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Protein

SUN domain-containing protein 2

Gene

Sun2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, Syne2 and Sun2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for Rab5-GDP and participate in the activation of Rab5.5 Publications

GO - Molecular functioni

GO - Biological processi

  • centrosome localization Source: UniProtKB
  • cytoskeletal anchoring at nuclear membrane Source: MGI
  • nuclear envelope organization Source: MGI
  • nuclear matrix anchoring at nuclear membrane Source: MGI
  • nuclear migration along microfilament Source: UniProtKB
  • positive regulation of cell migration Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-1221632. Meiotic synapsis.
R-MMU-1221633. Meiotic Synapsis.

Names & Taxonomyi

Protein namesi
Recommended name:
SUN domain-containing protein 2
Alternative name(s):
Protein unc-84 homolog B
Sad1/unc-84 protein-like 2
Gene namesi
Name:Sun2
Synonyms:Unc84b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2443011. Sun2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 226NuclearBy similarityAdd BLAST226
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248 – 731Perinuclear spaceAdd BLAST484

GO - Cellular componenti

  • condensed nuclear chromosome Source: MGI
  • endosome membrane Source: UniProtKB-SubCell
  • integral component of nuclear inner membrane Source: InterPro
  • LINC complex Source: MGI
  • nuclear chromosome, telomeric region Source: MGI
  • nuclear envelope Source: MGI
  • nuclear inner membrane Source: UniProtKB
  • nuclear membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002189141 – 731SUN domain-containing protein 2Add BLAST731

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineCombined sources1
Modified residuei39PhosphoserineCombined sources1
Modified residuei55PhosphoserineCombined sources1
Modified residuei117PhosphothreonineCombined sources1
Modified residuei120PhosphoserineCombined sources1
Modified residuei123PhosphoserineCombined sources1
Modified residuei147PhosphoserineCombined sources1
Glycosylationi650N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8BJS4.
PeptideAtlasiQ8BJS4.
PRIDEiQ8BJS4.

PTM databases

iPTMnetiQ8BJS4.
PhosphoSitePlusiQ8BJS4.

Expressioni

Tissue specificityi

Highly expressed in heart, placenta and muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000042524.
CleanExiMM_UNC84B.
ExpressionAtlasiQ8BJS4. baseline and differential.
GenevisibleiQ8BJS4. MM.

Interactioni

Subunit structurei

Core component of the LINC complex which is composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN domain-containing proteins interact with A-type lamins of the nuclear lamina, while at the other end of the complex, nesprins interact with unique cytoskeletal components. Interacts with A-type lamin. Interaction with lamins B1 and C is hardly detectable. Interacts with SYNE1, SYNE2 and SYNE3. Interacts with EMD. Interacts with RAB5A. Interacts with TMEM43 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230179. 4 interactors.
DIPiDIP-49694N.
IntActiQ8BJS4. 2 interactors.
STRINGi10090.ENSMUSP00000047864.

Structurei

Secondary structure

1731
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi414 – 467Combined sources54
Helixi471 – 478Combined sources8
Helixi495 – 510Combined sources16
Helixi511 – 513Combined sources3
Helixi518 – 529Combined sources12
Helixi539 – 549Combined sources11
Helixi566 – 568Combined sources3
Helixi574 – 576Combined sources3
Beta strandi584 – 588Combined sources5
Beta strandi594 – 598Combined sources5
Helixi602 – 606Combined sources5
Beta strandi615 – 621Combined sources7
Beta strandi623 – 641Combined sources19
Helixi645 – 647Combined sources3
Helixi649 – 651Combined sources3
Beta strandi659 – 667Combined sources9
Beta strandi674 – 680Combined sources7
Beta strandi687 – 692Combined sources6
Beta strandi701 – 708Combined sources8
Beta strandi711 – 713Combined sources3
Beta strandi715 – 729Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5ED8X-ray2.50A470-731[»]
5ED9X-ray2.01A/B/C410-481[»]
ProteinModelPortaliQ8BJS4.
SMRiQ8BJS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini569 – 730SUNPROSITE-ProRule annotationAdd BLAST162

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 128LMNA-bindingAdd BLAST128

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili396 – 452Sequence analysisAdd BLAST57
Coiled coili486 – 519Sequence analysisAdd BLAST34

Domaini

The SUN domain may play a role in the nuclear anchoring and/or migration.1 Publication

Sequence similaritiesi

Contains 1 SUN domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2687. Eukaryota.
ENOG410YM6S. LUCA.
GeneTreeiENSGT00390000011587.
HOGENOMiHOG000253025.
HOVERGENiHBG056957.
InParanoidiQ8BJS4.
KOiK19347.
OMAiEHQQDSE.
OrthoDBiEOG091G0AZ8.
PhylomeDBiQ8BJS4.
TreeFamiTF323915.

