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Protein

Brain-specific angiogenesis inhibitor 1-associated protein 2

Gene

Baiap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.1 Publication

GO - Molecular functioni

GO - Biological processi

  • actin crosslink formation Source: UniProtKB
  • actin filament bundle assembly Source: UniProtKB
  • dendrite development Source: MGI
  • insulin receptor signaling pathway Source: GO_Central
  • plasma membrane organization Source: InterPro
  • positive regulation of actin cytoskeleton reorganization Source: GO_Central
  • positive regulation of actin filament polymerization Source: GO_Central
  • positive regulation of dendritic spine morphogenesis Source: Ensembl
  • regulation of actin cytoskeleton organization Source: UniProtKB
  • regulation of cell shape Source: UniProtKB
  • regulation of synaptic plasticity Source: MGI
  • response to bacterium Source: UniProtKB
  • Rho protein signal transduction Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_315885. VEGFA-VEGFR2 Pathway.
REACT_344463. Regulation of actin dynamics for phagocytic cup formation.
REACT_358608. RHO GTPases Activate WASPs and WAVEs.

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific angiogenesis inhibitor 1-associated protein 2
Short name:
BAI-associated protein 2
Short name:
BAI1-associated protein 2
Alternative name(s):
Insulin receptor substrate protein of 53 kDa
Short name:
IRSp53
Short name:
Insulin receptor substrate p53
Insulin receptor tyrosine kinase 53 kDa substrate
Gene namesi
Name:Baiap2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2137336. Baiap2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 535535Brain-specific angiogenesis inhibitor 1-associated protein 2PRO_0000064817Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei324 – 3241PhosphoserineBy similarity
Modified residuei326 – 3261PhosphoserineBy similarity
Modified residuei341 – 3411PhosphothreonineBy similarity
Modified residuei347 – 3471PhosphoserineBy similarity
Modified residuei367 – 3671PhosphoserineBy similarity
Modified residuei455 – 4551PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated on tyrosine residues by INSR in response to insulin treatment.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BKX1.
PaxDbiQ8BKX1.
PRIDEiQ8BKX1.

PTM databases

PhosphoSiteiQ8BKX1.

Expressioni

Tissue specificityi

Detected in liver, brain, olfactory bulb, brain cortex, caudate putamen, hypothalamus and cerebellum.1 Publication

Gene expression databases

BgeeiQ8BKX1.
ExpressionAtlasiQ8BKX1. baseline and differential.
GenevisibleiQ8BKX1. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with CDC42 and RAC1 that have been activated by GTP binding. Binds DIAPH1. Interacts with ATN1, BAI1, SHANK1, SHANK2, SHANK3, TIAM1, WASF1 and WASF2. Interacts with ENAH after recruitment of CDC42 (By similarity). Interacts with EPS8.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Diaph1O088083EBI-771498,EBI-1026445
Dlg4Q621083EBI-771498,EBI-300895
Iqsec2A4GZ267EBI-771498,EBI-8526464

Protein-protein interaction databases

BioGridi223833. 1 interaction.
DIPiDIP-32392N.
IntActiQ8BKX1. 5 interactions.
MINTiMINT-4122910.
STRINGi10090.ENSMUSP00000026436.

Structurei

3D structure databases

ProteinModelPortaliQ8BKX1.
SMRiQ8BKX1. Positions 2-229, 264-292, 375-437.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 250250IMDPROSITE-ProRule annotationAdd
BLAST
Domaini375 – 43864SH3PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili88 – 15366Sequence AnalysisAdd
BLAST

Domaini

The IMD domain forms a coiled coil. The isolated domain can induce actin bundling and filopodia formation. In the absence of G-proteins intramolecular interaction between the IMD and the SH3 domain gives rise to an auto-inhibited state of the protein. Interaction of the IMD with RAC1 or CDC42 leads to activation (By similarity).By similarity
The SH3 domain interacts with ATN1, BAI1, WASF1, WASF2, SHANK1, DIAPH1 and ENAH.By similarity

Sequence similaritiesi

Contains 1 IMD (IRSp53/MIM homology) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiNOG71665.
GeneTreeiENSGT00390000005995.
HOGENOMiHOG000038005.
HOVERGENiHBG054462.
InParanoidiQ8BKX1.
KOiK05627.
OMAiGENEKTR.
OrthoDBiEOG7N0C3W.
PhylomeDBiQ8BKX1.
TreeFamiTF325648.

