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Protein

Gamma-tubulin complex component 5

Gene

Tubgcp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-tubulin complex component 5
Short name:
GCP-5
Gene namesi
Name:Tubgcp5
Synonyms:Kiaa1899
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2178836 Tubgcp5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003236051 – 1024Gamma-tubulin complex component 5Add BLAST1024

Proteomic databases

PaxDbiQ8BKN5
PeptideAtlasiQ8BKN5
PRIDEiQ8BKN5

PTM databases

iPTMnetiQ8BKN5
PhosphoSitePlusiQ8BKN5

Expressioni

Gene expression databases

BgeeiENSMUSG00000033790
CleanExiMM_TUBGCP5
ExpressionAtlasiQ8BKN5 baseline and differential
GenevisibleiQ8BKN5 MM

Interactioni

Subunit structurei

Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231399, 16 interactors
IntActiQ8BKN5, 16 interactors
STRINGi10090.ENSMUSP00000032627

Family & Domainsi

Sequence similaritiesi

Belongs to the TUBGCP family.Curated

Phylogenomic databases

eggNOGiKOG4344 Eukaryota
ENOG410ZYW9 LUCA
GeneTreeiENSGT00850000132278
HOGENOMiHOG000290706
HOVERGENiHBG025895
InParanoidiQ8BKN5
KOiK16572
OMAiFRLQEFI
OrthoDBiEOG091G0ABS
PhylomeDBiQ8BKN5
TreeFamiTF329759

Family and domain databases

InterProiView protein in InterPro
IPR007259 GCP
PANTHERiPTHR19302 PTHR19302, 2 hits
PfamiView protein in Pfam
PF04130 Spc97_Spc98, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BKN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARPKSSGSR MDRQLEHDVC ELVRQVTGLQ DEADPNFQLA LDFVWSNFRF
60 70 80 90 100
HRFLDVNSHK VEKTIEGIYE KFTIHSDLNK AASWKRLTKE FLNASLPSTE
110 120 130 140 150
KIKTDAHYSI LSLLLCLSDS PSNSNYVETP REKEVEKKDD FDWGKYLMEG
160 170 180 190 200
EEIGLGPNID TPNWSEDSDD EDAQQPLSRE DSGIQVDRTP LEEQDHNRKG
210 220 230 240 250
GPQVCWEDEP DSRSWLEQHV VHQYWTTRRF RIPHSAHLHS NLAAVWDQHL
260 270 280 290 300
YSSDPLYVPD DRVVVTETQV IRETLWLLSG VKKMFIFQLI DGKVTVRNNI
310 320 330 340 350
IVTHLTHSCL RSVLEQIAAY GQVVFRLQEF IDEVMGHSSE SLPPGNGPIP
360 370 380 390 400
KKQPDAPFRT YQAFMWALYK YFINFKEELT DIEKCVISSD TTITLAIVVN
410 420 430 440 450
KLAPRLAQLK VLDKVFSTGV AEVPPDTRNV VRASHLLNTL YKAILEYDNV
460 470 480 490 500
GEASEQTVSL LFSLWVETVR PYLQTVDEWI VHGHLWDGAR EFIIQRNKNV
510 520 530 540 550
PVNHRDFWYA TYTLYSVSEK TENEDKVSDS ASASSGSDQG PSSRQHTMVS
560 570 580 590 600
FLKPVLKQII MAGKSMQLLK NLNCAEGPAC QAAARDAERK SLYTLFLESI
610 620 630 640 650
QLRLQHGEDS APHIVNEDQT TKENLIKMQS IAERHLELDD IHDPLLAINF
660 670 680 690 700
ARLYLEQSDF HEKFAGGDIC VDRSSESVTC QTFELTLRSC LYPHIDKQYL
710 720 730 740 750
HCCGNLMQTL KRDFRLVEYL QAMRNFFLME GGDTMYDFYT SIFDKIREKE
760 770 780 790 800
TWQNVSFLNV QLQEAVGQRY PEDSLRLSIS FENVDTTKKK LPVHILDGLT
810 820 830 840 850
LSYKVPWPVD IVISVECQKI YNQVFLLLLQ IKWAKYSLDV LLFGELGNAA
860 870 880 890 900
ERSQAKEDIP RDQDTPSQFG PPKESLRQQI HRMFLLRVKL MHFVNSLHNY
910 920 930 940 950
IMTRILHSTG LEFQHQVEEA KDLDQLIKIH YRYLSTIHDR CLLREKVSFV
960 970 980 990 1000
KEAIMKVLNL ALMFAEGWQA GLGAWQMESI EKMESDFKNC HMFLVTILNK
1010 1020
AVCRGSFPHL ESLALSLMAG MEQS
Length:1,024
Mass (Da):117,977
Last modified:March 18, 2008 - v2
Checksum:iF975E340C0A7CE77
GO
Isoform 2 (identifier: Q8BKN5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     654-716: Missing.

Note: No experimental confirmation available.
Show »
Length:961
Mass (Da):110,604
Checksum:iFEA4262850CDB4BB
GO
Isoform 3 (identifier: Q8BKN5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     977-1024: Missing.

Note: No experimental confirmation available.
Show »
Length:976
Mass (Da):112,590
Checksum:i85D220B0BE909E05
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9S → L in BAD32569 (PubMed:15368895).Curated1
Sequence conflicti82A → G in BAC27661 (PubMed:16141072).Curated1
Sequence conflicti172 – 366Missing in BAD32569 (PubMed:15368895).CuratedAdd BLAST195
Sequence conflicti225W → L in BAC27661 (PubMed:16141072).Curated1
Sequence conflicti332D → Y in BAE31930 (PubMed:16141072).Curated1
Sequence conflicti332D → Y in BAE31910 (PubMed:16141072).Curated1
Sequence conflicti332D → Y in BAE30892 (PubMed:16141072).Curated1
Sequence conflicti332D → Y in BAE30414 (PubMed:16141072).Curated1
Sequence conflicti587A → E in BAC34603 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032040654 – 716Missing in isoform 2. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_032041977 – 1024Missing in isoform 3. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032031 mRNA Translation: BAC27661.1
AK044887 mRNA Translation: BAC32128.1
AK051326 mRNA Translation: BAC34603.1
AK151454 mRNA Translation: BAE30414.1
AK152033 mRNA Translation: BAE30892.1
AK153331 mRNA Translation: BAE31910.1
AK153357 mRNA Translation: BAE31930.1
AK173291 Transcribed RNA Translation: BAD32569.1
CCDSiCCDS21314.1 [Q8BKN5-1]
RefSeqiNP_666302.2, NM_146190.2 [Q8BKN5-1]
UniGeneiMm.284306

Genome annotation databases

EnsembliENSMUST00000032627; ENSMUSP00000032627; ENSMUSG00000033790 [Q8BKN5-1]
ENSMUST00000205796; ENSMUSP00000146111; ENSMUSG00000033790 [Q8BKN5-2]
GeneIDi233276
KEGGimmu:233276
UCSCiuc009hdd.1 mouse [Q8BKN5-1]
uc009hdf.1 mouse [Q8BKN5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGCP5_MOUSE
AccessioniPrimary (citable) accession number: Q8BKN5
Secondary accession number(s): Q3U8X5
, Q69Z75, Q8BLJ9, Q8C083
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: March 28, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health