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Protein

Protein phosphatase 1 regulatory subunit 37

Gene

Ppp1r37

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 37
Alternative name(s):
Leucine-rich repeat-containing protein 68
Gene namesi
Name:Ppp1r37
Synonyms:Lrrc68
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2687042. Ppp1r37.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003209401 – 712Protein phosphatase 1 regulatory subunit 37Add BLAST712

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56PhosphoserineBy similarity1
Modified residuei62PhosphoserineBy similarity1
Modified residuei583PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BKR5.
PaxDbiQ8BKR5.
PeptideAtlasiQ8BKR5.
PRIDEiQ8BKR5.

PTM databases

iPTMnetiQ8BKR5.
PhosphoSitePlusiQ8BKR5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000051403.
GenevisibleiQ8BKR5. MM.

Interactioni

Subunit structurei

Interacts with PPP1CA.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060233.

Structurei

3D structure databases

ProteinModelPortaliQ8BKR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati226 – 246LRR 1Add BLAST21
Repeati254 – 275LRR 2Add BLAST22
Repeati283 – 303LRR 3Add BLAST21
Repeati312 – 332LRR 4Add BLAST21
Repeati340 – 360LRR 5Add BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi523 – 530Poly-Glu8
Compositional biasi599 – 672Pro-richAdd BLAST74

Sequence similaritiesi

Belongs to the PPP1R37 family.Curated
Contains 5 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG1908. Eukaryota.
ENOG410XSTR. LUCA.
GeneTreeiENSGT00730000111194.
HOGENOMiHOG000074153.
HOVERGENiHBG108102.
InParanoidiQ8BKR5.
KOiK17576.
OMAiNGCKRNL.
OrthoDBiEOG091G0KU7.
PhylomeDBiQ8BKR5.
TreeFamiTF328391.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BKR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIPPQEAPP GPGADADADA EAETEEASAE AESPTGTSPP ADGRLKAAAK
60 70 80 90 100
RVTFPSDEDI VSGAVEPKDP WRHAQNVTVD EVISAYRQAC QKLNCRQIPK
110 120 130 140 150
LLRQLQEFTD LEQRINCLDL KGEKLDYKTC EALEEVFKRL QFKVVDLEQT
160 170 180 190 200
NLDEDGASAL FDMIEYYESA THLNISFNKH IGTRGWQAAA HMMRKTSCLQ
210 220 230 240 250
YLDARNTPLL DHSAPFVARA LRIRSSLAVL HLENASLSGR PLMLLATALK
260 270 280 290 300
MNMNLRELYL ADNKLNGLQD SAQLGNLLKF NCSLQILDLR NNHVLDSGLA
310 320 330 340 350
YICEGLKEQR KGLVTLVLWN NQLTHTGMAF LGMALPHTQS LETLNLGHNP
360 370 380 390 400
IGNEGVRNLK NGLISNRSVL RLGLASTKLT CEGAVAVAEF IAESPRLLRL
410 420 430 440 450
DLRENEIKTG GLMALSLALK VNHSLLRLDL DREPKKEPVK SFIETQKALL
460 470 480 490 500
AEIQNGCKRN FVLVREREEK QQLQLSASMP EITITAPQPL EESGELPAVG
510 520 530 540 550
SQNGAPRPGP GPDSDSDSDS DREEQEEEEE DQRNQQRDEG GNDQSSLASC
560 570 580 590 600
PALIPSTDSL GPGDKSPPSS PSSPTEQRIS VSSPGRGHKV FVVTRVESPP
610 620 630 640 650
ERPEPPVPPT FVSSPPPSPP SPPASPPSQT MDTQDPESSE AQPQLEPSQA
660 670 680 690 700
GQPLPNGLKP EFALALPPEP PPGLEAKGGS CSLEHALHRS QGVSKLEELL
710
LEASQEAPRD TL
Length:712
Mass (Da):77,574
Last modified:March 1, 2003 - v1
Checksum:i046EE80CE36D3159
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050946 mRNA. Translation: BAC34471.1.
BC070402 mRNA. Translation: AAH70402.1.
CCDSiCCDS20906.1.
RefSeqiNP_954600.1. NM_199149.3.
UniGeneiMm.219662.

Genome annotation databases

EnsembliENSMUST00000058444; ENSMUSP00000060233; ENSMUSG00000051403.
GeneIDi232947.
KEGGimmu:232947.
UCSCiuc009fmh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050946 mRNA. Translation: BAC34471.1.
BC070402 mRNA. Translation: AAH70402.1.
CCDSiCCDS20906.1.
RefSeqiNP_954600.1. NM_199149.3.
UniGeneiMm.219662.

3D structure databases

ProteinModelPortaliQ8BKR5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060233.

PTM databases

iPTMnetiQ8BKR5.
PhosphoSitePlusiQ8BKR5.

Proteomic databases

MaxQBiQ8BKR5.
PaxDbiQ8BKR5.
PeptideAtlasiQ8BKR5.
PRIDEiQ8BKR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058444; ENSMUSP00000060233; ENSMUSG00000051403.
GeneIDi232947.
KEGGimmu:232947.
UCSCiuc009fmh.1. mouse.

Organism-specific databases

CTDi284352.
MGIiMGI:2687042. Ppp1r37.

Phylogenomic databases

eggNOGiKOG1908. Eukaryota.
ENOG410XSTR. LUCA.
GeneTreeiENSGT00730000111194.
HOGENOMiHOG000074153.
HOVERGENiHBG108102.
InParanoidiQ8BKR5.
KOiK17576.
OMAiNGCKRNL.
OrthoDBiEOG091G0KU7.
PhylomeDBiQ8BKR5.
TreeFamiTF328391.

Miscellaneous databases

PROiQ8BKR5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051403.
GenevisibleiQ8BKR5. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPR37_MOUSE
AccessioniPrimary (citable) accession number: Q8BKR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.