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Q8BJU0 (SGTA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Small glutamine-rich tetratricopeptide repeat-containing protein alpha
Alternative name(s):
Alpha-SGT
Gene names
Name:Sgta
Synonyms:Sgt
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity By similarity.

Subunit structure

Homooligomerize By similarity. Interacts with DNAJC5 and DNAJC5B. Ref.3

Sequence similarities

Belongs to the SGT family.

Contains 3 TPR repeats.

Ontologies

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8BJU0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8BJU0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     70-70: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Small glutamine-rich tetratricopeptide repeat-containing protein alpha
PRO_0000106366

Regions

Repeat92 – 12534TPR 1
Repeat126 – 15934TPR 2
Repeat160 – 19334TPR 3
Compositional bias276 – 28813Gln-rich

Amino acid modifications

Modified residue821Phosphothreonine Ref.4 Ref.5
Modified residue1381N6-acetyllysine By similarity
Modified residue3031Phosphoserine By similarity
Modified residue3051Phosphothreonine By similarity
Modified residue3071Phosphoserine By similarity

Natural variations

Alternative sequence701Missing in isoform 2.
VSP_009300

Experimental info

Sequence conflict2071L → F in BAC37566. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 16, 2004. Version 2.
Checksum: 6FB8D3978CF56D4C

FASTA31534,322
        10         20         30         40         50         60 
MDNRKRLAYA IIQFLHGQLR HGGLSCDAQE SLEVAIQCLE TAFGVTLEDS DLALPQTLPE 

        70         80         90        100        110        120 
IFEAATSSKQ EMPQDPRAPD RTPPSEEDSA EAERLKTEGN EQMKLENFEA AVHLYGKAIE 

       130        140        150        160        170        180 
LNPANAVYFC NRAAAYSKLG NYVGAVQDCE RAIGIDPGYS KAYGRMGLAL SSLNKHAEAV 

       190        200        210        220        230        240 
AYYKKALELD PDNDTYKSNL KIAELKLREA PSPTGGVGSL DIAGLLNNPH FITMASSLMN 

       250        260        270        280        290        300 
SPQLQQLMSG MISGGHNPLG TPGSSPQQSD LASLIQAGQQ FAQQMQQQNP EFVEQIRSQV 

       310 
VRSRTPSASH EEQQE 

« Hide

Isoform 2 [UniParc].

Checksum: B011B0CAAE4508A9
Show »

FASTA31434,194

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Embryo and Thymus.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"Cysteine-string protein isoform beta (Cspbeta) is targeted to the trans-Golgi network as a non-palmitoylated CSP in clonal beta-cells."
Boal F., Le Pevelen S., Cziepluch C., Scotti P., Lang J.
Biochim. Biophys. Acta 1773:109-119(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH DNAJC5 AND DNAJC5B.
[4]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-82, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[5]"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-82, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK039966 mRNA. Translation: BAC30486.1.
AK051005 mRNA. Translation: BAC34494.1.
AK079168 mRNA. Translation: BAC37566.1.
BC003836 mRNA. Translation: AAH03836.1.
RefSeqNP_078775.1. NM_024499.1.
XP_006513939.1. XM_006513876.1.
XP_006513940.1. XM_006513877.1.
UniGeneMm.30068.

3D structure databases

ProteinModelPortalQ8BJU0.
SMRQ8BJU0. Positions 4-248.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid206659. 5 interactions.

PTM databases

PhosphoSiteQ8BJU0.

Proteomic databases

PaxDbQ8BJU0.
PRIDEQ8BJU0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000005067; ENSMUSP00000005067; ENSMUSG00000004937. [Q8BJU0-1]
GeneID52551.
KEGGmmu:52551.
UCSCuc007gft.1. mouse. [Q8BJU0-1]

Organism-specific databases

CTD6449.
MGIMGI:1098703. Sgta.

Phylogenomic databases

eggNOGCOG0457.
GeneTreeENSGT00730000110724.
HOGENOMHOG000208193.
HOVERGENHBG000885.
InParanoidQ8BJU0.
KOK16365.
OMAASGQHEK.
OrthoDBEOG78SQJJ.
PhylomeDBQ8BJU0.
TreeFamTF313092.

Gene expression databases

ArrayExpressQ8BJU0.
BgeeQ8BJU0.
GenevestigatorQ8BJU0.

Family and domain databases

Gene3D1.25.40.10. 2 hits.
InterProIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamPF00515. TPR_1. 1 hit.
[Graphical view]
SMARTSM00028. TPR. 3 hits.
[Graphical view]
PROSITEPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSGTA. mouse.
NextBio309129.
PROQ8BJU0.
SOURCESearch...

Entry information

Entry nameSGTA_MOUSE
AccessionPrimary (citable) accession number: Q8BJU0
Secondary accession number(s): Q8BGA6, Q99L52
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: April 16, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot