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Q8BKG3

- PTK7_MOUSE

UniProt

Q8BKG3 - PTK7_MOUSE

Protein

Inactive tyrosine-protein kinase 7

Gene

Ptk7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.3 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei613 – 6142Cleavage; by MMP14By similarity

    GO - Molecular functioni

    1. transferase activity, transferring phosphorus-containing groups Source: InterPro

    GO - Biological processi

    1. actin cytoskeleton reorganization Source: Ensembl
    2. axis elongation Source: MGI
    3. canonical Wnt signaling pathway Source: Ensembl
    4. cell adhesion Source: UniProtKB-KW
    5. cell migration Source: Ensembl
    6. cellular response to retinoic acid Source: Ensembl
    7. cochlea morphogenesis Source: MGI
    8. convergent extension Source: MGI
    9. establishment of epithelial cell apical/basal polarity Source: MGI
    10. establishment of planar polarity Source: MGI
    11. lung-associated mesenchyme development Source: MGI
    12. neural tube closure Source: MGI
    13. planar cell polarity pathway involved in neural tube closure Source: MGI
    14. positive regulation of neuron projection development Source: Ensembl
    15. wound healing Source: MGI

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Cell adhesion, Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inactive tyrosine-protein kinase 7
    Alternative name(s):
    Protein chuzhoi
    Protein-tyrosine kinase 7
    Pseudo tyrosine kinase receptor 7
    Tyrosine-protein kinase-like 7
    Gene namesi
    Name:Ptk7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1918711. Ptk7.

    Subcellular locationi

    Membrane; Single-pass type I membrane protein. Cell junction By similarity
    Note: Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells.

    GO - Cellular componenti

    1. cell-cell junction Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: MGI
    4. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell junction, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Mice die perinatally and display craniorachischisis, a severe form of neural tube defect in which the neural tube fails to close from the midbrain hindbrain boundary to the base of the spine. Chuzhoi mutants also display disruption of planar cell polarity in the inner ear, and defective heart and lung development.3 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 10621040Inactive tyrosine-protein kinase 7PRO_0000260435Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi45 ↔ 93PROSITE-ProRule annotation
    Glycosylationi98 – 981N-linked (GlcNAc...)1 Publication
    Glycosylationi108 – 1081N-linked (GlcNAc...)1 Publication
    Disulfide bondi142 ↔ 192PROSITE-ProRule annotation
    Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi238 ↔ 293PROSITE-ProRule annotation
    Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi275 – 2751N-linked (GlcNAc...)1 Publication
    Disulfide bondi335 ↔ 383PROSITE-ProRule annotation
    Glycosylationi397 – 3971N-linked (GlcNAc...)2 Publications
    Disulfide bondi425 ↔ 473PROSITE-ProRule annotation
    Glycosylationi455 – 4551N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi516 ↔ 562PROSITE-ProRule annotation
    Glycosylationi559 – 5591N-linked (GlcNAc...)1 Publication
    Disulfide bondi605 ↔ 656PROSITE-ProRule annotation
    Glycosylationi638 – 6381N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    MMP14 cleaves PTK7 between Pro-613 and Leu-614 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ8BKG3.
    PaxDbiQ8BKG3.
    PRIDEiQ8BKG3.

    PTM databases

    PhosphoSiteiQ8BKG3.

    Expressioni

    Tissue specificityi

    Expressed at high levels in lung and un-pregnant uterus among adult tissues, and in the tail, limbs, somites, gut and craniofacial regions among embryonic tissues.1 Publication

    Gene expression databases

    ArrayExpressiQ8BKG3.
    BgeeiQ8BKG3.
    CleanExiMM_PTK7.
    GenevestigatoriQ8BKG3.

    Interactioni

    Subunit structurei

    Interacts with CTNNB1.By similarity

    Protein-protein interaction databases

    IntActiQ8BKG3. 1 interaction.
    MINTiMINT-4111157.
    STRINGi10090.ENSMUSP00000043703.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BKG3.
    SMRiQ8BKG3. Positions 26-674, 794-1046.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 696674ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini718 – 1062345CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei697 – 71721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 11290Ig-like C2-type 1Add
    BLAST
    Domaini120 – 21091Ig-like C2-type 2Add
    BLAST
    Domaini217 – 30993Ig-like C2-type 3Add
    BLAST
    Domaini301 – 39999Ig-like C2-type 4Add
    BLAST
    Domaini404 – 48986Ig-like C2-type 5Add
    BLAST
    Domaini495 – 57884Ig-like C2-type 6Add
    BLAST
    Domaini570 – 672103Ig-like C2-type 7Add
    BLAST
    Domaini788 – 1058271Protein kinase; inactivePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni786 – 1062277Interaction with CTNNB1By similarityAdd
    BLAST

    Domaini

    The protein kinase domain is predicted to be catalytically inactive.

