Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gamma-tubulin complex component 5

Gene

Tubgcp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-380320. Recruitment of NuMA to mitotic centrosomes.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-tubulin complex component 5
Short name:
GCP-5
Gene namesi
Name:Tubgcp5
Synonyms:Kiaa1899
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2178836. Tubgcp5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10241024Gamma-tubulin complex component 5PRO_0000323605Add
BLAST

Proteomic databases

EPDiQ8BKN5.
MaxQBiQ8BKN5.
PaxDbiQ8BKN5.
PeptideAtlasiQ8BKN5.
PRIDEiQ8BKN5.

PTM databases

iPTMnetiQ8BKN5.
PhosphoSiteiQ8BKN5.

Expressioni

Gene expression databases

BgeeiQ8BKN5.
CleanExiMM_TUBGCP5.
GenevisibleiQ8BKN5. MM.

Interactioni

Subunit structurei

Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231399. 16 interactions.
IntActiQ8BKN5. 16 interactions.
STRINGi10090.ENSMUSP00000032627.

Family & Domainsi

Sequence similaritiesi

Belongs to the TUBGCP family.Curated

Phylogenomic databases

eggNOGiKOG4344. Eukaryota.
ENOG410ZYW9. LUCA.
GeneTreeiENSGT00840000129856.
HOGENOMiHOG000290706.
HOVERGENiHBG025895.
InParanoidiQ8BKN5.
KOiK16572.
OMAiTARPSQF.
OrthoDBiEOG7JMGCP.
PhylomeDBiQ8BKN5.
TreeFamiTF329759.

Family and domain databases

InterProiIPR007259. GCP.
[Graphical view]
PANTHERiPTHR19302. PTHR19302. 1 hit.
PfamiPF04130. Spc97_Spc98. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BKN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARPKSSGSR MDRQLEHDVC ELVRQVTGLQ DEADPNFQLA LDFVWSNFRF
60 70 80 90 100
HRFLDVNSHK VEKTIEGIYE KFTIHSDLNK AASWKRLTKE FLNASLPSTE
110 120 130 140 150
KIKTDAHYSI LSLLLCLSDS PSNSNYVETP REKEVEKKDD FDWGKYLMEG
160 170 180 190 200
EEIGLGPNID TPNWSEDSDD EDAQQPLSRE DSGIQVDRTP LEEQDHNRKG
210 220 230 240 250
GPQVCWEDEP DSRSWLEQHV VHQYWTTRRF RIPHSAHLHS NLAAVWDQHL
260 270 280 290 300
YSSDPLYVPD DRVVVTETQV IRETLWLLSG VKKMFIFQLI DGKVTVRNNI
310 320 330 340 350
IVTHLTHSCL RSVLEQIAAY GQVVFRLQEF IDEVMGHSSE SLPPGNGPIP
360 370 380 390 400
KKQPDAPFRT YQAFMWALYK YFINFKEELT DIEKCVISSD TTITLAIVVN
410 420 430 440 450
KLAPRLAQLK VLDKVFSTGV AEVPPDTRNV VRASHLLNTL YKAILEYDNV
460 470 480 490 500
GEASEQTVSL LFSLWVETVR PYLQTVDEWI VHGHLWDGAR EFIIQRNKNV
510 520 530 540 550
PVNHRDFWYA TYTLYSVSEK TENEDKVSDS ASASSGSDQG PSSRQHTMVS
560 570 580 590 600
FLKPVLKQII MAGKSMQLLK NLNCAEGPAC QAAARDAERK SLYTLFLESI
610 620 630 640 650
QLRLQHGEDS APHIVNEDQT TKENLIKMQS IAERHLELDD IHDPLLAINF
660 670 680 690 700
ARLYLEQSDF HEKFAGGDIC VDRSSESVTC QTFELTLRSC LYPHIDKQYL
710 720 730 740 750
HCCGNLMQTL KRDFRLVEYL QAMRNFFLME GGDTMYDFYT SIFDKIREKE
760 770 780 790 800
TWQNVSFLNV QLQEAVGQRY PEDSLRLSIS FENVDTTKKK LPVHILDGLT
810 820 830 840 850
LSYKVPWPVD IVISVECQKI YNQVFLLLLQ IKWAKYSLDV LLFGELGNAA
860 870 880 890 900
ERSQAKEDIP RDQDTPSQFG PPKESLRQQI HRMFLLRVKL MHFVNSLHNY
910 920 930 940 950
IMTRILHSTG LEFQHQVEEA KDLDQLIKIH YRYLSTIHDR CLLREKVSFV
960 970 980 990 1000
KEAIMKVLNL ALMFAEGWQA GLGAWQMESI EKMESDFKNC HMFLVTILNK
1010 1020
AVCRGSFPHL ESLALSLMAG MEQS
Length:1,024
Mass (Da):117,977
Last modified:March 18, 2008 - v2
Checksum:iF975E340C0A7CE77
GO
Isoform 2 (identifier: Q8BKN5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     654-716: Missing.

Note: No experimental confirmation available.
Show »
Length:961
Mass (Da):110,604
Checksum:iFEA4262850CDB4BB
GO
Isoform 3 (identifier: Q8BKN5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     977-1024: Missing.

