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Protein

Brain-specific angiogenesis inhibitor 1-associated protein 2

Gene

Baiap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.1 Publication

GO - Molecular functioni

GO - Biological processi

  • actin crosslink formation Source: UniProtKB
  • actin filament bundle assembly Source: UniProtKB
  • brain development Source: Ensembl
  • cellular response to epidermal growth factor stimulus Source: Ensembl
  • cellular response to L-glutamate Source: Ensembl
  • dendrite development Source: MGI
  • insulin receptor signaling pathway Source: GO_Central
  • plasma membrane organization Source: InterPro
  • positive regulation of actin cytoskeleton reorganization Source: GO_Central
  • positive regulation of actin filament polymerization Source: GO_Central
  • positive regulation of dendritic spine morphogenesis Source: Ensembl
  • positive regulation of excitatory postsynaptic potential Source: Ensembl
  • protein localization to synapse Source: Ensembl
  • regulation of actin cytoskeleton organization Source: UniProtKB
  • regulation of cell shape Source: UniProtKB
  • regulation of synaptic plasticity Source: MGI
  • response to bacterium Source: UniProtKB
  • Rho protein signal transduction Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-4420097 VEGFA-VEGFR2 Pathway
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific angiogenesis inhibitor 1-associated protein 2
Short name:
BAI-associated protein 2
Short name:
BAI1-associated protein 2
Alternative name(s):
Insulin receptor substrate protein of 53 kDa
Short name:
IRSp53
Short name:
Insulin receptor substrate p53
Insulin receptor tyrosine kinase 53 kDa substrate
Gene namesi
Name:Baiap2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:2137336 Baiap2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000648171 – 535Brain-specific angiogenesis inhibitor 1-associated protein 2Add BLAST535

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei262PhosphoserineBy similarity1
Modified residuei324PhosphoserineBy similarity1
Modified residuei326PhosphoserineBy similarity1
Modified residuei337PhosphoserineBy similarity1
Modified residuei341PhosphothreonineBy similarity1
Modified residuei347PhosphoserineBy similarity1
Modified residuei361PhosphothreonineBy similarity1
Modified residuei367PhosphoserineBy similarity1
Modified residuei385PhosphoserineBy similarity1
Modified residuei396PhosphoserineCombined sources1
Modified residuei455PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine residues by INSR in response to insulin treatment.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BKX1
PeptideAtlasiQ8BKX1
PRIDEiQ8BKX1

PTM databases

iPTMnetiQ8BKX1
PhosphoSitePlusiQ8BKX1

Expressioni

Tissue specificityi

Detected in liver, brain, olfactory bulb, brain cortex, caudate putamen, hypothalamus and cerebellum.1 Publication

Gene expression databases

BgeeiENSMUSG00000025372
ExpressionAtlasiQ8BKX1 baseline and differential
GenevisibleiQ8BKX1 MM

Interactioni

Subunit structurei

Homodimer. Interacts with CDC42 and RAC1 that have been activated by GTP binding. Binds DIAPH1. Interacts with ATN1, ADGRB1, SHANK1, SHANK2, SHANK3, TIAM1, WASF1 and WASF2. Interacts with ENAH after recruitment of CDC42 (By similarity). Interacts with EPS8.By similarity2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi223833, 11 interactors
DIPiDIP-32392N
IntActiQ8BKX1, 14 interactors
MINTiQ8BKX1
STRINGi10090.ENSMUSP00000026436

Structurei

3D structure databases

ProteinModelPortaliQ8BKX1
SMRiQ8BKX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 250IMDPROSITE-ProRule annotationAdd BLAST250
Domaini375 – 438SH3PROSITE-ProRule annotationAdd BLAST64

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili88 – 153Sequence analysisAdd BLAST66

Domaini

The IMD domain forms a coiled coil. The isolated domain can induce actin bundling and filopodia formation. In the absence of G-proteins intramolecular interaction between the IMD and the SH3 domain gives rise to an auto-inhibited state of the protein. Interaction of the IMD with RAC1 or CDC42 leads to activation (By similarity).By similarity
The SH3 domain interacts with ATN1, ADGRB1, WASF1, WASF2, SHANK1, DIAPH1 and ENAH.By similarity

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiENOG410IKMM Eukaryota
ENOG41110CD LUCA
GeneTreeiENSGT00390000005995
HOGENOMiHOG000038005
HOVERGENiHBG054462
InParanoidiQ8BKX1
KOiK05627
OMAiEDYSPWA
OrthoDBiEOG091G05ZV
PhylomeDBiQ8BKX1
TreeFamiTF325648