Family and domain databases

InterProiIPR013606. I-BAR_dom.
IPR030128. IRSp53.
IPR027681. IRSp53/IRTKS/Pinkbar.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR14206. PTHR14206. 1 hit.
PTHR14206:SF3. PTHR14206:SF3. 1 hit.
PfamiPF08397. IMD. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51338. IMD. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BKX1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLSRSEEMH RLTENVYKTI MEQFNPSLRN FIAMGKNYEK ALAGVTFAAK
60 70 80 90 100
GYFDALVKMG ELASESQGSK ELGDVLFQMA EVHRQIQNQL EETLKSFHNE
110 120 130 140 150
LLTQLEQKVE LDSRYLSAAL KKYQTEQRSK GDALDKCQAE LKKLRKKSQG
160 170 180 190 200
SKNPQKYSDK ELQYIDAISN KQGELENYVS DGYKTALTEE RRRFCFLVEK
210 220 230 240 250
QCAVAKNSAA YHSKGKELLA QKLPLWQQAC ADPNKIPDRA VQLMQQMANS
260 270 280 290 300
NGSILPSALS ASKSNLVISD PIPGAKPLPV PPELAPFVGR MSAQENVPVM
310 320 330 340 350
NGVAGPDSED YNPWADRKAA QPKSLSPPQS QSKLSDSYSN TLPVRKSVTP
360 370 380 390 400
KNSYATTENK TLPRSSSMAA GLERNGRMRV KAIFSHAAGD NSTLLSFKEG
410 420 430 440 450
DLITLLVPEA RDGWHYGESE KTKMRGWFPF SYTRVLDSDG SDRLHMSLQQ
460 470 480 490 500
GKSSSTGNLL DKDDLALPPP DYGTSSRAFP TQTAGTFKQR PYSVAVPAFS
510 520 530
QGLDDYGARS VSRNPFANVH LKPTVTNDRS APLLS
Length:535
Mass (Da):59,237
Last modified:August 30, 2005 - v2
Checksum:i45B4C660FBB07F72
GO
Isoform 2 (identifier: Q8BKX1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     513-535: RNPFANVHLKPTVTNDRSAPLLS → SGSGTLVSTV

Show »
Length:522
Mass (Da):57,596
Checksum:i8E65752157FD3F99
GO
Isoform 3 (identifier: Q8BKX1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     514-535: Missing.

Show »
Length:513
Mass (Da):56,863
Checksum:i5EDD57E315AF4005
GO
Isoform 4 (identifier: Q8BKX1-4) [UniParc]FASTAAdd to basket

Also known as: Short form

The sequence of this isoform differs from the canonical sequence as follows:
     290-329: Missing.
     513-535: RNPFANVHLKPTVTNDRSAPLLS → SGSGTLVSTV

Show »
Length:482
Mass (Da):53,274
Checksum:iF3FA1DFDC1E0D579
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti87 – 882QN → HI in BAC33764 (PubMed:16141072).Curated
Sequence conflicti326 – 3261S → F in BAC33764 (PubMed:16141072).Curated
Sequence conflicti330 – 3301S → F in BAC33764 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei290 – 32940Missing in isoform 4. 1 PublicationVSP_015507Add
BLAST
Alternative sequencei513 – 53523RNPFA…APLLS → SGSGTLVSTV in isoform 2 and isoform 4. 1 PublicationVSP_015508Add
BLAST
Alternative sequencei514 – 53522Missing in isoform 3. 1 PublicationVSP_015509Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF390178 mRNA. Translation: AAK68153.1.
AF390179 mRNA. Translation: AAK81838.1.
AB105196 Genomic DNA. Translation: BAC65241.1.
AB105196 Genomic DNA. Translation: BAC65242.1.
AK049469 mRNA. Translation: BAC33764.1.
BC006620 mRNA. Translation: AAH06620.1.
BC016411 mRNA. Translation: AAH16411.1.
CCDSiCCDS25722.1. [Q8BKX1-1]
CCDS25723.1. [Q8BKX1-4]
CCDS25724.1. [Q8BKX1-2]
RefSeqiNP_001032843.1. NM_001037754.3. [Q8BKX1-4]
NP_001032844.2. NM_001037755.3. [Q8BKX1-1]
NP_570932.2. NM_130862.4. [Q8BKX1-2]
UniGeneiMm.197534.

Genome annotation databases

EnsembliENSMUST00000026436; ENSMUSP00000026436; ENSMUSG00000025372. [Q8BKX1-1]
ENSMUST00000103021; ENSMUSP00000099310; ENSMUSG00000025372. [Q8BKX1-4]
ENSMUST00000106231; ENSMUSP00000101838; ENSMUSG00000025372. [Q8BKX1-3]
GeneIDi108100.
KEGGimmu:108100.
UCSCiuc007mrh.1. mouse. [Q8BKX1-4]
uc007mri.1. mouse. [Q8BKX1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF390178 mRNA. Translation: AAK68153.1.
AF390179 mRNA. Translation: AAK81838.1.
AB105196 Genomic DNA. Translation: BAC65241.1.
AB105196 Genomic DNA. Translation: BAC65242.1.
AK049469 mRNA. Translation: BAC33764.1.
BC006620 mRNA. Translation: AAH06620.1.
BC016411 mRNA. Translation: AAH16411.1.
CCDSiCCDS25722.1. [Q8BKX1-1]
CCDS25723.1. [Q8BKX1-4]
CCDS25724.1. [Q8BKX1-2]
RefSeqiNP_001032843.1. NM_001037754.3. [Q8BKX1-4]
NP_001032844.2. NM_001037755.3. [Q8BKX1-1]
NP_570932.2. NM_130862.4. [Q8BKX1-2]
UniGeneiMm.197534.

