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Q8BKF1

- RPOM_MOUSE

UniProt

Q8BKF1 - RPOM_MOUSE

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Protein
DNA-directed RNA polymerase, mitochondrial
Gene
Polrmt
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei893 – 8931 By similarity
Active sitei962 – 9621 By similarity
Active sitei1121 – 11211 By similarity

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. DNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase, mitochondrial (EC:2.7.7.6)
Short name:
MtRPOL
Gene namesi
Name:Polrmt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1915843. Polrmt.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrial nucleoid Source: Ensembl
  2. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4141Mitochondrion Reviewed prediction
Add
BLAST
Chaini42 – 12071166DNA-directed RNA polymerase, mitochondrial
PRO_0000031069Add
BLAST

Proteomic databases

PaxDbiQ8BKF1.
PRIDEiQ8BKF1.

PTM databases

PhosphoSiteiQ8BKF1.

Expressioni

Gene expression databases

ArrayExpressiQ8BKF1.
BgeeiQ8BKF1.
CleanExiMM_POLRMT.
GenevestigatoriQ8BKF1.

Interactioni

Subunit structurei

Interacts with TFB1M and TFB2M, leading to the stimulation of transcription. Interacts with TEFM By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020580.

Structurei

3D structure databases

ProteinModelPortaliQ8BKF1.
SMRiQ8BKF1. Positions 195-1207.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati232 – 26635PPR 1
Add
BLAST
Repeati267 – 30236PPR 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni773 – 1207435Mediates interaction with TEFM By similarity
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiCOG5108.
GeneTreeiENSGT00390000008060.
HOGENOMiHOG000044061.
HOVERGENiHBG078730.
InParanoidiQ8BKF1.
KOiK10908.
OMAiREMFTST.
OrthoDBiEOG7RBZ7T.
PhylomeDBiQ8BKF1.
TreeFamiTF105700.

Family and domain databases

Gene3Di1.10.1320.10. 1 hit.
1.10.287.260. 1 hit.
InterProiIPR024075. DNA-dir_RNA_pol_helix_hairpin.
IPR002092. DNA-dir_Rpol_phage-type.
IPR002885. Pentatricopeptide_repeat.
IPR029262. RPOL_N.
[Graphical view]
PANTHERiPTHR10102. PTHR10102. 1 hit.
PfamiPF00940. RNA_pol. 1 hit.
PF14700. RPOL_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00756. PPR. 1 hit.
PROSITEiPS51375. PPR. 2 hits.
PS00900. RNA_POL_PHAGE_1. 1 hit.
PS00489. RNA_POL_PHAGE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BKF1-1 [UniParc]FASTAAdd to Basket

