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Q8BKG4

- FZD10_MOUSE

UniProt

Q8BKG4 - FZD10_MOUSE

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Protein
Frizzled-10
Gene
Fzd10, Fz10
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues By similarity.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. PDZ domain binding Source: RefGenome
  3. Wnt-activated receptor activity Source: RefGenome
  4. Wnt-protein binding Source: MGI

GO - Biological processi

  1. Wnt signaling pathway Source: MGI
  2. brain development Source: RefGenome
  3. canonical Wnt signaling pathway Source: RefGenome
  4. gonad development Source: RefGenome
  5. negative regulation of Rho GTPase activity Source: Ensembl
  6. non-canonical Wnt signaling pathway via JNK cascade Source: Ensembl
  7. positive regulation of JUN kinase activity Source: Ensembl
  8. positive regulation of Rac GTPase activity Source: Ensembl
  9. regulation of actin cytoskeleton organization Source: Ensembl
  10. regulation of transcription from RNA polymerase II promoter Source: RefGenome
  11. vasculature development Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Wnt signaling pathway

Protein family/group databases

MEROPSiI93.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-10
Short name:
Fz-10
Alternative name(s):
CD_antigen: CD350
Gene namesi
Name:Fzd10
Synonyms:Fz10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:2136761. Fzd10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 226205Extracellular Reviewed prediction
Add
BLAST
Transmembranei227 – 24721Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini248 – 26316Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei264 – 28421Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini285 – 31228Extracellular Reviewed prediction
Add
BLAST
Transmembranei313 – 33321Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini334 – 35219Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei353 – 37321Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini374 – 39421Extracellular Reviewed prediction
Add
BLAST
Transmembranei395 – 41521Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini416 – 44429Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei445 – 46521Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini466 – 50338Extracellular Reviewed prediction
Add
BLAST
Transmembranei504 – 52421Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini525 – 58258Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell projection Source: RefGenome
  2. cell surface Source: Ensembl
  3. cytoplasm Source: RefGenome
  4. integral component of membrane Source: UniProtKB-KW
  5. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 582561Frizzled-10
PRO_0000013006Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 ↔ 96 By similarity
Disulfide bondi43 ↔ 89 By similarity
Glycosylationi49 – 491N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi80 ↔ 118 By similarity
Disulfide bondi107 ↔ 148 By similarity
Disulfide bondi111 ↔ 135 By similarity
Glycosylationi154 – 1541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi486 – 4861N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ8BKG4.

Expressioni

Gene expression databases

ArrayExpressiQ8BKG4.
BgeeiQ8BKG4.
CleanExiMM_FZD10.
GenevestigatoriQ8BKG4.

Interactioni

Subunit structurei

Interacts with MYOC By similarity.

Protein-protein interaction databases

BioGridi220362. 2 interactions.
STRINGi10090.ENSMUSP00000114114.

Structurei

3D structure databases

ProteinModelPortaliQ8BKG4.
SMRiQ8BKG4. Positions 35-151, 194-538.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 151122FZ
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi527 – 5326Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members By similarity
Motifi580 – 5823PDZ-binding

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway By similarity.
The FZ domain is involved in binding with Wnt ligands By similarity.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257258.
GeneTreeiENSGT00750000117488.
HOVERGENiHBG006977.
InParanoidiQ8BKG4.
KOiK02842.
OMAiQSWQNVC.
OrthoDBiEOG7M3J01.
TreeFamiTF317907.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026549. FZD10.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF86. PTHR11309:SF86. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BKG4-1 [UniParc]FASTAAdd to Basket

« Hide

MQHPGPRLWL VLQVMIGSCT AISSMDLERP GDGKCQPVEI PMCKDIGYNT    50
TRMPNLMGHE NQREAAIQLH EFAPLVEYGC HSHLRFFLCS LYAPMCTEQV 100
STPIPACRVM CEQARLKCSP IMEQFKFRWP DSLDCSKLPN KNDPNYLCME 150
APNNGSDEPS RGSGMFPPLF RPQRPHSAQE HPLKDGGPGR AGCDNPGKFH 200
HVEKSESCAP LCTPGVDVYW SRDDKRFAVV WLAIWSVLCF FSSAFTVLTF 250
LIDPSRFRYP ERPIIFLSMC YCVYSVGYII RLFAGAESIA CDRDSGQLYV 300
IQEGLESTGC TLVFLVLYYF GMASSLWWVV LTLTWFLAAG KKWGHEAIEA 350
NSSYFHLAAW AIPAVKTILI LVMRRVAGDE LTGVCYVGSM DVNALTGFVL 400
VPLACYLVIG TSFILSGFVA LFHIRRVMKT GGENTDKLEK LMVRIGVFSL 450
LYTVPATCVI ACYFYERLNM DYWKMLATQH KCKMNNQTKT PDCLMTTSIP 500
AVEVFMVKVS MLLVVGITSG VWVWTSKTLQ SWQHVCSRGL KRKSRRKPAS 550
VVTSAGIYKK AQHPQKPHLG KYELPAQPSA CV 582
Length:582
Mass (Da):65,318
Last modified:March 1, 2003 - v1
Checksum:i3ED4F5340B1505E0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY509002 mRNA. Translation: AAR92468.1.
AK052950 mRNA. Translation: BAC35217.1.
CCDSiCCDS51652.1.
RefSeqiNP_780493.1. NM_175284.3.
UniGeneiMm.197628.

Genome annotation databases

EnsembliENSMUST00000117102; ENSMUSP00000114114; ENSMUSG00000081683.
GeneIDi93897.
KEGGimmu:93897.
UCSCiuc008zsh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY509002 mRNA. Translation: AAR92468.1 .
AK052950 mRNA. Translation: BAC35217.1 .
CCDSi CCDS51652.1.
RefSeqi NP_780493.1. NM_175284.3.
UniGenei Mm.197628.

3D structure databases

ProteinModelPortali Q8BKG4.
SMRi Q8BKG4. Positions 35-151, 194-538.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 220362. 2 interactions.
STRINGi 10090.ENSMUSP00000114114.

Protein family/group databases

MEROPSi I93.001.
GPCRDBi Search...

Proteomic databases

PRIDEi Q8BKG4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000117102 ; ENSMUSP00000114114 ; ENSMUSG00000081683 .
GeneIDi 93897.
KEGGi mmu:93897.
UCSCi uc008zsh.1. mouse.

Organism-specific databases

CTDi 11211.
MGIi MGI:2136761. Fzd10.

Phylogenomic databases

eggNOGi NOG257258.
GeneTreei ENSGT00750000117488.
HOVERGENi HBG006977.
InParanoidi Q8BKG4.
KOi K02842.
OMAi QSWQNVC.
OrthoDBi EOG7M3J01.
TreeFami TF317907.

Miscellaneous databases

NextBioi 351851.
PROi Q8BKG4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BKG4.
Bgeei Q8BKG4.
CleanExi MM_FZD10.
Genevestigatori Q8BKG4.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026549. FZD10.
IPR017981. GPCR_2-like.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
PTHR11309:SF86. PTHR11309:SF86. 1 hit.
Pfami PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view ]
PRINTSi PR00489. FRIZZLED.
SMARTi SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of Fz10 expression in mouse embryos."
    Nunnally A.P., Parr B.A.
    Dev. Genes Evol. 214:144-148(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.

Entry informationi

Entry nameiFZD10_MOUSE
AccessioniPrimary (citable) accession number: Q8BKG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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