Family and domain databases

CDDicd11915 SH3_Irsp53, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR013606 I-BAR_dom
IPR030128 IRSp53
IPR027681 IRSp53/IRTKS/Pinkbar
IPR035594 Irsp53_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR14206 PTHR14206, 1 hit
PTHR14206:SF3 PTHR14206:SF3, 1 hit
PfamiView protein in Pfam
PF08397 IMD, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51338 IMD, 1 hit
PS50002 SH3, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BKX1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLSRSEEMH RLTENVYKTI MEQFNPSLRN FIAMGKNYEK ALAGVTFAAK
60 70 80 90 100
GYFDALVKMG ELASESQGSK ELGDVLFQMA EVHRQIQNQL EETLKSFHNE
110 120 130 140 150
LLTQLEQKVE LDSRYLSAAL KKYQTEQRSK GDALDKCQAE LKKLRKKSQG
160 170 180 190 200
SKNPQKYSDK ELQYIDAISN KQGELENYVS DGYKTALTEE RRRFCFLVEK
210 220 230 240 250
QCAVAKNSAA YHSKGKELLA QKLPLWQQAC ADPNKIPDRA VQLMQQMANS
260 270 280 290 300
NGSILPSALS ASKSNLVISD PIPGAKPLPV PPELAPFVGR MSAQENVPVM
310 320 330 340 350
NGVAGPDSED YNPWADRKAA QPKSLSPPQS QSKLSDSYSN TLPVRKSVTP
360 370 380 390 400
KNSYATTENK TLPRSSSMAA GLERNGRMRV KAIFSHAAGD NSTLLSFKEG
410 420 430 440 450
DLITLLVPEA RDGWHYGESE KTKMRGWFPF SYTRVLDSDG SDRLHMSLQQ
460 470 480 490 500
GKSSSTGNLL DKDDLALPPP DYGTSSRAFP TQTAGTFKQR PYSVAVPAFS
510 520 530
QGLDDYGARS VSRNPFANVH LKPTVTNDRS APLLS
Length:535
Mass (Da):59,237
Last modified:August 30, 2005 - v2
Checksum:i45B4C660FBB07F72
GO
Isoform 2 (identifier: Q8BKX1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     513-535: RNPFANVHLKPTVTNDRSAPLLS → SGSGTLVSTV

Show »
Length:522
Mass (Da):57,596
Checksum:i8E65752157FD3F99
GO
Isoform 3 (identifier: Q8BKX1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     514-535: Missing.

Show »
Length:513
Mass (Da):56,863
Checksum:i5EDD57E315AF4005
GO
Isoform 4 (identifier: Q8BKX1-4) [UniParc]FASTAAdd to basket
Also known as: Short form

The sequence of this isoform differs from the canonical sequence as follows:
     290-329: Missing.
     513-535: RNPFANVHLKPTVTNDRSAPLLS → SGSGTLVSTV

Show »
Length:482
Mass (Da):53,274
Checksum:iF3FA1DFDC1E0D579
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87 – 88QN → HI in BAC33764 (PubMed:16141072).Curated2
Sequence conflicti326S → F in BAC33764 (PubMed:16141072).Curated1
Sequence conflicti330S → F in BAC33764 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015507290 – 329Missing in isoform 4. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_015508513 – 535RNPFA…APLLS → SGSGTLVSTV in isoform 2 and isoform 4. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_015509514 – 535Missing in isoform 3. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF390178 mRNA Translation: AAK68153.1
AF390179 mRNA Translation: AAK81838.1
AB105196 Genomic DNA Translation: BAC65241.1
AB105196 Genomic DNA Translation: BAC65242.1
AK049469 mRNA Translation: BAC33764.1
BC006620 mRNA Translation: AAH06620.1
BC016411 mRNA Translation: AAH16411.1
CCDSiCCDS25722.1 [Q8BKX1-1]
CCDS25723.1 [Q8BKX1-4]
CCDS25724.1 [Q8BKX1-2]
RefSeqiNP_001032843.1, NM_001037754.3 [Q8BKX1-4]
NP_001032844.2, NM_001037755.3 [Q8BKX1-1]
NP_570932.2, NM_130862.4 [Q8BKX1-2]
UniGeneiMm.197534

Genome annotation databases

EnsembliENSMUST00000026436; ENSMUSP00000026436; ENSMUSG00000025372 [Q8BKX1-1]
ENSMUST00000075180; ENSMUSP00000074674; ENSMUSG00000025372 [Q8BKX1-2]
ENSMUST00000103021; ENSMUSP00000099310; ENSMUSG00000025372 [Q8BKX1-4]
ENSMUST00000106231; ENSMUSP00000101838; ENSMUSG00000025372 [Q8BKX1-3]
GeneIDi108100
KEGGimmu:108100
UCSCiuc007mrh.1 mouse [Q8BKX1-4]
uc007mri.1 mouse [Q8BKX1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBAIP2_MOUSE
AccessioniPrimary (citable) accession number: Q8BKX1
Secondary accession number(s): Q91V97, Q923V9, Q923W0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: May 23, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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