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Q8BKX6

- SMG1_MOUSE

UniProt

Q8BKX6 - SMG1_MOUSE

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Protein

Serine/threonine-protein kinase SMG1

Gene

Smg1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Manganese.By similarity

Enzyme regulationi

Inhibited by caffeine, LY294002 and wortmannin.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. poly(A) RNA binding Source: Ensembl
  4. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. DNA repair Source: UniProtKB-KW
  2. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB-KW
  3. peptidyl-serine phosphorylation Source: Ensembl
  4. phosphatidylinositol phosphorylation Source: Ensembl
  5. protein autophosphorylation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

DNA damage, DNA repair, Nonsense-mediated mRNA decay

Keywords - Ligandi

ATP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SMG1 (EC:2.7.11.1)
Short name:
SMG-1
Gene namesi
Name:Smg1
Synonyms:Kiaa0421
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1919742. Smg1.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 36583658Serine/threonine-protein kinase SMG1PRO_0000229792Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei171 – 1711N6-acetyllysine1 Publication
Modified residuei3547 – 35471PhosphothreonineBy similarity
Modified residuei3553 – 35531PhosphoserineBy similarity
Modified residuei3567 – 35671PhosphoserineBy similarity
Modified residuei3570 – 35701PhosphothreonineBy similarity

Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8BKX6.
PaxDbiQ8BKX6.
PRIDEiQ8BKX6.

PTM databases

PhosphoSiteiQ8BKX6.

Expressioni

Gene expression databases

BgeeiQ8BKX6.
CleanExiMM_2610207I05RIK.
ExpressionAtlasiQ8BKX6. baseline and differential.
GenevestigatoriQ8BKX6.

