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Protein

Fibrinogen silencer-binding protein

Gene

Fsbp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrinogen silencer-binding protein
Gene namesi
Name:Fsbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:5301008. Fsbp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Fibrinogen silencer-binding proteinPRO_0000087353Add
BLAST

Proteomic databases

PaxDbiQ8BKE5.
PRIDEiQ8BKE5.

Expressioni

Gene expression databases

BgeeiQ8BKE5.
GenevisibleiQ8BKE5. MM.

Interactioni

Subunit structurei

Interacts with APBA1 (via PDZ 1 and 2 domains).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000137082.

Structurei

3D structure databases

ProteinModelPortaliQ8BKE5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IVMX. Eukaryota.
ENOG4111FZT. LUCA.
GeneTreeiENSGT00390000008778.
HOGENOMiHOG000112654.
HOVERGENiHBG051662.
OMAiCWDIIAD.
OrthoDBiEOG7TXKH3.
PhylomeDBiQ8BKE5.
TreeFamiTF331896.

Family and domain databases

InterProiIPR028002. Myb_DNA-bind_5.
[Graphical view]
PfamiPF13873. Myb_DNA-bind_5. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BKE5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVGKARSSNF TLSEKLDLLN LVKPYVKILE EHTNKNSVIV EKNRCWDVIA
60 70 80 90 100
VNYNAIGVDR PPRTAQGLRS LYKRLKEYAK QELLQQKEAQ SEFKSSVSEP
110 120 130 140 150
TKQVMEMIPQ IASFGLIRDR SHIQSANLDE TAQAGTSSLQ VMVDHHPVAI
160 170 180 190 200
TVEVKQEEDI KPSPPLVSNP QLSDTLEQRE EHELMHVVEG SESPSLSSVD
210 220 230 240 250
MRMTSSPSSV PRRDEIFHQE SGEHFRSLLR CDPQVLQMLK EEHQIILENQ
260 270 280 290
KNFGLYVQEK RDGLRRRQRL EEELLRAKIE VEKLKATRLR RDLPEYSSL
Length:299
Mass (Da):34,403
Last modified:March 1, 2003 - v1
Checksum:iCC0A2936D0642E7E
GO
Isoform 2 (identifier: Q8BKE5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-141: Missing.

Note: No experimental confirmation available.
Show »
Length:158
Mass (Da):18,487
Checksum:iE30E7AA8B09070E3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 141141Missing in isoform 2. 1 PublicationVSP_010775Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053419 mRNA. Translation: BAC35379.1.
AK078439 mRNA. Translation: BAC37274.1.
CCDSiCCDS57263.1. [Q8BKE5-1]
RefSeqiNP_001243071.1. NM_001256142.1. [Q8BKE5-1]
NP_001243074.1. NM_001256145.1.
UniGeneiMm.249437.
Mm.491200.

Genome annotation databases

EnsembliENSMUST00000180239; ENSMUSP00000137082; ENSMUSG00000094595. [Q8BKE5-1]
GeneIDi100503583.
623474.
KEGGimmu:100503583.
UCSCiuc008rzt.2. mouse. [Q8BKE5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053419 mRNA. Translation: BAC35379.1.
AK078439 mRNA. Translation: BAC37274.1.
CCDSiCCDS57263.1. [Q8BKE5-1]
RefSeqiNP_001243071.1. NM_001256142.1. [Q8BKE5-1]
NP_001243074.1. NM_001256145.1.
UniGeneiMm.249437.
Mm.491200.

3D structure databases

ProteinModelPortaliQ8BKE5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000137082.

Proteomic databases

PaxDbiQ8BKE5.
PRIDEiQ8BKE5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000180239; ENSMUSP00000137082; ENSMUSG00000094595. [Q8BKE5-1]
GeneIDi100503583.
623474.
KEGGimmu:100503583.
UCSCiuc008rzt.2. mouse. [Q8BKE5-1]

Organism-specific databases

CTDi100861412.
25788.
MGIiMGI:5301008. Fsbp.

Phylogenomic databases

eggNOGiENOG410IVMX. Eukaryota.
ENOG4111FZT. LUCA.
GeneTreeiENSGT00390000008778.
HOGENOMiHOG000112654.
HOVERGENiHBG051662.
OMAiCWDIIAD.
OrthoDBiEOG7TXKH3.
PhylomeDBiQ8BKE5.
TreeFamiTF331896.

Miscellaneous databases

PROiQ8BKE5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BKE5.
GenevisibleiQ8BKE5. MM.

Family and domain databases

InterProiIPR028002. Myb_DNA-bind_5.
[Graphical view]
PfamiPF13873. Myb_DNA-bind_5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Eye and Mesonephros.

Entry informationi

Entry nameiFSBP_MOUSE
AccessioniPrimary (citable) accession number: Q8BKE5
Secondary accession number(s): Q8BJX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.