Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8BKF1

- RPOM_MOUSE

UniProt

Q8BKF1 - RPOM_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

DNA-directed RNA polymerase, mitochondrial

Gene

Polrmt

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei893 – 8931By similarity
Active sitei962 – 9621By similarity
Active sitei1121 – 11211By similarity

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. DNA-directed RNA polymerase activity Source: UniProtKB-KW
  3. poly(A) RNA binding Source: Ensembl

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Enzyme and pathway databases

ReactomeiREACT_238550. Mitochondrial transcription initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase, mitochondrial (EC:2.7.7.6)
Short name:
MtRPOL
Gene namesi
Name:Polrmt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1915843. Polrmt.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrial nucleoid Source: Ensembl
  2. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4141MitochondrionSequence AnalysisAdd
BLAST
Chaini42 – 12071166DNA-directed RNA polymerase, mitochondrialPRO_0000031069Add
BLAST

Proteomic databases

MaxQBiQ8BKF1.
PaxDbiQ8BKF1.
PRIDEiQ8BKF1.

PTM databases

PhosphoSiteiQ8BKF1.

Expressioni

Gene expression databases

BgeeiQ8BKF1.
CleanExiMM_POLRMT.
ExpressionAtlasiQ8BKF1. baseline and differential.
GenevestigatoriQ8BKF1.

Interactioni

Subunit structurei

Interacts with TFB1M and TFB2M, leading to the stimulation of transcription. Interacts with TEFM (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020580.

Structurei

3D structure databases

ProteinModelPortaliQ8BKF1.
SMRiQ8BKF1. Positions 195-1207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati232 – 26635PPR 1Add
BLAST
Repeati267 – 30236PPR 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni773 – 1207435Mediates interaction with TEFMBy similarityAdd
BLAST

Sequence similaritiesi

Contains 2 PPR (pentatricopeptide) repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiCOG5108.
GeneTreeiENSGT00390000008060.
HOGENOMiHOG000044061.
HOVERGENiHBG078730.
InParanoidiQ8BKF1.
KOiK10908.
OMAiREMFTST.
OrthoDBiEOG7RBZ7T.
PhylomeDBiQ8BKF1.
TreeFamiTF105700.

Family and domain databases

Gene3Di1.10.1320.10. 1 hit.
1.10.287.260. 1 hit.
InterProiIPR024075. DNA-dir_RNA_pol_helix_hairpin.
IPR002092. DNA-dir_Rpol_phage-type.
IPR002885. Pentatricopeptide_repeat.
IPR029262. RPOL_N.
[Graphical view]
PANTHERiPTHR10102. PTHR10102. 1 hit.
PfamiPF00940. RNA_pol. 1 hit.
PF14700. RPOL_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00756. PPR. 1 hit.
PROSITEiPS51375. PPR. 2 hits.
PS00900. RNA_POL_PHAGE_1. 1 hit.
PS00489. RNA_POL_PHAGE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BKF1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSALRWTRSA AGLGRVLRSP GPHRPPSEEG TFGGFCSSRR SSAASPREQH
60 70 80 90 100
VLREWGHAEL LEVLEARVRQ LRAEGTPEMR VKKVQVDRPP QGHSSRWAQK
110 120 130 140 150
LEAEKRVKQR RQKEVDQQKQ ALTQEFWTLH KEPKIWNKKL AGYLQPSKKG
160 170 180 190 200
TPTNSEEKQL AQALQAALGR LSSREAEALA RKKAKAVEAQ ILVLQQKFLA
210 220 230 240 250
FFECCVCTGQ VPLAHHVLVT HHNNGDRQQV LTLHMYNTVM LGWARKGSFR
260 270 280 290 300
ELVYVFLMLK DAGLSPDLCS YAAALQCMGR RDQDVRTIQR CLKQMMEEGF
310 320 330 340 350
QPQLLFTDLV LEEEDRAALL RAVVKAEPAF RPPPQAPSPV NTSTLLKDIY
360 370 380 390 400
SKEGPVSYPK LHLPLDTLQD LFYQQLHVEL SSSVCVQSVE KAPVMSKEVI
410 420 430 440 450
EARKTLQALR EQWEVELLRV LRETKATMGR QAYEGQPTLY PFLCLLSEGE
460 470 480 490 500
FVSILMQVLK VLPAQGEPLI QLAHNLGLRV LNRHLVKQKQ VTNHVQKLGQ
510 520 530 540 550
RYSQYLQLLA SDTQVAPCLP REYWESLGPL EAPAQQPWSV PVLLQLGKQL
560 570 580 590 600
AELLVQAVQM PRSLAARQGA QRSIPVLYHV YSFRSYRQVG ILKPHPAFTH
610 620 630 640 650
LLETAAEPTL TFETTEVPML CPPLPWTSLH SGAYLLSSTK LMRATEGTTQ
660 670 680 690 700
HQRLLEQCPP AQLHGPLDAL TQLGNCAWRV NGHLLDLVLQ IFRDKGCMPL
710 720 730 740 750
GVPPPRSEAP RPARYQLPPG STPVHKSELR KELARCLKVA REMHSLRSEA
760 770 780 790 800
LYRLSLAQHL RHRVFWLPHN MDFRGRTYPC PPHFNHLGSD LARALLEFAE
810 820 830 840 850
GRPLGPRGLD WLKIHLINLT GLKKGDSLRM RLAFADEVME EILDSADNPL
860 870 880 890 900
TGRKWWMEAD EPWQTLACCM EVAHAVRSPD PAAYISHLPV HQDGSCNGLQ
910 920 930 940 950
HYAALGRDSV GAASVNLTPS DLPQDVYREV ATQVEEFRQQ DAKEGLRVAQ
960 970 980 990 1000
VLEGFISRKV VKQTVMTVVY GVTRYGGRLQ IEKRLRELSD FPQEFVWEAS
1010 1020 1030 1040 1050
HYLVRQVFKS LQEMFTSTRA IQHWLTESAN LISHAGWPVE WVTPLGIPII
1060 1070 1080 1090 1100
QPYHRESKVQ VKGGLQSITL TSSVDESQKP NTLKQKNGFP PNFIHSLDSS
1110 1120 1130 1140 1150
HMMLTALHCY RKGLIFVSVH DCFWTHAADI PTMNEVCREQ FVRLHSQPIL
1160 1170 1180 1190 1200
EDLAKFLKKR FCSVSSIKSL KSSERALVTK LQETLQSLPK TGTFDLGQVI

RSTYFFS
Length:1,207
Mass (Da):136,705
Last modified:March 1, 2003 - v1
Checksum:i674601A6BC001CE4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231H → Q in BAC39500. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053356 mRNA. Translation: BAC35360.1.
AK085666 mRNA. Translation: BAC39500.1.
CCDSiCCDS23987.1.
RefSeqiNP_766139.2. NM_172551.3.
UniGeneiMm.39001.

Genome annotation databases

EnsembliENSMUST00000020580; ENSMUSP00000020580; ENSMUSG00000020329.
GeneIDi216151.
KEGGimmu:216151.
UCSCiuc007fzo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053356 mRNA. Translation: BAC35360.1 .
AK085666 mRNA. Translation: BAC39500.1 .
CCDSi CCDS23987.1.
RefSeqi NP_766139.2. NM_172551.3.
UniGenei Mm.39001.

3D structure databases

ProteinModelPortali Q8BKF1.
SMRi Q8BKF1. Positions 195-1207.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000020580.

PTM databases

PhosphoSitei Q8BKF1.

Proteomic databases

MaxQBi Q8BKF1.
PaxDbi Q8BKF1.
PRIDEi Q8BKF1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020580 ; ENSMUSP00000020580 ; ENSMUSG00000020329 .
GeneIDi 216151.
KEGGi mmu:216151.
UCSCi uc007fzo.2. mouse.

Organism-specific databases

CTDi 5442.
MGIi MGI:1915843. Polrmt.

Phylogenomic databases

eggNOGi COG5108.
GeneTreei ENSGT00390000008060.
HOGENOMi HOG000044061.
HOVERGENi HBG078730.
InParanoidi Q8BKF1.
KOi K10908.
OMAi REMFTST.
OrthoDBi EOG7RBZ7T.
PhylomeDBi Q8BKF1.
TreeFami TF105700.

Enzyme and pathway databases

Reactomei REACT_238550. Mitochondrial transcription initiation.

Miscellaneous databases

NextBioi 375012.
PROi Q8BKF1.
SOURCEi Search...

Gene expression databases

Bgeei Q8BKF1.
CleanExi MM_POLRMT.
ExpressionAtlasi Q8BKF1. baseline and differential.
Genevestigatori Q8BKF1.

Family and domain databases

Gene3Di 1.10.1320.10. 1 hit.
1.10.287.260. 1 hit.
InterProi IPR024075. DNA-dir_RNA_pol_helix_hairpin.
IPR002092. DNA-dir_Rpol_phage-type.
IPR002885. Pentatricopeptide_repeat.
IPR029262. RPOL_N.
[Graphical view ]
PANTHERi PTHR10102. PTHR10102. 1 hit.
Pfami PF00940. RNA_pol. 1 hit.
PF14700. RPOL_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00756. PPR. 1 hit.
PROSITEi PS51375. PPR. 2 hits.
PS00900. RNA_POL_PHAGE_1. 1 hit.
PS00489. RNA_POL_PHAGE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye and Mammary gland.

Entry informationi

Entry nameiRPOM_MOUSE
AccessioniPrimary (citable) accession number: Q8BKF1
Secondary accession number(s): Q8BJE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3