ID   RT35_MOUSE              Reviewed;         320 AA.
AC   Q8BJZ4; B2KFS5; Q8VCG7;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 2.
DT   24-JAN-2024, entry version 122.
DE   RecName: Full=Small ribosomal subunit protein mS35 {ECO:0000305};
DE   AltName: Full=28S ribosomal protein S35, mitochondrial;
DE            Short=MRP-S35;
DE            Short=S35mt;
DE   Flags: Precursor;
GN   Name=Mrps35 {ECO:0000312|MGI:MGI:2385255};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000312|EMBL:BAC36950.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J {ECO:0000312|EMBL:BAC36950.1}, and NOD
RC   {ECO:0000312|EMBL:BAE41824.1};
RC   TISSUE=Embryo {ECO:0000312|EMBL:BAC36950.1};
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0000305, ECO:0000312|EMBL:AAH19964.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-320.
RC   STRAIN=FVB/N {ECO:0000312|EMBL:AAH19964.1};
RC   TISSUE=Liver {ECO:0000312|EMBL:AAH19964.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung,
RC   Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBUNIT: Component of the mitochondrial ribosome small subunit (28S)
CC       which comprises a 12S rRNA and about 30 distinct proteins.
CC       {ECO:0000250|UniProtKB:Q2YDF6}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q2YDF6}.
CC   -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC       mS35 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH19964.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK077677; BAC36950.1; -; mRNA.
DR   EMBL; AK170480; BAE41824.1; -; mRNA.
DR   EMBL; CU207396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC019964; AAH19964.1; ALT_INIT; mRNA.
DR   CCDS; CCDS51959.1; -.
DR   RefSeq; NP_663548.2; NM_145573.2.
DR   PDB; 7PNT; EM; 3.19 A; 1=1-320.
DR   PDB; 7PNU; EM; 3.06 A; 1=1-320.
DR   PDB; 7PNV; EM; 3.06 A; 1=1-320.
DR   PDB; 7PNW; EM; 3.09 A; 1=1-320.
DR   PDBsum; 7PNT; -.
DR   PDBsum; 7PNU; -.
DR   PDBsum; 7PNV; -.
DR   PDBsum; 7PNW; -.
DR   AlphaFoldDB; Q8BJZ4; -.
DR   EMDB; EMD-13551; -.
DR   EMDB; EMD-13552; -.
DR   EMDB; EMD-13553; -.
DR   EMDB; EMD-13554; -.
DR   SMR; Q8BJZ4; -.
DR   BioGRID; 231269; 8.
DR   ComplexPortal; CPX-5301; 28S mitochondrial small ribosomal subunit.
DR   IntAct; Q8BJZ4; 1.
DR   STRING; 10090.ENSMUSP00000048348; -.
DR   iPTMnet; Q8BJZ4; -.
DR   PhosphoSitePlus; Q8BJZ4; -.
DR   SwissPalm; Q8BJZ4; -.
DR   EPD; Q8BJZ4; -.
DR   MaxQB; Q8BJZ4; -.
DR   PaxDb; 10090-ENSMUSP00000048348; -.
DR   PeptideAtlas; Q8BJZ4; -.
DR   ProteomicsDB; 257049; -.
DR   Pumba; Q8BJZ4; -.
DR   DNASU; 232536; -.
DR   GeneID; 232536; -.
DR   KEGG; mmu:232536; -.
DR   UCSC; uc009ess.1; mouse.
DR   AGR; MGI:2385255; -.
DR   CTD; 60488; -.
DR   MGI; MGI:2385255; Mrps35.
DR   eggNOG; KOG3933; Eukaryota.
DR   InParanoid; Q8BJZ4; -.
DR   OrthoDB; 2913023at2759; -.
DR   PhylomeDB; Q8BJZ4; -.
DR   TreeFam; TF318686; -.
DR   Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR   Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR   BioGRID-ORCS; 232536; 23 hits in 114 CRISPR screens.
DR   ChiTaRS; Mrps35; mouse.
DR   PRO; PR:Q8BJZ4; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q8BJZ4; Protein.
DR   GO; GO:0005743; C:mitochondrial inner membrane; NAS:ComplexPortal.
DR   GO; GO:0005763; C:mitochondrial small ribosomal subunit; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0032543; P:mitochondrial translation; NAS:ComplexPortal.
DR   InterPro; IPR019349; Ribosomal_mS35_mit.
DR   InterPro; IPR039848; Ribosomal_mS35_mt.
DR   PANTHER; PTHR13490:SF0; 28S RIBOSOMAL PROTEIN S35, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR13490; MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28; 1.
DR   Pfam; PF10213; MRP-S28; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Mitochondrion; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein; Transit peptide.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000305"
FT   CHAIN           ?..320
FT                   /note="Small ribosomal subunit protein mS35"
FT                   /id="PRO_0000046056"
FT   REGION          24..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..60
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        11
FT                   /note="S -> T (in Ref. 1; BAC36950/BAE41824)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        16
FT                   /note="P -> A (in Ref. 1; BAC36950/BAE41824)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        216
FT                   /note="Y -> C (in Ref. 1; BAC36950/BAE41824)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        293
FT                   /note="V -> I (in Ref. 1; BAC36950/BAE41824)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   320 AA;  35975 MW;  83A35D706DFB806E CRC64;
     MAAAALQLRQ SLCPGPRVLR TFSSVASPAA PRAGPRTASR SERPMRRKAL PPRTEKMDTD
     QDWPSVYPTA APFKPSAVPL PVRMGYPVKK GVPMAKEGNL ELLKIPNFLH LTPVAIKRHC
     AALKDFCTEW PAALDSDEKC EEHFPVEIDT ADYVSSGPSI RNPKARAVTL RVKLSSLNLD
     NHAKKKLIKL VGERYCKATD VLTITTDRCP LKRQNYDYAV YLLTVLYHES WKTEDWENSK
     TEEDMDEYVW AKSSSENSVL QTLLQMRAAE SSVAPSREEL LGTKEVEDYQ KCVVRLKNEG
     ENEASLAQYK ESVKRLLNLA
//