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00750000117404.
    HOGENOMiHOG000115767.
    HOVERGENiHBG008320.
    InParanoidiQ8BKG3.
    KOiK05127.
    OMAiDGTWYRC.
    OrthoDBiEOG790G1M.
    PhylomeDBiQ8BKG3.
    TreeFamiTF326835.

    Family and domain databases

    Gene3Di2.60.40.10. 7 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF07679. I-set. 5 hits.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00409. IG. 1 hit.
    SM00408. IGc2. 6 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50835. IG_LIKE. 7 hits.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8BKG3-1 [UniParc]FASTAAdd to Basket

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    MGARPLTLLR ALLLPLLAGA QAAIVFIKEP SSQDALQGRR ALLRCEVEAP     50
    DPVHVYWLLN GVPVQDTERR FAQGSSLSFA AVDRLQDSGA FQCVARDNVT 100
    GEEVRSTNAS FNIKWIEAGP VVLKHPASEA EIQPQTQVTL RCHIDGHPRP 150
    TYQWFRDGTP LSDDQSTHTV SSRERNLTLR PASPEHSGLY SCCAHNAFGQ 200
    ACSSQNFTLS VADESFARVV LAPQDVVVAR NEEAMFHCQF SAQPPPSLQW 250
    VFEDETPITN RSRPPHLRRA VVFANGSLLL TQVRPRNAGV YRCIGQGQRG 300
    PPIVLEATLH LAEIEDMLPF EPRVFIAGDE ERVTCPAPQG LPTPSVWWEH 350
    AGVPLPAHGR VHQKGLELVF VTIAESDTGV YTCHASNLAG QRRQDVNITV 400
    ATVPTWLRKP QDSQLEEGKP GYLHCLTQAT PKPTVIWYRN QMLISEDSRF 450
    EVSKNGTLRI NSVEVYDGTL YRCVSSTPAG SIEAQARVQV LEKLKFTPPP 500
    QPQQCMEFDK EATVPCSATG REKPTVKWVR ADGSSLPEWV TDNAGTLHFA 550
    RVTRDDAGNY TCIASNEPQG QIRAHVQLTV AVFITFKVEP ERTTVYQGHT 600
    ALLRCEAQGD PKPLIQWKGK DRILDPTKLG PRMHIFQNGS LVIHDVAPED 650
    SGSYTCIAGN SCNIRHTEAP LLVVDKPVME DSEGPGSPPP YKMIQTIGLS 700
    VGAAVAYIIA VLGLMFYCKK RCKAKRLQKQ PEGEEPEMEC LNGGPLQNGQ 750
    PSAEIQEEVA LTSLGSGPPA TNKRHSAGDR MHFPRASLQP ITTLGKSEFG 800
    EVFLAKAQGV EEGATETLVL VKSLQSRDEQ QQLDFRREVE MFGKLNHANV 850
    VRLLGLCREA EPHYMVLEYV DLGDLKQFLR ISKNKDEKLK SQPLSTKQKV 900
    ALCSQVALGM EHLSNNRFVH KDLAARNCLI SAQRQVKVSA LGLSKDVYNS 950
    EYYHFRQAWV PLRWMSPEAV LEGDFSTKSD VWAFGVLMWE VFTHGEMPHG 1000
    GQADDEVLAD LQAGKARLPQ PEGCPSKLYR LMQRCWAPNP KDRPSFSEIA 1050
    STLGDSPADS KQ 1062
    Length:1,062
    Mass (Da):117,532
    Last modified:March 1, 2003 - v1
    Checksum:i138E25198A21E6A1
    GO

    Sequence cautioni

    The sequence AAH27800.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti818 – 8181L → R in BAC53806. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF531873 mRNA. Translation: AAQ10071.1.
    AY303976 Genomic DNA. Translation: AAQ73496.1.
    AK018379 mRNA. Translation: BAE43251.1.
    AK053044 mRNA. Translation: BAC35248.1.
    AK163135 mRNA. Translation: BAE37208.1.
    BC027800 mRNA. Translation: AAH27800.1. Different initiation.
    BC076578 mRNA. Translation: AAH76578.1.
    AB055408 mRNA. Translation: BAC53806.1.
    CCDSiCCDS37637.1.
    RefSeqiNP_780377.1. NM_175168.4.
    UniGeneiMm.181833.