Interactioni

Subunit structurei

Component of the SMG1C complex composed of SMG1, SMG8 and SMG9; the recruitment of SMG8 to SMG1 N-terminus induces a large conformational change in the SMG1 C-terminal head domain containing the catalytic domain. Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. Interacts with PRKCI. Interacts with TELO2 and TTI1. Interacts with RUVBL1 and RUVBL2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1129 – 1864736FATPROSITE-ProRule annotationAdd
BLAST
Repeati1815 – 185036HEATAdd
BLAST
Domaini2148 – 2476329PI3K/PI4KPROSITE-ProRule annotationAdd
BLAST
Domaini3626 – 365833FATCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.Curated
Contains 1 FAT domain.PROSITE-ProRule annotation
Contains 1 FATC domain.PROSITE-ProRule annotation
Contains 1 HEAT repeat.Curated
Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5032.
GeneTreeiENSGT00760000119359.
HOVERGENiHBG093965.
InParanoidiQ8BKX6.
KOiK08873.
OMAiLMIVHGD.
OrthoDBiEOG7RV9F7.
TreeFamiTF352560.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
InterProiIPR016024. ARM-type_fold.
IPR003152. FATC.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR014009. PIK_FAT.
[Graphical view]
PfamiPF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8BKX6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRRAPGSRL SSGGGGTKYP RSWNDWQPRT DSASADPDTL KYSSSRDRGV
60 70 80 90 100
SSSYGLQPSN SAVVSRQRHD DTRGHADIQN DEKGGYSVNG GSGENTYGRK
110 120 130 140 150
SLGQELRINN VTSPEFTSVQ HGSRALATKD MRKSQERSMS YSDESRLSNL
160 170 180 190 200
LRRITREDDR DRRLATVKQL KEFIQQPENK LVLVKQLDNI LAAVHDVLNE
210 220 230 240 250
SSKLLQELRQ EGACCLGLLC ASLSYEAEKI FKWIFSKFSS SAKDEVKLLY
260 270 280 290 300
LCATYRALET VGEKKAFSSV MQLVMTSLQS ILENVDTPEL LCKCVKCILL
310 320 330 340 350
VARCYPHIFS TNFRDTVDIL VGWHIDHTQK PSLTQQVSGW LQSLEPFWVA
360 370 380 390 400
DLAFSTTLLG QFLEDMEAYA EDLSHVASGE SVDEDVPPPS VSLPKLAALL
410 420 430 440 450
RVFSTVVRSI GERFSPIRGP PITEAYVTDV LYRVMRCVTA ANQVFFSEAV
460 470 480 490 500
LTAANECVGV LLGSLDPSMT IHCDMVITYG LDQLENCQTC GTDYIISVLN
510 520 530 540 550
LLTLIVEQIN TKLPSSFVEK LFIPSSKLLF LRYHKEKEVV AVAHAVYQAV
560 570 580 590 600
LSLKNIPVLE TAYKLILGEM TCALNNLLHS LQLPDACSEI KHEAFQNHVF
610 620 630 640 650
NIDNANFVVI FDLSALTTIG NAKNSLIGMW ALSPTVFALL SKNLMIVHSD
660 670 680 690 700
LAVHFPAIQY AVLYTLYSHC TRHDHFISSS LSSSSPSLFD GAVISTVTTA
710 720 730 740 750
TKKHFSIILN LLGILLKKDN LNQDTRKLLM TWALEVAVLM KKSETYAPLF
760 770 780 790 800
SLPSFHKFSK GLLANTLVED VNICLQACSS LHALSSSLPD DLLQRCVDVC
810 820 830 840 850
RVQLVHSGTR IRQAFGKLLK SIPLDVVLSN NNHTEIQEIS LALRSHMSKA
860 870 880 890 900
PSNTFHPQDF SDVISFILYG NSHRTGKDNW LERLFYSCQR LDKRDQSTIP
910 920 930 940 950
RNLLKTDAVL WQWAIWEAAQ FTVLSKLRTP LGRAQDTFQT IEGIIRSLAA
960 970 980 990 1000
HTLNPDQDVS QWTTADNDEG HGSNQLRLVL LLQYLENLEK LMYNAYEGCA
1010 1020 1030 1040 1050
NALTSPPKVI RTFFYTNRQT CQDWLTRIRL SIMRVGLLAG QPAVTVRHGF
1060 1070 1080 1090 1100
DLLTEMKTNS LTQGSELEVT IMMVVEALCE LHCPEAIQGI AVWSSSAVGK
1110 1120 1130 1140 1150
NLLWINSVAQ QAEGRFEKAS VEYQEHLCAM TGVDCCISSF DKSVLTLANA
1160 1170 1180 1190 1200
GRNSASPKHS LNGESRKTVL SKSIDSSPEV ISYLGNKACE CYISIADWAA
1210 1220 1230 1240 1250
VQEWQNAVHD LKKNSSSTSL NLKADFNYIK SLSSFESGEF VECTEQLELL
1260 1270 1280 1290 1300
PGENINLLAG GSKEKIDMKK LLPNMLSPDP RELQKSIEVQ LLRSSVFLAT
1310 1320 1330 1340 1350
ALNHMEQDQK WQSLTENVVK YLKQTSRIAI GPLRLSTLTV SQSLPVLSTL
1360 1370 1380 1390 1400
QLYCSSALEN TVSNRLSTED CLIPLFSDAL RSCKQHDVRP WMQALRYTMY
1410 1420 1430 1440 1450
QNQLLEKIKE QTVPIRSHLM ELGLTAAKFA RKRGNVSLAT RLLAQCSEVQ
1460 1470 1480 1490 1500
LGKTTTAQDL VQHFKKLSTQ GQVDEKWGPE LDIEKTKLLY TAGQSTHAME
1510 1520 1530 1540 1550
MLSSCAISFC KSAKAEYAVA KSILTLAKWV QAEWKEISGQ LRQVYRAQQQ
1560 1570 1580 1590 1600
QNLSGLSTLS RNILALIELP SANTVGEEHP RIESESTVHI GVGEPDFILG
1610 1620 1630 1640 1650
QLYHLSSVQA PEVAKSWAAL ASWAYRWGRK VVDNASQGEG VRLLPREKSE
1660 1670 1680 1690 1700
VQNLLPDTIT EEEKERIYGI LGQAVCRPAG IQDEDITLQI TESEDNEDDD
1710 1720 1730 1740 1750
MVDVIWRQLI SSCPWLSELD ENATEGVIKV WRKVVDRIFS LYKLSCSAYF
1760 1770 1780 1790 1800
TFLKLNAGQV LLDEDDPRLH LSHRAEQSTD DVIVMATLRL LRLLVKHAGE
1810 1820 1830 1840 1850
LRQYLEHGLE TTPTAPWRGI IPQLFSRLNH PEVYVRQSIC NLLCRVAQDS
1860 1870 1880 1890 1900
PHLILYPAIV GTISLSSESQ ASGNKYSSAI PTLLGNIQGE ELLVSECEGG
1910 1920 1930 1940 1950
SPPASQDSNK DEPKSGLNED QAMMQDCYSK IVDKLSSANP TMVLQVQMLV
1960 1970 1980 1990 2000
AELRRVTVLW DELWLGVLLQ QHMYVLRRIQ QLEDEVKRVQ NNNTLRKEEK
2010 2020 2030 2040 2050
IAIMREKHTA LMKPIVFALE HVRSITAAPA ETPHEKWFQD NYGDAIDNAL
2060 2070 2080 2090 2100
EKLKTPSNPA KPGSSWIPFK EIMLSLQQRA QKRASYILRL DEISPWLAAM
2110 2120 2130 2140 2150
TNTEIALPGE VSARDTVTIH SVGGTITILP TKTKPKKLLF LGSDGKSYPY
2160 2170 2180 2190 2200
LFKGLEDLHL DERIMQFLSI VNTMFATINR QETPRFHARH YSVTPLGTRS
2210 2220 2230 2240 2250
GLIQWVDGAT PLFGLYKRWQ QREAALQAQK AQDSYQTPQN PSIVPRPSEL
2260 2270 2280 2290 2300
YYSKIGPALK TVGLSLDVSR RDWPLHVMKA VLEELMEATP PNLLAKELWS
2310 2320 2330 2340 2350
SCTTPDEWWR VTQSYARSTA VMSMVGYIIG LGDRHLDNVL IDMTTGEVVH
2360 2370 2380 2390 2400
IDYNVCFEKG KSLRVPEKVP FRMTQNIETA LGVTGVEGVF RLSCEQVLHI
2410 2420 2430 2440 2450
MRRGRETLLT LLEAFVYDPL VDWTAGGEAG FAGAVYGGGG QQAESKQSKR
2460 2470 2480 2490 2500
EMEREITRSL FSSRVAEIKV NWFKNRDEML VVLPKLDSSL DEYLSLQEQL
2510 2520 2530 2540 2550
TDVEKLQGKL LEEIEFLEGA EGVDHPSHTL QHRYSEHTQL QTQQRAVQEA
2560 2570 2580 2590 2600
IQVKLNEFEQ WITHYQAAFN NLEATQLASL LQEISTQMDL GPPSYVPATA
2610 2620 2630 2640 2650
FLQNAGQAHL ISQCEQLEGE VGALLQQRRS VLRGCLEQLH HYATVALQYP
2660 2670 2680 2690 2700
KAIFQKHRIE QWKAWMEELI CNTTVERCQE LYRKYEMQYA PQPPPTVCQF
2710 2720 2730 2740 2750
ITATEMTLQR YAADINSRLI RQVERLKQEA VTVPVCEDQL KEIERCIKVF
2760 2770 2780 2790 2800
LHENGEEGSL SLASVIISAL CTLTRRNLMM EGAASSAGEQ LVDLTSRDGA
2810 2820 2830 2840 2850
WFLEELCSMS GNVTCLVQLL KQCHLVPQDL DIPNPVEASE AVHLANGVYT
2860 2870 2880 2890 2900
SLQELNSNFR QIIFPEALRC LMKGECTLES MLHELDSLIE QTTDGVPLQT
2910 2920 2930 2940 2950
LVESLQAYLR NTAMGLEEET HAHYIDVARM LHAQYGELIQ PRNGSVDETP
2960 2970 2980 2990 3000
KMSAGQMLLV AFDGMFAQVE TAFGLLVEKL NKMEIPVAWR KIDIIREARS
3010 3020 3030 3040 3050
TQVNFFDDDN HRQVLEEIFF LKRLQTIKEF FRLCGTFSKT LSGSSSLEDQ
3060 3070 3080 3090 3100
NTVNGPVQIV NVKTLFRNSC FSEDQMAKPI KAFTADFVRQ LLIGLPNQAL
3110 3120 3130 3140 3150
GLTLCSFISA LGVDIIAQVE AKDFGAESKV SVDDLCKKAV EHNIQVGKFS
3160 3170 3180 3190 3200
QLVMNRATVL ASSYDTAWKK HDLVRRLETS ISSCKTSLQR VQLHIAMFQW
3210 3220 3230 3240 3250
QHEDLLISRP QAMSVTPPRS AILTSMKKKL HALSQIETSI GTVQEKLAAL
3260 3270 3280 3290 3300
EASIEQRLKW AGGANPALAP VLQDFEATIA ERRNLVLKES QRANQVTFLC
3310 3320 3330 3340 3350
SNIIHFESLR TRTAEALSLD AALFELIKRC QQMCSFASQF NSSVSELELR
3360 3370 3380 3390 3400
LLQRVDTTLE HPIGSSEWLL SAHKQLTQDM STQRAVQTEK EQQIETVCET
3410 3420 3430 3440 3450
IQSLVDSVKT VLTGHNRQLG DVKHLLKAMA KDEEAALADA EDIPYESSVR
3460 3470 3480 3490 3500
QFLAEYKSWQ DNIQTVLFTL VQAMGQVRSQ EHVEMLQEIT PTLKELKTQS
3510 3520 3530 3540 3550
QSIYNNLVSF ASPLVTDAAN ECSSPTSSAT YQPSFAAAVR SNTGQKTQPD
3560 3570 3580 3590 3600
VMSQNAKKLI QKNLATSADT PPSTIPGTGK SIACSPKKAV RDPKTGKAVQ
3610 3620 3630 3640 3650
ERNSYAVSVW KRVKAKLEGR DVDPNRRMSV AEQVDYVIKE ATNLDNLAQL

