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Q8BKX6 (SMG1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase SMG1

Short name=SMG-1
EC=2.7.11.1
Gene names
Name:Smg1
Synonyms:Kiaa0421
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length3658 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Manganese By similarity.

Enzyme regulation

Inhibited by caffeine, LY294002 and wortmannin.

Subunit structure

Component of the SMG1C complex composed of SMG1, SMG8 and SMG9; the recruitment of SMG8 to SMG1 N-terminus induces a large conformational change in the SMG1 C-terminal head domain containing the catalytic domain. Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. Interacts with PRKCI. Interacts with TELO2 and TTI1. Interacts with RUVBL1 and RUVBL2.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity.

Post-translational modification

Autophosphorylated.

Sequence similarities

Belongs to the PI3/PI4-kinase family.

Contains 1 FAT domain.

Contains 1 FATC domain.

Contains 1 HEAT repeat.

Contains 1 PI3K/PI4K domain.

Sequence caution

The sequence BAD90238.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8BKX6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8BKX6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     273-284: LVMTSLQSILEN → VRARDPQCSAVR
     285-3658: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8BKX6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     431-433: LYR → SVF
     434-3658: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 36583658Serine/threonine-protein kinase SMG1
PRO_0000229792

Regions

Domain1129 – 1864736FAT
Repeat1815 – 185036HEAT
Domain2148 – 2476329PI3K/PI4K
Domain3626 – 365833FATC

Amino acid modifications

Modified residue1711N6-acetyllysine Ref.6
Modified residue35471Phosphothreonine By similarity
Modified residue35531Phosphoserine By similarity
Modified residue35671Phosphoserine By similarity
Modified residue35701Phosphothreonine By similarity

Natural variations

Alternative sequence273 – 28412LVMTS…SILEN → VRARDPQCSAVR in isoform 2.
VSP_017749
Alternative sequence285 – 36583374Missing in isoform 2.
VSP_017750
Alternative sequence431 – 4333LYR → SVF in isoform 3.
VSP_017751
Alternative sequence434 – 36583225Missing in isoform 3.
VSP_017752

Experimental info

Sequence conflict5661I → V in BAC33168. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 8C13F45BE0D35042

FASTA3,658409,769
        10         20         30         40         50         60 
MSRRAPGSRL SSGGGGTKYP RSWNDWQPRT DSASADPDTL KYSSSRDRGV SSSYGLQPSN 

        70         80         90        100        110        120 
SAVVSRQRHD DTRGHADIQN DEKGGYSVNG GSGENTYGRK SLGQELRINN VTSPEFTSVQ 

       130        140        150        160        170        180 
HGSRALATKD MRKSQERSMS YSDESRLSNL LRRITREDDR DRRLATVKQL KEFIQQPENK 

       190        200        210        220        230        240 
LVLVKQLDNI LAAVHDVLNE SSKLLQELRQ EGACCLGLLC ASLSYEAEKI FKWIFSKFSS 

       250        260        270        280        290        300 
SAKDEVKLLY LCATYRALET VGEKKAFSSV MQLVMTSLQS ILENVDTPEL LCKCVKCILL 

       310        320        330        340        350        360 
VARCYPHIFS TNFRDTVDIL VGWHIDHTQK PSLTQQVSGW LQSLEPFWVA DLAFSTTLLG 

       370        380        390        400        410        420 
QFLEDMEAYA EDLSHVASGE SVDEDVPPPS VSLPKLAALL RVFSTVVRSI GERFSPIRGP 

       430        440        450        460        470        480 
PITEAYVTDV LYRVMRCVTA ANQVFFSEAV LTAANECVGV LLGSLDPSMT IHCDMVITYG 

       490        500        510        520        530        540 
LDQLENCQTC GTDYIISVLN LLTLIVEQIN TKLPSSFVEK LFIPSSKLLF LRYHKEKEVV 

       550        560        570        580        590        600 
AVAHAVYQAV LSLKNIPVLE TAYKLILGEM TCALNNLLHS LQLPDACSEI KHEAFQNHVF 

       610        620        630        640        650        660 
NIDNANFVVI FDLSALTTIG NAKNSLIGMW ALSPTVFALL SKNLMIVHSD LAVHFPAIQY 

