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Protein

Inactive tyrosine-protein kinase 7

Gene

Ptk7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.3 Publications

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton reorganization Source: MGI
  • axis elongation Source: MGI
  • canonical Wnt signaling pathway Source: MGI
  • cell adhesion Source: UniProtKB-KW
  • cell migration Source: MGI
  • cellular response to retinoic acid Source: MGI
  • cochlea morphogenesis Source: MGI
  • convergent extension Source: MGI
  • coronary vasculature development Source: MGI
  • establishment of epithelial cell apical/basal polarity Source: MGI
  • establishment of planar polarity Source: MGI
  • heart development Source: MGI
  • lung-associated mesenchyme development Source: MGI
  • neural tube closure Source: MGI
  • planar cell polarity pathway involved in neural tube closure Source: MGI
  • positive regulation of neuron projection development Source: MGI
  • ventricular septum development Source: MGI
  • wound healing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive tyrosine-protein kinase 7
Alternative name(s):
Protein chuzhoi
Protein-tyrosine kinase 7
Pseudo tyrosine kinase receptor 7
Tyrosine-protein kinase-like 7
Gene namesi
Name:Ptk7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1918711. Ptk7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 696ExtracellularSequence analysisAdd BLAST674
Transmembranei697 – 717HelicalSequence analysisAdd BLAST21
Topological domaini718 – 1062CytoplasmicSequence analysisAdd BLAST345

GO - Cellular componenti

  • cell-cell junction Source: MGI
  • focal adhesion Source: MGI
  • integral component of plasma membrane Source: InterPro
  • membrane Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice die perinatally and display craniorachischisis, a severe form of neural tube defect in which the neural tube fails to close from the midbrain hindbrain boundary to the base of the spine. Chuzhoi mutants also display disruption of planar cell polarity in the inner ear, and defective heart and lung development.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000026043523 – 1062Inactive tyrosine-protein kinase 7Add BLAST1040

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 93PROSITE-ProRule annotation
Glycosylationi98N-linked (GlcNAc...)1 Publication1
Glycosylationi108N-linked (GlcNAc...)1 Publication1
Disulfide bondi142 ↔ 192PROSITE-ProRule annotation
Glycosylationi176N-linked (GlcNAc...)Sequence analysis1
Glycosylationi206N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi238 ↔ 293PROSITE-ProRule annotation
Glycosylationi260N-linked (GlcNAc...)Sequence analysis1
Glycosylationi275N-linked (GlcNAc...)1 Publication1
Disulfide bondi335 ↔ 383PROSITE-ProRule annotation
Glycosylationi397N-linked (GlcNAc...)2 Publications1
Disulfide bondi425 ↔ 473PROSITE-ProRule annotation
Glycosylationi455N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi516 ↔ 562PROSITE-ProRule annotation
Glycosylationi559N-linked (GlcNAc...)1 Publication1
Disulfide bondi605 ↔ 656PROSITE-ProRule annotation
Glycosylationi638N-linked (GlcNAc...)Sequence analysis1
Modified residuei1056PhosphoserineCombined sources1

Post-translational modificationi

MMP14 cleaves PTK7 between Pro-613 and Leu-614 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei613 – 614Cleavage; by MMP14By similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8BKG3.
PaxDbiQ8BKG3.
PeptideAtlasiQ8BKG3.
PRIDEiQ8BKG3.

PTM databases

iPTMnetiQ8BKG3.
PhosphoSitePlusiQ8BKG3.
SwissPalmiQ8BKG3.

Expressioni

Tissue specificityi

Expressed at high levels in lung and un-pregnant uterus among adult tissues, and in the tail, limbs, somites, gut and craniofacial regions among embryonic tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000023972.
CleanExiMM_PTK7.
GenevisibleiQ8BKG3. MM.

Interactioni

Subunit structurei

Interacts with CTNNB1.By similarity

Protein-protein interaction databases

IntActiQ8BKG3. 1 interactor.
MINTiMINT-4111157.
STRINGi10090.ENSMUSP00000043703.

