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Protein

Zinc finger protein 689

Gene

Znf689

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri149 – 171C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri177 – 199C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri205 – 227C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 483C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST27

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • skeletal muscle cell differentiation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 689
Gene namesi
Name:Znf689
Synonyms:Zfp689
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1918381. Zfp689.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002340091 – 500Zinc finger protein 689Add BLAST500

Proteomic databases

PaxDbiQ8BKK5.
PRIDEiQ8BKK5.

PTM databases

iPTMnetiQ8BKK5.
PhosphoSitePlusiQ8BKK5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000048921.
CleanExiMM_ZFP689.
ExpressionAtlasiQ8BKK5. baseline and differential.
GenevisibleiQ8BKK5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056610.

Structurei

3D structure databases

ProteinModelPortaliQ8BKK5.
SMRiQ8BKK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 100KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri149 – 171C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri177 – 199C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri205 – 227C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 483C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST27

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00560000077257.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8BKK5.
KOiK09228.
OMAiQSHKCAQ.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8BKK5.
TreeFamiTF336948.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BKK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPSAPLLL RAVGEAGPTR KRGRRPRALK FVDVAVYFSS EEWGCLQPAQ
60 70 80 90 100
RTLYRDVMRE TYGLLGALGC AGPKPALISW LERNTDDWEP AALDPQEYRR
110 120 130 140 150
WVTFQRKTRS KQKTEEKDVF PPKEAPRKGK RGRKPSKPRL IPRQTSGGPI
160 170 180 190 200
CPDCGCTFPD HLALESHKCA QNLKKPYPCP DCGRRFSYPS LLVSHRRAHS
210 220 230 240 250
GECPYVCDQC GKRFSQRKNL SQHQVIHTGE KPYHCPDCGR CFRRSRSLAN
260 270 280 290 300
HRTTHTGEKP HQCPSCGRRF AYPSLLAIHQ RTHTGEKPYT CLECSRRFRQ
310 320 330 340 350
RTALVIHQRI HTGEKPYPCP DCERRFSSSS RLVSHRRVHS GERPYACENC
360 370 380 390 400
EARFSQRSTL LQHQLLHTGE KPYPCPDCGR AFRRSGSLAI HRSTHTEEKL
410 420 430 440 450
HACDDCGRRF AYPSLLASHR RVHSGERPYA CDLCSKRFAQ WSHLSQHQLL
460 470 480 490 500
HTGEKPFPCL ECGRCFRQRW SLAVHKCCPN TPNGSPRPLI GGPSQRSSAL
Length:500
Mass (Da):57,082
Last modified:March 1, 2003 - v1
Checksum:i5BF3B828B151E4D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti450L → V in BAC25939 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028417 mRNA. Translation: BAC25939.1.
AK051667 mRNA. Translation: BAC34710.1.
BC052084 mRNA. Translation: AAH52084.1.
CCDSiCCDS21867.1.
RefSeqiNP_780372.2. NM_175163.3.
UniGeneiMm.474533.

Genome annotation databases

EnsembliENSMUST00000053392; ENSMUSP00000056610; ENSMUSG00000048921.
GeneIDi71131.
KEGGimmu:71131.
UCSCiuc009jvl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028417 mRNA. Translation: BAC25939.1.
AK051667 mRNA. Translation: BAC34710.1.
BC052084 mRNA. Translation: AAH52084.1.
CCDSiCCDS21867.1.
RefSeqiNP_780372.2. NM_175163.3.
UniGeneiMm.474533.

3D structure databases

ProteinModelPortaliQ8BKK5.
SMRiQ8BKK5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056610.

PTM databases

iPTMnetiQ8BKK5.
PhosphoSitePlusiQ8BKK5.

Proteomic databases

PaxDbiQ8BKK5.
PRIDEiQ8BKK5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053392; ENSMUSP00000056610; ENSMUSG00000048921.
GeneIDi71131.
KEGGimmu:71131.
UCSCiuc009jvl.2. mouse.

Organism-specific databases

CTDi71131.
MGIiMGI:1918381. Zfp689.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00560000077257.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8BKK5.
KOiK09228.
OMAiQSHKCAQ.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8BKK5.
TreeFamiTF336948.

Miscellaneous databases

PROiQ8BKK5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048921.
CleanExiMM_ZFP689.
ExpressionAtlasiQ8BKK5. baseline and differential.
GenevisibleiQ8BKK5. MM.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN689_MOUSE
AccessioniPrimary (citable) accession number: Q8BKK5
Secondary accession number(s): Q8C1C6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.