3D structure databases

ProteinModelPortaliQ8BKX1.
SMRiQ8BKX1. Positions 2-229, 264-292, 375-437.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi223833. 1 interaction.
DIPiDIP-32392N.
IntActiQ8BKX1. 5 interactions.
MINTiMINT-4122910.
STRINGi10090.ENSMUSP00000026436.

PTM databases

PhosphoSiteiQ8BKX1.

Proteomic databases

MaxQBiQ8BKX1.
PaxDbiQ8BKX1.
PRIDEiQ8BKX1.

Protocols and materials databases

DNASUi108100.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026436; ENSMUSP00000026436; ENSMUSG00000025372. [Q8BKX1-1]
ENSMUST00000103021; ENSMUSP00000099310; ENSMUSG00000025372. [Q8BKX1-4]
ENSMUST00000106231; ENSMUSP00000101838; ENSMUSG00000025372. [Q8BKX1-3]
GeneIDi108100.
KEGGimmu:108100.
UCSCiuc007mrh.1. mouse. [Q8BKX1-4]
uc007mri.1. mouse. [Q8BKX1-1]

Organism-specific databases

CTDi10458.
MGIiMGI:2137336. Baiap2.

Phylogenomic databases

eggNOGiNOG71665.
GeneTreeiENSGT00390000005995.
HOGENOMiHOG000038005.
HOVERGENiHBG054462.
InParanoidiQ8BKX1.
KOiK05627.
OMAiGENEKTR.
OrthoDBiEOG7N0C3W.
PhylomeDBiQ8BKX1.
TreeFamiTF325648.

Enzyme and pathway databases

ReactomeiREACT_315885. VEGFA-VEGFR2 Pathway.
REACT_344463. Regulation of actin dynamics for phagocytic cup formation.
REACT_358608. RHO GTPases Activate WASPs and WAVEs.

Miscellaneous databases

NextBioi360066.
PROiQ8BKX1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BKX1.
ExpressionAtlasiQ8BKX1. baseline and differential.
GenevisibleiQ8BKX1. MM.

Family and domain databases

InterProiIPR013606. I-BAR_dom.
IPR030128. IRSp53.
IPR027681. IRSp53/IRTKS/Pinkbar.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR14206. PTHR14206. 1 hit.
PTHR14206:SF3. PTHR14206:SF3. 1 hit.
PfamiPF08397. IMD. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51338. IMD. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Insulin receptor substrate protein p53 localization in rats suggests mechanism for specific polyglutamine neurodegeneration."
    Thomas E.A., Foye P.E., Alvarez C.E., Usui H., Sutcliffe J.G.
    Neurosci. Lett. 309:145-148(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4).
    Strain: C57BL/6J.
    Tissue: Brain.
  2. "Genomic structure and alternative splicing of the insulin receptor tyrosine kinase substrate of 53-kDa protein."
    Miyahara A., Okumura-Oho Y., Miyashita T., Hoshika A., Yamada M.
    J. Hum. Genet. 48:410-414(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 2 AND 4).
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Embryo.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: FVB/N.
    Tissue: Mammary gland.
  5. "Rho small G-protein-dependent binding of mDia to an Src homology 3 domain-containing IRSp53/BAIAP2."
    Fujiwara T., Mammoto A., Kim Y., Takai Y.
    Biochem. Biophys. Res. Commun. 271:626-629(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DIAPH1.
  6. "Novel isoform of insulin receptor substrate p53/p58 is generated by alternative splicing in the CRIB/SH3-binding region."
    Alvarez C.E., Sutcliffe J.G., Thomas E.A.
    J. Biol. Chem. 277:24728-24734(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
  7. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  9. "Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex."
    Disanza A., Mantoani S., Hertzog M., Gerboth S., Frittoli E., Steffen A., Berhoerster K., Kreienkamp H.J., Milanesi F., Di Fiore P.P., Ciliberto A., Stradal T.E., Scita G.
    Nat. Cell Biol. 8:1337-1347(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH EPS8.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiBAIP2_MOUSE
AccessioniPrimary (citable) accession number: Q8BKX1
Secondary accession number(s): Q91V97, Q923V9, Q923W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: July 22, 2015
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.