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Protein

Serine protease 27

Gene

Prss27

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei78 – 781Charge relay systemBy similarity
Active sitei127 – 1271Charge relay systemBy similarity
Active sitei232 – 2321Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.074.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease 27 (EC:3.4.21.-)
Alternative name(s):
Marapsin
Pancreasin
Gene namesi
Name:Prss27
Synonyms:Mpn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2450123. Prss27.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – 3715Activation peptideSequence analysisPRO_0000027508Add
BLAST
Chaini38 – 328291Serine protease 27PRO_0000027509Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi63 ↔ 79PROSITE-ProRule annotation
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence analysis
Disulfide bondi161 ↔ 238PROSITE-ProRule annotation
Disulfide bondi194 ↔ 217PROSITE-ProRule annotation
Disulfide bondi228 ↔ 256PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ8BJR6.
PRIDEiQ8BJR6.

Expressioni

Gene expression databases

BgeeiQ8BJR6.
CleanExiMM_PRSS27.
GenevisibleiQ8BJR6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056483.

Structurei

3D structure databases

ProteinModelPortaliQ8BJR6.
SMRiQ8BJR6. Positions 38-280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 280243Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118810.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ8BJR6.
KOiK09628.
OMAiFESGMNC.
OrthoDBiEOG75B84T.
PhylomeDBiQ8BJR6.
TreeFamiTF351676.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BJR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQPHIAALL LLPLLLRSGT EGARTLRACG HPKMFNRMVG GENALEGEWP
60 70 80 90 100
WQVSIQRNGI HFCGGSLIAP TWVLTAAHCF SNTSDISIYQ VLLGALKLQQ
110 120 130 140 150
PGPHALYVPV KQVKSNPQYQ GMASSADVAL VELQGPVTFT NYILPVCLPD
160 170 180 190 200
PSVIFESGMN CWVTGWGSPS EQDRLPNPRV LQKLAVPIID TPKCNLLYNK
210 220 230 240 250
DVESDFQLKT IKDDMLCAGF AEGKKDACKG DSGGPLVCLV DQSWVQAGVI
260 270 280 290 300
SWGEGCARRN RPGVYIRVTS HHKWIHQIIP ELQFQGRAGT QQQQKDSQGQ
310 320
QRLAGNSAPC LAAHAMVLAL GALLLRIV
Length:328
Mass (Da):35,789
Last modified:March 1, 2003 - v1
Checksum:iDC0B20F1AB3EB840
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF542056 mRNA. Translation: AAO27572.1.
AK080281 mRNA. Translation: BAC37864.1.
AY162410 Genomic DNA. Translation: AAO17162.1.
BC117009 mRNA. Translation: AAI17010.1.
BC117011 mRNA. Translation: AAI17012.1.
CCDSiCCDS28472.1.
RefSeqiNP_780649.1. NM_175440.4.
UniGeneiMm.133083.

Genome annotation databases

EnsembliENSMUST00000059482; ENSMUSP00000056483; ENSMUSG00000050762.
GeneIDi213171.
KEGGimmu:213171.
UCSCiuc008aug.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF542056 mRNA. Translation: AAO27572.1.
AK080281 mRNA. Translation: BAC37864.1.
AY162410 Genomic DNA. Translation: AAO17162.1.
BC117009 mRNA. Translation: AAI17010.1.
BC117011 mRNA. Translation: AAI17012.1.
CCDSiCCDS28472.1.
RefSeqiNP_780649.1. NM_175440.4.
UniGeneiMm.133083.

3D structure databases

ProteinModelPortaliQ8BJR6.
SMRiQ8BJR6. Positions 38-280.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056483.

Protein family/group databases

MEROPSiS01.074.

Proteomic databases

PaxDbiQ8BJR6.
PRIDEiQ8BJR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059482; ENSMUSP00000056483; ENSMUSG00000050762.
GeneIDi213171.
KEGGimmu:213171.
UCSCiuc008aug.1. mouse.

Organism-specific databases

CTDi83886.
MGIiMGI:2450123. Prss27.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118810.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ8BJR6.
KOiK09628.
OMAiFESGMNC.
OrthoDBiEOG75B84T.
PhylomeDBiQ8BJR6.
TreeFamiTF351676.

Miscellaneous databases

PROiQ8BJR6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BJR6.
CleanExiMM_PRSS27.
GenevisibleiQ8BJR6. MM.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas."
    Bhagwandin V.J., Hau L.W.-T., Mallen-St Clair J., Wolters P.J., Caughey G.H.
    J. Biol. Chem. 278:3363-3371(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Urinary bladder.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  3. "Genomic sequence analysis in the mouse T-complex region."
    Brathwaite M.E., Waeltz P., Qian Y., Dudekula D., Schlessinger D., Nagaraja R.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 129/SvJ.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.

Entry informationi

Entry nameiPRS27_MOUSE
AccessioniPrimary (citable) accession number: Q8BJR6
Secondary accession number(s): Q14A25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.