       670        680        690        700        710        720 
AVLYTLYSHC TRHDHFISSS LSSSSPSLFD GAVISTVTTA TKKHFSIILN LLGILLKKDN 

       730        740        750        760        770        780 
LNQDTRKLLM TWALEVAVLM KKSETYAPLF SLPSFHKFSK GLLANTLVED VNICLQACSS 

       790        800        810        820        830        840 
LHALSSSLPD DLLQRCVDVC RVQLVHSGTR IRQAFGKLLK SIPLDVVLSN NNHTEIQEIS 

       850        860        870        880        890        900 
LALRSHMSKA PSNTFHPQDF SDVISFILYG NSHRTGKDNW LERLFYSCQR LDKRDQSTIP 

       910        920        930        940        950        960 
RNLLKTDAVL WQWAIWEAAQ FTVLSKLRTP LGRAQDTFQT IEGIIRSLAA HTLNPDQDVS 

       970        980        990       1000       1010       1020 
QWTTADNDEG HGSNQLRLVL LLQYLENLEK LMYNAYEGCA NALTSPPKVI RTFFYTNRQT 

      1030       1040       1050       1060       1070       1080 
CQDWLTRIRL SIMRVGLLAG QPAVTVRHGF DLLTEMKTNS LTQGSELEVT IMMVVEALCE 

      1090       1100       1110       1120       1130       1140 
LHCPEAIQGI AVWSSSAVGK NLLWINSVAQ QAEGRFEKAS VEYQEHLCAM TGVDCCISSF 

      1150       1160       1170       1180       1190       1200 
DKSVLTLANA GRNSASPKHS LNGESRKTVL SKSIDSSPEV ISYLGNKACE CYISIADWAA 

      1210       1220       1230       1240       1250       1260 
VQEWQNAVHD LKKNSSSTSL NLKADFNYIK SLSSFESGEF VECTEQLELL PGENINLLAG 

      1270       1280       1290       1300       1310       1320 
GSKEKIDMKK LLPNMLSPDP RELQKSIEVQ LLRSSVFLAT ALNHMEQDQK WQSLTENVVK 

      1330       1340       1350       1360       1370       1380 
YLKQTSRIAI GPLRLSTLTV SQSLPVLSTL QLYCSSALEN TVSNRLSTED CLIPLFSDAL 

      1390       1400       1410       1420       1430       1440 
RSCKQHDVRP WMQALRYTMY QNQLLEKIKE QTVPIRSHLM ELGLTAAKFA RKRGNVSLAT 

      1450       1460       1470       1480       1490       1500 
RLLAQCSEVQ LGKTTTAQDL VQHFKKLSTQ GQVDEKWGPE LDIEKTKLLY TAGQSTHAME 

      1510       1520       1530       1540       1550       1560 
MLSSCAISFC KSAKAEYAVA KSILTLAKWV QAEWKEISGQ LRQVYRAQQQ QNLSGLSTLS 

      1570       1580       1590       1600       1610       1620 
RNILALIELP SANTVGEEHP RIESESTVHI GVGEPDFILG QLYHLSSVQA PEVAKSWAAL 

      1630       1640       1650       1660       1670       1680 
ASWAYRWGRK VVDNASQGEG VRLLPREKSE VQNLLPDTIT EEEKERIYGI LGQAVCRPAG 

      1690       1700       1710       1720       1730       1740 
IQDEDITLQI TESEDNEDDD MVDVIWRQLI SSCPWLSELD ENATEGVIKV WRKVVDRIFS 

      1750       1760       1770       1780       1790       1800 
LYKLSCSAYF TFLKLNAGQV LLDEDDPRLH LSHRAEQSTD DVIVMATLRL LRLLVKHAGE 

      1810       1820       1830       1840       1850       1860 
LRQYLEHGLE TTPTAPWRGI IPQLFSRLNH PEVYVRQSIC NLLCRVAQDS PHLILYPAIV 

      1870       1880       1890       1900       1910       1920 
GTISLSSESQ ASGNKYSSAI PTLLGNIQGE ELLVSECEGG SPPASQDSNK DEPKSGLNED 