Family and domain databases

InterProiIPR030272. SUN2.
IPR012919. SUN_dom.
[Graphical view]
PANTHERiPTHR12911:SF22. PTHR12911:SF22. 1 hit.
PfamiPF07738. Sad1_UNC. 1 hit.
[Graphical view]
PROSITEiPS51469. SUN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BJS4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRRSQRLTR YSQDDNDGGS SSSGASSVAG SQGTVFKDSP LRTLKRKSSN
60 70 80 90 100
MKHLSPAPQL GPSSDSHTSY YSESVVRESY IGSPRAVSLA RSALLDDHLH
110 120 130 140 150
SEPYWSGDLR GRRRRGTGGS ESSKANGLTA ESKASEDFFG SSSGYSSEDD
160 170 180 190 200
LAGYTDSDQH SSGSRLRSAA SRAGSFVWTL VTFPGRLFGL LYWWIGTTWY
210 220 230 240 250
RLTTAASLLD VFVLTRSRHF SLNLKSFLWF LLLLLLLTGL TYGAWHFYPL
260 270 280 290 300
GLQTLQPAVV SWWAAKESRK QPEVWESRDA SQHFQAEQRV LSRVHSLERR
310 320 330 340 350
LEALAADFSS NWQKEAIRLE RLELRQGAAG HGGGSSLSHE DALSLLEGLV
360 370 380 390 400
SRREATLKED LRRDTVAHIQ EELATLRAEH HQDSEDLFKK IVQASQESEA
410 420 430 440 450
RVQQLKTEWK SMTQEAFQES SVKELGRLEA QLASLRQELA ALTLKQNSVA
460 470 480 490 500
DEVGLLPQKI QAARADVESQ FPDWIRQFLL GDRGARSGLL QRDEMHAQLQ
510 520 530 540 550
ELENKILTKM AEMQGKSARE AAASLGQILQ KEGIVGVTEE QVHRIVKQAL
560 570 580 590 600
QRYSEDRIGM VDYALESGGA SVISTRCSET YETKTALLSL FGIPLWYHSQ
610 620 630 640 650
SPRVILQPDV HPGNCWAFQG PQGFAVVRLS ARIRPTAVTL EHVPKALSPN
660 670 680 690 700
STISSAPKDF AIFGFDEDLQ QEGTLLGTFA YDQDGEPIQT FYFQASKMAT
710 720 730
YQVVELRILT NWGHPEYTCI YRFRVHGEPA H
Note: No experimental confirmation available.
Length:731
Mass (Da):81,605
Last modified:August 10, 2010 - v3
Checksum:i67830D40C33E3DBA
GO
Isoform 2 (identifier: Q8BJS4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-218: Missing.

Show »
Length:729
Mass (Da):81,362
Checksum:iAB32E4A3F02D9A52
GO
Isoform 3 (identifier: Q8BJS4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     154-185: Missing.

Note: No experimental confirmation available.
Show »
Length:699
Mass (Da):78,179
Checksum:iEC15665AAA8365B0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106S → G in BAE42217 (PubMed:16141072).Curated1
Sequence conflicti412M → V in BAC87662 (Ref. 2) Curated1
Sequence conflicti451D → Y in BAC87662 (Ref. 2) Curated1
Sequence conflicti579E → K in BAE42217 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039553154 – 185Missing in isoform 3. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_039554217 – 218Missing in isoform 2. 2 Publications2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY682987 mRNA. Translation: AAT90499.1.
AK128958 mRNA. Translation: BAC87662.1.
AK080116 mRNA. Translation: BAC37829.1.
AK156246 mRNA. Translation: BAE33640.1.
AK171058 mRNA. Translation: BAE42217.1.
CH466550 Genomic DNA. Translation: EDL04635.1.
CCDSiCCDS27649.1. [Q8BJS4-3]
CCDS56992.1. [Q8BJS4-2]
CCDS56993.1. [Q8BJS4-1]
RefSeqiNP_001192274.1. NM_001205345.1. [Q8BJS4-1]
NP_001192275.1. NM_001205346.1. [Q8BJS4-2]
NP_919323.2. NM_194342.3. [Q8BJS4-3]
UniGeneiMm.202715.

