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Protein

26S proteasome non-ATPase regulatory subunit 5

Gene

Psmd5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5 (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-MMU-1169091. Activation of NF-kappaB in B cells.
R-MMU-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-MMU-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-MMU-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-MMU-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-MMU-174154. APC/C:Cdc20 mediated degradation of Securin.
R-MMU-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-MMU-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-MMU-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-MMU-195253. Degradation of beta-catenin by the destruction complex.
R-MMU-202424. Downstream TCR signaling.
R-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2871837. FCERI mediated NF-kB activation.
R-MMU-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-MMU-350562. Regulation of ornithine decarboxylase (ODC).
R-MMU-382556. ABC-family proteins mediated transport.
R-MMU-446652. Interleukin-1 family signaling.
R-MMU-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-MMU-4608870. Asymmetric localization of PCP proteins.
R-MMU-4641257. Degradation of AXIN.
R-MMU-4641258. Degradation of DVL.
R-MMU-5358346. Hedgehog ligand biogenesis.
R-MMU-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-MMU-5607764. CLEC7A (Dectin-1) signaling.
R-MMU-5610780. Degradation of GLI1 by the proteasome.
R-MMU-5610785. GLI3 is processed to GLI3R by the proteasome.
R-MMU-5632684. Hedgehog 'on' state.
R-MMU-5658442. Regulation of RAS by GAPs.
R-MMU-5668541. TNFR2 non-canonical NF-kB pathway.
R-MMU-5676590. NIK-->noncanonical NF-kB signaling.
R-MMU-5687128. MAPK6/MAPK4 signaling.
R-MMU-5689603. UCH proteinases.
R-MMU-5689880. Ub-specific processing proteases.
R-MMU-68827. CDT1 association with the CDC6:ORC:origin complex.
R-MMU-68949. Orc1 removal from chromatin.
R-MMU-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-MMU-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-MMU-69481. G2/M Checkpoints.
R-MMU-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-MMU-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-MMU-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-MMU-8939236. RUNX1 regulates transcription of genes involved in differentiation of HSCs.
R-MMU-8939902. Regulation of RUNX2 expression and activity.
R-MMU-8941858. Regulation of RUNX3 expression and activity.
R-MMU-8948751. Regulation of PTEN stability and activity.
R-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 5
Alternative name(s):
26S protease subunit S5 basic
26S proteasome subunit S5B
Gene namesi
Name:Psmd5
Synonyms:Kiaa0072
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914248. Psmd5.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001738372 – 50426S proteasome non-ATPase regulatory subunit 5Add BLAST503

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BJY1.
MaxQBiQ8BJY1.
PaxDbiQ8BJY1.
PeptideAtlasiQ8BJY1.
PRIDEiQ8BJY1.

PTM databases

iPTMnetiQ8BJY1.
PhosphoSitePlusiQ8BJY1.
SwissPalmiQ8BJY1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026869.
ExpressionAtlasiQ8BJY1. baseline and differential.
GenevisibleiQ8BJY1. MM.

Interactioni

Subunit structurei

Interacts with PSMC1, PSMC2, PSMD1 and PSMD6. Part of transient complex containing PSMD5, PSMC2, PSMC1 and PSMD2 formed during the assembly of the 26S proteasome.1 Publication

Protein-protein interaction databases

BioGridi211865. 2 interactors.
IntActiQ8BJY1. 1 interactor.
MINTiMINT-2514524.
STRINGi10090.ENSMUSP00000028225.

Structurei

3D structure databases

ProteinModelPortaliQ8BJY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Rich in dileucine repeats, which have been implicated in trafficking of a variety of transmembrane proteins.

Sequence similaritiesi

Belongs to the proteasome subunit S5B/HSM3 family.Curated

Phylogenomic databases

eggNOGiKOG4413. Eukaryota.
ENOG410XTFA. LUCA.
GeneTreeiENSGT00390000013040.
HOGENOMiHOG000231963.
HOVERGENiHBG053741.
InParanoidiQ8BJY1.
KOiK06692.
OMAiDSPQQVC.
OrthoDBiEOG091G09IW.
PhylomeDBiQ8BJY1.
TreeFamiTF106231.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR019538. PSMD5.
PANTHERiPTHR13554. PTHR13554. 1 hit.
PfamiView protein in Pfam
PF10508. Proteasom_PSMB. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BJY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQAVSLLR EVARLEAPLE ELRALQSVVQ AVPLHELREQ AAELRLRPLF
60 70 80 90 100
SLLNQNNREQ TALCVSILER LLQAVEPIHL ARNLRLDLQR GLTHPDDSVK
110 120 130 140 150
TLTLSQIGRI VENSEAVTEI LNNAELLKQI VYCIGGENLS VAKAAIKSLS
160 170 180 190 200
RISLTQAGLE ALFESNLLDD LKNVMKTNDV VRYRVYELII DISSVSSESL
210 220 230 240 250
NYCTTSGLVT QLLKELTGED VLVRATCIEM VTSLAYTHHG RQYLAQEGVI
260 270 280 290 300
DQISNIIVGA DSDPFSGFYL PGFVKFFGNL AVMDSPQQIC ERYPVFLEKV
310 320 330 340 350
FEMADSQDPT MIGVAVDTVG ILGSSVEGKQ VLQKTGTRFE RVLMRVGYQA
360 370 380 390 400
KNASTELKIR CLDAVSSLLY LSPEQQTDDF LGMTESWFSS MSRDSLELFR
410 420 430 440 450
GISNQPFPEL HCAALKVFTA IADQPWAQRL MFNSPGFVEF VMDRSVEHDK
460 470 480 490 500
ASKDAKYELV KALANSKTVA EIFGNSNYLR LRAYLSEGPY YVKPVATTAV

EGAD
Length:504
Mass (Da):55,972
Last modified:January 23, 2007 - v4
Checksum:i66D56A2BD43B895C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158G → V in BAC37265 (PubMed:16141072).Curated1
Sequence conflicti398L → P in BC019112 (PubMed:15489334).Curated1
Sequence conflicti448H → L in BAD90393 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032992 mRNA. Translation: BAC28117.1.
AK078419 mRNA. Translation: BAC37265.1.
AK145587 mRNA. Translation: BAE26526.1.
AK148284 mRNA. Translation: BAE28457.1.
AL929068 Genomic DNA. Translation: CAM27595.1.
CH466542 Genomic DNA. Translation: EDL08630.1.
BC019112 mRNA. No translation available.
AK220321 mRNA. Translation: BAD90393.1.
CCDSiCCDS15953.1.
RefSeqiNP_542121.2. NM_080554.2.
UniGeneiMm.270632.

Genome annotation databases

EnsembliENSMUST00000028225; ENSMUSP00000028225; ENSMUSG00000026869.
GeneIDi66998.
KEGGimmu:66998.
UCSCiuc008jje.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiPSMD5_MOUSE
AccessioniPrimary (citable) accession number: Q8BJY1
Secondary accession number(s): A2AUB0
, Q3UFV2, Q5DU49, Q8BMA9, Q8VEE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 121 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families