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Protein

NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

Gene

Ndufv3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
Alternative name(s):
Complex I-9kD
Short name:
CI-9kD
NADH-ubiquinone oxidoreductase 9 kDa subunit
Gene namesi
Name:Ndufv3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1890894. Ndufv3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35MitochondrionBy similarityAdd BLAST35
ChainiPRO_000025188336 – 104NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrialAdd BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei101PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BK30.
MaxQBiQ8BK30.
PaxDbiQ8BK30.
PeptideAtlasiQ8BK30.
PRIDEiQ8BK30.

PTM databases

iPTMnetiQ8BK30.
PhosphoSitePlusiQ8BK30.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024038.
CleanExiMM_1500032D16RIK.
ExpressionAtlasiQ8BK30. baseline and differential.
GenevisibleiQ8BK30. MM.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049000.

Structurei

3D structure databases

ProteinModelPortaliQ8BK30.
SMRiQ8BK30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFV3 subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IXG2. Eukaryota.
ENOG410YVZC. LUCA.
GeneTreeiENSGT00390000012196.
HOGENOMiHOG000013001.
HOVERGENiHBG082013.
InParanoidiQ8BK30.
KOiK03944.

Family and domain databases

InterProiView protein in InterPro
IPR026193. NDUFV3.
PANTHERiPTHR17117. PTHR17117. 1 hit.
PfamiView protein in Pfam
PF15880. NDUFV3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BK30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVSLLLRGG RIRALKAVLL EARVFPGELV SVVRLSTESE KSAKEKELHP
60 70 80 90 100
KTQSVLKEPE PTDTTTYKNL QHHDYNTYTF LDLNLDLSKF RLPQPSSGRE

SPRH
Length:104
Mass (Da):11,813
Last modified:March 1, 2003 - v1
Checksum:i0674772FC8C17CA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077433 mRNA. Translation: BAC36798.1.
CCDSiCCDS37550.1.
RefSeqiNP_001077360.1. NM_001083891.1.
UniGeneiMm.28349.

Genome annotation databases

EnsembliENSMUST00000064798; ENSMUSP00000066303; ENSMUSG00000024038.
GeneIDi78330.
KEGGimmu:78330.
UCSCiuc008bvf.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiNDUV3_MOUSE
AccessioniPrimary (citable) accession number: Q8BK30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: September 27, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families