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Protein

Protein phosphatase 1 regulatory subunit 1C

Gene

Ppp1r1c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Inhibitor of protein-phosphatase 1. Promotes cell growth and cell cycle progress at the G1/S transition. May increase cell susceptibility to TNF-induced apoptosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 1C
Gene namesi
Name:Ppp1r1c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1923185. Ppp1r1c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 108108Protein phosphatase 1 regulatory subunit 1CPRO_0000286444Add
BLAST

Post-translational modificationi

Phosphorylation of Thr-34 is required for activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BKK4.
PaxDbiQ8BKK4.
PRIDEiQ8BKK4.

PTM databases

PhosphoSiteiQ8BKK4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034683.
GenevisibleiQ8BKK4. MM.

Interactioni

Subunit structurei

Interacts with PPP1CB.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088265.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IYYH. Eukaryota.
ENOG410YPKK. LUCA.
GeneTreeiENSGT00730000110965.
HOGENOMiHOG000115665.
HOVERGENiHBG055965.
InParanoidiQ8BKK4.
KOiK17549.
OMAiQNDSAFP.
OrthoDBiEOG091G1A3V.
PhylomeDBiQ8BKK4.
TreeFamiTF332576.

Family and domain databases

InterProiIPR008466. PPP1R1A/B/C.
[Graphical view]
PANTHERiPTHR15417. PTHR15417. 1 hit.
PfamiPF05395. DARPP-32. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BKK4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPNSPKKIQ FAVPLFQSQI APEAAEQIRK RRPTPASLVI LNEHNSPEID
60 70 80 90 100
EKRVTNTQES QNASPKQRKQ SVYTPPAMKG VKHLKDQNGS AFPEEEESAS

EREEKWNH
Length:108
Mass (Da):12,303
Last modified:March 1, 2003 - v1
Checksum:iFC9D1B070448DD3D
GO
Isoform 2 (identifier: Q8BKK4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-79: Missing.

Show »
Length:76
Mass (Da):8,631
Checksum:i2D6574B973377F5D
GO
Isoform 3 (identifier: Q8BKK4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-108: VKHLKDQNGSAFPEEEESASEREEKWNH → ASNQEEKKRWE

Note: No experimental confirmation available.
Show »
Length:91
Mass (Da):10,396
Checksum:i3636EFFB969D63CE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131V → E in BAC34644 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei48 – 7932Missing in isoform 2. 2 PublicationsVSP_025059Add
BLAST
Alternative sequencei81 – 10828VKHLK…EKWNH → ASNQEEKKRWE in isoform 3. 1 PublicationVSP_025060Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK051449 mRNA. Translation: BAC34644.1.
AK051670 mRNA. Translation: BAC34713.1.
AK157871 mRNA. Translation: BAE34243.1.
AL844577 Genomic DNA. Translation: CAM14502.1.
AL844577 Genomic DNA. Translation: CAM14503.1.
AL844577 Genomic DNA. Translation: CAM14504.1.
BC120706 mRNA. Translation: AAI20707.1.
BC132149 mRNA. Translation: AAI32150.1.
CCDSiCCDS16171.1. [Q8BKK4-1]
CCDS71081.1. [Q8BKK4-3]
CCDS79810.1. [Q8BKK4-2]
RefSeqiNP_001277672.1. NM_001290743.1. [Q8BKK4-3]
NP_001277673.1. NM_001290744.1. [Q8BKK4-2]
NP_766008.2. NM_172420.4. [Q8BKK4-1]
UniGeneiMm.257373.

Genome annotation databases

EnsembliENSMUST00000040863; ENSMUSP00000042784; ENSMUSG00000034683. [Q8BKK4-2]
ENSMUST00000090760; ENSMUSP00000088265; ENSMUSG00000034683. [Q8BKK4-1]
ENSMUST00000111780; ENSMUSP00000107410; ENSMUSG00000034683. [Q8BKK4-3]
GeneIDi75276.
KEGGimmu:75276.
UCSCiuc008kgy.2. mouse. [Q8BKK4-1]
uc008kha.1. mouse. [Q8BKK4-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK051449 mRNA. Translation: BAC34644.1.
AK051670 mRNA. Translation: BAC34713.1.
AK157871 mRNA. Translation: BAE34243.1.
AL844577 Genomic DNA. Translation: CAM14502.1.
AL844577 Genomic DNA. Translation: CAM14503.1.
AL844577 Genomic DNA. Translation: CAM14504.1.
BC120706 mRNA. Translation: AAI20707.1.
BC132149 mRNA. Translation: AAI32150.1.
CCDSiCCDS16171.1. [Q8BKK4-1]
CCDS71081.1. [Q8BKK4-3]
CCDS79810.1. [Q8BKK4-2]
RefSeqiNP_001277672.1. NM_001290743.1. [Q8BKK4-3]
NP_001277673.1. NM_001290744.1. [Q8BKK4-2]
NP_766008.2. NM_172420.4. [Q8BKK4-1]
UniGeneiMm.257373.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088265.

PTM databases

PhosphoSiteiQ8BKK4.

Proteomic databases

MaxQBiQ8BKK4.
PaxDbiQ8BKK4.
PRIDEiQ8BKK4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040863; ENSMUSP00000042784; ENSMUSG00000034683. [Q8BKK4-2]
ENSMUST00000090760; ENSMUSP00000088265; ENSMUSG00000034683. [Q8BKK4-1]
ENSMUST00000111780; ENSMUSP00000107410; ENSMUSG00000034683. [Q8BKK4-3]
GeneIDi75276.
KEGGimmu:75276.
UCSCiuc008kgy.2. mouse. [Q8BKK4-1]
uc008kha.1. mouse. [Q8BKK4-3]

Organism-specific databases

CTDi151242.
MGIiMGI:1923185. Ppp1r1c.

Phylogenomic databases

eggNOGiENOG410IYYH. Eukaryota.
ENOG410YPKK. LUCA.
GeneTreeiENSGT00730000110965.
HOGENOMiHOG000115665.
HOVERGENiHBG055965.
InParanoidiQ8BKK4.
KOiK17549.
OMAiQNDSAFP.
OrthoDBiEOG091G1A3V.
PhylomeDBiQ8BKK4.
TreeFamiTF332576.

Miscellaneous databases

PROiQ8BKK4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034683.
GenevisibleiQ8BKK4. MM.

Family and domain databases

InterProiIPR008466. PPP1R1A/B/C.
[Graphical view]
PANTHERiPTHR15417. PTHR15417. 1 hit.
PfamiPF05395. DARPP-32. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPR1C_MOUSE
AccessioniPrimary (citable) accession number: Q8BKK4
Secondary accession number(s): A2AQD1, Q3TZG5, Q8BKM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.