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Protein

Small glutamine-rich tetratricopeptide repeat-containing protein alpha

Gene

Sgta

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Small glutamine-rich tetratricopeptide repeat-containing protein alpha
Alternative name(s):
Alpha-SGT
Gene namesi
Name:Sgta
Synonyms:Sgt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1098703. Sgta.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Small glutamine-rich tetratricopeptide repeat-containing protein alphaPRO_0000106366Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei82 – 821Phosphothreonine2 Publications
Modified residuei138 – 1381N6-acetyllysineBy similarity
Modified residuei303 – 3031PhosphoserineBy similarity
Modified residuei305 – 3051PhosphothreonineBy similarity
Modified residuei307 – 3071PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8BJU0.
PaxDbiQ8BJU0.
PRIDEiQ8BJU0.

PTM databases

PhosphoSiteiQ8BJU0.

Expressioni

Gene expression databases

BgeeiQ8BJU0.
ExpressionAtlasiQ8BJU0. baseline and differential.
GenevisibleiQ8BJU0. MM.

Interactioni

Subunit structurei

Homooligomerize (By similarity). Interacts with DNAJC5 and DNAJC5B.By similarity1 Publication

Protein-protein interaction databases

BioGridi206659. 5 interactions.
STRINGi10090.ENSMUSP00000005067.

Structurei

3D structure databases

ProteinModelPortaliQ8BJU0.
SMRiQ8BJU0. Positions 4-211.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati92 – 12534TPR 1Add
BLAST
Repeati126 – 15934TPR 2Add
BLAST
Repeati160 – 19334TPR 3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi276 – 28813Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the SGT family.Curated
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG0457.
GeneTreeiENSGT00730000110724.
HOGENOMiHOG000208193.
HOVERGENiHBG000885.
InParanoidiQ8BJU0.
KOiK16365.
OMAiASGQHEK.
OrthoDBiEOG78SQJJ.
PhylomeDBiQ8BJU0.
TreeFamiTF313092.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BJU0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDNRKRLAYA IIQFLHGQLR HGGLSCDAQE SLEVAIQCLE TAFGVTLEDS
60 70 80 90 100
DLALPQTLPE IFEAATSSKQ EMPQDPRAPD RTPPSEEDSA EAERLKTEGN
110 120 130 140 150
EQMKLENFEA AVHLYGKAIE LNPANAVYFC NRAAAYSKLG NYVGAVQDCE
160 170 180 190 200
RAIGIDPGYS KAYGRMGLAL SSLNKHAEAV AYYKKALELD PDNDTYKSNL
210 220 230 240 250
KIAELKLREA PSPTGGVGSL DIAGLLNNPH FITMASSLMN SPQLQQLMSG
260 270 280 290 300
MISGGHNPLG TPGSSPQQSD LASLIQAGQQ FAQQMQQQNP EFVEQIRSQV
310
VRSRTPSASH EEQQE
Length:315
Mass (Da):34,322
Last modified:January 16, 2004 - v2
Checksum:i6FB8D3978CF56D4C
GO
Isoform 2 (identifier: Q8BJU0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-70: Missing.

Show »
Length:314
Mass (Da):34,194
Checksum:iB011B0CAAE4508A9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti207 – 2071L → F in BAC37566 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei70 – 701Missing in isoform 2. 1 PublicationVSP_009300

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039966 mRNA. Translation: BAC30486.1.
AK051005 mRNA. Translation: BAC34494.1.
AK079168 mRNA. Translation: BAC37566.1.
BC003836 mRNA. Translation: AAH03836.1.
CCDSiCCDS35990.1. [Q8BJU0-1]
RefSeqiNP_078775.1. NM_024499.1. [Q8BJU0-1]
XP_006513939.1. XM_006513876.2. [Q8BJU0-2]
XP_006513940.1. XM_006513877.1. [Q8BJU0-2]
UniGeneiMm.30068.

Genome annotation databases

EnsembliENSMUST00000005067; ENSMUSP00000005067; ENSMUSG00000004937. [Q8BJU0-1]
GeneIDi52551.
KEGGimmu:52551.
UCSCiuc007gft.1. mouse. [Q8BJU0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039966 mRNA. Translation: BAC30486.1.
AK051005 mRNA. Translation: BAC34494.1.
AK079168 mRNA. Translation: BAC37566.1.
BC003836 mRNA. Translation: AAH03836.1.
CCDSiCCDS35990.1. [Q8BJU0-1]
RefSeqiNP_078775.1. NM_024499.1. [Q8BJU0-1]
XP_006513939.1. XM_006513876.2. [Q8BJU0-2]
XP_006513940.1. XM_006513877.1. [Q8BJU0-2]
UniGeneiMm.30068.

3D structure databases

ProteinModelPortaliQ8BJU0.
SMRiQ8BJU0. Positions 4-211.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206659. 5 interactions.
STRINGi10090.ENSMUSP00000005067.

PTM databases

PhosphoSiteiQ8BJU0.

Proteomic databases

MaxQBiQ8BJU0.
PaxDbiQ8BJU0.
PRIDEiQ8BJU0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005067; ENSMUSP00000005067; ENSMUSG00000004937. [Q8BJU0-1]
GeneIDi52551.
KEGGimmu:52551.
UCSCiuc007gft.1. mouse. [Q8BJU0-1]

Organism-specific databases

CTDi6449.
MGIiMGI:1098703. Sgta.

Phylogenomic databases

eggNOGiCOG0457.
GeneTreeiENSGT00730000110724.
HOGENOMiHOG000208193.
HOVERGENiHBG000885.
InParanoidiQ8BJU0.
KOiK16365.
OMAiASGQHEK.
OrthoDBiEOG78SQJJ.
PhylomeDBiQ8BJU0.
TreeFamiTF313092.

Miscellaneous databases

ChiTaRSiSgta. mouse.
NextBioi309129.
PROiQ8BJU0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BJU0.
ExpressionAtlasiQ8BJU0. baseline and differential.
GenevisibleiQ8BJU0. MM.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Embryo and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Cysteine-string protein isoform beta (Cspbeta) is targeted to the trans-Golgi network as a non-palmitoylated CSP in clonal beta-cells."
    Boal F., Le Pevelen S., Cziepluch C., Scotti P., Lang J.
    Biochim. Biophys. Acta 1773:109-119(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DNAJC5 AND DNAJC5B.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-82, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-82, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiSGTA_MOUSE
AccessioniPrimary (citable) accession number: Q8BJU0
Secondary accession number(s): Q8BGA6, Q99L52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: June 24, 2015
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.