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Protein

Zinc transporter 6

Gene

Slc30a6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment.1 Publication

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: MGI

GO - Biological processi

  • Golgi to endosome transport Source: MGI
  • regulation of sequestering of zinc ion Source: GO_Central
  • response to zinc ion Source: GO_Central
  • zinc II ion transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiR-MMU-264876. Insulin processing.
R-MMU-435368. Zinc efflux and compartmentalization by the SLC30 family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 6
Short name:
ZnT-6
Alternative name(s):
Solute carrier family 30 member 6
Gene namesi
Name:Slc30a6
Synonyms:Znt6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2386741. Slc30a6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Topological domaini55 – 64ExtracellularSequence analysis10
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Topological domaini86 – 98CytoplasmicSequence analysisAdd BLAST13
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Topological domaini120 – 134ExtracellularSequence analysisAdd BLAST15
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Topological domaini156 – 200CytoplasmicSequence analysisAdd BLAST45
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 223ExtracellularSequence analysis2
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Topological domaini245 – 460CytoplasmicSequence analysisAdd BLAST216

GO - Cellular componenti

  • cytosol Source: GOC
  • Golgi apparatus Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: GO_Central
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003125741 – 460Zinc transporter 6Add BLAST460

Proteomic databases

EPDiQ8BJM5.
MaxQBiQ8BJM5.
PaxDbiQ8BJM5.
PRIDEiQ8BJM5.

PTM databases

iPTMnetiQ8BJM5.
PhosphoSitePlusiQ8BJM5.
SwissPalmiQ8BJM5.

Expressioni

Tissue specificityi

Expressed in brain and liver, and to a lower extent also in lung. Highly expressed in brain (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000024069.
ExpressionAtlasiQ8BJM5. baseline and differential.
GenevisibleiQ8BJM5. MM.

Interactioni

Subunit structurei

Heterooligomer. Interacts with ZNT5 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000136503.

Structurei

3D structure databases

ProteinModelPortaliQ8BJM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1484. Eukaryota.
COG1230. LUCA.
GeneTreeiENSGT00630000089781.
HOGENOMiHOG000060341.
HOVERGENiHBG106400.
InParanoidiQ8BJM5.
KOiK14693.
PhylomeDBiQ8BJM5.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 2 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BJM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTIHLFRKP QRSFFGKLLQ EFRLVAADRR SWKILLFGAI NVLCTGFLLM
60 70 80 90 100
WCSSTNSIAL TAYTYLTIFD LFSLITCLIS YWVMMRKPSP VYSFGFERLE
110 120 130 140 150
VLAVFASTVL AQLGALFILK ESAERFLEQP EIHTGRLLVG TFVALSFNLF
160 170 180 190 200
TMLSIRNKPF AYVSEAASTS WLQEHVADLS RSLCGLIPGL SSIFLPRMNP
210 220 230 240 250
FVLIDLAGAF ALCITYMLIE INNYFAVDTA SAIAIALMTF GTMYPMSVYS
260 270 280 290 300
GKVLLQTTPP HVIGQLDKLI REVSTLDGVL EVRNEHFWTL GFGSLAGSVH
310 320 330 340 350
VRIRRDANEQ MVLAHVSNRL CTLVSTLTVQ IFKDDWIRPA LSSGPVAPNV
360 370 380 390 400
LNFSDHHVIP MPLLKNVDER TPVTSTPAKP SSPPPEFSFN TPGKNVSPVI
410 420 430 440 450
LLNTQTRPYS LGLNRGHTPY SSVFSQGLAF PGVGAGQGLR PTFPHIPSRY
460
GINRMGQPRP
Length:460
Mass (Da):51,027
Last modified:March 1, 2003 - v1
Checksum:iA3E910CE96D16015
GO

