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Protein

Zinc finger protein 689

Gene

Znf689

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri149 – 171C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri177 – 199C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri205 – 227C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 483C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST27

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • skeletal muscle cell differentiation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 689
Gene namesi
Name:Znf689
Synonyms:Zfp689
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1918381. Zfp689.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002340091 – 500Zinc finger protein 689Add BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki455Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ8BKK5.
PRIDEiQ8BKK5.

PTM databases

iPTMnetiQ8BKK5.
PhosphoSitePlusiQ8BKK5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000048921.
CleanExiMM_ZFP689.
ExpressionAtlasiQ8BKK5. baseline and differential.
GenevisibleiQ8BKK5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056610.

Structurei

3D structure databases

ProteinModelPortaliQ8BKK5.
SMRiQ8BKK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 100KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri149 – 171C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri177 – 199C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri205 – 227C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 483C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST27

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00560000077257.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8BKK5.
KOiK09228.
OMAiQSHKCAQ.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8BKK5.
TreeFamiTF336948.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 6 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.

Sequencei

Sequence statusi: Complete.

Q8BKK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPSAPLLL RAVGEAGPTR KRGRRPRALK FVDVAVYFSS EEWGCLQPAQ
60 70 80 90 100
RTLYRDVMRE TYGLLGALGC AGPKPALISW LERNTDDWEP AALDPQEYRR
110 120 130 140 150
WVTFQRKTRS KQKTEEKDVF PPKEAPRKGK RGRKPSKPRL IPRQTSGGPI
160 170 180 190 200
CPDCGCTFPD HLALESHKCA QNLKKPYPCP DCGRRFSYPS LLVSHRRAHS
210 220 230 240 250
GECPYVCDQC GKRFSQRKNL SQHQVIHTGE KPYHCPDCGR CFRRSRSLAN
260 270 280 290 300
HRTTHTGEKP HQCPSCGRRF AYPSLLAIHQ RTHTGEKPYT CLECSRRFRQ
310 320 330 340 350
RTALVIHQRI HTGEKPYPCP DCERRFSSSS RLVSHRRVHS GERPYACENC
360 370 380 390 400
EARFSQRSTL LQHQLLHTGE KPYPCPDCGR AFRRSGSLAI HRSTHTEEKL
410 420 430 440 450
HACDDCGRRF AYPSLLASHR RVHSGERPYA CDLCSKRFAQ WSHLSQHQLL
460 470 480 490 500
HTGEKPFPCL ECGRCFRQRW SLAVHKCCPN TPNGSPRPLI GGPSQRSSAL
Length:500
Mass (Da):57,082
Last modified:March 1, 2003 - v1
Checksum:i5BF3B828B151E4D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti450L → V in BAC25939 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028417 mRNA. Translation: BAC25939.1.
AK051667 mRNA. Translation: BAC34710.1.
BC052084 mRNA. Translation: AAH52084.1.
CCDSiCCDS21867.1.
RefSeqiNP_780372.2. NM_175163.3.
UniGeneiMm.474533.

Genome annotation databases

EnsembliENSMUST00000053392; ENSMUSP00000056610; ENSMUSG00000048921.
GeneIDi71131.
KEGGimmu:71131.
UCSCiuc009jvl.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiZN689_MOUSE
AccessioniPrimary (citable) accession number: Q8BKK5
Secondary accession number(s): Q8C1C6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2003
Last modified: August 30, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families