Note: No experimental confirmation available.
Show »
Length:976
Mass (Da):112,590
Checksum:i85D220B0BE909E05
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91S → L in BAD32569 (PubMed:15368895).Curated
Sequence conflicti82 – 821A → G in BAC27661 (PubMed:16141072).Curated
Sequence conflicti172 – 366195Missing in BAD32569 (PubMed:15368895).CuratedAdd
BLAST
Sequence conflicti225 – 2251W → L in BAC27661 (PubMed:16141072).Curated
Sequence conflicti332 – 3321D → Y in BAE31930 (PubMed:16141072).Curated
Sequence conflicti332 – 3321D → Y in BAE31910 (PubMed:16141072).Curated
Sequence conflicti332 – 3321D → Y in BAE30892 (PubMed:16141072).Curated
Sequence conflicti332 – 3321D → Y in BAE30414 (PubMed:16141072).Curated
Sequence conflicti587 – 5871A → E in BAC34603 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei654 – 71663Missing in isoform 2. 1 PublicationVSP_032040Add
BLAST
Alternative sequencei977 – 102448Missing in isoform 3. 1 PublicationVSP_032041Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032031 mRNA. Translation: BAC27661.1.
AK044887 mRNA. Translation: BAC32128.1.
AK051326 mRNA. Translation: BAC34603.1.
AK151454 mRNA. Translation: BAE30414.1.
AK152033 mRNA. Translation: BAE30892.1.
AK153331 mRNA. Translation: BAE31910.1.
AK153357 mRNA. Translation: BAE31930.1.
AK173291 Transcribed RNA. Translation: BAD32569.1.
CCDSiCCDS21314.1. [Q8BKN5-1]
RefSeqiNP_666302.2. NM_146190.2. [Q8BKN5-1]
XP_011249162.1. XM_011250860.1. [Q8BKN5-2]
UniGeneiMm.284306.

Genome annotation databases

EnsembliENSMUST00000032627; ENSMUSP00000032627; ENSMUSG00000033790. [Q8BKN5-1]
ENSMUST00000205796; ENSMUSP00000146111; ENSMUSG00000033790. [Q8BKN5-2]
GeneIDi233276.
KEGGimmu:233276.
UCSCiuc009hdd.1. mouse. [Q8BKN5-1]
uc009hdf.1. mouse. [Q8BKN5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032031 mRNA. Translation: BAC27661.1.
AK044887 mRNA. Translation: BAC32128.1.
AK051326 mRNA. Translation: BAC34603.1.
AK151454 mRNA. Translation: BAE30414.1.
AK152033 mRNA. Translation: BAE30892.1.
AK153331 mRNA. Translation: BAE31910.1.
AK153357 mRNA. Translation: BAE31930.1.
AK173291 Transcribed RNA. Translation: BAD32569.1.
CCDSiCCDS21314.1. [Q8BKN5-1]
RefSeqiNP_666302.2. NM_146190.2. [Q8BKN5-1]
XP_011249162.1. XM_011250860.1. [Q8BKN5-2]
UniGeneiMm.284306.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231399. 16 interactions.
IntActiQ8BKN5. 16 interactions.
STRINGi10090.ENSMUSP00000032627.

PTM databases

iPTMnetiQ8BKN5.
PhosphoSiteiQ8BKN5.

Proteomic databases

EPDiQ8BKN5.
MaxQBiQ8BKN5.
PaxDbiQ8BKN5.
PeptideAtlasiQ8BKN5.
PRIDEiQ8BKN5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032627; ENSMUSP00000032627; ENSMUSG00000033790. [Q8BKN5-1]
ENSMUST00000205796; ENSMUSP00000146111; ENSMUSG00000033790. [Q8BKN5-2]
GeneIDi233276.
KEGGimmu:233276.
UCSCiuc009hdd.1. mouse. [Q8BKN5-1]
uc009hdf.1. mouse. [Q8BKN5-2]

Organism-specific databases

CTDi114791.
MGIiMGI:2178836. Tubgcp5.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4344. Eukaryota.
ENOG410ZYW9. LUCA.
GeneTreeiENSGT00840000129856.
HOGENOMiHOG000290706.
HOVERGENiHBG025895.
InParanoidiQ8BKN5.
KOiK16572.
OMAiTARPSQF.
OrthoDBiEOG7JMGCP.
PhylomeDBiQ8BKN5.
TreeFamiTF329759.

Enzyme and pathway databases

ReactomeiR-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-380320. Recruitment of NuMA to mitotic centrosomes.

Miscellaneous databases

PROiQ8BKN5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BKN5.
CleanExiMM_TUBGCP5.
GenevisibleiQ8BKN5. MM.

Family and domain databases

InterProiIPR007259. GCP.
[Graphical view]
PANTHERiPTHR19302. PTHR19302. 1 hit.
PfamiPF04130. Spc97_Spc98. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Strain: C57BL/6J.
    Tissue: Bone marrow, Medulla oblongata and Spinal ganglion.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-1024 (ISOFORM 1).
    Tissue: Embryonic tail.

Entry informationi

Entry nameiGCP5_MOUSE
AccessioniPrimary (citable) accession number: Q8BKN5
Secondary accession number(s): Q3U8X5
, Q69Z75, Q8BLJ9, Q8C083
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: July 6, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.