YEGWTAWV
Length:3,658
Mass (Da):409,769
Last modified:July 27, 2011 - v3
Checksum:i8C13F45BE0D35042
GO
Isoform 2 (identifier: Q8BKX6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     273-284: LVMTSLQSILEN → VRARDPQCSAVR
     285-3658: Missing.

Note: No experimental confirmation available.

Show »
Length:284
Mass (Da):31,739
Checksum:i8B0693F8E27FF13D
GO
Isoform 3 (identifier: Q8BKX6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     431-433: LYR → SVF
     434-3658: Missing.

Note: No experimental confirmation available.

Show »
Length:433
Mass (Da):48,246
Checksum:i4A48D537C9327637
GO

Sequence cautioni

The sequence BAD90238.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti566 – 5661I → V in BAC33168. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei273 – 28412LVMTS…SILEN → VRARDPQCSAVR in isoform 2. 1 PublicationVSP_017749Add
BLAST
Alternative sequencei285 – 36583374Missing in isoform 2. 1 PublicationVSP_017750Add
BLAST
Alternative sequencei431 – 4333LYR → SVF in isoform 3. 1 PublicationVSP_017751
Alternative sequencei434 – 36583225Missing in isoform 3. 1 PublicationVSP_017752Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC131788 Genomic DNA. No translation available.
AC132432 Genomic DNA. No translation available.
AK129136 mRNA. Translation: BAC97946.1.
AK220328 mRNA. Translation: BAD90238.1. Different initiation.
AK041264 mRNA. Translation: BAC30884.2.
AK047829 mRNA. Translation: BAC33168.2.
AK049391 mRNA. Translation: BAC33729.1.
AK052331 mRNA. Translation: BAC34941.1.
CCDSiCCDS40102.1. [Q8BKX6-1]
RefSeqiNP_001026984.1. NM_001031814.1. [Q8BKX6-1]
UniGeneiMm.309053.

Genome annotation databases

EnsembliENSMUST00000032891; ENSMUSP00000032891; ENSMUSG00000030655. [Q8BKX6-1]
GeneIDi233789.
KEGGimmu:233789.
UCSCiuc009jjp.1. mouse. [Q8BKX6-1]
uc009jjq.1. mouse. [Q8BKX6-3]
uc009jjr.1. mouse. [Q8BKX6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC131788 Genomic DNA. No translation available.
AC132432 Genomic DNA. No translation available.
AK129136 mRNA. Translation: BAC97946.1 .
AK220328 mRNA. Translation: BAD90238.1 . Different initiation.
AK041264 mRNA. Translation: BAC30884.2 .
AK047829 mRNA. Translation: BAC33168.2 .
AK049391 mRNA. Translation: BAC33729.1 .
AK052331 mRNA. Translation: BAC34941.1 .
CCDSi CCDS40102.1. [Q8BKX6-1 ]
RefSeqi NP_001026984.1. NM_001031814.1. [Q8BKX6-1 ]
UniGenei Mm.309053.

3D structure databases

ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BKX6.

Proteomic databases

MaxQBi Q8BKX6.
PaxDbi Q8BKX6.
PRIDEi Q8BKX6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032891 ; ENSMUSP00000032891 ; ENSMUSG00000030655 . [Q8BKX6-1 ]
GeneIDi 233789.
KEGGi mmu:233789.
UCSCi uc009jjp.1. mouse. [Q8BKX6-1 ]
uc009jjq.1. mouse. [Q8BKX6-3 ]
uc009jjr.1. mouse. [Q8BKX6-2 ]

Organism-specific databases

CTDi 23049.
MGIi MGI:1919742. Smg1.
Rougei Search...

Phylogenomic databases

eggNOGi COG5032.
GeneTreei ENSGT00760000119359.
HOVERGENi HBG093965.
InParanoidi Q8BKX6.
KOi K08873.
OMAi LMIVHGD.
OrthoDBi EOG7RV9F7.
TreeFami TF352560.

Enzyme and pathway databases

Reactomei REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSi SMG1. mouse.
NextBioi 381825.
PROi Q8BKX6.
SOURCEi Search...

Gene expression databases

Bgeei Q8BKX6.
CleanExi MM_2610207I05RIK.
ExpressionAtlasi Q8BKX6. baseline and differential.
Genevestigatori Q8BKX6.

Family and domain databases

Gene3Di 1.10.1070.11. 3 hits.
InterProi IPR016024. ARM-type_fold.
IPR003152. FATC.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR014009. PIK_FAT.
[Graphical view ]
Pfami PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view ]
SMARTi SM00146. PI3Kc. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 4 hits.
SSF56112. SSF56112. 2 hits.
PROSITEi PS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2976-3658.
    Tissue: Fetal brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1996 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Aorta, Head, Heart and Vein.
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 67-73, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-171, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiSMG1_MOUSE
AccessioniPrimary (citable) accession number: Q8BKX6
Secondary accession number(s): E9QLR6
, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3