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Protein

Protein phosphatase 1 regulatory subunit 37

Gene

Ppp1r37

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 37
Alternative name(s):
Leucine-rich repeat-containing protein 68
Gene namesi
Name:Ppp1r37
Synonyms:Lrrc68
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2687042. Ppp1r37.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 712712Protein phosphatase 1 regulatory subunit 37PRO_0000320940Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei62 – 621PhosphoserineBy similarity
Modified residuei583 – 5831PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BKR5.
MaxQBiQ8BKR5.
PaxDbiQ8BKR5.
PRIDEiQ8BKR5.

PTM databases

iPTMnetiQ8BKR5.
PhosphoSiteiQ8BKR5.

Expressioni

Gene expression databases

BgeeiQ8BKR5.
GenevisibleiQ8BKR5. MM.

Interactioni

Subunit structurei

Interacts with PPP1CA.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060233.

Structurei

3D structure databases

ProteinModelPortaliQ8BKR5.
SMRiQ8BKR5. Positions 95-428.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati226 – 24621LRR 1Add
BLAST
Repeati254 – 27522LRR 2Add
BLAST
Repeati283 – 30321LRR 3Add
BLAST
Repeati312 – 33221LRR 4Add
BLAST
Repeati340 – 36021LRR 5Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi523 – 5308Poly-Glu
Compositional biasi599 – 67274Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the PPP1R37 family.Curated
Contains 5 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG1908. Eukaryota.
ENOG410XSTR. LUCA.
GeneTreeiENSGT00730000111194.
HOGENOMiHOG000074153.
HOVERGENiHBG108102.
InParanoidiQ8BKR5.
KOiK17576.
OMAiNGCKRNL.
OrthoDBiEOG79KPDW.
PhylomeDBiQ8BKR5.
TreeFamiTF328391.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BKR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIPPQEAPP GPGADADADA EAETEEASAE AESPTGTSPP ADGRLKAAAK
60 70 80 90 100
RVTFPSDEDI VSGAVEPKDP WRHAQNVTVD EVISAYRQAC QKLNCRQIPK
110 120 130 140 150
LLRQLQEFTD LEQRINCLDL KGEKLDYKTC EALEEVFKRL QFKVVDLEQT
160 170 180 190 200
NLDEDGASAL FDMIEYYESA THLNISFNKH IGTRGWQAAA HMMRKTSCLQ
210 220 230 240 250
YLDARNTPLL DHSAPFVARA LRIRSSLAVL HLENASLSGR PLMLLATALK
260 270 280 290 300
MNMNLRELYL ADNKLNGLQD SAQLGNLLKF NCSLQILDLR NNHVLDSGLA
310 320 330 340 350
YICEGLKEQR KGLVTLVLWN NQLTHTGMAF LGMALPHTQS LETLNLGHNP
360 370 380 390 400
IGNEGVRNLK NGLISNRSVL RLGLASTKLT CEGAVAVAEF IAESPRLLRL
410 420 430 440 450
DLRENEIKTG GLMALSLALK VNHSLLRLDL DREPKKEPVK SFIETQKALL
460 470 480 490 500
AEIQNGCKRN FVLVREREEK QQLQLSASMP EITITAPQPL EESGELPAVG
510 520 530 540 550
SQNGAPRPGP GPDSDSDSDS DREEQEEEEE DQRNQQRDEG GNDQSSLASC
560 570 580 590 600
PALIPSTDSL GPGDKSPPSS PSSPTEQRIS VSSPGRGHKV FVVTRVESPP
610 620 630 640 650
ERPEPPVPPT FVSSPPPSPP SPPASPPSQT MDTQDPESSE AQPQLEPSQA
660 670 680 690 700
GQPLPNGLKP EFALALPPEP PPGLEAKGGS CSLEHALHRS QGVSKLEELL
710
LEASQEAPRD TL
Length:712
Mass (Da):77,574
Last modified:March 1, 2003 - v1
Checksum:i046EE80CE36D3159
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050946 mRNA. Translation: BAC34471.1.
BC070402 mRNA. Translation: AAH70402.1.
CCDSiCCDS20906.1.
RefSeqiNP_954600.1. NM_199149.3.
UniGeneiMm.219662.

Genome annotation databases

EnsembliENSMUST00000058444; ENSMUSP00000060233; ENSMUSG00000051403.
GeneIDi232947.
KEGGimmu:232947.
UCSCiuc009fmh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050946 mRNA. Translation: BAC34471.1.
BC070402 mRNA. Translation: AAH70402.1.
CCDSiCCDS20906.1.
RefSeqiNP_954600.1. NM_199149.3.
UniGeneiMm.219662.

3D structure databases

ProteinModelPortaliQ8BKR5.
SMRiQ8BKR5. Positions 95-428.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060233.

PTM databases

iPTMnetiQ8BKR5.
PhosphoSiteiQ8BKR5.

Proteomic databases

EPDiQ8BKR5.
MaxQBiQ8BKR5.
PaxDbiQ8BKR5.
PRIDEiQ8BKR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058444; ENSMUSP00000060233; ENSMUSG00000051403.
GeneIDi232947.
KEGGimmu:232947.
UCSCiuc009fmh.1. mouse.

Organism-specific databases

CTDi284352.
MGIiMGI:2687042. Ppp1r37.

Phylogenomic databases

eggNOGiKOG1908. Eukaryota.
ENOG410XSTR. LUCA.
GeneTreeiENSGT00730000111194.
HOGENOMiHOG000074153.
HOVERGENiHBG108102.
InParanoidiQ8BKR5.
KOiK17576.
OMAiNGCKRNL.
OrthoDBiEOG79KPDW.
PhylomeDBiQ8BKR5.
TreeFamiTF328391.

Miscellaneous databases

NextBioi381365.
PROiQ8BKR5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BKR5.
GenevisibleiQ8BKR5. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung and Testis.

Entry informationi

Entry nameiPPR37_MOUSE
AccessioniPrimary (citable) accession number: Q8BKR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.