Sequence cautioni

The sequence AAH05753 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80S → R in BAE29482 (PubMed:16141072).Curated1
Sequence conflicti80S → R in AAH68169 (PubMed:15489334).Curated1
Sequence conflicti81Y → H in AAM27917 (PubMed:11997387).Curated1
Sequence conflicti128E → G in AAM27917 (PubMed:11997387).Curated1
Sequence conflicti161 – 168AYVSEAAS → GRVGGRVG in AAH05753 (PubMed:15489334).Curated8
Sequence conflicti225F → C in AAH68169 (PubMed:15489334).Curated1
Sequence conflicti292F → L in AAM27917 (PubMed:11997387).Curated1
Sequence conflicti308N → S in BAE29482 (PubMed:16141072).Curated1
Sequence conflicti308N → S in AAH68169 (PubMed:15489334).Curated1
Sequence conflicti314A → T in AAL83717 (Ref. 2) Curated1
Sequence conflicti324 – 326VST → ASS in AAL83717 (Ref. 2) Curated3
Sequence conflicti331I → N in AAL83717 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395840 mRNA. Translation: AAM27917.1.
AF233346 mRNA. Translation: AAL83717.1.
AK082907 mRNA. Translation: BAC38680.1.
AK150342 mRNA. Translation: BAE29482.1.
AK151120 mRNA. Translation: BAE30129.1.
BC005753 mRNA. Translation: AAH05753.1. Different initiation.
BC066162 mRNA. Translation: AAH66162.1.
BC068169 mRNA. Translation: AAH68169.1.
CCDSiCCDS37691.1.
RefSeqiNP_659047.2. NM_144798.6.
UniGeneiMm.243943.

Genome annotation databases

EnsembliENSMUST00000024870; ENSMUSP00000024870; ENSMUSG00000024069.
GeneIDi210148.
KEGGimmu:210148.
UCSCiuc008dob.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395840 mRNA. Translation: AAM27917.1.
AF233346 mRNA. Translation: AAL83717.1.
AK082907 mRNA. Translation: BAC38680.1.
AK150342 mRNA. Translation: BAE29482.1.
AK151120 mRNA. Translation: BAE30129.1.
BC005753 mRNA. Translation: AAH05753.1. Different initiation.
BC066162 mRNA. Translation: AAH66162.1.
BC068169 mRNA. Translation: AAH68169.1.
CCDSiCCDS37691.1.
RefSeqiNP_659047.2. NM_144798.6.
UniGeneiMm.243943.

3D structure databases

ProteinModelPortaliQ8BJM5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000136503.

PTM databases

iPTMnetiQ8BJM5.
PhosphoSitePlusiQ8BJM5.
SwissPalmiQ8BJM5.

Proteomic databases

EPDiQ8BJM5.
MaxQBiQ8BJM5.
PaxDbiQ8BJM5.
PRIDEiQ8BJM5.

Protocols and materials databases

DNASUi210148.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024870; ENSMUSP00000024870; ENSMUSG00000024069.
GeneIDi210148.
KEGGimmu:210148.
UCSCiuc008dob.2. mouse.

Organism-specific databases

CTDi55676.
MGIiMGI:2386741. Slc30a6.

Phylogenomic databases

eggNOGiKOG1484. Eukaryota.
COG1230. LUCA.
GeneTreeiENSGT00630000089781.
HOGENOMiHOG000060341.
HOVERGENiHBG106400.
InParanoidiQ8BJM5.
KOiK14693.
PhylomeDBiQ8BJM5.

Enzyme and pathway databases

ReactomeiR-MMU-264876. Insulin processing.
R-MMU-435368. Zinc efflux and compartmentalization by the SLC30 family.

Miscellaneous databases

PROiQ8BJM5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024069.
ExpressionAtlasiQ8BJM5. baseline and differential.
GenevisibleiQ8BJM5. MM.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 2 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZNT6_MOUSE
AccessioniPrimary (citable) accession number: Q8BJM5
Secondary accession number(s): Q3UB35
, Q6NVE0, Q8K4H6, Q8R4Z2, Q99JQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Seems to have lost most of the histidine residues in the loop between the fourth and fifth transmembrane regions and appears to exert transport function by forming complexes with ZNT5.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.