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Protein

Activator of 90 kDa heat shock protein ATPase homolog 1

Gene

Ahsa1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Co-chaperone that stimulates HSP90 ATPase activity. May affect a step in the endoplasmic reticulum to Golgi trafficking (By similarity).By similarity

GO - Molecular functioni

  1. ATPase activator activity Source: UniProtKB
  2. chaperone binding Source: MGI

GO - Biological processi

  1. positive regulation of ATPase activity Source: GOC
  2. protein folding Source: UniProtKB
  3. response to stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Activator of 90 kDa heat shock protein ATPase homolog 1
Short name:
AHA1
Gene namesi
Name:Ahsa1
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:2387603. Ahsa1.

Subcellular locationi

Cytoplasmcytosol By similarity. Endoplasmic reticulum By similarity
Note: May transiently interact with the endoplasmic reticulum.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: UniProtKB-SubCell
  3. endoplasmic reticulum Source: UniProtKB-SubCell
  4. extracellular vesicular exosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 338337Activator of 90 kDa heat shock protein ATPase homolog 1PRO_0000215821Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei3 – 31N6-acetyllysineBy similarity
Modified residuei193 – 1931PhosphoserineBy similarity
Modified residuei212 – 2121N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8BK64.
PaxDbiQ8BK64.
PRIDEiQ8BK64.

2D gel databases

REPRODUCTION-2DPAGEQ8BK64.

PTM databases

PhosphoSiteiQ8BK64.

Expressioni

Inductioni

By heat shock and treatment with the HSP90 inhibitor 17-demethoxygeldanamycin (17AAG).

Gene expression databases

BgeeiQ8BK64.
GenevestigatoriQ8BK64.

Interactioni

Subunit structurei

Interacts with HSPCA/HSP90. Interacts with GCH1 (By similarity). Interacts with SRPK1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi229959. 2 interactions.
IntActiQ8BK64. 3 interactions.
MINTiMINT-4087362.
STRINGi10090.ENSMUSP00000021425.

Structurei

3D structure databases

ProteinModelPortaliQ8BK64.
SMRiQ8BK64. Positions 25-126, 204-335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AHA1 family.Curated

Phylogenomic databases

eggNOGiCOG5580.
GeneTreeiENSGT00390000006429.
HOGENOMiHOG000242852.
HOVERGENiHBG065806.
InParanoidiQ8BK64.
OMAiRNWLEYY.
OrthoDBiEOG77DJ64.
PhylomeDBiQ8BK64.
TreeFamiTF313680.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR013538. Activator_of_Hsp90_ATPase.
IPR015310. AHSA1_N.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF09229. Aha1_N. 1 hit.
PF08327. AHSA1. 1 hit.
[Graphical view]
SMARTiSM01000. Aha1_N. 1 hit.
[Graphical view]
SUPFAMiSSF103111. SSF103111. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BK64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKWGEGDPR WIVEERADAT NVNNWHWTER DASNWSTEKL KTLFLAVRVE
60 70 80 90 100
NEEGKCEVTE VNKLDGEASI NNRKGKLIFF YEWTIKLNWT GTSKSGVQYK
110 120 130 140 150
GHVEIPNLSD ENSVDEVEIS VSLAKDEPDT NLVALMKEDG VKLLREAVGI
160 170 180 190 200
YISTLKTEFT QGMILPTVNG ESVDPVGQPA LKTETCKAKS APSKSQAKPV
210 220 230 240 250
GVKIPTCKIT LKETFLTSPE ELYRVFTTQE LVQAFTHAPA ALEADRGGKF
260 270 280 290 300
HMVDGNVTGE FTDLVPEKHI AMKWRFKSWP EGHFATITLT FIDKNGETEL
310 320 330
CMEGRGIPAP EEERTRQGWQ RYYFEGIKQT FGYGARLF
Length:338
Mass (Da):38,117
Last modified:April 30, 2003 - v2
Checksum:iC4F0F94FF44F9FB3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti192 – 1921P → L in BAC36160 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076069 mRNA. Translation: BAC36160.1.
BC023857 mRNA. Translation: AAH23857.1.
BC025552 mRNA. Translation: AAH25552.1.
CCDSiCCDS26075.1.
RefSeqiNP_666148.1. NM_146036.1.
UniGeneiMm.22626.

Genome annotation databases

EnsembliENSMUST00000021425; ENSMUSP00000021425; ENSMUSG00000021037.
GeneIDi217737.
KEGGimmu:217737.
UCSCiuc007oit.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076069 mRNA. Translation: BAC36160.1.
BC023857 mRNA. Translation: AAH23857.1.
BC025552 mRNA. Translation: AAH25552.1.
CCDSiCCDS26075.1.
RefSeqiNP_666148.1. NM_146036.1.
UniGeneiMm.22626.

3D structure databases

ProteinModelPortaliQ8BK64.
SMRiQ8BK64. Positions 25-126, 204-335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229959. 2 interactions.
IntActiQ8BK64. 3 interactions.
MINTiMINT-4087362.
STRINGi10090.ENSMUSP00000021425.

PTM databases

PhosphoSiteiQ8BK64.

2D gel databases

REPRODUCTION-2DPAGEQ8BK64.

Proteomic databases

MaxQBiQ8BK64.
PaxDbiQ8BK64.
PRIDEiQ8BK64.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021425; ENSMUSP00000021425; ENSMUSG00000021037.
GeneIDi217737.
KEGGimmu:217737.
UCSCiuc007oit.1. mouse.

Organism-specific databases

CTDi10598.
MGIiMGI:2387603. Ahsa1.

Phylogenomic databases

eggNOGiCOG5580.
GeneTreeiENSGT00390000006429.
HOGENOMiHOG000242852.
HOVERGENiHBG065806.
InParanoidiQ8BK64.
OMAiRNWLEYY.
OrthoDBiEOG77DJ64.
PhylomeDBiQ8BK64.
TreeFamiTF313680.

Miscellaneous databases

ChiTaRSiAhsa1. mouse.
NextBioi376016.
PROiQ8BK64.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BK64.
GenevestigatoriQ8BK64.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR013538. Activator_of_Hsp90_ATPase.
IPR015310. AHSA1_N.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF09229. Aha1_N. 1 hit.
PF08327. AHSA1. 1 hit.
[Graphical view]
SMARTiSM01000. Aha1_N. 1 hit.
[Graphical view]
SUPFAMiSSF103111. SSF103111. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiAHSA1_MOUSE
AccessioniPrimary (citable) accession number: Q8BK64
Secondary accession number(s): Q8R3E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: April 30, 2003
Last modified: March 4, 2015
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.