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Protein

NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

Gene

Ndufv3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
Alternative name(s):
Complex I-9kD
Short name:
CI-9kD
NADH-ubiquinone oxidoreductase 9 kDa subunit
Gene namesi
Name:Ndufv3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1890894. Ndufv3.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial respiratory chain complex I Source: MGI
  • mitochondrion Source: MGI
  • nucleoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35MitochondrionBy similarityAdd BLAST35
ChainiPRO_000025188336 – 104NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrialAdd BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei101PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BK30.
MaxQBiQ8BK30.
PaxDbiQ8BK30.
PeptideAtlasiQ8BK30.
PRIDEiQ8BK30.

PTM databases

iPTMnetiQ8BK30.
PhosphoSitePlusiQ8BK30.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024038.
CleanExiMM_1500032D16RIK.
ExpressionAtlasiQ8BK30. baseline and differential.
GenevisibleiQ8BK30. MM.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049000.

Structurei

3D structure databases

ProteinModelPortaliQ8BK30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFV3 subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IXG2. Eukaryota.
ENOG410YVZC. LUCA.
GeneTreeiENSGT00390000012196.
HOGENOMiHOG000013001.
HOVERGENiHBG082013.
InParanoidiQ8BK30.
KOiK03944.

Family and domain databases

InterProiIPR026193. NDUFV3.
[Graphical view]
PANTHERiPTHR17117. PTHR17117. 1 hit.
PfamiPF15880. NDUFV3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BK30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVSLLLRGG RIRALKAVLL EARVFPGELV SVVRLSTESE KSAKEKELHP
60 70 80 90 100
KTQSVLKEPE PTDTTTYKNL QHHDYNTYTF LDLNLDLSKF RLPQPSSGRE

SPRH
Length:104
Mass (Da):11,813
Last modified:March 1, 2003 - v1
Checksum:i0674772FC8C17CA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077433 mRNA. Translation: BAC36798.1.
CCDSiCCDS37550.1.
RefSeqiNP_001077360.1. NM_001083891.1.
UniGeneiMm.28349.

Genome annotation databases

EnsembliENSMUST00000064798; ENSMUSP00000066303; ENSMUSG00000024038.
GeneIDi78330.
KEGGimmu:78330.
UCSCiuc008bvf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077433 mRNA. Translation: BAC36798.1.
CCDSiCCDS37550.1.
RefSeqiNP_001077360.1. NM_001083891.1.
UniGeneiMm.28349.

3D structure databases

ProteinModelPortaliQ8BK30.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049000.

PTM databases

iPTMnetiQ8BK30.
PhosphoSitePlusiQ8BK30.

Proteomic databases

EPDiQ8BK30.
MaxQBiQ8BK30.
PaxDbiQ8BK30.
PeptideAtlasiQ8BK30.
PRIDEiQ8BK30.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064798; ENSMUSP00000066303; ENSMUSG00000024038.
GeneIDi78330.
KEGGimmu:78330.
UCSCiuc008bvf.1. mouse.

Organism-specific databases

CTDi4731.
MGIiMGI:1890894. Ndufv3.

Phylogenomic databases

eggNOGiENOG410IXG2. Eukaryota.
ENOG410YVZC. LUCA.
GeneTreeiENSGT00390000012196.
HOGENOMiHOG000013001.
HOVERGENiHBG082013.
InParanoidiQ8BK30.
KOiK03944.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

ChiTaRSiNdufv3. mouse.
PROiQ8BK30.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024038.
CleanExiMM_1500032D16RIK.
ExpressionAtlasiQ8BK30. baseline and differential.
GenevisibleiQ8BK30. MM.

Family and domain databases

InterProiIPR026193. NDUFV3.
[Graphical view]
PANTHERiPTHR17117. PTHR17117. 1 hit.
PfamiPF15880. NDUFV3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDUV3_MOUSE
AccessioniPrimary (citable) accession number: Q8BK30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.