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Protein

Tetraspanin-9

Gene

Tspan9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-9
Short name:
Tspan-9
Alternative name(s):
Tetraspan NET-5
Gene namesi
Name:Tspan9
Synonyms:Net5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1924558 Tspan9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 55ExtracellularSequence analysisAdd BLAST21
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 85CytoplasmicSequence analysis9
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 203ExtracellularSequence analysisAdd BLAST97
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Topological domaini225 – 239CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192541 – 239Tetraspanin-9Add BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi180N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BJU2
PaxDbiQ8BJU2
PeptideAtlasiQ8BJU2
PRIDEiQ8BJU2

PTM databases

iPTMnetiQ8BJU2
SwissPalmiQ8BJU2

Expressioni

Tissue specificityi

Strongly expressed in megakaryocytes, platelets and lung. Weakly expressed in bone marrow, brain and kidney (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000030352
CleanExiMM_TSPAN9
ExpressionAtlasiQ8BJU2 baseline and differential
GenevisibleiQ8BJU2 MM

Interactioni

Subunit structurei

Found in a complex with GP6.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032503

Structurei

3D structure databases

ProteinModelPortaliQ8BJU2
SMRiQ8BJU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiQ8BJU2
OMAiYEGYATL
OrthoDBiEOG091G0CQO
PhylomeDBiQ8BJU2
TreeFamiTF352892

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BJU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGCLCCLK YTMFLFNLIF WLCGCGLLGV GIWLSVSQGN FATFSPSFPS
60 70 80 90 100
LSAANLVIAI GTIVMVTGFL GCLGAIKENK CLLLSFFIVL LIILLAELIL
110 120 130 140 150
IILFFVYMDK VNENAKQDLK EGLLLYNTEN NVGLKNAWNI IQAEMRCCGV
160 170 180 190 200
TDYTDWYPVL GENTVPDRCC MENSQGCGRN STTPLWRTGC YEKVKLWFDD
210 220 230
NKHVLGTVGM CILIMQILGM AFSMTLFQHI HRTGKKYDA
Length:239
Mass (Da):26,738
Last modified:March 1, 2003 - v1
Checksum:iB3DC47ADA1D877DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK079139 mRNA Translation: BAC37559.1
AK158729 mRNA Translation: BAE34632.1
AK163395 mRNA Translation: BAE37332.1
BC052503 mRNA Translation: AAH52503.1
CCDSiCCDS20568.1
RefSeqiNP_780623.1, NM_175414.4
XP_006505396.1, XM_006505333.3
XP_006505398.1, XM_006505335.2
UniGeneiMm.21814
Mm.29608

Genome annotation databases

EnsembliENSMUST00000032503; ENSMUSP00000032503; ENSMUSG00000030352
ENSMUST00000112171; ENSMUSP00000107794; ENSMUSG00000030352
ENSMUST00000112173; ENSMUSP00000107796; ENSMUSG00000030352
GeneIDi109246
UCSCiuc009eco.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTSN9_MOUSE
AccessioniPrimary (citable) accession number: Q8BJU2
Secondary accession number(s): Q3TQQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health