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Q8BK64

- AHSA1_MOUSE

UniProt

Q8BK64 - AHSA1_MOUSE

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Protein

Activator of 90 kDa heat shock protein ATPase homolog 1

Gene

Ahsa1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Co-chaperone that stimulates HSP90 ATPase activity. May affect a step in the endoplasmic reticulum to Golgi trafficking (By similarity).By similarity

GO - Molecular functioni

  1. ATPase activator activity Source: UniProtKB

GO - Biological processi

  1. positive regulation of ATPase activity Source: GOC
  2. protein folding Source: UniProtKB
  3. response to stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Activator of 90 kDa heat shock protein ATPase homolog 1
Short name:
AHA1
Gene namesi
Name:Ahsa1
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:2387603. Ahsa1.

Subcellular locationi

Cytoplasmcytosol By similarity. Endoplasmic reticulum By similarity
Note: May transiently interact with the endoplasmic reticulum.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endoplasmic reticulum Source: UniProtKB-KW
  3. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 338337Activator of 90 kDa heat shock protein ATPase homolog 1PRO_0000215821Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei3 – 31N6-acetyllysineBy similarity
Modified residuei193 – 1931PhosphoserineBy similarity
Modified residuei212 – 2121N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8BK64.
PaxDbiQ8BK64.
PRIDEiQ8BK64.

2D gel databases

REPRODUCTION-2DPAGEQ8BK64.

PTM databases

PhosphoSiteiQ8BK64.

Expressioni

Inductioni

By heat shock and treatment with the HSP90 inhibitor 17-demethoxygeldanamycin (17AAG).

Gene expression databases

BgeeiQ8BK64.
GenevestigatoriQ8BK64.

Interactioni

Subunit structurei

Interacts with HSPCA/HSP90. Interacts with GCH1 (By similarity). Interacts with SRPK1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi229959. 2 interactions.
IntActiQ8BK64. 3 interactions.
MINTiMINT-4087362.
STRINGi10090.ENSMUSP00000021425.

Structurei

3D structure databases

ProteinModelPortaliQ8BK64.
SMRiQ8BK64. Positions 25-126, 204-335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AHA1 family.Curated

Phylogenomic databases

eggNOGiCOG5580.
GeneTreeiENSGT00390000006429.
HOGENOMiHOG000242852.
HOVERGENiHBG065806.
InParanoidiQ8BK64.
OMAiMRVEWTG.
OrthoDBiEOG77DJ64.
PhylomeDBiQ8BK64.
TreeFamiTF313680.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR013538. Activator_of_Hsp90_ATPase.
IPR015310. AHSA1_N.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF09229. Aha1_N. 1 hit.
PF08327. AHSA1. 1 hit.
[Graphical view]
SMARTiSM01000. Aha1_N. 1 hit.
[Graphical view]
SUPFAMiSSF103111. SSF103111. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BK64-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKWGEGDPR WIVEERADAT NVNNWHWTER DASNWSTEKL KTLFLAVRVE
60 70 80 90 100
NEEGKCEVTE VNKLDGEASI NNRKGKLIFF YEWTIKLNWT GTSKSGVQYK
110 120 130 140 150
GHVEIPNLSD ENSVDEVEIS VSLAKDEPDT NLVALMKEDG VKLLREAVGI
160 170 180 190 200
YISTLKTEFT QGMILPTVNG ESVDPVGQPA LKTETCKAKS APSKSQAKPV
210 220 230 240 250
GVKIPTCKIT LKETFLTSPE ELYRVFTTQE LVQAFTHAPA ALEADRGGKF
260 270 280 290 300
HMVDGNVTGE FTDLVPEKHI AMKWRFKSWP EGHFATITLT FIDKNGETEL
310 320 330
CMEGRGIPAP EEERTRQGWQ RYYFEGIKQT FGYGARLF
Length:338
Mass (Da):38,117
Last modified:April 30, 2003 - v2
Checksum:iC4F0F94FF44F9FB3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti192 – 1921P → L in BAC36160. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK076069 mRNA. Translation: BAC36160.1.
BC023857 mRNA. Translation: AAH23857.1.
BC025552 mRNA. Translation: AAH25552.1.
CCDSiCCDS26075.1.
RefSeqiNP_666148.1. NM_146036.1.
UniGeneiMm.22626.

Genome annotation databases

EnsembliENSMUST00000021425; ENSMUSP00000021425; ENSMUSG00000021037.
GeneIDi217737.
KEGGimmu:217737.
UCSCiuc007oit.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK076069 mRNA. Translation: BAC36160.1 .
BC023857 mRNA. Translation: AAH23857.1 .
BC025552 mRNA. Translation: AAH25552.1 .
CCDSi CCDS26075.1.
RefSeqi NP_666148.1. NM_146036.1.
UniGenei Mm.22626.

3D structure databases

ProteinModelPortali Q8BK64.
SMRi Q8BK64. Positions 25-126, 204-335.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 229959. 2 interactions.
IntActi Q8BK64. 3 interactions.
MINTi MINT-4087362.
STRINGi 10090.ENSMUSP00000021425.

PTM databases

PhosphoSitei Q8BK64.

2D gel databases

REPRODUCTION-2DPAGE Q8BK64.

Proteomic databases

MaxQBi Q8BK64.
PaxDbi Q8BK64.
PRIDEi Q8BK64.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021425 ; ENSMUSP00000021425 ; ENSMUSG00000021037 .
GeneIDi 217737.
KEGGi mmu:217737.
UCSCi uc007oit.1. mouse.

Organism-specific databases

CTDi 10598.
MGIi MGI:2387603. Ahsa1.

Phylogenomic databases

eggNOGi COG5580.
GeneTreei ENSGT00390000006429.
HOGENOMi HOG000242852.
HOVERGENi HBG065806.
InParanoidi Q8BK64.
OMAi MRVEWTG.
OrthoDBi EOG77DJ64.
PhylomeDBi Q8BK64.
TreeFami TF313680.

Miscellaneous databases

ChiTaRSi AHSA1. mouse.
NextBioi 376016.
PROi Q8BK64.
SOURCEi Search...

Gene expression databases

Bgeei Q8BK64.
Genevestigatori Q8BK64.

Family and domain databases

Gene3Di 3.30.530.20. 1 hit.
InterProi IPR013538. Activator_of_Hsp90_ATPase.
IPR015310. AHSA1_N.
IPR023393. START-like_dom.
[Graphical view ]
Pfami PF09229. Aha1_N. 1 hit.
PF08327. AHSA1. 1 hit.
[Graphical view ]
SMARTi SM01000. Aha1_N. 1 hit.
[Graphical view ]
SUPFAMi SSF103111. SSF103111. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiAHSA1_MOUSE
AccessioniPrimary (citable) accession number: Q8BK64
Secondary accession number(s): Q8R3E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: April 30, 2003
Last modified: October 29, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3