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Q8BKE6 (CP20A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 20A1

EC=1.14.-.-
Gene names
Name:Cyp20a1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length462 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 462462Cytochrome P450 20A1
PRO_0000318096

Regions

Transmembrane4 – 2421Helical; Potential

Sites

Metal binding4091Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8BKE6 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 4ADF835E04E291F3

FASTA46252,149
        10         20         30         40         50         60 
MLDFAIFAVT FLLALVGAVL YLYPASRQAS GIPGLTPTEE KDGNLPDIVN SGSLHEFLVN 

        70         80         90        100        110        120 
LHERYGPVVS FWFGRRLVVS LGTTDVLKQH FNPNKTSDPF ETMLKSLLGY QSGGGSAGED 

       130        140        150        160        170        180 
HVRRKLYGDA VTASLHSNFP LLLQLSEELL DKWLSYPETQ HIPLSQHMLG FALKFVTRMV 

       190        200        210        220        230        240 
LGSTFEDEQE VIRFQKIHGT VWSEIGKGFL DGSLDKNTTR KKQYQEALMQ LESTLKKIIK 

       250        260        270        280        290        300 
ERKGGNFRQH TFIDSLTQGK LNEQQILEDC VVFSLASCII TARLCTWTIH FLTTTGEVQK 

       310        320        330        340        350        360 
KLCKEIDQVL GEGPITSEKI EQLSYCQQVL FETVRTAKLT PVSARLQDIE GKVGPFVIPK 

       370        380        390        400        410        420 
ETLVLYALGV VLQDPSTWPL PHRFDPDRFA DEPVMKVFSS LGFSGTWECP ELRFAYMVTA 

       430        440        450        460 
VLVSVLLKRL RLLAVDRQVF EMKYELVTSA REEAWITVSK RH 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK053388 mRNA. Translation: BAC35373.1.
CCDSCCDS14990.1.
RefSeqNP_084289.1. NM_030013.2.
UniGeneMm.197640.

3D structure databases

ProteinModelPortalQ8BKE6.
SMRQ8BKE6. Positions 31-461.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8BKE6.

Proteomic databases

MaxQBQ8BKE6.
PaxDbQ8BKE6.
PRIDEQ8BKE6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000060608; ENSMUSP00000050823; ENSMUSG00000049439.
GeneID77951.
KEGGmmu:77951.
UCSCuc007ben.1. mouse.

Organism-specific databases

CTD57404.
MGIMGI:1925201. Cyp20a1.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00500000044939.
HOGENOMHOG000111913.
HOVERGENHBG076231.
InParanoidQ8BKE6.
KOK07435.
OMAQKNHGTV.
PhylomeDBQ8BKE6.
TreeFamTF105089.

Gene expression databases

BgeeQ8BKE6.
GenevestigatorQ8BKE6.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
SUPFAMSSF48264. SSF48264. 1 hit.
ProtoNetSearch...

Other

NextBio347877.
PROQ8BKE6.
SOURCESearch...

Entry information

Entry nameCP20A_MOUSE
AccessionPrimary (citable) accession number: Q8BKE6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot