Q8BKX6 (SMG1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase SMG1
Short name=SMG-1
EC=2.7.11.1

Gene names

Name:	Smg1
Synonyms:	Kiaa0421

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	3658 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Cofactor	Manganese By similarity.
Enzyme regulation	Inhibited by caffeine, LY294002 and wortmannin.
Subunit structure	Component of the SMG1C complex composed of SMG1, SMG8 and SMG9; the recruitment of SMG8 to SMG1 N-terminus induces a large conformational change in the SMG1 C-terminal head domain containing the catalytic domain. Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. Interacts with PRKCI. Interacts with TELO2 and TTI1. Interacts with RUVBL1 and RUVBL2.
Subcellular location	Nucleus By similarity. Cytoplasm By similarity.
Post-translational modification	Autophosphorylated.
Sequence similarities	Belongs to the PI3/PI4-kinase family. Contains 1 FAT domain. Contains 1 FATC domain. Contains 1 HEAT repeat. Contains 1 PI3K/PI4K domain.
Sequence caution	The sequence BAD90238.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	DNA damage DNA repair Nonsense-mediated mRNA decay
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Ligand	ATP-binding Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Inferred from electronic annotation. Source: UniProtKB-KW peptidyl-serine phosphorylation Inferred from electronic annotation. Source: Compara phosphatidylinositol phosphorylation Inferred from electronic annotation. Source: Compara protein autophosphorylation Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8BKX6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8BKX6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     273-284: LVMTSLQSILEN → VRARDPQCSAVR
     285-3658: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8BKX6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     431-433: LYR → SVF
     434-3658: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 3658	3658	Serine/threonine-protein kinase SMG1		PRO_0000229792
Regions
	Domain	1129 – 1864	736	FAT
	Repeat	1815 – 1850	36	HEAT
	Domain	2148 – 2476	329	PI3K/PI4K
	Domain	3626 – 3658	33	FATC
Amino acid modifications
	Modified residue	171	1	N6-acetyllysine By similarity
	Modified residue	3547	1	Phosphothreonine By similarity
	Modified residue	3553	1	Phosphoserine By similarity
	Modified residue	3567	1	Phosphoserine By similarity
	Modified residue	3570	1	Phosphothreonine By similarity
	Modified residue	3574	1	Phosphothreonine Ref.5
Natural variations
