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Protein

HSPB1-associated protein 1

Gene

Hspbap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in cellular stress response.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
HSPB1-associated protein 1
Alternative name(s):
27 kDa heat shock protein-associated protein 1
Protein associated with small stress protein 1
Gene namesi
Name:Hspbap1
Synonyms:Pass1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1913917. Hspbap1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002841141 – 483HSPB1-associated protein 1Add BLAST483

Proteomic databases

EPDiQ8BK58.
MaxQBiQ8BK58.
PaxDbiQ8BK58.
PeptideAtlasiQ8BK58.
PRIDEiQ8BK58.

PTM databases

PhosphoSitePlusiQ8BK58.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022849.
CleanExiMM_HSPBAP1.
GenevisibleiQ8BK58. MM.

Interactioni

Subunit structurei

Interacts with CRYAB and HSPB1.1 Publication

Protein-protein interaction databases

BioGridi211634. 1 interactor.
STRINGi10090.ENSMUSP00000023555.

Structurei

3D structure databases

ProteinModelPortaliQ8BK58.
SMRiQ8BK58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 288JmjCPROSITE-ProRule annotationAdd BLAST165

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni88 – 208Interaction with HSPB1By similarityAdd BLAST121

Sequence similaritiesi

Contains 1 JmjC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2132. Eukaryota.
ENOG410XQDR. LUCA.
GeneTreeiENSGT00530000062914.
HOGENOMiHOG000068192.
HOVERGENiHBG099816.
InParanoidiQ8BK58.
KOiK19375.
OMAiNCHYLNG.
OrthoDBiEOG091G0DDY.
TreeFamiTF315056.

Family and domain databases

InterProiIPR013296. HSPB1-associated_protein_1.
IPR003347. JmjC_dom.
[Graphical view]
PRINTSiPR01886. PASS1.
SMARTiSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BK58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGCEGIAP PTLGERTVGE EGEPVKPFTP EKAKEIIMSL QQPAIFCNMV
60 70 80 90 100
FDWPSRHWTA KHLSKVLEGK QIRFRMGLRG TGTVPQYETE CSYVDATLEE
110 120 130 140 150
FLTWNCDQSS ISGPFKDYEH SKFWAYADYK YFVTLFEDKT DVFQEVVWSD
160 170 180 190 200
FGFPGRNGQE STLWIGSFGA HTPCHLDSYG CNLVFQVQGR KRWHLFPPED
210 220 230 240 250
TPFLYPTRIP YEESSVFSKI NVVNPDLKCF PQFQKARRHM VTLSPGQVLF
260 270 280 290 300
VPRHWWHYVE SLDPVTVSIN SWIELEEDHL ARVEEAITRM LVCTLKTAED
310 320 330 340 350
PHHPRTWLNP TEVEETSHEV NSCYLNSAVC AFFDHCEKAK AVELQVLSAN
360 370 380 390 400
GAEPRVQEEH MEVEQAQGPS LTSRAEKQEA VSLFGPDLIP VTPASEERGG
410 420 430 440 450
ALEGDSEESV SSNGGHFAEL PCARRQQTSK GASALTEPLA PRGPMAHSRV
460 470 480
FVSTDDLLDC LVNPQVTRMV AQLLIQGKSC DTF
Length:483
Mass (Da):54,395
Last modified:July 27, 2011 - v2
Checksum:i520906E6F7F73EBB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti268S → G in BAC36242 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076189 mRNA. Translation: BAC36242.1.
AC129574 Genomic DNA. No translation available.
CCDSiCCDS28142.1.
RefSeqiNP_780320.2. NM_175111.3.
UniGeneiMm.45272.

Genome annotation databases

EnsembliENSMUST00000023555; ENSMUSP00000023555; ENSMUSG00000022849.
GeneIDi66667.
KEGGimmu:66667.
UCSCiuc007zbq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076189 mRNA. Translation: BAC36242.1.
AC129574 Genomic DNA. No translation available.
CCDSiCCDS28142.1.
RefSeqiNP_780320.2. NM_175111.3.
UniGeneiMm.45272.

3D structure databases

ProteinModelPortaliQ8BK58.
SMRiQ8BK58.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211634. 1 interactor.
STRINGi10090.ENSMUSP00000023555.

PTM databases

PhosphoSitePlusiQ8BK58.

Proteomic databases

EPDiQ8BK58.
MaxQBiQ8BK58.
PaxDbiQ8BK58.
PeptideAtlasiQ8BK58.
PRIDEiQ8BK58.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023555; ENSMUSP00000023555; ENSMUSG00000022849.
GeneIDi66667.
KEGGimmu:66667.
UCSCiuc007zbq.1. mouse.

Organism-specific databases

CTDi79663.
MGIiMGI:1913917. Hspbap1.

Phylogenomic databases

eggNOGiKOG2132. Eukaryota.
ENOG410XQDR. LUCA.
GeneTreeiENSGT00530000062914.
HOGENOMiHOG000068192.
HOVERGENiHBG099816.
InParanoidiQ8BK58.
KOiK19375.
OMAiNCHYLNG.
OrthoDBiEOG091G0DDY.
TreeFamiTF315056.

Miscellaneous databases

ChiTaRSiHspbap1. mouse.
PROiQ8BK58.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022849.
CleanExiMM_HSPBAP1.
GenevisibleiQ8BK58. MM.

Family and domain databases

InterProiIPR013296. HSPB1-associated_protein_1.
IPR003347. JmjC_dom.
[Graphical view]
PRINTSiPR01886. PASS1.
SMARTiSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBAP1_MOUSE
AccessioniPrimary (citable) accession number: Q8BK58
Secondary accession number(s): E9QML8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.