Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 11, mitochondrial

Gene

Tmem11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in mitochondrial morphogenesis.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 11, mitochondrial
Alternative name(s):
Protein PM1
Gene namesi
Name:Tmem11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2144726 Tmem11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei84 – 100HelicalSequence analysisAdd BLAST17
Transmembranei107 – 124HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000725631 – 190Transmembrane protein 11, mitochondrialAdd BLAST190

Proteomic databases

EPDiQ8BK08
MaxQBiQ8BK08
PaxDbiQ8BK08
PeptideAtlasiQ8BK08
PRIDEiQ8BK08

PTM databases

iPTMnetiQ8BK08
PhosphoSitePlusiQ8BK08
SwissPalmiQ8BK08

Expressioni

Gene expression databases

BgeeiENSMUSG00000043284
CleanExiMM_TMEM11
ExpressionAtlasiQ8BK08 baseline and differential
GenevisibleiQ8BK08 MM

Interactioni

Subunit structurei

Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. Interacts with IMMT/MIC60.By similarity

Protein-protein interaction databases

BioGridi229795, 1 interactor
IntActiQ8BK08, 1 interactor
MINTiQ8BK08
STRINGi10090.ENSMUSP00000059494

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM11 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGFW Eukaryota
ENOG410Z9AV LUCA
GeneTreeiENSGT00390000006617
HOGENOMiHOG000007261
HOVERGENiHBG002057
InParanoidiQ8BK08
OMAiLYTVSWQ
OrthoDBiEOG091G0SRJ
PhylomeDBiQ8BK08
TreeFamiTF324685

Family and domain databases

InterProiView protein in InterPro
IPR026120 TMEM11
PANTHERiPTHR15099 PTHR15099, 1 hit
PfamiView protein in Pfam
PF14972 Mito_morph_reg, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BK08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAWGRRRLG PGGGGSRERV SLSATDCYIV HEIYSGENAQ DQFEYELEQA
60 70 80 90 100
LEAQYKYIVI EPTRIGDETA RWITVGNCLH KTAVLAGTAC LFTPLALPLD
110 120 130 140 150
YSHYISLPAG VLSLACCTLY GISWQFDPCC KYQVEYDAYK LSRLPLHTLT
160 170 180 190
SSTPVVLVRK DDLHRKRLHN TIALAALVYC VKKVYELYAV
Length:190
Mass (Da):21,312
Last modified:March 1, 2003 - v1
Checksum:i84ECC3BA30BB2EA5
GO

Sequence cautioni

The sequence CAI35260 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077600 mRNA Translation: BAC36891.1
AL596215 Genomic DNA Translation: CAI35259.1
AL596215 Genomic DNA Translation: CAI35260.1 Sequence problems.
BC048514 mRNA Translation: AAH48514.1
CCDSiCCDS24801.1
RefSeqiNP_775655.1, NM_173453.3
UniGeneiMm.28063
Mm.485803

Genome annotation databases

EnsembliENSMUST00000062677; ENSMUSP00000059494; ENSMUSG00000043284
GeneIDi216821
KEGGimmu:216821
UCSCiuc007jgs.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTMM11_MOUSE
AccessioniPrimary (citable) accession number: Q8BK08
Secondary accession number(s): Q5NCT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health