Q8BKG4 (FZD10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Frizzled-10
Short name=Fz-10

Alternative name(s):
CD_antigen=CD350

Gene names

Name:	Fzd10
Synonyms:	Fz10

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	582 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Domain	Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway By similarity. The FZ domain is involved in binding with Wnt ligands By similarity.
Post-translational modification	Ubiquitinated by ZNRF3, leading to its degradation by the proteasome By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor Fz/Smo family. Contains 1 FZ (frizzled) domain.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Cell membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Developmental protein G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	brain development Inferred from Biological aspect of Ancestor. Source: RefGenome canonical Wnt receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome embryo development Inferred from Biological aspect of Ancestor. Source: RefGenome gonad development Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of Rho GTPase activity Inferred from electronic annotation. Source: Compara non-canonical Wnt receptor signaling pathway via JNK cascade Inferred from electronic annotation. Source: Compara positive regulation of JUN kinase activity Inferred from electronic annotation. Source: Compara positive regulation of Rac GTPase activity Inferred from electronic annotation. Source: Compara regulation of actin cytoskeleton organization Inferred from electronic annotation. Source: Compara regulation of transcription from RNA polymerase II promoter Inferred from Biological aspect of Ancestor. Source: RefGenome vasculature development Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	cell projection Inferred from Biological aspect of Ancestor. Source: RefGenome cell surface Inferred from electronic annotation. Source: Compara cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW PDZ domain binding Inferred from Biological aspect of Ancestor. Source: RefGenome Wnt-activated receptor activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 582	561	Frizzled-10		PRO_0000013006
Regions
	Topological domain	22 – 226	205	Extracellular Potential
	Transmembrane	227 – 247	21	Helical; Name=1; Potential
	Topological domain	248 – 263	16	Cytoplasmic Potential
	Transmembrane	264 – 284	21	Helical; Name=2; Potential
	Topological domain	285 – 312	28	Extracellular Potential
	Transmembrane	313 – 333	21	Helical; Name=3; Potential
	Topological domain	334 – 352	19	Cytoplasmic Potential
	Transmembrane	353 – 373	21	Helical; Name=4; Potential
	Topological domain	374 – 394	21	Extracellular Potential
	Transmembrane	395 – 415	21	Helical; Name=5; Potential
	Topological domain	416 – 444	29	Cytoplasmic Potential
	Transmembrane	445 – 465	21	Helical; Name=6; Potential
	Topological domain	466 – 503	38	Extracellular Potential
	Transmembrane	504 – 524	21	Helical; Name=7; Potential
	Topological domain	525 – 582	58	Cytoplasmic Potential
	Domain	30 – 151	122	FZ
	Motif	527 – 532	6	Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members By similarity
	Motif	580 – 582	3	PDZ-binding
Amino acid modifications
	Glycosylation	49	1	N-linked (GlcNAc...) Potential
	Glycosylation	154	1	N-linked (GlcNAc...) Potential
	Glycosylation	486	1	N-linked (GlcNAc...) Potential
	Disulfide bond	35 ↔ 96		By similarity
	Disulfide bond	43 ↔ 89		By similarity
	Disulfide bond	80 ↔ 118		By similarity
	Disulfide bond	107 ↔ 148		By similarity
	Disulfide bond	111 ↔ 135		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8BKG4 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 3ED4F5340B1505E0	FASTA	582	65,318
	10 20 30 40 50 60 MQHPGPRLWL VLQVMIGSCT AISSMDLERP GDGKCQPVEI PMCKDIGYNT TRMPNLMGHE 70 80 90 100 110 120 NQREAAIQLH EFAPLVEYGC HSHLRFFLCS LYAPMCTEQV STPIPACRVM CEQARLKCSP 130 140 150 160 170 180 IMEQFKFRWP DSLDCSKLPN KNDPNYLCME APNNGSDEPS RGSGMFPPLF RPQRPHSAQE 190 200 210 220 230 240 HPLKDGGPGR AGCDNPGKFH HVEKSESCAP LCTPGVDVYW SRDDKRFAVV WLAIWSVLCF 250 260 270 280 290 300 FSSAFTVLTF LIDPSRFRYP ERPIIFLSMC YCVYSVGYII RLFAGAESIA CDRDSGQLYV 310 320 330 340 350 360 IQEGLESTGC TLVFLVLYYF GMASSLWWVV LTLTWFLAAG KKWGHEAIEA NSSYFHLAAW 370 380 390 400 410 420 AIPAVKTILI LVMRRVAGDE LTGVCYVGSM DVNALTGFVL VPLACYLVIG TSFILSGFVA 430 440 450 460 470 480 LFHIRRVMKT GGENTDKLEK LMVRIGVFSL LYTVPATCVI ACYFYERLNM DYWKMLATQH 490 500 510 520 530 540 KCKMNNQTKT PDCLMTTSIP AVEVFMVKVS MLLVVGITSG VWVWTSKTLQ SWQHVCSRGL 550 560 570 580 KRKSRRKPAS VVTSAGIYKK AQHPQKPHLG KYELPAQPSA CV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of Fz10 expression in mouse embryos." Nunnally A.P., Parr B.A. Dev. Genes Evol. 214:144-148(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: CD-1.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Head.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY509002 mRNA. Translation: AAR92468.1. AK052950 mRNA. Translation: BAC35217.1.
IPI	IPI00222590.
RefSeq	NP_780493.1. NM_175284.3.
UniGene	Mm.197628.
3D structure databases
ProteinModelPortal	Q8BKG4.
SMR	Q8BKG4. Positions 35-151.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000114114.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	Q8BKG4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000117102; ENSMUSP00000114114; ENSMUSG00000081683.
GeneID	93897.
KEGG	mmu:93897.
Organism-specific databases
CTD	11211.
MGI	MGI:2136761. Fzd10.
Phylogenomic databases
eggNOG	NOG257258.
GeneTree	ENSGT00660000095421.
HOVERGEN	HBG006977.
InParanoid	Q8BKG4.
KO	K02842.
OMA	LQSWQNV.
OrthoDB	EOG4C2H93.
Gene expression databases
ArrayExpress	Q8BKG4.
Bgee	Q8BKG4.
CleanEx	MM_FZD10.
Genevestigator	Q8BKG4.
Family and domain databases
Gene3D	1.10.2000.10. 1 hit.
InterPro	IPR000539. Frizzled. IPR015526. Frizzled/SFRP. IPR020067. Frizzled_dom. IPR026549. FZD10. IPR017981. GPCR_2-like. [Graphical view]
PANTHER	PTHR11309. PTHR11309. 1 hit. PTHR11309:SF24. PTHR11309:SF24. 1 hit.
Pfam	PF01534. Frizzled. 1 hit. PF01392. Fz. 1 hit. [Graphical view]
PRINTS	PR00489. FRIZZLED.
SMART	SM00063. FRI. 1 hit. [Graphical view]
SUPFAM	SSF63501. Frizzled_Cys-rich. 1 hit.
PROSITE	PS50038. FZ. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	351851.
SOURCE	Search...

Entry information

Entry name

FZD10_MOUSE

Accession

Primary (citable) accession number: Q8BKG4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program