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Protein

Tetraspanin-9

Gene

Tspan9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-9
Short name:
Tspan-9
Alternative name(s):
Tetraspan NET-5
Gene namesi
Name:Tspan9
Synonyms:Net5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1924558. Tspan9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313CytoplasmicSequence analysisAdd
BLAST
Transmembranei14 – 3421HelicalSequence analysisAdd
BLAST
Topological domaini35 – 5521ExtracellularSequence analysisAdd
BLAST
Transmembranei56 – 7621HelicalSequence analysisAdd
BLAST
Topological domaini77 – 859CytoplasmicSequence analysis
Transmembranei86 – 10621HelicalSequence analysisAdd
BLAST
Topological domaini107 – 20397ExtracellularSequence analysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence analysisAdd
BLAST
Topological domaini225 – 23915CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239Tetraspanin-9PRO_0000219254Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi180 – 1801N-linked (GlcNAc...)1 Publication

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BJU2.
PaxDbiQ8BJU2.
PRIDEiQ8BJU2.

PTM databases

SwissPalmiQ8BJU2.

Expressioni

Tissue specificityi

Strongly expressed in megakaryocytes, platelets and lung. Weakly expressed in bone marrow, brain and kidney (at protein level).1 Publication

Gene expression databases

BgeeiQ8BJU2.
CleanExiMM_TSPAN9.
ExpressionAtlasiQ8BJU2. baseline and differential.
GenevisibleiQ8BJU2. MM.

Interactioni

Subunit structurei

Found in a complex with GP6.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032503.

Structurei

3D structure databases

ProteinModelPortaliQ8BJU2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiQ8BJU2.
KOiK17350.
OMAiDTIFMAI.
OrthoDBiEOG7PGDRZ.
PhylomeDBiQ8BJU2.
TreeFamiTF352892.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BJU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGCLCCLK YTMFLFNLIF WLCGCGLLGV GIWLSVSQGN FATFSPSFPS
60 70 80 90 100
LSAANLVIAI GTIVMVTGFL GCLGAIKENK CLLLSFFIVL LIILLAELIL
110 120 130 140 150
IILFFVYMDK VNENAKQDLK EGLLLYNTEN NVGLKNAWNI IQAEMRCCGV
160 170 180 190 200
TDYTDWYPVL GENTVPDRCC MENSQGCGRN STTPLWRTGC YEKVKLWFDD
210 220 230
NKHVLGTVGM CILIMQILGM AFSMTLFQHI HRTGKKYDA
Length:239
Mass (Da):26,738
Last modified:March 1, 2003 - v1
Checksum:iB3DC47ADA1D877DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK079139 mRNA. Translation: BAC37559.1.
AK158729 mRNA. Translation: BAE34632.1.
AK163395 mRNA. Translation: BAE37332.1.
BC052503 mRNA. Translation: AAH52503.1.
CCDSiCCDS20568.1.
RefSeqiNP_780623.1. NM_175414.4.
XP_006505396.1. XM_006505333.2.
XP_006505398.1. XM_006505335.2.
XP_011239431.1. XM_011241129.1.
UniGeneiMm.21814.
Mm.29608.

Genome annotation databases

EnsembliENSMUST00000032503; ENSMUSP00000032503; ENSMUSG00000030352.
ENSMUST00000112171; ENSMUSP00000107794; ENSMUSG00000030352.
ENSMUST00000112173; ENSMUSP00000107796; ENSMUSG00000030352.
GeneIDi109246.
KEGGimmu:109246.
UCSCiuc009eco.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK079139 mRNA. Translation: BAC37559.1.
AK158729 mRNA. Translation: BAE34632.1.
AK163395 mRNA. Translation: BAE37332.1.
BC052503 mRNA. Translation: AAH52503.1.
CCDSiCCDS20568.1.
RefSeqiNP_780623.1. NM_175414.4.
XP_006505396.1. XM_006505333.2.
XP_006505398.1. XM_006505335.2.
XP_011239431.1. XM_011241129.1.
UniGeneiMm.21814.
Mm.29608.

3D structure databases

ProteinModelPortaliQ8BJU2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032503.

PTM databases

SwissPalmiQ8BJU2.

Proteomic databases

MaxQBiQ8BJU2.
PaxDbiQ8BJU2.
PRIDEiQ8BJU2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032503; ENSMUSP00000032503; ENSMUSG00000030352.
ENSMUST00000112171; ENSMUSP00000107794; ENSMUSG00000030352.
ENSMUST00000112173; ENSMUSP00000107796; ENSMUSG00000030352.
GeneIDi109246.
KEGGimmu:109246.
UCSCiuc009eco.1. mouse.

Organism-specific databases

CTDi10867.
MGIiMGI:1924558. Tspan9.

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiQ8BJU2.
KOiK17350.
OMAiDTIFMAI.
OrthoDBiEOG7PGDRZ.
PhylomeDBiQ8BJU2.
TreeFamiTF352892.

Miscellaneous databases

ChiTaRSiTspan9. mouse.
NextBioi361827.
PROiQ8BJU2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BJU2.
CleanExiMM_TSPAN9.
ExpressionAtlasiQ8BJU2. baseline and differential.
GenevisibleiQ8BJU2. MM.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Visual cortex.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Lung.
  3. "Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains."
    Protty M.B., Watkins N.A., Colombo D., Thomas S.G., Heath V.L., Herbert J.M., Bicknell R., Senis Y.A., Ashman L.K., Berditchevski F., Ouwehand W.H., Watson S.P., Tomlinson M.G.
    Biochem. J. 417:391-400(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH GP6, SUBCELLULAR LOCATION, GLYCOSYLATION, TISSUE SPECIFICITY.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart, Kidney, Liver, Lung and Spleen.

Entry informationi

Entry nameiTSN9_MOUSE
AccessioniPrimary (citable) accession number: Q8BJU2
Secondary accession number(s): Q3TQQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.