.1. mouse. [Q8BKX6-3]
uc009jjr.1. mouse. [Q8BKX6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC131788 Genomic DNA. No translation available.
AC132432 Genomic DNA. No translation available.
AK129136 mRNA. Translation: BAC97946.1 .
AK220328 mRNA. Translation: BAD90238.1 . Different initiation.
AK041264 mRNA. Translation: BAC30884.2 .
AK047829 mRNA. Translation: BAC33168.2 .
AK049391 mRNA. Translation: BAC33729.1 .
AK052331 mRNA. Translation: BAC34941.1 .
CCDSi CCDS40102.1. [Q8BKX6-1 ]
RefSeqi NP_001026984.1. NM_001031814.1. [Q8BKX6-1 ]
UniGenei Mm.309053.

3D structure databases

ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BKX6.

Proteomic databases

MaxQBi Q8BKX6.
PaxDbi Q8BKX6.
PRIDEi Q8BKX6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032891 ; ENSMUSP00000032891 ; ENSMUSG00000030655 . [Q8BKX6-1 ]
GeneIDi 233789.
KEGGi mmu:233789.
UCSCi uc009jjp.1. mouse. [Q8BKX6-1 ]
uc009jjq.1. mouse. [Q8BKX6-3 ]
uc009jjr.1. mouse. [Q8BKX6-2 ]

Organism-specific databases

CTDi 23049.
MGIi MGI:1919742. Smg1.
Rougei Search...

Phylogenomic databases

eggNOGi COG5032.
GeneTreei ENSGT00720000108744.
HOVERGENi HBG093965.
InParanoidi Q8BKX6.
KOi K08873.
OMAi LMIVHGD.
OrthoDBi EOG7RV9F7.
TreeFami TF352560.

Enzyme and pathway databases

Reactomei REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSi SMG1. mouse.
NextBioi 381825.
PROi Q8BKX6.
SOURCEi Search...

Gene expression databases

Bgeei Q8BKX6.
CleanExi MM_2610207I05RIK.
Genevestigatori Q8BKX6.

Family and domain databases

Gene3Di 1.10.1070.11. 3 hits.
InterProi IPR016024. ARM-type_fold.
IPR003152. FATC.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR014009. PIK_FAT.
[Graphical view ]
Pfami PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view ]
SMARTi SM00146. PI3Kc. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 4 hits.
SSF56112. SSF56112. 2 hits.
PROSITEi PS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2976-3658.
    Tissue: Fetal brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1996 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Aorta, Head, Heart and Vein.
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 67-73, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-171, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiSMG1_MOUSE
AccessioniPrimary (citable) accession number: Q8BKX6
Secondary accession number(s): E9QLR6
, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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