Structurei

3D structure databases

ProteinModelPortaliQ8BKG3.
SMRiQ8BKG3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 112Ig-like C2-type 1Add BLAST90
Domaini120 – 210Ig-like C2-type 2Add BLAST91
Domaini217 – 309Ig-like C2-type 3Add BLAST93
Domaini301 – 399Ig-like C2-type 4Add BLAST99
Domaini404 – 489Ig-like C2-type 5Add BLAST86
Domaini495 – 578Ig-like C2-type 6Add BLAST84
Domaini570 – 672Ig-like C2-type 7Add BLAST103
Domaini788 – 1058Protein kinase; inactivePROSITE-ProRule annotationAdd BLAST271

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni786 – 1062Interaction with CTNNB1By similarityAdd BLAST277

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1026. Eukaryota.
KOG4475. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118818.
HOGENOMiHOG000115767.
HOVERGENiHBG008320.
InParanoidiQ8BKG3.
KOiK05127.
OMAiLHFPRAN.
OrthoDBiEOG091G0BWE.
PhylomeDBiQ8BKG3.
TreeFamiTF326835.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR033592. PTK7.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PANTHERiPTHR26391:SF15. PTHR26391:SF15. 2 hits.
PfamiPF07679. I-set. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00409. IG. 7 hits.
SM00408. IGc2. 7 hits.
SM00406. IGv. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 8 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 7 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BKG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGARPLTLLR ALLLPLLAGA QAAIVFIKEP SSQDALQGRR ALLRCEVEAP
60 70 80 90 100
DPVHVYWLLN GVPVQDTERR FAQGSSLSFA AVDRLQDSGA FQCVARDNVT
110 120 130 140 150
GEEVRSTNAS FNIKWIEAGP VVLKHPASEA EIQPQTQVTL RCHIDGHPRP
160 170 180 190 200
TYQWFRDGTP LSDDQSTHTV SSRERNLTLR PASPEHSGLY SCCAHNAFGQ
210 220 230 240 250
ACSSQNFTLS VADESFARVV LAPQDVVVAR NEEAMFHCQF SAQPPPSLQW
260 270 280 290 300
VFEDETPITN RSRPPHLRRA VVFANGSLLL TQVRPRNAGV YRCIGQGQRG
310 320 330 340 350
PPIVLEATLH LAEIEDMLPF EPRVFIAGDE ERVTCPAPQG LPTPSVWWEH
360 370 380 390 400
AGVPLPAHGR VHQKGLELVF VTIAESDTGV YTCHASNLAG QRRQDVNITV
410 420 430 440 450
ATVPTWLRKP QDSQLEEGKP GYLHCLTQAT PKPTVIWYRN QMLISEDSRF
460 470 480 490 500
EVSKNGTLRI NSVEVYDGTL YRCVSSTPAG SIEAQARVQV LEKLKFTPPP
510 520 530 540 550
QPQQCMEFDK EATVPCSATG REKPTVKWVR ADGSSLPEWV TDNAGTLHFA
560 570 580 590 600
RVTRDDAGNY TCIASNEPQG QIRAHVQLTV AVFITFKVEP ERTTVYQGHT
610 620 630 640 650
ALLRCEAQGD PKPLIQWKGK DRILDPTKLG PRMHIFQNGS LVIHDVAPED
660 670 680 690 700
SGSYTCIAGN SCNIRHTEAP LLVVDKPVME DSEGPGSPPP YKMIQTIGLS
710 720 730 740 750
VGAAVAYIIA VLGLMFYCKK RCKAKRLQKQ PEGEEPEMEC LNGGPLQNGQ
760 770 780 790 800
PSAEIQEEVA LTSLGSGPPA TNKRHSAGDR MHFPRASLQP ITTLGKSEFG
810 820 830 840 850
EVFLAKAQGV EEGATETLVL VKSLQSRDEQ QQLDFRREVE MFGKLNHANV
860 870 880 890 900
VRLLGLCREA EPHYMVLEYV DLGDLKQFLR ISKNKDEKLK SQPLSTKQKV
910 920 930 940 950
ALCSQVALGM EHLSNNRFVH KDLAARNCLI SAQRQVKVSA LGLSKDVYNS
960 970 980 990 1000
EYYHFRQAWV PLRWMSPEAV LEGDFSTKSD VWAFGVLMWE VFTHGEMPHG
1010 1020 1030 1040 1050
GQADDEVLAD LQAGKARLPQ PEGCPSKLYR LMQRCWAPNP KDRPSFSEIA
1060
STLGDSPADS KQ
Length:1,062
Mass (Da):117,532
Last modified:March 1, 2003 - v1
Checksum:i138E25198A21E6A1
GO

