Q8BJU0 (SGTA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

Alternative name(s):
Alpha-SGT

Gene names

Name:	Sgta
Synonyms:	Sgt

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity By similarity.
Subunit structure	Homooligomerize By similarity. Interacts with DNAJC5 and DNAJC5B. Ref.3
Sequence similarities	Belongs to the SGT family. Contains 3 TPR repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Repeat TPR repeat
Molecular function	Chaperone
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara
Molecular_function	protein heterodimerization activity Inferred from sequence alignment PubMed 12878599. Source: MGI protein homodimerization activity Inferred from sequence alignment PubMed 12878599. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8BJU0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8BJU0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     70-70: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Small glutamine-rich tetratricopeptide repeat-containing protein alpha		PRO_0000106366
Regions
	Repeat	92 – 125	34	TPR 1
	Repeat	126 – 159	34	TPR 2
	Repeat	160 – 193	34	TPR 3
	Compositional bias	276 – 288	13	Gln-rich
Amino acid modifications
	Modified residue	82	1	Phosphothreonine Ref.4 Ref.5 Ref.6
	Modified residue	138	1	N6-acetyllysine By similarity
	Modified residue	303	1	Phosphoserine By similarity
	Modified residue	305	1	Phosphothreonine By similarity
	Modified residue	307	1	Phosphoserine Ref.5
Natural variations
	Alternative sequence	70	1	Missing in isoform 2.		VSP_009300
Experimental info
	Sequence conflict	207	1	L → F in BAC37566. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 16, 2004. Version 2. Checksum: 6FB8D3978CF56D4C	FASTA	315	34,322
	10 20 30 40 50 60 MDNRKRLAYA IIQFLHGQLR HGGLSCDAQE SLEVAIQCLE TAFGVTLEDS DLALPQTLPE 70 80 90 100 110 120 IFEAATSSKQ EMPQDPRAPD RTPPSEEDSA EAERLKTEGN EQMKLENFEA AVHLYGKAIE 130 140 150 160 170 180 LNPANAVYFC NRAAAYSKLG NYVGAVQDCE RAIGIDPGYS KAYGRMGLAL SSLNKHAEAV 190 200 210 220 230 240 AYYKKALELD PDNDTYKSNL KIAELKLREA PSPTGGVGSL DIAGLLNNPH FITMASSLMN 250 260 270 280 290 300 SPQLQQLMSG MISGGHNPLG TPGSSPQQSD LASLIQAGQQ FAQQMQQQNP EFVEQIRSQV 310 VRSRTPSASH EEQQE
	Isoform 2 [UniParc]. Checksum: B011B0CAAE4508A9	FASTA	314	34,194
	10 20 30 40 50 60 MDNRKRLAYA IIQFLHGQLR HGGLSCDAQE SLEVAIQCLE TAFGVTLEDS DLALPQTLPE 70 80 90 100 110 120 IFEAATSSKE MPQDPRAPDR TPPSEEDSAE AERLKTEGNE QMKLENFEAA VHLYGKAIEL 130 140 150 160 170 180 NPANAVYFCN RAAAYSKLGN YVGAVQDCER AIGIDPGYSK AYGRMGLALS SLNKHAEAVA 190 200 210 220 230 240 YYKKALELDP DNDTYKSNLK IAELKLREAP SPTGGVGSLD IAGLLNNPHF ITMASSLMNS 250 260 270 280 290 300 PQLQQLMSGM ISGGHNPLGT PGSSPQQSDL ASLIQAGQQF AQQMQQQNPE FVEQIRSQVV 310 RSRTPSASHE EQQE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: C57BL/6J. Tissue: Embryo and Thymus.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"Cysteine-string protein isoform beta (Cspbeta) is targeted to the trans-Golgi network as a non-palmitoylated CSP in clonal beta-cells." Boal F., Le Pevelen S., Cziepluch C., Scotti P., Lang J. Biochim. Biophys. Acta 1773:109-119(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH DNAJC5 AND DNAJC5B.
[4]	"Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis." Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H. J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-82, MASS SPECTROMETRY. Tissue: Liver.
[5]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-82 AND SER-307, MASS SPECTROMETRY. Tissue: Melanoma.
[6]	"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry." Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J. Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-82, MASS SPECTROMETRY. Tissue: Embryonic fibroblast.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK039966 mRNA. Translation: BAC30486.1. AK051005 mRNA. Translation: BAC34494.1. AK079168 mRNA. Translation: BAC37566.1. BC003836 mRNA. Translation: AAH03836.1.
IPI	IPI00116331. IPI00399631.
RefSeq	NP_078775.1. NM_024499.1.
UniGene	Mm.30068.
3D structure databases
ProteinModelPortal	Q8BJU0.
SMR	Q8BJU0. Positions 4-211.
ModBase	Search...
PTM databases
PhosphoSite	Q8BJU0.
Proteomic databases
PaxDb	Q8BJU0.
PRIDE	Q8BJU0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000005067; ENSMUSP00000005067; ENSMUSG00000004937.
GeneID	52551.
KEGG	mmu:52551.
UCSC	uc007gft.1. mouse.
Organism-specific databases
CTD	6449.
MGI	MGI:1098703. Sgta.
Phylogenomic databases
eggNOG	COG0457.
GeneTree	ENSGT00650000093277.
HOGENOM	HOG000208193.
HOVERGEN	HBG000885.
InParanoid	Q8BJU0.
KO	K16365.
OMA	VRDCERA.
OrthoDB	EOG4DJJWZ.
Gene expression databases
ArrayExpress	Q8BJU0.
Bgee	Q8BJU0.
Genevestigator	Q8BJU0.
GermOnline	ENSMUSG00000004937. Mus musculus.
Family and domain databases
Gene3D	1.25.40.10. 2 hits.
InterPro	IPR001440. TPR-1. IPR013026. TPR-contain_dom. IPR011990. TPR-like_helical. IPR019734. TPR_repeat. [Graphical view]
Pfam	PF00515. TPR_1. 1 hit. [Graphical view]
SMART	SM00028. TPR. 3 hits. [Graphical view]
PROSITE	PS50005. TPR. 3 hits. PS50293. TPR_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SGTA. mouse.
NextBio	309129.
SOURCE	Search...

Entry information

Entry name

SGTA_MOUSE

Accession

Primary (citable) accession number: Q8BJU0
Secondary accession number(s): Q8BGA6, Q99L52

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	January 16, 2004
Last modified:	May 1, 2013
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program