Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8BKF1

- RPOM_MOUSE

UniProt

Q8BKF1 - RPOM_MOUSE

Protein

DNA-directed RNA polymerase, mitochondrial

Gene

Polrmt

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates.

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei893 – 8931By similarity
    Active sitei962 – 9621By similarity
    Active sitei1121 – 11211By similarity

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. DNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Transcription

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymerase, mitochondrial (EC:2.7.7.6)
    Short name:
    MtRPOL
    Gene namesi
    Name:Polrmt
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1915843. Polrmt.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrial nucleoid Source: Ensembl
    2. mitochondrion Source: MGI

    Keywords - Cellular componenti

    DNA-directed RNA polymerase, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4141MitochondrionSequence AnalysisAdd
    BLAST
    Chaini42 – 12071166DNA-directed RNA polymerase, mitochondrialPRO_0000031069Add
    BLAST

    Proteomic databases

    PaxDbiQ8BKF1.
    PRIDEiQ8BKF1.

    PTM databases

    PhosphoSiteiQ8BKF1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BKF1.
    BgeeiQ8BKF1.
    CleanExiMM_POLRMT.
    GenevestigatoriQ8BKF1.

    Interactioni

    Subunit structurei

    Interacts with TFB1M and TFB2M, leading to the stimulation of transcription. Interacts with TEFM By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000020580.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BKF1.
    SMRiQ8BKF1. Positions 195-1207.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati232 – 26635PPR 1Add
    BLAST
    Repeati267 – 30236PPR 2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni773 – 1207435Mediates interaction with TEFMBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 2 PPR (pentatricopeptide) repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transit peptide

    Phylogenomic databases

    eggNOGiCOG5108.
    GeneTreeiENSGT00390000008060.
    HOGENOMiHOG000044061.
    HOVERGENiHBG078730.
    InParanoidiQ8BKF1.
    KOiK10908.
    OMAiREMFTST.
    OrthoDBiEOG7RBZ7T.
    PhylomeDBiQ8BKF1.
    TreeFamiTF105700.

    Family and domain databases

    Gene3Di1.10.1320.10. 1 hit.
    1.10.287.260. 1 hit.
    InterProiIPR024075. DNA-dir_RNA_pol_helix_hairpin.
    IPR002092. DNA-dir_Rpol_phage-type.
    IPR002885. Pentatricopeptide_repeat.
    IPR029262. RPOL_N.
    [Graphical view]
    PANTHERiPTHR10102. PTHR10102. 1 hit.
    PfamiPF00940. RNA_pol. 1 hit.
    PF14700. RPOL_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00756. PPR. 1 hit.
    PROSITEiPS51375. PPR. 2 hits.
    PS00900. RNA_POL_PHAGE_1. 1 hit.
    PS00489. RNA_POL_PHAGE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8BKF1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSALRWTRSA AGLGRVLRSP GPHRPPSEEG TFGGFCSSRR SSAASPREQH     50
    VLREWGHAEL LEVLEARVRQ LRAEGTPEMR VKKVQVDRPP QGHSSRWAQK 100
    LEAEKRVKQR RQKEVDQQKQ ALTQEFWTLH KEPKIWNKKL AGYLQPSKKG 150
    TPTNSEEKQL AQALQAALGR LSSREAEALA RKKAKAVEAQ ILVLQQKFLA 200
    FFECCVCTGQ VPLAHHVLVT HHNNGDRQQV LTLHMYNTVM LGWARKGSFR 250
    ELVYVFLMLK DAGLSPDLCS YAAALQCMGR RDQDVRTIQR CLKQMMEEGF 300
    QPQLLFTDLV LEEEDRAALL RAVVKAEPAF RPPPQAPSPV NTSTLLKDIY 350
    SKEGPVSYPK LHLPLDTLQD LFYQQLHVEL SSSVCVQSVE KAPVMSKEVI 400
    EARKTLQALR EQWEVELLRV LRETKATMGR QAYEGQPTLY PFLCLLSEGE 450
    FVSILMQVLK VLPAQGEPLI QLAHNLGLRV LNRHLVKQKQ VTNHVQKLGQ 500
    RYSQYLQLLA SDTQVAPCLP REYWESLGPL EAPAQQPWSV PVLLQLGKQL 550
    AELLVQAVQM PRSLAARQGA QRSIPVLYHV YSFRSYRQVG ILKPHPAFTH 600
    LLETAAEPTL TFETTEVPML CPPLPWTSLH SGAYLLSSTK LMRATEGTTQ 650
    HQRLLEQCPP AQLHGPLDAL TQLGNCAWRV NGHLLDLVLQ IFRDKGCMPL 700
    GVPPPRSEAP RPARYQLPPG STPVHKSELR KELARCLKVA REMHSLRSEA 750
    LYRLSLAQHL RHRVFWLPHN MDFRGRTYPC PPHFNHLGSD LARALLEFAE 800
    GRPLGPRGLD WLKIHLINLT GLKKGDSLRM RLAFADEVME EILDSADNPL 850
    TGRKWWMEAD EPWQTLACCM EVAHAVRSPD PAAYISHLPV HQDGSCNGLQ 900
    HYAALGRDSV GAASVNLTPS DLPQDVYREV ATQVEEFRQQ DAKEGLRVAQ 950
    VLEGFISRKV VKQTVMTVVY GVTRYGGRLQ IEKRLRELSD FPQEFVWEAS 1000
    HYLVRQVFKS LQEMFTSTRA IQHWLTESAN LISHAGWPVE WVTPLGIPII 1050
    QPYHRESKVQ VKGGLQSITL TSSVDESQKP NTLKQKNGFP PNFIHSLDSS 1100
    HMMLTALHCY RKGLIFVSVH DCFWTHAADI PTMNEVCREQ FVRLHSQPIL 1150
    EDLAKFLKKR FCSVSSIKSL KSSERALVTK LQETLQSLPK TGTFDLGQVI 1200
    RSTYFFS 1207
    Length:1,207
    Mass (Da):136,705
    Last modified:March 1, 2003 - v1
    Checksum:i674601A6BC001CE4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti23 – 231H → Q in BAC39500. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK053356 mRNA. Translation: BAC35360.1.
    AK085666 mRNA. Translation: BAC39500.1.
    CCDSiCCDS23987.1.
    RefSeqiNP_766139.2. NM_172551.3.
    UniGeneiMm.39001.