« Hide

MSALRWTRSA AGLGRVLRSP GPHRPPSEEG TFGGFCSSRR SSAASPREQH     50
VLREWGHAEL LEVLEARVRQ LRAEGTPEMR VKKVQVDRPP QGHSSRWAQK 100
LEAEKRVKQR RQKEVDQQKQ ALTQEFWTLH KEPKIWNKKL AGYLQPSKKG 150
TPTNSEEKQL AQALQAALGR LSSREAEALA RKKAKAVEAQ ILVLQQKFLA 200
FFECCVCTGQ VPLAHHVLVT HHNNGDRQQV LTLHMYNTVM LGWARKGSFR 250
ELVYVFLMLK DAGLSPDLCS YAAALQCMGR RDQDVRTIQR CLKQMMEEGF 300
QPQLLFTDLV LEEEDRAALL RAVVKAEPAF RPPPQAPSPV NTSTLLKDIY 350
SKEGPVSYPK LHLPLDTLQD LFYQQLHVEL SSSVCVQSVE KAPVMSKEVI 400
EARKTLQALR EQWEVELLRV LRETKATMGR QAYEGQPTLY PFLCLLSEGE 450
FVSILMQVLK VLPAQGEPLI QLAHNLGLRV LNRHLVKQKQ VTNHVQKLGQ 500
RYSQYLQLLA SDTQVAPCLP REYWESLGPL EAPAQQPWSV PVLLQLGKQL 550
AELLVQAVQM PRSLAARQGA QRSIPVLYHV YSFRSYRQVG ILKPHPAFTH 600
LLETAAEPTL TFETTEVPML CPPLPWTSLH SGAYLLSSTK LMRATEGTTQ 650
HQRLLEQCPP AQLHGPLDAL TQLGNCAWRV NGHLLDLVLQ IFRDKGCMPL 700
GVPPPRSEAP RPARYQLPPG STPVHKSELR KELARCLKVA REMHSLRSEA 750
LYRLSLAQHL RHRVFWLPHN MDFRGRTYPC PPHFNHLGSD LARALLEFAE 800
GRPLGPRGLD WLKIHLINLT GLKKGDSLRM RLAFADEVME EILDSADNPL 850
TGRKWWMEAD EPWQTLACCM EVAHAVRSPD PAAYISHLPV HQDGSCNGLQ 900
HYAALGRDSV GAASVNLTPS DLPQDVYREV ATQVEEFRQQ DAKEGLRVAQ 950
VLEGFISRKV VKQTVMTVVY GVTRYGGRLQ IEKRLRELSD FPQEFVWEAS 1000
HYLVRQVFKS LQEMFTSTRA IQHWLTESAN LISHAGWPVE WVTPLGIPII 1050
QPYHRESKVQ VKGGLQSITL TSSVDESQKP NTLKQKNGFP PNFIHSLDSS 1100
HMMLTALHCY RKGLIFVSVH DCFWTHAADI PTMNEVCREQ FVRLHSQPIL 1150
EDLAKFLKKR FCSVSSIKSL KSSERALVTK LQETLQSLPK TGTFDLGQVI 1200
RSTYFFS 1207
Length:1,207
Mass (Da):136,705
Last modified:March 1, 2003 - v1
Checksum:i674601A6BC001CE4
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231H → Q in BAC39500. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK053356 mRNA. Translation: BAC35360.1.
AK085666 mRNA. Translation: BAC39500.1.
CCDSiCCDS23987.1.
RefSeqiNP_766139.2. NM_172551.3.
UniGeneiMm.39001.

Genome annotation databases

EnsembliENSMUST00000020580; ENSMUSP00000020580; ENSMUSG00000020329.
GeneIDi216151.
KEGGimmu:216151.
UCSCiuc007fzo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK053356 mRNA. Translation: BAC35360.1 .
AK085666 mRNA. Translation: BAC39500.1 .
CCDSi CCDS23987.1.
RefSeqi NP_766139.2. NM_172551.3.
UniGenei Mm.39001.

3D structure databases

ProteinModelPortali Q8BKF1.
SMRi Q8BKF1. Positions 195-1207.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000020580.

PTM databases

PhosphoSitei Q8BKF1.

Proteomic databases

PaxDbi Q8BKF1.
PRIDEi Q8BKF1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020580 ; ENSMUSP00000020580 ; ENSMUSG00000020329 .
GeneIDi 216151.
KEGGi mmu:216151.
UCSCi uc007fzo.2. mouse.

Organism-specific databases

CTDi 5442.
MGIi MGI:1915843. Polrmt.

Phylogenomic databases

eggNOGi COG5108.
GeneTreei ENSGT00390000008060.
HOGENOMi HOG000044061.
HOVERGENi HBG078730.
InParanoidi Q8BKF1.
KOi K10908.
OMAi REMFTST.
OrthoDBi EOG7RBZ7T.
PhylomeDBi Q8BKF1.
TreeFami TF105700.

Miscellaneous databases

NextBioi 375012.
PROi Q8BKF1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BKF1.
Bgeei Q8BKF1.
CleanExi MM_POLRMT.
Genevestigatori Q8BKF1.

Family and domain databases

Gene3Di 1.10.1320.10. 1 hit.
1.10.287.260. 1 hit.
InterProi IPR024075. DNA-dir_RNA_pol_helix_hairpin.
IPR002092. DNA-dir_Rpol_phage-type.
IPR002885. Pentatricopeptide_repeat.
IPR029262. RPOL_N.
[Graphical view ]
PANTHERi PTHR10102. PTHR10102. 1 hit.
Pfami PF00940. RNA_pol. 1 hit.
PF14700. RPOL_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00756. PPR. 1 hit.
PROSITEi PS51375. PPR. 2 hits.
PS00900. RNA_POL_PHAGE_1. 1 hit.
PS00489. RNA_POL_PHAGE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye and Mammary gland.

Entry informationi

Entry nameiRPOM_MOUSE
AccessioniPrimary (citable) accession number: Q8BKF1
Secondary accession number(s): Q8BJE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi