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Protein

SUN domain-containing protein 2

Gene

Sun2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, Syne2 and Sun2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for Rab5-GDP and participate in the activation of Rab5.5 Publications

GO - Molecular functioni

GO - Biological processi

  • centrosome localization Source: UniProtKB
  • cytoskeletal anchoring at nuclear membrane Source: MGI
  • nuclear envelope organization Source: MGI
  • nuclear matrix anchoring at nuclear membrane Source: MGI
  • nuclear migration along microfilament Source: UniProtKB
  • positive regulation of cell migration Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-1221632. Meiotic synapsis.
R-MMU-1221633. Meiotic Synapsis.

Names & Taxonomyi

Protein namesi
Recommended name:
SUN domain-containing protein 2
Alternative name(s):
Protein unc-84 homolog B
Sad1/unc-84 protein-like 2
Gene namesi
Name:Sun2
Synonyms:Unc84b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2443011. Sun2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 226226NuclearBy similarityAdd
BLAST
Transmembranei227 – 24721HelicalSequence analysisAdd
BLAST
Topological domaini248 – 731484Perinuclear spaceAdd
BLAST

GO - Cellular componenti

  • condensed nuclear chromosome Source: MGI
  • endosome membrane Source: UniProtKB-SubCell
  • integral component of nuclear inner membrane Source: InterPro
  • LINC complex Source: MGI
  • nuclear chromosome, telomeric region Source: MGI
  • nuclear envelope Source: MGI
  • nuclear inner membrane Source: UniProtKB
  • nuclear membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 731731SUN domain-containing protein 2PRO_0000218914Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121PhosphoserineCombined sources
Modified residuei39 – 391PhosphoserineCombined sources
Modified residuei55 – 551PhosphoserineCombined sources
Modified residuei117 – 1171PhosphothreonineCombined sources
Modified residuei120 – 1201PhosphoserineCombined sources
Modified residuei123 – 1231PhosphoserineCombined sources
Modified residuei147 – 1471PhosphoserineCombined sources
Glycosylationi650 – 6501N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8BJS4.
PaxDbiQ8BJS4.
PeptideAtlasiQ8BJS4.
PRIDEiQ8BJS4.

PTM databases

iPTMnetiQ8BJS4.
PhosphoSiteiQ8BJS4.

Expressioni

Tissue specificityi

Highly expressed in heart, placenta and muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000042524.
CleanExiMM_UNC84B.
ExpressionAtlasiQ8BJS4. baseline and differential.
GenevisibleiQ8BJS4. MM.

Interactioni

Subunit structurei

Core component of the LINC complex which is composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN domain-containing proteins interact with A-type lamins of the nuclear lamina, while at the other end of the complex, nesprins interact with unique cytoskeletal components. Interacts with A-type lamin. Interaction with lamins B1 and C is hardly detectable. Interacts with SYNE1, SYNE2 and SYNE3. Interacts with EMD. Interacts with RAB5A. Interacts with TMEM43 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230179. 4 interactions.
IntActiQ8BJS4. 1 interaction.
STRINGi10090.ENSMUSP00000047864.

Structurei

Secondary structure

1
731
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi414 – 46754Combined sources
Helixi471 – 4788Combined sources
Helixi495 – 51016Combined sources
Helixi511 – 5133Combined sources
Helixi518 – 52912Combined sources
Helixi539 – 54911Combined sources
Helixi566 – 5683Combined sources
Helixi574 – 5763Combined sources
Beta strandi584 – 5885Combined sources
Beta strandi594 – 5985Combined sources
Helixi602 – 6065Combined sources
Beta strandi615 – 6217Combined sources
Beta strandi623 – 64119Combined sources
Helixi645 – 6473Combined sources
Helixi649 – 6513Combined sources
Beta strandi659 – 6679Combined sources
Beta strandi674 – 6807Combined sources
Beta strandi687 – 6926Combined sources
Beta strandi701 – 7088Combined sources
Beta strandi711 – 7133Combined sources
Beta strandi715 – 72915Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5ED8X-ray2.50A470-731[»]
5ED9X-ray2.01A/B/C410-481[»]
ProteinModelPortaliQ8BJS4.
SMRiQ8BJS4. Positions 536-731.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini569 – 730162SUNPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 128128LMNA-bindingAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili396 – 45257Sequence analysisAdd
BLAST
Coiled coili486 – 51934Sequence analysisAdd
BLAST

Domaini

The SUN domain may play a role in the nuclear anchoring and/or migration.1 Publication

Sequence similaritiesi

Contains 1 SUN domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2687. Eukaryota.
ENOG410YM6S. LUCA.
GeneTreeiENSGT00390000011587.
HOGENOMiHOG000253025.
HOVERGENiHBG056957.
InParanoidiQ8BJS4.
KOiK19347.
OMAiEHQQDSE.
OrthoDBiEOG091G0AZ8.
PhylomeDBiQ8BJS4.
TreeFamiTF323915.