    Genome annotation databases

    EnsembliENSMUST00000020580; ENSMUSP00000020580; ENSMUSG00000020329.
    GeneIDi216151.
    KEGGimmu:216151.
    UCSCiuc007fzo.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK053356 mRNA. Translation: BAC35360.1 .
    AK085666 mRNA. Translation: BAC39500.1 .
    CCDSi CCDS23987.1.
    RefSeqi NP_766139.2. NM_172551.3.
    UniGenei Mm.39001.

    3D structure databases

    ProteinModelPortali Q8BKF1.
    SMRi Q8BKF1. Positions 195-1207.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000020580.

    PTM databases

    PhosphoSitei Q8BKF1.

    Proteomic databases

    PaxDbi Q8BKF1.
    PRIDEi Q8BKF1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020580 ; ENSMUSP00000020580 ; ENSMUSG00000020329 .
    GeneIDi 216151.
    KEGGi mmu:216151.
    UCSCi uc007fzo.2. mouse.

    Organism-specific databases

    CTDi 5442.
    MGIi MGI:1915843. Polrmt.

    Phylogenomic databases

    eggNOGi COG5108.
    GeneTreei ENSGT00390000008060.
    HOGENOMi HOG000044061.
    HOVERGENi HBG078730.
    InParanoidi Q8BKF1.
    KOi K10908.
    OMAi REMFTST.
    OrthoDBi EOG7RBZ7T.
    PhylomeDBi Q8BKF1.
    TreeFami TF105700.

    Miscellaneous databases

    NextBioi 375012.
    PROi Q8BKF1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BKF1.
    Bgeei Q8BKF1.
    CleanExi MM_POLRMT.
    Genevestigatori Q8BKF1.

    Family and domain databases

    Gene3Di 1.10.1320.10. 1 hit.
    1.10.287.260. 1 hit.
    InterProi IPR024075. DNA-dir_RNA_pol_helix_hairpin.
    IPR002092. DNA-dir_Rpol_phage-type.
    IPR002885. Pentatricopeptide_repeat.
    IPR029262. RPOL_N.
    [Graphical view ]
    PANTHERi PTHR10102. PTHR10102. 1 hit.
    Pfami PF00940. RNA_pol. 1 hit.
    PF14700. RPOL_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00756. PPR. 1 hit.
    PROSITEi PS51375. PPR. 2 hits.
    PS00900. RNA_POL_PHAGE_1. 1 hit.
    PS00489. RNA_POL_PHAGE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Eye and Mammary gland.

    Entry informationi

    Entry nameiRPOM_MOUSE
    AccessioniPrimary (citable) accession number: Q8BKF1
    Secondary accession number(s): Q8BJE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3