	Alternative sequence	273 – 284	12	LVMTS…SILEN → VRARDPQCSAVR in isoform 2.		VSP_017749
	Alternative sequence	285 – 3658	3374	Missing in isoform 2.		VSP_017750
	Alternative sequence	431 – 433	3	LYR → SVF in isoform 3.		VSP_017751
	Alternative sequence	434 – 3658	3225	Missing in isoform 3.		VSP_017752
Experimental info
	Sequence conflict	566	1	I → V in BAC33168. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 27, 2011. Version 3. Checksum: 8C13F45BE0D35042	FASTA	3,658	409,769
	10 20 30 40 50 60 MSRRAPGSRL SSGGGGTKYP RSWNDWQPRT DSASADPDTL KYSSSRDRGV SSSYGLQPSN 70 80 90 100 110 120 SAVVSRQRHD DTRGHADIQN DEKGGYSVNG GSGENTYGRK SLGQELRINN VTSPEFTSVQ 130 140 150 160 170 180 HGSRALATKD MRKSQERSMS YSDESRLSNL LRRITREDDR DRRLATVKQL KEFIQQPENK 190 200 210 220 230 240 LVLVKQLDNI LAAVHDVLNE SSKLLQELRQ EGACCLGLLC ASLSYEAEKI FKWIFSKFSS 250 260 270 280 290 300 SAKDEVKLLY LCATYRALET VGEKKAFSSV MQLVMTSLQS ILENVDTPEL LCKCVKCILL 310 320 330 340 350 360 VARCYPHIFS TNFRDTVDIL VGWHIDHTQK PSLTQQVSGW LQSLEPFWVA DLAFSTTLLG 370 380 390 400 410 420 QFLEDMEAYA EDLSHVASGE SVDEDVPPPS VSLPKLAALL RVFSTVVRSI GERFSPIRGP 430 440 450 460 470 480 PITEAYVTDV LYRVMRCVTA ANQVFFSEAV LTAANECVGV LLGSLDPSMT IHCDMVITYG 490 500 510 520 530 540 LDQLENCQTC GTDYIISVLN LLTLIVEQIN TKLPSSFVEK LFIPSSKLLF LRYHKEKEVV 550 560 570 580 590 600 AVAHAVYQAV LSLKNIPVLE TAYKLILGEM TCALNNLLHS LQLPDACSEI KHEAFQNHVF 610 620 630 640 650 660 NIDNANFVVI FDLSALTTIG NAKNSLIGMW ALSPTVFALL SKNLMIVHSD LAVHFPAIQY 670 680 690 700 710 720 AVLYTLYSHC TRHDHFISSS LSSSSPSLFD GAVISTVTTA TKKHFSIILN LLGILLKKDN 730 740 750 760 770 780 LNQDTRKLLM TWALEVAVLM KKSETYAPLF SLPSFHKFSK GLLANTLVED VNICLQACSS 790 800 810 820 830 840 LHALSSSLPD DLLQRCVDVC RVQLVHSGTR IRQAFGKLLK SIPLDVVLSN NNHTEIQEIS 850 860 870 880 890 900 LALRSHMSKA PSNTFHPQDF SDVISFILYG NSHRTGKDNW LERLFYSCQR LDKRDQSTIP 910 920 930 940 950 960 RNLLKTDAVL WQWAIWEAAQ FTVLSKLRTP LGRAQDTFQT IEGIIRSLAA HTLNPDQDVS 970 980 990 1000 1010 1020 QWTTADNDEG HGSNQLRLVL LLQYLENLEK LMYNAYEGCA NALTSPPKVI RTFFYTNRQT 1030 1040 1050 1060 1070 1080 CQDWLTRIRL SIMRVGLLAG QPAVTVRHGF DLLTEMKTNS LTQGSELEVT IMMVVEALCE 1090 1100 1110 1120 1130 1140 LHCPEAIQGI AVWSSSAVGK NLLWINSVAQ QAEGRFEKAS VEYQEHLCAM TGVDCCISSF 1150 1160 1170 1180 1190 1200 DKSVLTLANA GRNSASPKHS LNGESRKTVL SKSIDSSPEV ISYLGNKACE CYISIADWAA 1210 1220 1230 1240 1250 1260 VQEWQNAVHD LKKNSSSTSL NLKADFNYIK SLSSFESGEF VECTEQLELL PGENINLLAG 1270 1280 1290 1300 1310 1320 GSKEKIDMKK LLPNMLSPDP RELQKSIEVQ LLRSSVFLAT ALNHMEQDQK WQSLTENVVK 1330 1340 1350 1360 1370 1380 YLKQTSRIAI GPLRLSTLTV SQSLPVLSTL QLYCSSALEN TVSNRLSTED CLIPLFSDAL 