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Q8BKE6

- CP20A_MOUSE

UniProt

Q8BKE6 - CP20A_MOUSE

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Protein

Cytochrome P450 20A1

Gene

Cyp20a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi409 – 4091Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 20A1 (EC:1.14.-.-)
Gene namesi
Name:Cyp20a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1925201. Cyp20a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 462462Cytochrome P450 20A1PRO_0000318096Add
BLAST

Proteomic databases

MaxQBiQ8BKE6.
PaxDbiQ8BKE6.
PRIDEiQ8BKE6.

PTM databases

PhosphoSiteiQ8BKE6.

Expressioni

Gene expression databases

BgeeiQ8BKE6.
ExpressionAtlasiQ8BKE6. baseline and differential.
GenevestigatoriQ8BKE6.

Structurei

3D structure databases

ProteinModelPortaliQ8BKE6.
SMRiQ8BKE6. Positions 31-461.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00500000044939.
HOGENOMiHOG000111913.
HOVERGENiHBG076231.
InParanoidiQ8BKE6.
KOiK07435.
OMAiQKNHGTV.
PhylomeDBiQ8BKE6.
TreeFamiTF105089.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
SUPFAMiSSF48264. SSF48264. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BKE6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLDFAIFAVT FLLALVGAVL YLYPASRQAS GIPGLTPTEE KDGNLPDIVN
60 70 80 90 100
SGSLHEFLVN LHERYGPVVS FWFGRRLVVS LGTTDVLKQH FNPNKTSDPF
110 120 130 140 150
ETMLKSLLGY QSGGGSAGED HVRRKLYGDA VTASLHSNFP LLLQLSEELL
160 170 180 190 200
DKWLSYPETQ HIPLSQHMLG FALKFVTRMV LGSTFEDEQE VIRFQKIHGT
210 220 230 240 250
VWSEIGKGFL DGSLDKNTTR KKQYQEALMQ LESTLKKIIK ERKGGNFRQH
260 270 280 290 300
TFIDSLTQGK LNEQQILEDC VVFSLASCII TARLCTWTIH FLTTTGEVQK
310 320 330 340 350
KLCKEIDQVL GEGPITSEKI EQLSYCQQVL FETVRTAKLT PVSARLQDIE
360 370 380 390 400
GKVGPFVIPK ETLVLYALGV VLQDPSTWPL PHRFDPDRFA DEPVMKVFSS
410 420 430 440 450
LGFSGTWECP ELRFAYMVTA VLVSVLLKRL RLLAVDRQVF EMKYELVTSA
460
REEAWITVSK RH
Length:462
Mass (Da):52,149
Last modified:March 1, 2003 - v1
Checksum:i4ADF835E04E291F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053388 mRNA. Translation: BAC35373.1.
CCDSiCCDS14990.1.
RefSeqiNP_084289.1. NM_030013.2.
UniGeneiMm.197640.

Genome annotation databases

EnsembliENSMUST00000060608; ENSMUSP00000050823; ENSMUSG00000049439.
GeneIDi77951.
KEGGimmu:77951.
UCSCiuc007ben.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053388 mRNA. Translation: BAC35373.1 .
CCDSi CCDS14990.1.
RefSeqi NP_084289.1. NM_030013.2.
UniGenei Mm.197640.

3D structure databases

ProteinModelPortali Q8BKE6.
SMRi Q8BKE6. Positions 31-461.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BKE6.

Proteomic databases

MaxQBi Q8BKE6.
PaxDbi Q8BKE6.
PRIDEi Q8BKE6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000060608 ; ENSMUSP00000050823 ; ENSMUSG00000049439 .
GeneIDi 77951.
KEGGi mmu:77951.
UCSCi uc007ben.1. mouse.

Organism-specific databases

CTDi 57404.
MGIi MGI:1925201. Cyp20a1.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00500000044939.
HOGENOMi HOG000111913.
HOVERGENi HBG076231.
InParanoidi Q8BKE6.
KOi K07435.
OMAi QKNHGTV.
PhylomeDBi Q8BKE6.
TreeFami TF105089.

Miscellaneous databases

NextBioi 347877.
PROi Q8BKE6.
SOURCEi Search...

Gene expression databases

Bgeei Q8BKE6.
ExpressionAtlasi Q8BKE6. baseline and differential.
Genevestigatori Q8BKE6.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
SUPFAMi SSF48264. SSF48264. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye.

Entry informationi

Entry nameiCP20A_MOUSE
AccessioniPrimary (citable) accession number: Q8BKE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3