Sequence cautioni

The sequence AAH27800 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti818L → R in BAC53806 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF531873 mRNA. Translation: AAQ10071.1.
AY303976 Genomic DNA. Translation: AAQ73496.1.
AK018379 mRNA. Translation: BAE43251.1.
AK053044 mRNA. Translation: BAC35248.1.
AK163135 mRNA. Translation: BAE37208.1.
BC027800 mRNA. Translation: AAH27800.1. Different initiation.
BC076578 mRNA. Translation: AAH76578.1.
AB055408 mRNA. Translation: BAC53806.1.
CCDSiCCDS37637.1.
RefSeqiNP_780377.1. NM_175168.4.
UniGeneiMm.181833.

Genome annotation databases

EnsembliENSMUST00000044442; ENSMUSP00000043703; ENSMUSG00000023972.
GeneIDi71461.
KEGGimmu:71461.
UCSCiuc008cth.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF531873 mRNA. Translation: AAQ10071.1.
AY303976 Genomic DNA. Translation: AAQ73496.1.
AK018379 mRNA. Translation: BAE43251.1.
AK053044 mRNA. Translation: BAC35248.1.
AK163135 mRNA. Translation: BAE37208.1.
BC027800 mRNA. Translation: AAH27800.1. Different initiation.
BC076578 mRNA. Translation: AAH76578.1.
AB055408 mRNA. Translation: BAC53806.1.
CCDSiCCDS37637.1.
RefSeqiNP_780377.1. NM_175168.4.
UniGeneiMm.181833.

3D structure databases

ProteinModelPortaliQ8BKG3.
SMRiQ8BKG3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BKG3. 1 interactor.
MINTiMINT-4111157.
STRINGi10090.ENSMUSP00000043703.

PTM databases

iPTMnetiQ8BKG3.
PhosphoSitePlusiQ8BKG3.
SwissPalmiQ8BKG3.

Proteomic databases

MaxQBiQ8BKG3.
PaxDbiQ8BKG3.
PeptideAtlasiQ8BKG3.
PRIDEiQ8BKG3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044442; ENSMUSP00000043703; ENSMUSG00000023972.
GeneIDi71461.
KEGGimmu:71461.
UCSCiuc008cth.2. mouse.

Organism-specific databases

CTDi5754.
MGIiMGI:1918711. Ptk7.

Phylogenomic databases

eggNOGiKOG1026. Eukaryota.
KOG4475. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118818.
HOGENOMiHOG000115767.
HOVERGENiHBG008320.
InParanoidiQ8BKG3.
KOiK05127.
OMAiLHFPRAN.
OrthoDBiEOG091G0BWE.
PhylomeDBiQ8BKG3.
TreeFamiTF326835.

Miscellaneous databases

PROiQ8BKG3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023972.
CleanExiMM_PTK7.
GenevisibleiQ8BKG3. MM.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR033592. PTK7.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PANTHERiPTHR26391:SF15. PTHR26391:SF15. 2 hits.
PfamiPF07679. I-set. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00409. IG. 7 hits.
SM00408. IGc2. 7 hits.
SM00406. IGv. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 8 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 7 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTK7_MOUSE
AccessioniPrimary (citable) accession number: Q8BKG3
Secondary accession number(s): Q3V422
, Q6W8S9, Q8CHK5, Q8K178
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.