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Protein

F-box only protein 44

Gene

Fbxo44

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 44
Alternative name(s):
F-box only protein 6a
Gene namesi
Name:Fbxo44
Synonyms:Fbxo6a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1354744. Fbxo44.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255F-box only protein 44PRO_0000119946Add
BLAST

Proteomic databases

MaxQBiQ8BK26.
PaxDbiQ8BK26.
PRIDEiQ8BK26.

PTM databases

PhosphoSiteiQ8BK26.

Expressioni

Tissue specificityi

Expressed in brain, liver, pancreas and adipose tissue (at protein level). Widely expressed.1 Publication

Developmental stagei

Strong expression in embryos. Maximally expressed in brain during embryonic development but declined thereafter.1 Publication

Gene expression databases

CleanExiMM_FBXO44.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054022.

Structurei

3D structure databases

ProteinModelPortaliQ8BK26.
SMRiQ8BK26. Positions 2-253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 5048F-boxPROSITE-ProRule annotationAdd
BLAST
Domaini71 – 252182FBAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 1 FBA (F-box associated) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IK6V. Eukaryota.
ENOG4111MF5. LUCA.
HOGENOMiHOG000231084.
HOVERGENiHBG003593.
InParanoidiQ8BK26.
KOiK10103.
PhylomeDBiQ8BK26.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR007397. F-box-assoc_dom.
IPR001810. F-box_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF04300. FBA. 1 hit.
[Graphical view]
SMARTiSM01198. FBA. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS51114. FBA. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BK26-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVGNINELP ENILLELFIH IPARQLLLRC RPVCSLWRDL IDLVTLWKRK
60 70 80 90 100
CLQEGFITED WDQPVADWKI FYFLRSLQRN LLHNPCAEEG FEFWSLDVNG
110 120 130 140 150
GDEWKVEDLS KDQRKEFPND QVKKYFVTSY YTCLKSQVVD LKAEGYWEEL
160 170 180 190 200
MDTTRPDIEV KDWFAARPDC GSKYQLCVQL LSSAHAPLGT FQPDPVMIQQ
210 220 230 240 250
KSDAKWSEVS HTFSNYPPGV RYIWFQHGGV DTHYWAGWYG PRVTNSSITI

GPPLP
Length:255
Mass (Da):29,723
Last modified:March 1, 2003 - v1
Checksum:i54CC79D58BA00938
GO
Isoform 2 (identifier: Q8BK26-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     207-211: SEVSH → REGLM
     212-255: Missing.

Show »
Length:211
Mass (Da):24,794
Checksum:i1E23E2DC45F9C3F2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei207 – 2115SEVSH → REGLM in isoform 2. 1 PublicationVSP_011348
Alternative sequencei212 – 25544Missing in isoform 2. 1 PublicationVSP_011349Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077452 mRNA. Translation: BAC36807.1.
BC028884 mRNA. Translation: AAH28884.1.
CCDSiCCDS18934.1. [Q8BK26-1]
RefSeqiNP_001155323.1. NM_001161851.2.
NP_001155324.1. NM_001161852.2.
NP_775577.2. NM_173401.5.
XP_011248538.1. XM_011250236.1. [Q8BK26-2]
XP_011249446.1. XM_011251144.1. [Q8BK26-2]
UniGeneiMm.220327.

Genome annotation databases

GeneIDi230903.
KEGGimmu:230903.
UCSCiuc008vui.3. mouse. [Q8BK26-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077452 mRNA. Translation: BAC36807.1.
BC028884 mRNA. Translation: AAH28884.1.
CCDSiCCDS18934.1. [Q8BK26-1]
RefSeqiNP_001155323.1. NM_001161851.2.
NP_001155324.1. NM_001161852.2.
NP_775577.2. NM_173401.5.
XP_011248538.1. XM_011250236.1. [Q8BK26-2]
XP_011249446.1. XM_011251144.1. [Q8BK26-2]
UniGeneiMm.220327.

3D structure databases

ProteinModelPortaliQ8BK26.
SMRiQ8BK26. Positions 2-253.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054022.

PTM databases

PhosphoSiteiQ8BK26.

Proteomic databases

MaxQBiQ8BK26.
PaxDbiQ8BK26.
PRIDEiQ8BK26.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi230903.
KEGGimmu:230903.
UCSCiuc008vui.3. mouse. [Q8BK26-2]

Organism-specific databases

CTDi93611.
MGIiMGI:1354744. Fbxo44.

Phylogenomic databases

eggNOGiENOG410IK6V. Eukaryota.
ENOG4111MF5. LUCA.
HOGENOMiHOG000231084.
HOVERGENiHBG003593.
InParanoidiQ8BK26.
KOiK10103.
PhylomeDBiQ8BK26.

Miscellaneous databases

PROiQ8BK26.
SOURCEiSearch...

Gene expression databases

CleanExiMM_FBXO44.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR007397. F-box-assoc_dom.
IPR001810. F-box_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF04300. FBA. 1 hit.
[Graphical view]
SMARTiSM01198. FBA. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS51114. FBA. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Salivary gland.
  3. "Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases."
    Glenn K.A., Nelson R.F., Wen H.M., Mallinger A.J., Paulson H.L.
    J. Biol. Chem. 283:12717-12729(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiFBX44_MOUSE
AccessioniPrimary (citable) accession number: Q8BK26
Secondary accession number(s): Q8K128
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.