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Protein

Frizzled-10

Gene

Fzd10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-10
Short name:
Fz-10
Alternative name(s):
CD_antigen: CD350
Gene namesi
Name:Fzd10
Synonyms:Fz10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2136761. Fzd10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 226ExtracellularSequence analysisAdd BLAST205
Transmembranei227 – 247Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini248 – 263CytoplasmicSequence analysisAdd BLAST16
Transmembranei264 – 284Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini285 – 312ExtracellularSequence analysisAdd BLAST28
Transmembranei313 – 333Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini334 – 352CytoplasmicSequence analysisAdd BLAST19
Transmembranei353 – 373Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini374 – 394ExtracellularSequence analysisAdd BLAST21
Transmembranei395 – 415Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini416 – 444CytoplasmicSequence analysisAdd BLAST29
Transmembranei445 – 465Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini466 – 503ExtracellularSequence analysisAdd BLAST38
Transmembranei504 – 524Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini525 – 582CytoplasmicSequence analysisAdd BLAST58

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001300622 – 582Frizzled-10Add BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 96PROSITE-ProRule annotation
Disulfide bondi43 ↔ 89PROSITE-ProRule annotation
Glycosylationi49N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi80 ↔ 118PROSITE-ProRule annotation
Disulfide bondi107 ↔ 148PROSITE-ProRule annotation
Disulfide bondi111 ↔ 135PROSITE-ProRule annotation
Glycosylationi154N-linked (GlcNAc...)Sequence analysis1
Glycosylationi486N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8BKG4.
PRIDEiQ8BKG4.

PTM databases

PhosphoSitePlusiQ8BKG4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000081683.
CleanExiMM_FZD10.
ExpressionAtlasiQ8BKG4. baseline and differential.
GenevisibleiQ8BKG4. MM.

Interactioni

Subunit structurei

Interacts with MYOC.By similarity

GO - Molecular functioni

  • Wnt-protein binding Source: MGI

Protein-protein interaction databases

BioGridi220362. 2 interactors.
STRINGi10090.ENSMUSP00000114114.

Structurei

3D structure databases

ProteinModelPortaliQ8BKG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 151FZPROSITE-ProRule annotationAdd BLAST122

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi527 – 532Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity6
Motifi580 – 582PDZ-binding3

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
GeneTreeiENSGT00760000118864.
HOVERGENiHBG006977.
InParanoidiQ8BKG4.
KOiK02842.
OMAiEYGCHGH.
OrthoDBiEOG091G0N5M.
TreeFamiTF317907.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026549. FZD10.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF86. PTHR11309:SF86. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
SM01330. Frizzled. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BKG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQHPGPRLWL VLQVMIGSCT AISSMDLERP GDGKCQPVEI PMCKDIGYNT
60 70 80 90 100
TRMPNLMGHE NQREAAIQLH EFAPLVEYGC HSHLRFFLCS LYAPMCTEQV
110 120 130 140 150
STPIPACRVM CEQARLKCSP IMEQFKFRWP DSLDCSKLPN KNDPNYLCME
160 170 180 190 200
APNNGSDEPS RGSGMFPPLF RPQRPHSAQE HPLKDGGPGR AGCDNPGKFH
210 220 230 240 250
HVEKSESCAP LCTPGVDVYW SRDDKRFAVV WLAIWSVLCF FSSAFTVLTF
260 270 280 290 300
LIDPSRFRYP ERPIIFLSMC YCVYSVGYII RLFAGAESIA CDRDSGQLYV
310 320 330 340 350
IQEGLESTGC TLVFLVLYYF GMASSLWWVV LTLTWFLAAG KKWGHEAIEA
360 370 380 390 400
NSSYFHLAAW AIPAVKTILI LVMRRVAGDE LTGVCYVGSM DVNALTGFVL
410 420 430 440 450
VPLACYLVIG TSFILSGFVA LFHIRRVMKT GGENTDKLEK LMVRIGVFSL
460 470 480 490 500
LYTVPATCVI ACYFYERLNM DYWKMLATQH KCKMNNQTKT PDCLMTTSIP
510 520 530 540 550
AVEVFMVKVS MLLVVGITSG VWVWTSKTLQ SWQHVCSRGL KRKSRRKPAS
560 570 580
VVTSAGIYKK AQHPQKPHLG KYELPAQPSA CV
Length:582
Mass (Da):65,318
Last modified:March 1, 2003 - v1
Checksum:i3ED4F5340B1505E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY509002 mRNA. Translation: AAR92468.1.
AK052950 mRNA. Translation: BAC35217.1.
CCDSiCCDS51652.1.
RefSeqiNP_780493.1. NM_175284.3.
UniGeneiMm.197628.

Genome annotation databases

EnsembliENSMUST00000117102; ENSMUSP00000114114; ENSMUSG00000081683.
GeneIDi93897.
KEGGimmu:93897.
UCSCiuc008zsh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY509002 mRNA. Translation: AAR92468.1.
AK052950 mRNA. Translation: BAC35217.1.
CCDSiCCDS51652.1.
RefSeqiNP_780493.1. NM_175284.3.
UniGeneiMm.197628.

3D structure databases

ProteinModelPortaliQ8BKG4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi220362. 2 interactors.
STRINGi10090.ENSMUSP00000114114.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ8BKG4.

Proteomic databases

PaxDbiQ8BKG4.
PRIDEiQ8BKG4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000117102; ENSMUSP00000114114; ENSMUSG00000081683.
GeneIDi93897.
KEGGimmu:93897.
UCSCiuc008zsh.1. mouse.

Organism-specific databases

CTDi11211.
MGIiMGI:2136761. Fzd10.

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
GeneTreeiENSGT00760000118864.
HOVERGENiHBG006977.
InParanoidiQ8BKG4.
KOiK02842.
OMAiEYGCHGH.
OrthoDBiEOG091G0N5M.
TreeFamiTF317907.

Miscellaneous databases

PROiQ8BKG4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000081683.
CleanExiMM_FZD10.
ExpressionAtlasiQ8BKG4. baseline and differential.
GenevisibleiQ8BKG4. MM.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026549. FZD10.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF86. PTHR11309:SF86. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
SM01330. Frizzled. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFZD10_MOUSE
AccessioniPrimary (citable) accession number: Q8BKG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.