Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactomedin-like protein 3

Gene

Olfml3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactomedin-like protein 3
Gene namesi
Name:Olfml3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1914877. Olfml3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002009322 – 406Olfactomedin-like protein 3Add BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi135 ↔ 328PROSITE-ProRule annotation
Glycosylationi177N-linked (GlcNAc...)Sequence analysis1
Glycosylationi248N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8BK62.
PaxDbiQ8BK62.
PeptideAtlasiQ8BK62.
PRIDEiQ8BK62.

PTM databases

iPTMnetiQ8BK62.
PhosphoSitePlusiQ8BK62.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027848.
CleanExiMM_OLFML3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029440.

Structurei

3D structure databases

ProteinModelPortaliQ8BK62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 401Olfactomedin-likePROSITE-ProRule annotationAdd BLAST268

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili25 – 101Sequence analysisAdd BLAST77

Sequence similaritiesi

Belongs to the OLFML3 family.Curated
Contains 1 olfactomedin-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG3545. Eukaryota.
ENOG410ZJ72. LUCA.
HOGENOMiHOG000115263.
HOVERGENiHBG108213.
InParanoidiQ8BK62.
PhylomeDBiQ8BK62.
TreeFamiTF352000.

Family and domain databases

InterProiIPR003112. Olfac-like_dom.
IPR031230. OLFML3.
[Graphical view]
PANTHERiPTHR23192:SF8. PTHR23192:SF8. 1 hit.
PfamiPF02191. OLF. 1 hit.
[Graphical view]
SMARTiSM00284. OLF. 1 hit.
[Graphical view]
PROSITEiPS51132. OLF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BK62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPSAPLLLL FFLSWTGPLQ GQQHHLVEYM ERRLAALEER LAQCQDQSSR
60 70 80 90 100
LAAELRDFKN KMLPLLEVAE KERETLRTEA DSISGRVDRL EREVDYLETQ
110 120 130 140 150
NPALPCVELD EKVTGGPGAK GKGRRNEKYD MVTDCSYTVA QVRSMKILKR
160 170 180 190 200
FGGSAGLWTK DPLGPAEKIY VLDGTQNDTA FVFPRLRDFT LAMAARKASR
210 220 230 240 250
IRVPFPWVGT GQLVYGGFLY YARRPPGGPG GGGELENTLQ LIKFHLANRT
260 270 280 290 300
VVDSSVFPAE SLIPPYGLTA DTYIDLAADE EGLWAVYATR DDDRHLCLAK
310 320 330 340 350
LDPQTLDTEQ QWDTPCPREN AEAAFVICGT LYVVYNTRPA SRARIQCSFD
360 370 380 390 400
ASGTLAPERA ALSYFPRRYG AHASLRYNPR ERQLYAWDDG YQIVYKLEMK

KKEEEV
Length:406
Mass (Da):45,746
Last modified:January 20, 2009 - v2
Checksum:i4BD11DD376F0A684
GO

Sequence cautioni

The sequence BAC24996 differs from that shown. Reason: Frameshift at positions 249 and 312.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51L → H in BAC24996 (PubMed:16141072).Curated1
Sequence conflicti51L → H in BAC36170 (PubMed:16141072).Curated1
Sequence conflicti51L → H in BAE20846 (PubMed:16141072).Curated1
Sequence conflicti51L → H in AAH05485 (PubMed:15489334).Curated1
Sequence conflicti155A → V in BAC24996 (PubMed:16141072).Curated1
Sequence conflicti155A → V in BAC36170 (PubMed:16141072).Curated1
Sequence conflicti155A → V in BAE20846 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002518 mRNA. Translation: BAC24996.1. Frameshift.
AK076084 mRNA. Translation: BAC36170.1.
AK131879 mRNA. Translation: BAE20846.1.
CU210935 Genomic DNA. Translation: CAP58491.1.
BC005485 mRNA. Translation: AAH05485.1.
CCDSiCCDS17693.1.
RefSeqiNP_598620.2. NM_133859.2.
UniGeneiMm.211535.

Genome annotation databases

GeneIDi99543.
KEGGimmu:99543.
UCSCiuc008qte.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002518 mRNA. Translation: BAC24996.1. Frameshift.
AK076084 mRNA. Translation: BAC36170.1.
AK131879 mRNA. Translation: BAE20846.1.
CU210935 Genomic DNA. Translation: CAP58491.1.
BC005485 mRNA. Translation: AAH05485.1.
CCDSiCCDS17693.1.
RefSeqiNP_598620.2. NM_133859.2.
UniGeneiMm.211535.

3D structure databases

ProteinModelPortaliQ8BK62.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029440.

PTM databases

iPTMnetiQ8BK62.
PhosphoSitePlusiQ8BK62.

Proteomic databases

MaxQBiQ8BK62.
PaxDbiQ8BK62.
PeptideAtlasiQ8BK62.
PRIDEiQ8BK62.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi99543.
KEGGimmu:99543.
UCSCiuc008qte.1. mouse.

Organism-specific databases

CTDi56944.
MGIiMGI:1914877. Olfml3.

Phylogenomic databases

eggNOGiKOG3545. Eukaryota.
ENOG410ZJ72. LUCA.
HOGENOMiHOG000115263.
HOVERGENiHBG108213.
InParanoidiQ8BK62.
PhylomeDBiQ8BK62.
TreeFamiTF352000.

Miscellaneous databases

PROiQ8BK62.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027848.
CleanExiMM_OLFML3.

Family and domain databases

InterProiIPR003112. Olfac-like_dom.
IPR031230. OLFML3.
[Graphical view]
PANTHERiPTHR23192:SF8. PTHR23192:SF8. 1 hit.
PfamiPF02191. OLF. 1 hit.
[Graphical view]
SMARTiSM00284. OLF. 1 hit.
[Graphical view]
PROSITEiPS51132. OLF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOLFL3_MOUSE
AccessioniPrimary (citable) accession number: Q8BK62
Secondary accession number(s): A9R9W9
, Q3V2F2, Q8C1T0, Q99K37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: January 20, 2009
Last modified: November 2, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.