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Protein

Transporter

Gene

Slc6a11

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. gamma-aminobutyric acid:sodium symporter activity Source: Ensembl
  2. neurotransmitter:sodium symporter activity Source: InterPro
  3. neurotransmitter binding Source: Ensembl

GO - Biological processi

  1. brain development Source: Ensembl
  2. response to drug Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

SymportUniRule annotationSAAS annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
TransporterUniRule annotation
Gene namesi
Name:Slc6a11Imported
Synonyms:Gabt4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95630. Slc6a11.

Subcellular locationi

GO - Cellular componenti

  1. cell projection Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. integral component of plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ8BKG0.

Expressioni

Gene expression databases

BgeeiQ8BKG0.
ExpressionAtlasiQ8BKG0. baseline and differential.
GenevestigatoriQ8BKG0.

Structurei

3D structure databases

ProteinModelPortaliQ8BKG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sodium:neurotransmitter symporter (SNF) family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG071421.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002982. Na/ntran_symport_GABA_GAT3.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR01197. GAT3TRNSPORT.
PR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8BKG0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
VHERGHWNNK VEFVLSVAGE IIGLGNVWRF PYLCYKNGGG AFLIPYVVFF
60 70 80 90 100
ICCGIPVFFL ETALGQFTSE GGITCWRRVC PLFEGIGYAT QVIEAHLNVY
110 120 130 140 150
YIIILAWAIF YLSNCFTTEL PWATCGHEWN TEKCVEFQKL NFSNYSHVSL
160 170 180 190 200
QNATSPVMEF WERRVLAISD GIEHIGNLRW ELALCLLAAW TICYFCIWKG
210 220 230 240 250
TKSTGKVVYV TATFPYIMLL ILLIRGVTLP GASEGIKFYL YPDLSRLSDP
260 270 280 290 300
QVWVDAGTQI FFSYAICLGC LTALGSYNNY NNNCYRDCIM LCCLNSGTSF
310 320 330 340 350
VAGFAIFSVL GFMAYEQGVP IAEVAESGPG LAFIAYPKAV TMMPLSPLWA
360 370 380 390 400
TLFFMMLIFL GLDSQFVCVE SLVTAVVDMY PKVFRRGYRR ELLILALSII
410 420 430 440 450
SYFLGLVMLT EGGMYIFQLF DSYAASGMCL LFVAIFECVC IGWVYGSNRF
460 470 480 490 500
YDNIEDMIGY RPLSLIKWCW KVVTPGICAG IFIFFLVKYK PLKYNNVYTY
510 520 530 540 550
PAWGYGIGWL MALSSMLCIP LWIFIKLWKT EGTLPEKLQK LTVPSADLKM
560 570 580
RGKLGASPRT VTVNDCEAKV KGDGTISAIT EKETHF
Length:586
Mass (Da):66,065
Last modified:March 1, 2003 - v1
Checksum:i78EB41F1A9EB1A38
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053261 mRNA. Translation: BAC35326.1.
UniGeneiMm.44683.
Mm.448312.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053261 mRNA. Translation: BAC35326.1.
UniGeneiMm.44683.
Mm.448312.

3D structure databases

ProteinModelPortaliQ8BKG0.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ8BKG0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95630. Slc6a11.

Phylogenomic databases

HOVERGENiHBG071421.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ8BKG0.
ExpressionAtlasiQ8BKG0. baseline and differential.
GenevestigatoriQ8BKG0.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002982. Na/ntran_symport_GABA_GAT3.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR01197. GAT3TRNSPORT.
PR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.

Entry informationi

Entry nameiQ8BKG0_MOUSE
AccessioniPrimary (citable) accession number: Q8BKG0
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.