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Protein

Activator of 90 kDa heat shock protein ATPase homolog 1

Gene

Ahsa1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Activator of 90 kDa heat shock protein ATPase homolog 1
Short name:
AHA1
Gene namesi
Name:Ahsa1
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2387603. Ahsa1.

Subcellular locationi

  • Cytoplasmcytosol By similarity
  • Endoplasmic reticulum By similarity

  • Note: May transiently interact with the endoplasmic reticulum.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002158211 – 338Activator of 90 kDa heat shock protein ATPase homolog 1Add BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3N6-acetyllysineBy similarity1
Cross-linki182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei193PhosphoserineBy similarity1
Modified residuei212N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8BK64.
MaxQBiQ8BK64.
PaxDbiQ8BK64.
PRIDEiQ8BK64.

2D gel databases

REPRODUCTION-2DPAGEQ8BK64.

PTM databases

iPTMnetiQ8BK64.
PhosphoSitePlusiQ8BK64.
SwissPalmiQ8BK64.

Expressioni

Inductioni

By heat shock and treatment with the HSP90 inhibitor 17-demethoxygeldanamycin (17AAG).

Gene expression databases

BgeeiENSMUSG00000021037.
GenevisibleiQ8BK64. MM.

Interactioni

Subunit structurei

Interacts with HSPCA/HSP90. Interacts with GCH1. Interacts with SRPK1. Interacts with FLCN. Interacts with HSP90AA1: the interaction activates HSP90AA1 ATPase activity.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229959. 2 interactors.
IntActiQ8BK64. 3 interactors.
MINTiMINT-4087362.
STRINGi10090.ENSMUSP00000021425.

Structurei

3D structure databases

ProteinModelPortaliQ8BK64.
SMRiQ8BK64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AHA1 family.Curated

Phylogenomic databases

eggNOGiKOG2936. Eukaryota.
COG5580. LUCA.
GeneTreeiENSGT00390000006429.
HOGENOMiHOG000242852.
HOVERGENiHBG065806.
InParanoidiQ8BK64.
OMAiENEEGKC.
OrthoDBiEOG091G0BRP.
PhylomeDBiQ8BK64.
TreeFamiTF313680.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR013538. Activator_of_Hsp90_ATPase.
IPR015310. AHSA1_N.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF09229. Aha1_N. 1 hit.
PF08327. AHSA1. 1 hit.
[Graphical view]
SMARTiSM01000. Aha1_N. 1 hit.
[Graphical view]
SUPFAMiSSF103111. SSF103111. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BK64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKWGEGDPR WIVEERADAT NVNNWHWTER DASNWSTEKL KTLFLAVRVE
60 70 80 90 100
NEEGKCEVTE VNKLDGEASI NNRKGKLIFF YEWTIKLNWT GTSKSGVQYK
110 120 130 140 150
GHVEIPNLSD ENSVDEVEIS VSLAKDEPDT NLVALMKEDG VKLLREAVGI
160 170 180 190 200
YISTLKTEFT QGMILPTVNG ESVDPVGQPA LKTETCKAKS APSKSQAKPV
210 220 230 240 250
GVKIPTCKIT LKETFLTSPE ELYRVFTTQE LVQAFTHAPA ALEADRGGKF
260 270 280 290 300
HMVDGNVTGE FTDLVPEKHI AMKWRFKSWP EGHFATITLT FIDKNGETEL
310 320 330
CMEGRGIPAP EEERTRQGWQ RYYFEGIKQT FGYGARLF
Length:338
Mass (Da):38,117
Last modified:April 30, 2003 - v2
Checksum:iC4F0F94FF44F9FB3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti192P → L in BAC36160 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076069 mRNA. Translation: BAC36160.1.
BC023857 mRNA. Translation: AAH23857.1.
BC025552 mRNA. Translation: AAH25552.1.
CCDSiCCDS26075.1.
RefSeqiNP_666148.1. NM_146036.1.
UniGeneiMm.22626.

Genome annotation databases

EnsembliENSMUST00000021425; ENSMUSP00000021425; ENSMUSG00000021037.
GeneIDi217737.
KEGGimmu:217737.
UCSCiuc007oit.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076069 mRNA. Translation: BAC36160.1.
BC023857 mRNA. Translation: AAH23857.1.
BC025552 mRNA. Translation: AAH25552.1.
CCDSiCCDS26075.1.
RefSeqiNP_666148.1. NM_146036.1.
UniGeneiMm.22626.

3D structure databases

ProteinModelPortaliQ8BK64.
SMRiQ8BK64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229959. 2 interactors.
IntActiQ8BK64. 3 interactors.
MINTiMINT-4087362.
STRINGi10090.ENSMUSP00000021425.

PTM databases

iPTMnetiQ8BK64.
PhosphoSitePlusiQ8BK64.
SwissPalmiQ8BK64.

2D gel databases

REPRODUCTION-2DPAGEQ8BK64.

Proteomic databases

EPDiQ8BK64.
MaxQBiQ8BK64.
PaxDbiQ8BK64.
PRIDEiQ8BK64.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021425; ENSMUSP00000021425; ENSMUSG00000021037.
GeneIDi217737.
KEGGimmu:217737.
UCSCiuc007oit.1. mouse.

Organism-specific databases

CTDi10598.
MGIiMGI:2387603. Ahsa1.

Phylogenomic databases

eggNOGiKOG2936. Eukaryota.
COG5580. LUCA.
GeneTreeiENSGT00390000006429.
HOGENOMiHOG000242852.
HOVERGENiHBG065806.
InParanoidiQ8BK64.
OMAiENEEGKC.
OrthoDBiEOG091G0BRP.
PhylomeDBiQ8BK64.
TreeFamiTF313680.

Miscellaneous databases

ChiTaRSiAhsa1. mouse.
PROiQ8BK64.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021037.
GenevisibleiQ8BK64. MM.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR013538. Activator_of_Hsp90_ATPase.
IPR015310. AHSA1_N.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF09229. Aha1_N. 1 hit.
PF08327. AHSA1. 1 hit.
[Graphical view]
SMARTiSM01000. Aha1_N. 1 hit.
[Graphical view]
SUPFAMiSSF103111. SSF103111. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAHSA1_MOUSE
AccessioniPrimary (citable) accession number: Q8BK64
Secondary accession number(s): Q8R3E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: April 30, 2003
Last modified: November 30, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.