Genome annotation databases

EnsembliENSMUST00000046259; ENSMUSP00000047864; ENSMUSG00000042524. [Q8BJS4-1]
ENSMUST00000089311; ENSMUSP00000086724; ENSMUSG00000042524. [Q8BJS4-3]
ENSMUST00000100439; ENSMUSP00000098006; ENSMUSG00000042524. [Q8BJS4-2]
GeneIDi223697.
KEGGimmu:223697.
UCSCiuc007wuh.3. mouse. [Q8BJS4-1]
uc007wui.3. mouse. [Q8BJS4-2]
uc011zwc.2. mouse. [Q8BJS4-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY682987 mRNA. Translation: AAT90499.1.
AK128958 mRNA. Translation: BAC87662.1.
AK080116 mRNA. Translation: BAC37829.1.
AK156246 mRNA. Translation: BAE33640.1.
AK171058 mRNA. Translation: BAE42217.1.
CH466550 Genomic DNA. Translation: EDL04635.1.
CCDSiCCDS27649.1. [Q8BJS4-3]
CCDS56992.1. [Q8BJS4-2]
CCDS56993.1. [Q8BJS4-1]
RefSeqiNP_001192274.1. NM_001205345.1. [Q8BJS4-1]
NP_001192275.1. NM_001205346.1. [Q8BJS4-2]
NP_919323.2. NM_194342.3. [Q8BJS4-3]
UniGeneiMm.202715.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5ED8X-ray2.50A470-731[»]
5ED9X-ray2.01A/B/C410-481[»]
ProteinModelPortaliQ8BJS4.
SMRiQ8BJS4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230179. 4 interactors.
DIPiDIP-49694N.
IntActiQ8BJS4. 2 interactors.
STRINGi10090.ENSMUSP00000047864.

PTM databases

iPTMnetiQ8BJS4.
PhosphoSitePlusiQ8BJS4.

Proteomic databases

PaxDbiQ8BJS4.
PeptideAtlasiQ8BJS4.
PRIDEiQ8BJS4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046259; ENSMUSP00000047864; ENSMUSG00000042524. [Q8BJS4-1]
ENSMUST00000089311; ENSMUSP00000086724; ENSMUSG00000042524. [Q8BJS4-3]
ENSMUST00000100439; ENSMUSP00000098006; ENSMUSG00000042524. [Q8BJS4-2]
GeneIDi223697.
KEGGimmu:223697.
UCSCiuc007wuh.3. mouse. [Q8BJS4-1]
uc007wui.3. mouse. [Q8BJS4-2]
uc011zwc.2. mouse. [Q8BJS4-3]

Organism-specific databases

CTDi25777.
MGIiMGI:2443011. Sun2.

Phylogenomic databases

eggNOGiKOG2687. Eukaryota.
ENOG410YM6S. LUCA.
GeneTreeiENSGT00390000011587.
HOGENOMiHOG000253025.
HOVERGENiHBG056957.
InParanoidiQ8BJS4.
KOiK19347.
OMAiEHQQDSE.
OrthoDBiEOG091G0AZ8.
PhylomeDBiQ8BJS4.
TreeFamiTF323915.

Enzyme and pathway databases

ReactomeiR-MMU-1221632. Meiotic synapsis.
R-MMU-1221633. Meiotic Synapsis.

Miscellaneous databases

PROiQ8BJS4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042524.
CleanExiMM_UNC84B.
ExpressionAtlasiQ8BJS4. baseline and differential.
GenevisibleiQ8BJS4. MM.

Family and domain databases

InterProiIPR030272. SUN2.
IPR012919. SUN_dom.
[Graphical view]
PANTHERiPTHR12911:SF22. PTHR12911:SF22. 1 hit.
PfamiPF07738. Sad1_UNC. 1 hit.
[Graphical view]
PROSITEiPS51469. SUN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUN2_MOUSE
AccessioniPrimary (citable) accession number: Q8BJS4
Secondary accession number(s): Q3TBU0, Q3U160, Q6B4H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: August 10, 2010
Last modified: November 30, 2016
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.