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Protein

HAUS augmin-like complex subunit 7

Gene

Haus7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-MMU-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-MMU-380259. Loss of Nlp from mitotic centrosomes.
R-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-5620912. Anchoring of the basal body to the plasma membrane.
R-MMU-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
HAUS augmin-like complex subunit 7
Alternative name(s):
26S proteasome-associated UCH37-interacting protein 1
UCHL5-interacting protein
Gene namesi
Name:Haus7
Synonyms:Uchl5ip, Uip1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1920988. Haus7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000975531 – 364HAUS augmin-like complex subunit 7Add BLAST364

Proteomic databases

EPDiQ8BKT8.
PaxDbiQ8BKT8.
PeptideAtlasiQ8BKT8.
PRIDEiQ8BKT8.

PTM databases

iPTMnetiQ8BKT8.
PhosphoSitePlusiQ8BKT8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031371.
CleanExiMM_UCHL5IP.
GenevisibleiQ8BKT8. MM.

Interactioni

Subunit structurei

Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. Binds UCHL5 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi216223. 1 interactor.
IntActiQ8BKT8. 2 interactors.
MINTiMINT-1544024.
STRINGi10090.ENSMUSP00000033737.

Structurei

3D structure databases

ProteinModelPortaliQ8BKT8.
SMRiQ8BKT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HAUS7 family.Curated

Phylogenomic databases

eggNOGiENOG410IRC4. Eukaryota.
ENOG4111MKV. LUCA.
GeneTreeiENSGT00390000003937.
HOGENOMiHOG000231508.
HOVERGENiHBG074169.
InParanoidiQ8BKT8.
KOiK16590.
OMAiVISDFHQ.
OrthoDBiEOG091G0TFM.
TreeFamiTF333445.

Family and domain databases

InterProiIPR029711. Haus7-like.
[Graphical view]
PANTHERiPTHR14352:SF2. PTHR14352:SF2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BKT8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEEGAGAGS DDSYYKDVGD DCVVKAAVEV FEKLKGVNCP FLDGLYITEP
60 70 80 90 100
KTIMELLCRP SKYRLDILEW MCIRVCPSLQ DKFISLKGNA LDLKIQEMLK
110 120 130 140 150
LGHELMFCAP DDQDLLMGRE CPQKQLQFMD KILDMMQSLA TGCSSSSSLK
160 170 180 190 200
EHLEDTTEKN EALLGELFSS PNLRAILKPE SDPWPLDMQS SLNKQSDDLP
210 220 230 240 250
KADPSAQSEG EKVADLARQL QESATKLQTL RDQCFAQHKA GTDTSTIDQK
260 270 280 290 300
LRLVISDFYQ LILAFLQVYD DELRECCQRP VPSLHPSGPI IQAVYQTLAS
310 320 330 340 350
CGQLLRAVME IADTSAEAMK AARKQEGEPN CWSSNNSGIS LAARIDEVTQ
360
KYKILTDRFH RGTR
Length:364
Mass (Da):40,656
Last modified:April 5, 2011 - v2
Checksum:i53B9AE710D7C058F
GO
Isoform 2 (identifier: Q8BKT8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-233: Missing.

Note: No experimental confirmation available.
Show »
Length:248
Mass (Da):27,798
Checksum:iF5241D1E4DB954C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62K → R in BAC34395 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040922118 – 233Missing in isoform 2. 1 PublicationAdd BLAST116

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029337 mRNA. Translation: AAK38738.1.
AK050729 mRNA. Translation: BAC34395.1.
AL732461 Genomic DNA. Translation: CAM27431.1.
AL732461 Genomic DNA. Translation: CAM27432.1.
CH466650 Genomic DNA. Translation: EDL29899.1.
BC025464 mRNA. Translation: AAH25464.1.
CCDSiCCDS30202.1. [Q8BKT8-1]
CCDS30203.1. [Q8BKT8-2]
RefSeqiNP_082909.1. NM_028633.3. [Q8BKT8-1]
NP_996987.1. NM_207104.1. [Q8BKT8-2]
UniGeneiMm.264899.

Genome annotation databases

EnsembliENSMUST00000033737; ENSMUSP00000033737; ENSMUSG00000031371. [Q8BKT8-1]
ENSMUST00000077243; ENSMUSP00000076479; ENSMUSG00000031371. [Q8BKT8-2]
GeneIDi73738.
KEGGimmu:73738.
UCSCiuc009tlu.1. mouse. [Q8BKT8-1]
uc009tlv.1. mouse. [Q8BKT8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029337 mRNA. Translation: AAK38738.1.
AK050729 mRNA. Translation: BAC34395.1.
AL732461 Genomic DNA. Translation: CAM27431.1.
AL732461 Genomic DNA. Translation: CAM27432.1.
CH466650 Genomic DNA. Translation: EDL29899.1.
BC025464 mRNA. Translation: AAH25464.1.
CCDSiCCDS30202.1. [Q8BKT8-1]
CCDS30203.1. [Q8BKT8-2]
RefSeqiNP_082909.1. NM_028633.3. [Q8BKT8-1]
NP_996987.1. NM_207104.1. [Q8BKT8-2]
UniGeneiMm.264899.

3D structure databases

ProteinModelPortaliQ8BKT8.
SMRiQ8BKT8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216223. 1 interactor.
IntActiQ8BKT8. 2 interactors.
MINTiMINT-1544024.
STRINGi10090.ENSMUSP00000033737.

PTM databases

iPTMnetiQ8BKT8.
PhosphoSitePlusiQ8BKT8.

Proteomic databases

EPDiQ8BKT8.
PaxDbiQ8BKT8.
PeptideAtlasiQ8BKT8.
PRIDEiQ8BKT8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033737; ENSMUSP00000033737; ENSMUSG00000031371. [Q8BKT8-1]
ENSMUST00000077243; ENSMUSP00000076479; ENSMUSG00000031371. [Q8BKT8-2]
GeneIDi73738.
KEGGimmu:73738.
UCSCiuc009tlu.1. mouse. [Q8BKT8-1]
uc009tlv.1. mouse. [Q8BKT8-2]

Organism-specific databases

CTDi55559.
MGIiMGI:1920988. Haus7.

Phylogenomic databases

eggNOGiENOG410IRC4. Eukaryota.
ENOG4111MKV. LUCA.
GeneTreeiENSGT00390000003937.
HOGENOMiHOG000231508.
HOVERGENiHBG074169.
InParanoidiQ8BKT8.
KOiK16590.
OMAiVISDFHQ.
OrthoDBiEOG091G0TFM.
TreeFamiTF333445.

Enzyme and pathway databases

ReactomeiR-MMU-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-MMU-380259. Loss of Nlp from mitotic centrosomes.
R-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-5620912. Anchoring of the basal body to the plasma membrane.
R-MMU-8854518. AURKA Activation by TPX2.

Miscellaneous databases

PROiQ8BKT8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031371.
CleanExiMM_UCHL5IP.
GenevisibleiQ8BKT8. MM.

Family and domain databases

InterProiIPR029711. Haus7-like.
[Graphical view]
PANTHERiPTHR14352:SF2. PTHR14352:SF2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHAUS7_MOUSE
AccessioniPrimary (citable) accession number: Q8BKT8
Secondary accession number(s): A2AIF2, Q924Z7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: April 5, 2011
Last modified: November 2, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.