1390 1400 1410 1420 1430 1440 RSCKQHDVRP WMQALRYTMY QNQLLEKIKE QTVPIRSHLM ELGLTAAKFA RKRGNVSLAT 1450 1460 1470 1480 1490 1500 RLLAQCSEVQ LGKTTTAQDL VQHFKKLSTQ GQVDEKWGPE LDIEKTKLLY TAGQSTHAME 1510 1520 1530 1540 1550 1560 MLSSCAISFC KSAKAEYAVA KSILTLAKWV QAEWKEISGQ LRQVYRAQQQ QNLSGLSTLS 1570 1580 1590 1600 1610 1620 RNILALIELP SANTVGEEHP RIESESTVHI GVGEPDFILG QLYHLSSVQA PEVAKSWAAL 1630 1640 1650 1660 1670 1680 ASWAYRWGRK VVDNASQGEG VRLLPREKSE VQNLLPDTIT EEEKERIYGI LGQAVCRPAG 1690 1700 1710 1720 1730 1740 IQDEDITLQI TESEDNEDDD MVDVIWRQLI SSCPWLSELD ENATEGVIKV WRKVVDRIFS 1750 1760 1770 1780 1790 1800 LYKLSCSAYF TFLKLNAGQV LLDEDDPRLH LSHRAEQSTD DVIVMATLRL LRLLVKHAGE 1810 1820 1830 1840 1850 1860 LRQYLEHGLE TTPTAPWRGI IPQLFSRLNH PEVYVRQSIC NLLCRVAQDS PHLILYPAIV 1870 1880 1890 1900 1910 1920 GTISLSSESQ ASGNKYSSAI PTLLGNIQGE ELLVSECEGG SPPASQDSNK DEPKSGLNED 1930 1940 1950 1960 1970 1980 QAMMQDCYSK IVDKLSSANP TMVLQVQMLV AELRRVTVLW DELWLGVLLQ QHMYVLRRIQ 1990 2000 2010 2020 2030 2040 QLEDEVKRVQ NNNTLRKEEK IAIMREKHTA LMKPIVFALE HVRSITAAPA ETPHEKWFQD 2050 2060 2070 2080 2090 2100 NYGDAIDNAL EKLKTPSNPA KPGSSWIPFK EIMLSLQQRA QKRASYILRL DEISPWLAAM 2110 2120 2130 2140 2150 2160 TNTEIALPGE VSARDTVTIH SVGGTITILP TKTKPKKLLF LGSDGKSYPY LFKGLEDLHL 2170 2180 2190 2200 2210 2220 DERIMQFLSI VNTMFATINR QETPRFHARH YSVTPLGTRS GLIQWVDGAT PLFGLYKRWQ 2230 2240 2250 2260 2270 2280 QREAALQAQK AQDSYQTPQN PSIVPRPSEL YYSKIGPALK TVGLSLDVSR RDWPLHVMKA 2290 2300 2310 2320 2330 2340 VLEELMEATP PNLLAKELWS SCTTPDEWWR VTQSYARSTA VMSMVGYIIG LGDRHLDNVL 2350 2360 2370 2380 2390 2400 IDMTTGEVVH IDYNVCFEKG KSLRVPEKVP FRMTQNIETA LGVTGVEGVF RLSCEQVLHI 2410 2420 2430 2440 2450 2460 MRRGRETLLT LLEAFVYDPL VDWTAGGEAG FAGAVYGGGG QQAESKQSKR EMEREITRSL 2470 2480 2490 2500 2510 2520 FSSRVAEIKV NWFKNRDEML VVLPKLDSSL DEYLSLQEQL TDVEKLQGKL LEEIEFLEGA 2530 2540 2550 2560 2570 2580 EGVDHPSHTL QHRYSEHTQL QTQQRAVQEA IQVKLNEFEQ WITHYQAAFN NLEATQLASL 2590 2600 2610 2620 2630 2640 LQEISTQMDL GPPSYVPATA FLQNAGQAHL ISQCEQLEGE VGALLQQRRS VLRGCLEQLH 2650 2660 2670 2680 2690 2700 HYATVALQYP KAIFQKHRIE QWKAWMEELI CNTTVERCQE LYRKYEMQYA PQPPPTVCQF 2710 2720 2730 2740 2750 2760 ITATEMTLQR YAADINSRLI RQVERLKQEA VTVPVCEDQL KEIERCIKVF LHENGEEGSL 2770 2780 2790 2800 2810 2820 SLASVIISAL CTLTRRNLMM EGAASSAGEQ LVDLTSRDGA WFLEELCSMS GNVTCLVQLL 2830 2840 2850 2860 2870 2880 KQCHLVPQDL DIPNPVEASE AVHLANGVYT SLQELNSNFR QIIFPEALRC LMKGECTLES 2890 2900 2910 2920 2930 2940 MLHELDSLIE QTTDGVPLQT LVESLQAYLR NTAMGLEEET HAHYIDVARM LHAQYGELIQ 2950 2960 2970 2980 2990 3000 PRNGSVDETP KMSAGQMLLV