      1930       1940       1950       1960       1970       1980 
QAMMQDCYSK IVDKLSSANP TMVLQVQMLV AELRRVTVLW DELWLGVLLQ QHMYVLRRIQ 

      1990       2000       2010       2020       2030       2040 
QLEDEVKRVQ NNNTLRKEEK IAIMREKHTA LMKPIVFALE HVRSITAAPA ETPHEKWFQD 

      2050       2060       2070       2080       2090       2100 
NYGDAIDNAL EKLKTPSNPA KPGSSWIPFK EIMLSLQQRA QKRASYILRL DEISPWLAAM 

      2110       2120       2130       2140       2150       2160 
TNTEIALPGE VSARDTVTIH SVGGTITILP TKTKPKKLLF LGSDGKSYPY LFKGLEDLHL 

      2170       2180       2190       2200       2210       2220 
DERIMQFLSI VNTMFATINR QETPRFHARH YSVTPLGTRS GLIQWVDGAT PLFGLYKRWQ 

      2230       2240       2250       2260       2270       2280 
QREAALQAQK AQDSYQTPQN PSIVPRPSEL YYSKIGPALK TVGLSLDVSR RDWPLHVMKA 

      2290       2300       2310       2320       2330       2340 
VLEELMEATP PNLLAKELWS SCTTPDEWWR VTQSYARSTA VMSMVGYIIG LGDRHLDNVL 

      2350       2360       2370       2380       2390       2400 
IDMTTGEVVH IDYNVCFEKG KSLRVPEKVP FRMTQNIETA LGVTGVEGVF RLSCEQVLHI 

      2410       2420       2430       2440       2450       2460 
MRRGRETLLT LLEAFVYDPL VDWTAGGEAG FAGAVYGGGG QQAESKQSKR EMEREITRSL 

      2470       2480       2490       2500       2510       2520 
FSSRVAEIKV NWFKNRDEML VVLPKLDSSL DEYLSLQEQL TDVEKLQGKL LEEIEFLEGA 

      2530       2540       2550       2560       2570       2580 
EGVDHPSHTL QHRYSEHTQL QTQQRAVQEA IQVKLNEFEQ WITHYQAAFN NLEATQLASL 

      2590       2600       2610       2620       2630       2640 
LQEISTQMDL GPPSYVPATA FLQNAGQAHL ISQCEQLEGE VGALLQQRRS VLRGCLEQLH 

      2650       2660       2670       2680       2690       2700 
HYATVALQYP KAIFQKHRIE QWKAWMEELI CNTTVERCQE LYRKYEMQYA PQPPPTVCQF 

      2710       2720       2730       2740       2750       2760 
ITATEMTLQR YAADINSRLI RQVERLKQEA VTVPVCEDQL KEIERCIKVF LHENGEEGSL 

      2770       2780       2790       2800       2810       2820 
SLASVIISAL CTLTRRNLMM EGAASSAGEQ LVDLTSRDGA WFLEELCSMS GNVTCLVQLL 

      2830       2840       2850       2860       2870       2880 
KQCHLVPQDL DIPNPVEASE AVHLANGVYT SLQELNSNFR QIIFPEALRC LMKGECTLES 

      2890       2900       2910       2920       2930       2940 
MLHELDSLIE QTTDGVPLQT LVESLQAYLR NTAMGLEEET HAHYIDVARM LHAQYGELIQ 

      2950       2960       2970       2980       2990       3000 
PRNGSVDETP KMSAGQMLLV AFDGMFAQVE TAFGLLVEKL NKMEIPVAWR KIDIIREARS 

      3010       3020       3030       3040       3050       3060 
TQVNFFDDDN HRQVLEEIFF LKRLQTIKEF FRLCGTFSKT LSGSSSLEDQ NTVNGPVQIV 

      3070       3080       3090       3100       3110       3120 
NVKTLFRNSC FSEDQMAKPI KAFTADFVRQ LLIGLPNQAL GLTLCSFISA LGVDIIAQVE 

      3130       3140       3150       3160       3170       3180 
AKDFGAESKV SVDDLCKKAV EHNIQVGKFS QLVMNRATVL ASSYDTAWKK HDLVRRLETS 

      3190       3200       3210       3220       3230       3240 
ISSCKTSLQR VQLHIAMFQW QHEDLLISRP QAMSVTPPRS AILTSMKKKL HALSQIETSI 

      3250       3260       3270       3280       3290       3300 
GTVQEKLAAL EASIEQRLKW AGGANPALAP VLQDFEATIA ERRNLVLKES QRANQVTFLC 

      3310       3320       3330       3340       3350       3360 
SNIIHFESLR TRTAEALSLD AALFELIKRC QQMCSFASQF NSSVSELELR LLQRVDTTLE 

      3370       3380       3390       3400       3410       3420 
HPIGSSEWLL SAHKQLTQDM STQRAVQTEK EQQIETVCET IQSLVDSVKT VLTGHNRQLG 

      3430       3440       3450       3460       3470       3480 
DVKHLLKAMA KDEEAALADA EDIPYESSVR QFLAEYKSWQ DNIQTVLFTL VQAMGQVRSQ 

      3490       3500       3510       3520       3530       3540 
EHVEMLQEIT PTLKELKTQS QSIYNNLVSF ASPLVTDAAN ECSSPTSSAT YQPSFAAAVR 

      3550       3560       3570       3580       3590       3600 
SNTGQKTQPD VMSQNAKKLI QKNLATSADT PPSTIPGTGK SIACSPKKAV RDPKTGKAVQ 

      3610       3620       3630       3640       3650 
ERNSYAVSVW KRVKAKLEGR DVDPNRRMSV AEQVDYVIKE ATNLDNLAQL YEGWTAWV 

« Hide

Isoform 2 [UniParc].

Checksum: 8B0693F8E27FF13D
Show »

FASTA28431,739
Isoform 3 [UniParc].

Checksum: 4A48D537C9327637
Show »

FASTA43348,246

References

« Hide 'large scale' references
[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2976-3658.
Tissue: Fetal brain.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1996 (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Aorta, Head, Heart and Vein.
[4]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 67-73, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
[5]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[6]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-171, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC131788 Genomic DNA. No translation available.
AC132432 Genomic DNA. No translation available.
AK129136 mRNA. Translation: BAC97946.1.
AK220328 mRNA. Translation: BAD90238.1. Different initiation.
AK041264 mRNA. Translation: BAC30884.2.
AK047829 mRNA. Translation: BAC33168.2.
AK049391 mRNA. Translation: BAC33729.1.
AK052331 mRNA. Translation: BAC34941.1.
CCDSCCDS40102.1. [Q8BKX6-1]
RefSeqNP_001026984.1. NM_001031814.1. [Q8BKX6-1]
UniGeneMm.309053.

3D structure databases

ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8BKX6.

Proteomic databases

MaxQBQ8BKX6.
PaxDbQ8BKX6.
PRIDEQ8BKX6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032891; ENSMUSP00000032891; ENSMUSG00000030655. [Q8BKX6-1]
GeneID233789.
KEGGmmu:233789.
UCSCuc009jjp.1. mouse. [Q8BKX6-1]
uc009jjq.1. mouse. [Q8BKX6-3]
uc009jjr.1. mouse. [Q8BKX6-2]

Organism-specific databases

CTD23049.
MGIMGI:1919742. Smg1.
RougeSearch...

Phylogenomic databases

eggNOGCOG5032.
GeneTreeENSGT00720000108744.
HOVERGENHBG093965.
InParanoidQ8BKX6.
KOK08873.
OMALMIVHGD.
OrthoDBEOG7RV9F7.
TreeFamTF352560.

Gene expression databases

BgeeQ8BKX6.
CleanExMM_2610207I05RIK.
GenevestigatorQ8BKX6.

Family and domain databases

Gene3D1.10.1070.11. 3 hits.
InterProIPR016024. ARM-type_fold.
IPR003152. FATC.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR014009. PIK_FAT.
[Graphical view]
PfamPF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTSM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 4 hits.
SSF56112. SSF56112. 2 hits.
PROSITEPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSMG1. mouse.
NextBio381825.
PROQ8BKX6.
SOURCESearch...

Entry information

Entry nameSMG1_MOUSE
AccessionPrimary (citable) accession number: Q8BKX6
Secondary accession number(s): E9QLR6 expand/collapse secondary AC list , Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot