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Q8BKE6

- CP20A_MOUSE

UniProt

Q8BKE6 - CP20A_MOUSE

Protein

Cytochrome P450 20A1

Gene

Cyp20a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi409 – 4091Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. monooxygenase activity Source: UniProtKB-KW
    4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 20A1 (EC:1.14.-.-)
    Gene namesi
    Name:Cyp20a1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1925201. Cyp20a1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 462462Cytochrome P450 20A1PRO_0000318096Add
    BLAST

    Proteomic databases

    MaxQBiQ8BKE6.
    PaxDbiQ8BKE6.
    PRIDEiQ8BKE6.

    PTM databases

    PhosphoSiteiQ8BKE6.

    Expressioni

    Gene expression databases

    BgeeiQ8BKE6.
    GenevestigatoriQ8BKE6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BKE6.
    SMRiQ8BKE6. Positions 31-461.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00500000044939.
    HOGENOMiHOG000111913.
    HOVERGENiHBG076231.
    InParanoidiQ8BKE6.
    KOiK07435.
    OMAiQKNHGTV.
    PhylomeDBiQ8BKE6.
    TreeFamiTF105089.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    SUPFAMiSSF48264. SSF48264. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8BKE6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLDFAIFAVT FLLALVGAVL YLYPASRQAS GIPGLTPTEE KDGNLPDIVN    50
    SGSLHEFLVN LHERYGPVVS FWFGRRLVVS LGTTDVLKQH FNPNKTSDPF 100
    ETMLKSLLGY QSGGGSAGED HVRRKLYGDA VTASLHSNFP LLLQLSEELL 150
    DKWLSYPETQ HIPLSQHMLG FALKFVTRMV LGSTFEDEQE VIRFQKIHGT 200
    VWSEIGKGFL DGSLDKNTTR KKQYQEALMQ LESTLKKIIK ERKGGNFRQH 250
    TFIDSLTQGK LNEQQILEDC VVFSLASCII TARLCTWTIH FLTTTGEVQK 300
    KLCKEIDQVL GEGPITSEKI EQLSYCQQVL FETVRTAKLT PVSARLQDIE 350
    GKVGPFVIPK ETLVLYALGV VLQDPSTWPL PHRFDPDRFA DEPVMKVFSS 400
    LGFSGTWECP ELRFAYMVTA VLVSVLLKRL RLLAVDRQVF EMKYELVTSA 450
    REEAWITVSK RH 462
    Length:462
    Mass (Da):52,149
    Last modified:March 1, 2003 - v1
    Checksum:i4ADF835E04E291F3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK053388 mRNA. Translation: BAC35373.1.
    CCDSiCCDS14990.1.
    RefSeqiNP_084289.1. NM_030013.2.
    UniGeneiMm.197640.

    Genome annotation databases

    EnsembliENSMUST00000060608; ENSMUSP00000050823; ENSMUSG00000049439.
    GeneIDi77951.
    KEGGimmu:77951.
    UCSCiuc007ben.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK053388 mRNA. Translation: BAC35373.1 .
    CCDSi CCDS14990.1.
    RefSeqi NP_084289.1. NM_030013.2.
    UniGenei Mm.197640.

    3D structure databases

    ProteinModelPortali Q8BKE6.
    SMRi Q8BKE6. Positions 31-461.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BKE6.

    Proteomic databases

    MaxQBi Q8BKE6.
    PaxDbi Q8BKE6.
    PRIDEi Q8BKE6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000060608 ; ENSMUSP00000050823 ; ENSMUSG00000049439 .
    GeneIDi 77951.
    KEGGi mmu:77951.
    UCSCi uc007ben.1. mouse.

    Organism-specific databases

    CTDi 57404.
    MGIi MGI:1925201. Cyp20a1.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00500000044939.
    HOGENOMi HOG000111913.
    HOVERGENi HBG076231.
    InParanoidi Q8BKE6.
    KOi K07435.
    OMAi QKNHGTV.
    PhylomeDBi Q8BKE6.
    TreeFami TF105089.

    Miscellaneous databases

    NextBioi 347877.
    PROi Q8BKE6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BKE6.
    Genevestigatori Q8BKE6.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Eye.

    Entry informationi

    Entry nameiCP20A_MOUSE
    AccessioniPrimary (citable) accession number: Q8BKE6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3