AFDGMFAQVE TAFGLLVEKL NKMEIPVAWR KIDIIREARS 3010 3020 3030 3040 3050 3060 TQVNFFDDDN HRQVLEEIFF LKRLQTIKEF FRLCGTFSKT LSGSSSLEDQ NTVNGPVQIV 3070 3080 3090 3100 3110 3120 NVKTLFRNSC FSEDQMAKPI KAFTADFVRQ LLIGLPNQAL GLTLCSFISA LGVDIIAQVE 3130 3140 3150 3160 3170 3180 AKDFGAESKV SVDDLCKKAV EHNIQVGKFS QLVMNRATVL ASSYDTAWKK HDLVRRLETS 3190 3200 3210 3220 3230 3240 ISSCKTSLQR VQLHIAMFQW QHEDLLISRP QAMSVTPPRS AILTSMKKKL HALSQIETSI 3250 3260 3270 3280 3290 3300 GTVQEKLAAL EASIEQRLKW AGGANPALAP VLQDFEATIA ERRNLVLKES QRANQVTFLC 3310 3320 3330 3340 3350 3360 SNIIHFESLR TRTAEALSLD AALFELIKRC QQMCSFASQF NSSVSELELR LLQRVDTTLE 3370 3380 3390 3400 3410 3420 HPIGSSEWLL SAHKQLTQDM STQRAVQTEK EQQIETVCET IQSLVDSVKT VLTGHNRQLG 3430 3440 3450 3460 3470 3480 DVKHLLKAMA KDEEAALADA EDIPYESSVR QFLAEYKSWQ DNIQTVLFTL VQAMGQVRSQ 3490 3500 3510 3520 3530 3540 EHVEMLQEIT PTLKELKTQS QSIYNNLVSF ASPLVTDAAN ECSSPTSSAT YQPSFAAAVR 3550 3560 3570 3580 3590 3600 SNTGQKTQPD VMSQNAKKLI QKNLATSADT PPSTIPGTGK SIACSPKKAV RDPKTGKAVQ 3610 3620 3630 3640 3650 ERNSYAVSVW KRVKAKLEGR DVDPNRRMSV AEQVDYVIKE ATNLDNLAQL YEGWTAWV
	Isoform 2 [UniParc]. Checksum: 8B0693F8E27FF13D	FASTA	284	31,739
	10 20 30 40 50 60 MSRRAPGSRL SSGGGGTKYP RSWNDWQPRT DSASADPDTL KYSSSRDRGV SSSYGLQPSN 70 80 90 100 110 120 SAVVSRQRHD DTRGHADIQN DEKGGYSVNG GSGENTYGRK SLGQELRINN VTSPEFTSVQ 130 140 150 160 170 180 HGSRALATKD MRKSQERSMS YSDESRLSNL LRRITREDDR DRRLATVKQL KEFIQQPENK 190 200 210 220 230 240 LVLVKQLDNI LAAVHDVLNE SSKLLQELRQ EGACCLGLLC ASLSYEAEKI FKWIFSKFSS 250 260 270 280 SAKDEVKLLY LCATYRALET VGEKKAFSSV MQVRARDPQC SAVR
	Isoform 3 [UniParc]. Checksum: 4A48D537C9327637	FASTA	433	48,246
	10 20 30 40 50 60 MSRRAPGSRL SSGGGGTKYP RSWNDWQPRT DSASADPDTL KYSSSRDRGV SSSYGLQPSN 70 80 90 100 110 120 SAVVSRQRHD DTRGHADIQN DEKGGYSVNG GSGENTYGRK SLGQELRINN VTSPEFTSVQ 130 140 150 160 170 180 HGSRALATKD MRKSQERSMS YSDESRLSNL LRRITREDDR DRRLATVKQL KEFIQQPENK 190 200 210 220 230 240 LVLVKQLDNI LAAVHDVLNE SSKLLQELRQ EGACCLGLLC ASLSYEAEKI FKWIFSKFSS 250 260 270 280 290 300 SAKDEVKLLY LCATYRALET VGEKKAFSSV MQLVMTSLQS ILENVDTPEL LCKCVKCILL 310 320 330 340 350 360 VARCYPHIFS TNFRDTVDIL VGWHIDHTQK PSLTQQVSGW LQSLEPFWVA DLAFSTTLLG 370 380 390 400 410 420 QFLEDMEAYA EDLSHVASGE SVDEDVPPPS VSLPKLAALL RVFSTVVRSI GERFSPIRGP 430 PITEAYVTDV SVF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H. DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2976-3658. Tissue: Fetal brain.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1996 (ISOFORM 1). Strain: C57BL/6J. Tissue: Aorta, Head, Heart and Vein.