    Genome annotation databases

    EnsembliENSMUST00000044442; ENSMUSP00000043703; ENSMUSG00000023972.
    GeneIDi71461.
    KEGGimmu:71461.
    UCSCiuc008cth.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF531873 mRNA. Translation: AAQ10071.1 .
    AY303976 Genomic DNA. Translation: AAQ73496.1 .
    AK018379 mRNA. Translation: BAE43251.1 .
    AK053044 mRNA. Translation: BAC35248.1 .
    AK163135 mRNA. Translation: BAE37208.1 .
    BC027800 mRNA. Translation: AAH27800.1 . Different initiation.
    BC076578 mRNA. Translation: AAH76578.1 .
    AB055408 mRNA. Translation: BAC53806.1 .
    CCDSi CCDS37637.1.
    RefSeqi NP_780377.1. NM_175168.4.
    UniGenei Mm.181833.

    3D structure databases

    ProteinModelPortali Q8BKG3.
    SMRi Q8BKG3. Positions 26-674, 794-1046.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8BKG3. 1 interaction.
    MINTi MINT-4111157.
    STRINGi 10090.ENSMUSP00000043703.

    PTM databases

    PhosphoSitei Q8BKG3.

    Proteomic databases

    MaxQBi Q8BKG3.
    PaxDbi Q8BKG3.
    PRIDEi Q8BKG3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044442 ; ENSMUSP00000043703 ; ENSMUSG00000023972 .
    GeneIDi 71461.
    KEGGi mmu:71461.
    UCSCi uc008cth.2. mouse.

    Organism-specific databases

    CTDi 5754.
    MGIi MGI:1918711. Ptk7.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00750000117404.
    HOGENOMi HOG000115767.
    HOVERGENi HBG008320.
    InParanoidi Q8BKG3.
    KOi K05127.
    OMAi DGTWYRC.
    OrthoDBi EOG790G1M.
    PhylomeDBi Q8BKG3.
    TreeFami TF326835.

    Miscellaneous databases

    NextBioi 333833.
    PROi Q8BKG3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BKG3.
    Bgeei Q8BKG3.
    CleanExi MM_PTK7.
    Genevestigatori Q8BKG3.

    Family and domain databases

    Gene3Di 2.60.40.10. 7 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF07679. I-set. 5 hits.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00409. IG. 1 hit.
    SM00408. IGc2. 6 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50835. IG_LIKE. 7 hits.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the full-length mouse Ptk7 cDNA encoding a defective receptor protein tyrosine kinase."
      Jung J.-W., Shin W.S., Song J., Lee S.-T.
      Gene 328:75-84(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
      Strain: BALB/c and C57BL/6.
      Tissue: Liver.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head and Lung.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6 and FVB/N.
      Tissue: Brain and Mammary tumor.
    4. "Isolation and characterization of novel human and mouse genes, which are expressed in the digestive tract."
      Daigo Y., Takayama I., Fujino M.A.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 774-1062.
      Strain: W/Wv.
    5. "PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates."
      Lu X., Borchers A.G.M., Jolicoeur C., Rayburn H., Baker J.C., Tessier-Lavigne M.
      Nature 430:93-98(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    6. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
      Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
      Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-108 AND ASN-397.
      Tissue: Myoblast.
    7. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-98; ASN-275; ASN-397 AND ASN-559.
    8. "PTK7 is essential for polarized cell motility and convergent extension during mouse gastrulation."
      Yen W.W., Williams M., Periasamy A., Conaway M., Burdsal C., Keller R., Lu X., Sutherland A.
      Development 136:2039-2048(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    9. "The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear."
      Paudyal A., Damrau C., Patterson V.L., Ermakov A., Formstone C., Lalanne Z., Wells S., Lu X., Norris D.P., Dean C.H., Henderson D.J., Murdoch J.N.
      BMC Dev. Biol. 10:87-87(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiPTK7_MOUSE
    AccessioniPrimary (citable) accession number: Q8BKG3
    Secondary accession number(s): Q3V422
    , Q6W8S9, Q8CHK5, Q8K178
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3