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Q8BJU0

- SGTA_MOUSE

UniProt

Q8BJU0 - SGTA_MOUSE

Protein

Small glutamine-rich tetratricopeptide repeat-containing protein alpha

Gene

Sgta

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (16 Jan 2004)
      Previous versions | rss
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    Functioni

    Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.By similarity

    GO - Molecular functioni

    1. protein heterodimerization activity Source: MGI
    2. protein homodimerization activity Source: MGI

    Keywords - Molecular functioni

    Chaperone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Small glutamine-rich tetratricopeptide repeat-containing protein alpha
    Alternative name(s):
    Alpha-SGT
    Gene namesi
    Name:Sgta
    Synonyms:Sgt
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1098703. Sgta.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Small glutamine-rich tetratricopeptide repeat-containing protein alphaPRO_0000106366Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei82 – 821Phosphothreonine2 Publications
    Modified residuei138 – 1381N6-acetyllysineBy similarity
    Modified residuei303 – 3031PhosphoserineBy similarity
    Modified residuei305 – 3051PhosphothreonineBy similarity
    Modified residuei307 – 3071PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8BJU0.
    PaxDbiQ8BJU0.
    PRIDEiQ8BJU0.

    PTM databases

    PhosphoSiteiQ8BJU0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BJU0.
    BgeeiQ8BJU0.
    GenevestigatoriQ8BJU0.

    Interactioni

    Subunit structurei

    Homooligomerize By similarity. Interacts with DNAJC5 and DNAJC5B.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi206659. 5 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BJU0.
    SMRiQ8BJU0. Positions 4-211.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati92 – 12534TPR 1Add
    BLAST
    Repeati126 – 15934TPR 2Add
    BLAST
    Repeati160 – 19334TPR 3Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi276 – 28813Gln-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SGT family.Curated
    Contains 3 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0457.
    GeneTreeiENSGT00730000110724.
    HOGENOMiHOG000208193.
    HOVERGENiHBG000885.
    InParanoidiQ8BJU0.
    KOiK16365.
    OMAiASGQHEK.
    OrthoDBiEOG78SQJJ.
    PhylomeDBiQ8BJU0.
    TreeFamiTF313092.

    Family and domain databases

    Gene3Di1.25.40.10. 2 hits.
    InterProiIPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view]
    PfamiPF00515. TPR_1. 1 hit.
    [Graphical view]
    SMARTiSM00028. TPR. 3 hits.
    [Graphical view]
    PROSITEiPS50005. TPR. 3 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8BJU0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDNRKRLAYA IIQFLHGQLR HGGLSCDAQE SLEVAIQCLE TAFGVTLEDS    50
    DLALPQTLPE IFEAATSSKQ EMPQDPRAPD RTPPSEEDSA EAERLKTEGN 100
    EQMKLENFEA AVHLYGKAIE LNPANAVYFC NRAAAYSKLG NYVGAVQDCE 150
    RAIGIDPGYS KAYGRMGLAL SSLNKHAEAV AYYKKALELD PDNDTYKSNL 200
    KIAELKLREA PSPTGGVGSL DIAGLLNNPH FITMASSLMN SPQLQQLMSG 250
    MISGGHNPLG TPGSSPQQSD LASLIQAGQQ FAQQMQQQNP EFVEQIRSQV 300
    VRSRTPSASH EEQQE 315
    Length:315
    Mass (Da):34,322
    Last modified:January 16, 2004 - v2
    Checksum:i6FB8D3978CF56D4C
    GO
    Isoform 2 (identifier: Q8BJU0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         70-70: Missing.

    Show »
    Length:314
    Mass (Da):34,194
    Checksum:iB011B0CAAE4508A9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti207 – 2071L → F in BAC37566. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei70 – 701Missing in isoform 2. 1 PublicationVSP_009300

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK039966 mRNA. Translation: BAC30486.1.
    AK051005 mRNA. Translation: BAC34494.1.
    AK079168 mRNA. Translation: BAC37566.1.
    BC003836 mRNA. Translation: AAH03836.1.
    CCDSiCCDS35990.1. [Q8BJU0-1]
    RefSeqiNP_078775.1. NM_024499.1. [Q8BJU0-1]
    XP_006513939.1. XM_006513876.1. [Q8BJU0-2]
    XP_006513940.1. XM_006513877.1. [Q8BJU0-2]
    UniGeneiMm.30068.

    Genome annotation databases

    EnsembliENSMUST00000005067; ENSMUSP00000005067; ENSMUSG00000004937. [Q8BJU0-1]
    GeneIDi52551.
    KEGGimmu:52551.
    UCSCiuc007gft.1. mouse. [Q8BJU0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK039966 mRNA. Translation: BAC30486.1 .
    AK051005 mRNA. Translation: BAC34494.1 .
    AK079168 mRNA. Translation: BAC37566.1 .
    BC003836 mRNA. Translation: AAH03836.1 .
    CCDSi CCDS35990.1. [Q8BJU0-1 ]
    RefSeqi NP_078775.1. NM_024499.1. [Q8BJU0-1 ]
    XP_006513939.1. XM_006513876.1. [Q8BJU0-2 ]
    XP_006513940.1. XM_006513877.1. [Q8BJU0-2 ]
    UniGenei Mm.30068.

    3D structure databases

    ProteinModelPortali Q8BJU0.
    SMRi Q8BJU0. Positions 4-211.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 206659. 5 interactions.

    PTM databases

    PhosphoSitei Q8BJU0.

    Proteomic databases

    MaxQBi Q8BJU0.
    PaxDbi Q8BJU0.
    PRIDEi Q8BJU0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000005067 ; ENSMUSP00000005067 ; ENSMUSG00000004937 . [Q8BJU0-1 ]
    GeneIDi 52551.
    KEGGi mmu:52551.
    UCSCi uc007gft.1. mouse. [Q8BJU0-1 ]

    Organism-specific databases

    CTDi 6449.
    MGIi MGI:1098703. Sgta.

    Phylogenomic databases

    eggNOGi COG0457.
    GeneTreei ENSGT00730000110724.
    HOGENOMi HOG000208193.
    HOVERGENi HBG000885.
    InParanoidi Q8BJU0.
    KOi K16365.
    OMAi ASGQHEK.
    OrthoDBi EOG78SQJJ.
    PhylomeDBi Q8BJU0.
    TreeFami TF313092.

    Miscellaneous databases

    ChiTaRSi SGTA. mouse.
    NextBioi 309129.
    PROi Q8BJU0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BJU0.
    Bgeei Q8BJU0.
    Genevestigatori Q8BJU0.

    Family and domain databases

    Gene3Di 1.25.40.10. 2 hits.
    InterProi IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view ]
    Pfami PF00515. TPR_1. 1 hit.
    [Graphical view ]
    SMARTi SM00028. TPR. 3 hits.
    [Graphical view ]
    PROSITEi PS50005. TPR. 3 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Embryo and Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Cysteine-string protein isoform beta (Cspbeta) is targeted to the trans-Golgi network as a non-palmitoylated CSP in clonal beta-cells."
      Boal F., Le Pevelen S., Cziepluch C., Scotti P., Lang J.
      Biochim. Biophys. Acta 1773:109-119(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DNAJC5 AND DNAJC5B.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-82, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    5. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-82, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiSGTA_MOUSE
    AccessioniPrimary (citable) accession number: Q8BJU0
    Secondary accession number(s): Q8BGA6, Q99L52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: January 16, 2004
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3