[4]	Lubec G., Sunyer B., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 67-73, MASS SPECTROMETRY. Strain: OF1. Tissue: Hippocampus.
[5]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-3574, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC131788 Genomic DNA. No translation available. AC132432 Genomic DNA. No translation available. AK129136 mRNA. Translation: BAC97946.1. AK220328 mRNA. Translation: BAD90238.1. Different initiation. AK041264 mRNA. Translation: BAC30884.2. AK047829 mRNA. Translation: BAC33168.2. AK049391 mRNA. Translation: BAC33729.1. AK052331 mRNA. Translation: BAC34941.1.
IPI	IPI00403352. IPI00742306. IPI00742338.
RefSeq	NP_001026984.1. NM_001031814.1.
UniGene	Mm.309053.
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q8BKX6.
Proteomic databases
PaxDb	Q8BKX6.
PRIDE	Q8BKX6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000032891; ENSMUSP00000032891; ENSMUSG00000030655.
GeneID	233789.
KEGG	mmu:233789.
UCSC	uc009jjp.1. mouse. uc009jjq.1. mouse. uc009jjr.1. mouse.
Organism-specific databases
CTD	23049.
MGI	MGI:1919742. Smg1.
Rouge	Search...
Phylogenomic databases
eggNOG	COG5032.
GeneTree	ENSGT00700000104444.
HOVERGEN	HBG093965.
InParanoid	Q8BKX6.
KO	K08873.
OMA	LMIVHGD.
OrthoDB	EOG4320X5.
Gene expression databases
Bgee	Q8BKX6.
CleanEx	MM_2610207I05RIK.
Genevestigator	Q8BKX6.
GermOnline	ENSMUSG00000030655. Mus musculus.
Family and domain databases
Gene3D	1.10.1070.11. 3 hits.
InterPro	IPR016024. ARM-type_fold. IPR003152. FATC. IPR011009. Kinase-like_dom. IPR000403. PI3/4_kinase_cat_dom. IPR018936. PI3/4_kinase_CS. IPR014009. PIK_FAT. [Graphical view]
Pfam	PF02260. FATC. 1 hit. PF00454. PI3_PI4_kinase. 1 hit. [Graphical view]
SMART	SM00146. PI3Kc. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS51189. FAT. 1 hit. PS51190. FATC. 1 hit. PS50077. HEAT_REPEAT. False negative. PS00915. PI3_4_KINASE_1. False negative. PS00916. PI3_4_KINASE_2. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SMG1. mouse.
NextBio	381825.
SOURCE	Search...

Entry information

Entry name

SMG1_MOUSE

Accession

Primary (citable) accession number: Q8BKX6
Secondary accession number(s): E9QLR6 , Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	July 27, 2011
Last modified:	April 3, 2013
This is version 89 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program