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Protein

Tetraspanin-9

Gene

Tspan9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-9
Short name:
Tspan-9
Alternative name(s):
Tetraspan NET-5
Gene namesi
Name:Tspan9
Synonyms:Net5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1924558. Tspan9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 55ExtracellularSequence analysisAdd BLAST21
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 85CytoplasmicSequence analysis9
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 203ExtracellularSequence analysisAdd BLAST97
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Topological domaini225 – 239CytoplasmicSequence analysisAdd BLAST15

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192541 – 239Tetraspanin-9Add BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi180N-linked (GlcNAc...)1 Publication1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BJU2.
PaxDbiQ8BJU2.
PeptideAtlasiQ8BJU2.
PRIDEiQ8BJU2.

PTM databases

SwissPalmiQ8BJU2.

Expressioni

Tissue specificityi

Strongly expressed in megakaryocytes, platelets and lung. Weakly expressed in bone marrow, brain and kidney (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000030352.
CleanExiMM_TSPAN9.
ExpressionAtlasiQ8BJU2. baseline and differential.
GenevisibleiQ8BJU2. MM.

Interactioni

Subunit structurei

Found in a complex with GP6.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032503.

Structurei

3D structure databases

ProteinModelPortaliQ8BJU2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiQ8BJU2.
KOiK17350.
OMAiNENAKQD.
OrthoDBiEOG091G0CQO.
PhylomeDBiQ8BJU2.
TreeFamiTF352892.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BJU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGCLCCLK YTMFLFNLIF WLCGCGLLGV GIWLSVSQGN FATFSPSFPS
60 70 80 90 100
LSAANLVIAI GTIVMVTGFL GCLGAIKENK CLLLSFFIVL LIILLAELIL
110 120 130 140 150
IILFFVYMDK VNENAKQDLK EGLLLYNTEN NVGLKNAWNI IQAEMRCCGV
160 170 180 190 200
TDYTDWYPVL GENTVPDRCC MENSQGCGRN STTPLWRTGC YEKVKLWFDD
210 220 230
NKHVLGTVGM CILIMQILGM AFSMTLFQHI HRTGKKYDA
Length:239
Mass (Da):26,738
Last modified:March 1, 2003 - v1
Checksum:iB3DC47ADA1D877DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK079139 mRNA. Translation: BAC37559.1.
AK158729 mRNA. Translation: BAE34632.1.
AK163395 mRNA. Translation: BAE37332.1.
BC052503 mRNA. Translation: AAH52503.1.
CCDSiCCDS20568.1.
RefSeqiNP_780623.1. NM_175414.4.
XP_006505396.1. XM_006505333.3.
XP_006505398.1. XM_006505335.2.
UniGeneiMm.21814.
Mm.29608.

Genome annotation databases

EnsembliENSMUST00000032503; ENSMUSP00000032503; ENSMUSG00000030352.
ENSMUST00000112171; ENSMUSP00000107794; ENSMUSG00000030352.
ENSMUST00000112173; ENSMUSP00000107796; ENSMUSG00000030352.
GeneIDi109246.
KEGGimmu:109246.
UCSCiuc009eco.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK079139 mRNA. Translation: BAC37559.1.
AK158729 mRNA. Translation: BAE34632.1.
AK163395 mRNA. Translation: BAE37332.1.
BC052503 mRNA. Translation: AAH52503.1.
CCDSiCCDS20568.1.
RefSeqiNP_780623.1. NM_175414.4.
XP_006505396.1. XM_006505333.3.
XP_006505398.1. XM_006505335.2.
UniGeneiMm.21814.
Mm.29608.

3D structure databases

ProteinModelPortaliQ8BJU2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032503.

PTM databases

SwissPalmiQ8BJU2.

Proteomic databases

MaxQBiQ8BJU2.
PaxDbiQ8BJU2.
PeptideAtlasiQ8BJU2.
PRIDEiQ8BJU2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032503; ENSMUSP00000032503; ENSMUSG00000030352.
ENSMUST00000112171; ENSMUSP00000107794; ENSMUSG00000030352.
ENSMUST00000112173; ENSMUSP00000107796; ENSMUSG00000030352.
GeneIDi109246.
KEGGimmu:109246.
UCSCiuc009eco.1. mouse.

Organism-specific databases

CTDi10867.
MGIiMGI:1924558. Tspan9.

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiQ8BJU2.
KOiK17350.
OMAiNENAKQD.
OrthoDBiEOG091G0CQO.
PhylomeDBiQ8BJU2.
TreeFamiTF352892.

Miscellaneous databases

ChiTaRSiTspan9. mouse.
PROiQ8BJU2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030352.
CleanExiMM_TSPAN9.
ExpressionAtlasiQ8BJU2. baseline and differential.
GenevisibleiQ8BJU2. MM.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSN9_MOUSE
AccessioniPrimary (citable) accession number: Q8BJU2
Secondary accession number(s): Q3TQQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.