Family and domain databases

InterProiIPR030272. SUN2.
IPR012919. SUN_dom.
[Graphical view]
PANTHERiPTHR12911:SF22. PTHR12911:SF22. 1 hit.
PfamiPF07738. Sad1_UNC. 1 hit.
[Graphical view]
PROSITEiPS51469. SUN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BJS4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRRSQRLTR YSQDDNDGGS SSSGASSVAG SQGTVFKDSP LRTLKRKSSN
60 70 80 90 100
MKHLSPAPQL GPSSDSHTSY YSESVVRESY IGSPRAVSLA RSALLDDHLH
110 120 130 140 150
SEPYWSGDLR GRRRRGTGGS ESSKANGLTA ESKASEDFFG SSSGYSSEDD
160 170 180 190 200
LAGYTDSDQH SSGSRLRSAA SRAGSFVWTL VTFPGRLFGL LYWWIGTTWY
210 220 230 240 250
RLTTAASLLD VFVLTRSRHF SLNLKSFLWF LLLLLLLTGL TYGAWHFYPL
260 270 280 290 300
GLQTLQPAVV SWWAAKESRK QPEVWESRDA SQHFQAEQRV LSRVHSLERR
310 320 330 340 350
LEALAADFSS NWQKEAIRLE RLELRQGAAG HGGGSSLSHE DALSLLEGLV
360 370 380 390 400
SRREATLKED LRRDTVAHIQ EELATLRAEH HQDSEDLFKK IVQASQESEA
410 420 430 440 450
RVQQLKTEWK SMTQEAFQES SVKELGRLEA QLASLRQELA ALTLKQNSVA
460 470 480 490 500
DEVGLLPQKI QAARADVESQ FPDWIRQFLL GDRGARSGLL QRDEMHAQLQ
510 520 530 540 550
ELENKILTKM AEMQGKSARE AAASLGQILQ KEGIVGVTEE QVHRIVKQAL
560 570 580 590 600
QRYSEDRIGM VDYALESGGA SVISTRCSET YETKTALLSL FGIPLWYHSQ
610 620 630 640 650
SPRVILQPDV HPGNCWAFQG PQGFAVVRLS ARIRPTAVTL EHVPKALSPN
660 670 680 690 700
STISSAPKDF AIFGFDEDLQ QEGTLLGTFA YDQDGEPIQT FYFQASKMAT
710 720 730
YQVVELRILT NWGHPEYTCI YRFRVHGEPA H
Note: No experimental confirmation available.
Length:731
Mass (Da):81,605
Last modified:August 10, 2010 - v3
Checksum:i67830D40C33E3DBA
GO
Isoform 2 (identifier: Q8BJS4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-218: Missing.

Show »
Length:729
Mass (Da):81,362
Checksum:iAB32E4A3F02D9A52
GO
Isoform 3 (identifier: Q8BJS4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     154-185: Missing.

Note: No experimental confirmation available.
Show »
Length:699
Mass (Da):78,179
Checksum:iEC15665AAA8365B0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti106 – 1061S → G in BAE42217 (PubMed:16141072).Curated
Sequence conflicti412 – 4121M → V in BAC87662 (Ref. 2) Curated
Sequence conflicti451 – 4511D → Y in BAC87662 (Ref. 2) Curated
Sequence conflicti579 – 5791E → K in BAE42217 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei154 – 18532Missing in isoform 3. 1 PublicationVSP_039553Add
BLAST
Alternative sequencei217 – 2182Missing in isoform 2. 2 PublicationsVSP_039554

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY682987 mRNA. Translation: AAT90499.1.
AK128958 mRNA. Translation: BAC87662.1.
AK080116 mRNA. Translation: BAC37829.1.
AK156246 mRNA. Translation: BAE33640.1.
AK171058 mRNA. Translation: BAE42217.1.
CH466550 Genomic DNA. Translation: EDL04635.1.
CCDSiCCDS27649.1. [Q8BJS4-3]
CCDS56992.1. [Q8BJS4-2]
CCDS56993.1. [Q8BJS4-1]
RefSeqiNP_001192274.1. NM_001205345.1. [Q8BJS4-1]
NP_001192275.1. NM_001205346.1. [Q8BJS4-2]
NP_919323.2. NM_194342.3. [Q8BJS4-3]
UniGeneiMm.202715.

