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Protein

Transmembrane protein 11, mitochondrial

Gene

Tmem11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in mitochondrial morphogenesis.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 11, mitochondrial
Alternative name(s):
Protein PM1
Gene namesi
Name:Tmem11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2144726. Tmem11.

Subcellular locationi

  • Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei84 – 100HelicalSequence analysisAdd BLAST17
Transmembranei107 – 124HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

  • integral component of mitochondrial inner membrane Source: UniProtKB
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000725631 – 190Transmembrane protein 11, mitochondrialAdd BLAST190

Proteomic databases

EPDiQ8BK08.
MaxQBiQ8BK08.
PaxDbiQ8BK08.
PeptideAtlasiQ8BK08.
PRIDEiQ8BK08.

PTM databases

iPTMnetiQ8BK08.
PhosphoSitePlusiQ8BK08.

Expressioni

Gene expression databases

BgeeiENSMUSG00000043284.
CleanExiMM_TMEM11.
ExpressionAtlasiQ8BK08. baseline and differential.
GenevisibleiQ8BK08. MM.

Interactioni

Subunit structurei

Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. Interacts with IMMT/MIC60.By similarity

Protein-protein interaction databases

BioGridi229795. 1 interactor.
IntActiQ8BK08. 1 interactor.
MINTiMINT-4111033.
STRINGi10090.ENSMUSP00000059494.

Structurei

3D structure databases

ProteinModelPortaliQ8BK08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM11 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGFW. Eukaryota.
ENOG410Z9AV. LUCA.
GeneTreeiENSGT00390000006617.
HOGENOMiHOG000007261.
HOVERGENiHBG002057.
InParanoidiQ8BK08.
OMAiQVEYDSQ.
OrthoDBiEOG091G0SRJ.
PhylomeDBiQ8BK08.
TreeFamiTF324685.

Family and domain databases

InterProiIPR026120. TMEM11.
[Graphical view]
PfamiPF14972. Mito_morph_reg. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BK08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAWGRRRLG PGGGGSRERV SLSATDCYIV HEIYSGENAQ DQFEYELEQA
60 70 80 90 100
LEAQYKYIVI EPTRIGDETA RWITVGNCLH KTAVLAGTAC LFTPLALPLD
110 120 130 140 150
YSHYISLPAG VLSLACCTLY GISWQFDPCC KYQVEYDAYK LSRLPLHTLT
160 170 180 190
SSTPVVLVRK DDLHRKRLHN TIALAALVYC VKKVYELYAV
Length:190
Mass (Da):21,312
Last modified:March 1, 2003 - v1
Checksum:i84ECC3BA30BB2EA5
GO

Sequence cautioni

The sequence CAI35260 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077600 mRNA. Translation: BAC36891.1.
AL596215 Genomic DNA. Translation: CAI35259.1.
AL596215 Genomic DNA. Translation: CAI35260.1. Sequence problems.
BC048514 mRNA. Translation: AAH48514.1.
CCDSiCCDS24801.1.
RefSeqiNP_775655.1. NM_173453.3.
UniGeneiMm.28063.
Mm.485803.

Genome annotation databases

EnsembliENSMUST00000062677; ENSMUSP00000059494; ENSMUSG00000043284.
GeneIDi216821.
KEGGimmu:216821.
UCSCiuc007jgs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077600 mRNA. Translation: BAC36891.1.
AL596215 Genomic DNA. Translation: CAI35259.1.
AL596215 Genomic DNA. Translation: CAI35260.1. Sequence problems.
BC048514 mRNA. Translation: AAH48514.1.
CCDSiCCDS24801.1.
RefSeqiNP_775655.1. NM_173453.3.
UniGeneiMm.28063.
Mm.485803.

3D structure databases

ProteinModelPortaliQ8BK08.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229795. 1 interactor.
IntActiQ8BK08. 1 interactor.
MINTiMINT-4111033.
STRINGi10090.ENSMUSP00000059494.

PTM databases

iPTMnetiQ8BK08.
PhosphoSitePlusiQ8BK08.

Proteomic databases

EPDiQ8BK08.
MaxQBiQ8BK08.
PaxDbiQ8BK08.
PeptideAtlasiQ8BK08.
PRIDEiQ8BK08.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062677; ENSMUSP00000059494; ENSMUSG00000043284.
GeneIDi216821.
KEGGimmu:216821.
UCSCiuc007jgs.2. mouse.

Organism-specific databases

CTDi8834.
MGIiMGI:2144726. Tmem11.

Phylogenomic databases

eggNOGiENOG410IGFW. Eukaryota.
ENOG410Z9AV. LUCA.
GeneTreeiENSGT00390000006617.
HOGENOMiHOG000007261.
HOVERGENiHBG002057.
InParanoidiQ8BK08.
OMAiQVEYDSQ.
OrthoDBiEOG091G0SRJ.
PhylomeDBiQ8BK08.
TreeFamiTF324685.

Miscellaneous databases

ChiTaRSiTmem11. mouse.
PROiQ8BK08.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043284.
CleanExiMM_TMEM11.
ExpressionAtlasiQ8BK08. baseline and differential.
GenevisibleiQ8BK08. MM.

Family and domain databases

InterProiIPR026120. TMEM11.
[Graphical view]
PfamiPF14972. Mito_morph_reg. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMM11_MOUSE
AccessioniPrimary (citable) accession number: Q8BK08
Secondary accession number(s): Q5NCT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.