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Q8BKG4

- FZD10_MOUSE

UniProt

Q8BKG4 - FZD10_MOUSE

Protein

Frizzled-10

Gene

Fzd10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. PDZ domain binding Source: RefGenome
    3. Wnt-activated receptor activity Source: RefGenome
    4. Wnt-protein binding Source: MGI

    GO - Biological processi

    1. brain development Source: RefGenome
    2. canonical Wnt signaling pathway Source: RefGenome
    3. gonad development Source: RefGenome
    4. negative regulation of Rho GTPase activity Source: Ensembl
    5. non-canonical Wnt signaling pathway via JNK cascade Source: Ensembl
    6. positive regulation of JUN kinase activity Source: Ensembl
    7. positive regulation of Rac GTPase activity Source: Ensembl
    8. regulation of actin cytoskeleton organization Source: Ensembl
    9. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    10. vasculature development Source: RefGenome
    11. Wnt signaling pathway Source: MGI

    Keywords - Molecular functioni

    Developmental protein, G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Wnt signaling pathway

    Protein family/group databases

    MEROPSiI93.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Frizzled-10
    Short name:
    Fz-10
    Alternative name(s):
    CD_antigen: CD350
    Gene namesi
    Name:Fzd10
    Synonyms:Fz10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:2136761. Fzd10.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. cell projection Source: RefGenome
    2. cell surface Source: Ensembl
    3. cytoplasm Source: RefGenome
    4. integral component of membrane Source: UniProtKB-KW
    5. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 582561Frizzled-10PRO_0000013006Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi35 ↔ 96PROSITE-ProRule annotation
    Disulfide bondi43 ↔ 89PROSITE-ProRule annotation
    Glycosylationi49 – 491N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi80 ↔ 118PROSITE-ProRule annotation
    Disulfide bondi107 ↔ 148PROSITE-ProRule annotation
    Disulfide bondi111 ↔ 135PROSITE-ProRule annotation
    Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi486 – 4861N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiQ8BKG4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BKG4.
    BgeeiQ8BKG4.
    CleanExiMM_FZD10.
    GenevestigatoriQ8BKG4.

    Interactioni

    Subunit structurei

    Interacts with MYOC.By similarity

    Protein-protein interaction databases

    BioGridi220362. 2 interactions.
    STRINGi10090.ENSMUSP00000114114.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BKG4.
    SMRiQ8BKG4. Positions 35-151, 194-538.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 226205ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini248 – 26316CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini285 – 31228ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini334 – 35219CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini374 – 39421ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini416 – 44429CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini466 – 50338ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini525 – 58258CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei227 – 24721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei264 – 28421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei313 – 33321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei353 – 37321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei395 – 41521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei445 – 46521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei504 – 52421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 151122FZPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi527 – 5326Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity
    Motifi580 – 5823PDZ-binding

    Domaini

    Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
    The FZ domain is involved in binding with Wnt ligands.By similarity

    Sequence similaritiesi

    Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG257258.
    GeneTreeiENSGT00750000117488.
    HOVERGENiHBG006977.
    InParanoidiQ8BKG4.
    KOiK02842.
    OMAiQSWQNVC.
    OrthoDBiEOG7M3J01.
    TreeFamiTF317907.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR026549. FZD10.
    IPR017981. GPCR_2-like.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF86. PTHR11309:SF86. 1 hit.
    PfamiPF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view]
    PRINTSiPR00489. FRIZZLED.
    SMARTiSM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8BKG4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQHPGPRLWL VLQVMIGSCT AISSMDLERP GDGKCQPVEI PMCKDIGYNT    50
    TRMPNLMGHE NQREAAIQLH EFAPLVEYGC HSHLRFFLCS LYAPMCTEQV 100
    STPIPACRVM CEQARLKCSP IMEQFKFRWP DSLDCSKLPN KNDPNYLCME 150
    APNNGSDEPS RGSGMFPPLF RPQRPHSAQE HPLKDGGPGR AGCDNPGKFH 200
    HVEKSESCAP LCTPGVDVYW SRDDKRFAVV WLAIWSVLCF FSSAFTVLTF 250
    LIDPSRFRYP ERPIIFLSMC YCVYSVGYII RLFAGAESIA CDRDSGQLYV 300
    IQEGLESTGC TLVFLVLYYF GMASSLWWVV LTLTWFLAAG KKWGHEAIEA 350
    NSSYFHLAAW AIPAVKTILI LVMRRVAGDE LTGVCYVGSM DVNALTGFVL 400
    VPLACYLVIG TSFILSGFVA LFHIRRVMKT GGENTDKLEK LMVRIGVFSL 450
    LYTVPATCVI ACYFYERLNM DYWKMLATQH KCKMNNQTKT PDCLMTTSIP 500
    AVEVFMVKVS MLLVVGITSG VWVWTSKTLQ SWQHVCSRGL KRKSRRKPAS 550
    VVTSAGIYKK AQHPQKPHLG KYELPAQPSA CV 582
    Length:582
    Mass (Da):65,318
    Last modified:March 1, 2003 - v1
    Checksum:i3ED4F5340B1505E0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY509002 mRNA. Translation: AAR92468.1.
    AK052950 mRNA. Translation: BAC35217.1.
    CCDSiCCDS51652.1.
    RefSeqiNP_780493.1. NM_175284.3.
    UniGeneiMm.197628.

    Genome annotation databases

    EnsembliENSMUST00000117102; ENSMUSP00000114114; ENSMUSG00000081683.
    GeneIDi93897.
    KEGGimmu:93897.
    UCSCiuc008zsh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY509002 mRNA. Translation: AAR92468.1 .
    AK052950 mRNA. Translation: BAC35217.1 .
    CCDSi CCDS51652.1.
    RefSeqi NP_780493.1. NM_175284.3.
    UniGenei Mm.197628.

    3D structure databases

    ProteinModelPortali Q8BKG4.
    SMRi Q8BKG4. Positions 35-151, 194-538.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 220362. 2 interactions.
    STRINGi 10090.ENSMUSP00000114114.

    Protein family/group databases

    MEROPSi I93.001.
    GPCRDBi Search...

    Proteomic databases

    PRIDEi Q8BKG4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000117102 ; ENSMUSP00000114114 ; ENSMUSG00000081683 .
    GeneIDi 93897.
    KEGGi mmu:93897.
    UCSCi uc008zsh.1. mouse.

    Organism-specific databases

    CTDi 11211.
    MGIi MGI:2136761. Fzd10.

    Phylogenomic databases

    eggNOGi NOG257258.
    GeneTreei ENSGT00750000117488.
    HOVERGENi HBG006977.
    InParanoidi Q8BKG4.
    KOi K02842.
    OMAi QSWQNVC.
    OrthoDBi EOG7M3J01.
    TreeFami TF317907.

    Miscellaneous databases

    NextBioi 351851.
    PROi Q8BKG4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BKG4.
    Bgeei Q8BKG4.
    CleanExi MM_FZD10.
    Genevestigatori Q8BKG4.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR026549. FZD10.
    IPR017981. GPCR_2-like.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF86. PTHR11309:SF86. 1 hit.
    Pfami PF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view ]
    PRINTSi PR00489. FRIZZLED.
    SMARTi SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of Fz10 expression in mouse embryos."
      Nunnally A.P., Parr B.A.
      Dev. Genes Evol. 214:144-148(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head.

    Entry informationi

    Entry nameiFZD10_MOUSE
    AccessioniPrimary (citable) accession number: Q8BKG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3