Genome annotation databases

EnsembliENSMUST00000046259; ENSMUSP00000047864; ENSMUSG00000042524. [Q8BJS4-1]
ENSMUST00000089311; ENSMUSP00000086724; ENSMUSG00000042524. [Q8BJS4-3]
ENSMUST00000100439; ENSMUSP00000098006; ENSMUSG00000042524. [Q8BJS4-2]
GeneIDi223697.
KEGGimmu:223697.
UCSCiuc007wuh.3. mouse. [Q8BJS4-1]
uc007wui.3. mouse. [Q8BJS4-2]
uc011zwc.2. mouse. [Q8BJS4-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY682987 mRNA. Translation: AAT90499.1.
AK128958 mRNA. Translation: BAC87662.1.
AK080116 mRNA. Translation: BAC37829.1.
AK156246 mRNA. Translation: BAE33640.1.
AK171058 mRNA. Translation: BAE42217.1.
CH466550 Genomic DNA. Translation: EDL04635.1.
CCDSiCCDS27649.1. [Q8BJS4-3]
CCDS56992.1. [Q8BJS4-2]
CCDS56993.1. [Q8BJS4-1]
RefSeqiNP_001192274.1. NM_001205345.1. [Q8BJS4-1]
NP_001192275.1. NM_001205346.1. [Q8BJS4-2]
NP_919323.2. NM_194342.3. [Q8BJS4-3]
UniGeneiMm.202715.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5ED8X-ray2.50A470-731[»]
5ED9X-ray2.01A/B/C410-481[»]
ProteinModelPortaliQ8BJS4.
SMRiQ8BJS4. Positions 536-731.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230179. 4 interactions.
IntActiQ8BJS4. 1 interaction.
STRINGi10090.ENSMUSP00000047864.

PTM databases

iPTMnetiQ8BJS4.
PhosphoSiteiQ8BJS4.

Proteomic databases

MaxQBiQ8BJS4.
PaxDbiQ8BJS4.
PeptideAtlasiQ8BJS4.
PRIDEiQ8BJS4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046259; ENSMUSP00000047864; ENSMUSG00000042524. [Q8BJS4-1]
ENSMUST00000089311; ENSMUSP00000086724; ENSMUSG00000042524. [Q8BJS4-3]
ENSMUST00000100439; ENSMUSP00000098006; ENSMUSG00000042524. [Q8BJS4-2]
GeneIDi223697.
KEGGimmu:223697.
UCSCiuc007wuh.3. mouse. [Q8BJS4-1]
uc007wui.3. mouse. [Q8BJS4-2]
uc011zwc.2. mouse. [Q8BJS4-3]

Organism-specific databases

CTDi25777.
MGIiMGI:2443011. Sun2.

Phylogenomic databases

eggNOGiKOG2687. Eukaryota.
ENOG410YM6S. LUCA.
GeneTreeiENSGT00390000011587.
HOGENOMiHOG000253025.
HOVERGENiHBG056957.
InParanoidiQ8BJS4.
KOiK19347.
OMAiEHQQDSE.
OrthoDBiEOG091G0AZ8.
PhylomeDBiQ8BJS4.
TreeFamiTF323915.

Enzyme and pathway databases

ReactomeiR-MMU-1221632. Meiotic synapsis.
R-MMU-1221633. Meiotic Synapsis.

Miscellaneous databases

PROiQ8BJS4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042524.
CleanExiMM_UNC84B.
ExpressionAtlasiQ8BJS4. baseline and differential.
GenevisibleiQ8BJS4. MM.

Family and domain databases

InterProiIPR030272. SUN2.
IPR012919. SUN_dom.
[Graphical view]
PANTHERiPTHR12911:SF22. PTHR12911:SF22. 1 hit.
PfamiPF07738. Sad1_UNC. 1 hit.
[Graphical view]
PROSITEiPS51469. SUN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUN2_MOUSE
AccessioniPrimary (citable) accession number: Q8BJS4
Secondary accession number(s): Q3TBU0, Q3U160, Q6B4H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: August 10, 2010
Last modified: September 7, 2016
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.