Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc transporter 6

Gene

Slc30a6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment.1 Publication

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: MGI

GO - Biological processi

  • Golgi to endosome transport Source: MGI
  • zinc II ion transmembrane transport Source: GOC
  • zinc II ion transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiR-MMU-264876. Insulin processing.
R-MMU-435368. Zinc efflux and compartmentalization by the SLC30 family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 6
Short name:
ZnT-6
Alternative name(s):
Solute carrier family 30 member 6
Gene namesi
Name:Slc30a6
Synonyms:Znt6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2386741. Slc30a6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333CytoplasmicSequence analysisAdd
BLAST
Transmembranei34 – 5421HelicalSequence analysisAdd
BLAST
Topological domaini55 – 6410ExtracellularSequence analysis
Transmembranei65 – 8521HelicalSequence analysisAdd
BLAST
Topological domaini86 – 9813CytoplasmicSequence analysisAdd
BLAST
Transmembranei99 – 11921HelicalSequence analysisAdd
BLAST
Topological domaini120 – 13415ExtracellularSequence analysisAdd
BLAST
Transmembranei135 – 15521HelicalSequence analysisAdd
BLAST
Topological domaini156 – 20045CytoplasmicSequence analysisAdd
BLAST
Transmembranei201 – 22121HelicalSequence analysisAdd
BLAST
Topological domaini222 – 2232ExtracellularSequence analysis
Transmembranei224 – 24421HelicalSequence analysisAdd
BLAST
Topological domaini245 – 460216CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • Golgi apparatus Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460Zinc transporter 6PRO_0000312574Add
BLAST

Proteomic databases

EPDiQ8BJM5.
MaxQBiQ8BJM5.
PaxDbiQ8BJM5.
PRIDEiQ8BJM5.

PTM databases

PhosphoSiteiQ8BJM5.
SwissPalmiQ8BJM5.

Expressioni

Tissue specificityi

Expressed in brain and liver, and to a lower extent also in lung. Highly expressed in brain (at protein level).1 Publication

Gene expression databases

BgeeiQ8BJM5.
ExpressionAtlasiQ8BJM5. baseline and differential.
GenevisibleiQ8BJM5. MM.

Interactioni

Subunit structurei

Heterooligomer. Interacts with ZNT5 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000136503.

Structurei

3D structure databases

ProteinModelPortaliQ8BJM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1484. Eukaryota.
COG1230. LUCA.
GeneTreeiENSGT00630000089781.
HOGENOMiHOG000060341.
HOVERGENiHBG106400.
InParanoidiQ8BJM5.
KOiK14693.
PhylomeDBiQ8BJM5.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 2 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BJM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTIHLFRKP QRSFFGKLLQ EFRLVAADRR SWKILLFGAI NVLCTGFLLM
60 70 80 90 100
WCSSTNSIAL TAYTYLTIFD LFSLITCLIS YWVMMRKPSP VYSFGFERLE
110 120 130 140 150
VLAVFASTVL AQLGALFILK ESAERFLEQP EIHTGRLLVG TFVALSFNLF
160 170 180 190 200
TMLSIRNKPF AYVSEAASTS WLQEHVADLS RSLCGLIPGL SSIFLPRMNP
210 220 230 240 250
FVLIDLAGAF ALCITYMLIE INNYFAVDTA SAIAIALMTF GTMYPMSVYS
260 270 280 290 300
GKVLLQTTPP HVIGQLDKLI REVSTLDGVL EVRNEHFWTL GFGSLAGSVH
310 320 330 340 350
VRIRRDANEQ MVLAHVSNRL CTLVSTLTVQ IFKDDWIRPA LSSGPVAPNV
360 370 380 390 400
LNFSDHHVIP MPLLKNVDER TPVTSTPAKP SSPPPEFSFN TPGKNVSPVI
410 420 430 440 450
LLNTQTRPYS LGLNRGHTPY SSVFSQGLAF PGVGAGQGLR PTFPHIPSRY
460
GINRMGQPRP
Length:460
Mass (Da):51,027
Last modified:March 1, 2003 - v1
Checksum:iA3E910CE96D16015
GO

Sequence cautioni

The sequence AAH05753.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti80 – 801S → R in BAE29482 (PubMed:16141072).Curated
Sequence conflicti80 – 801S → R in AAH68169 (PubMed:15489334).Curated
Sequence conflicti81 – 811Y → H in AAM27917 (PubMed:11997387).Curated
Sequence conflicti128 – 1281E → G in AAM27917 (PubMed:11997387).Curated
Sequence conflicti161 – 1688AYVSEAAS → GRVGGRVG in AAH05753 (PubMed:15489334).Curated
Sequence conflicti225 – 2251F → C in AAH68169 (PubMed:15489334).Curated
Sequence conflicti292 – 2921F → L in AAM27917 (PubMed:11997387).Curated
Sequence conflicti308 – 3081N → S in BAE29482 (PubMed:16141072).Curated
Sequence conflicti308 – 3081N → S in AAH68169 (PubMed:15489334).Curated
Sequence conflicti314 – 3141A → T in AAL83717 (Ref. 2) Curated
Sequence conflicti324 – 3263VST → ASS in AAL83717 (Ref. 2) Curated
Sequence conflicti331 – 3311I → N in AAL83717 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395840 mRNA. Translation: AAM27917.1.
AF233346 mRNA. Translation: AAL83717.1.
AK082907 mRNA. Translation: BAC38680.1.
AK150342 mRNA. Translation: BAE29482.1.
AK151120 mRNA. Translation: BAE30129.1.
BC005753 mRNA. Translation: AAH05753.1. Different initiation.
BC066162 mRNA. Translation: AAH66162.1.
BC068169 mRNA. Translation: AAH68169.1.
CCDSiCCDS37691.1.
RefSeqiNP_659047.2. NM_144798.6.
UniGeneiMm.243943.

Genome annotation databases

EnsembliENSMUST00000024870; ENSMUSP00000024870; ENSMUSG00000024069.
GeneIDi210148.
KEGGimmu:210148.
UCSCiuc008dob.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395840 mRNA. Translation: AAM27917.1.
AF233346 mRNA. Translation: AAL83717.1.
AK082907 mRNA. Translation: BAC38680.1.
AK150342 mRNA. Translation: BAE29482.1.
AK151120 mRNA. Translation: BAE30129.1.
BC005753 mRNA. Translation: AAH05753.1. Different initiation.
BC066162 mRNA. Translation: AAH66162.1.
BC068169 mRNA. Translation: AAH68169.1.
CCDSiCCDS37691.1.
RefSeqiNP_659047.2. NM_144798.6.
UniGeneiMm.243943.

3D structure databases

ProteinModelPortaliQ8BJM5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000136503.

PTM databases

PhosphoSiteiQ8BJM5.
SwissPalmiQ8BJM5.

Proteomic databases

EPDiQ8BJM5.
MaxQBiQ8BJM5.
PaxDbiQ8BJM5.
PRIDEiQ8BJM5.

Protocols and materials databases

DNASUi210148.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024870; ENSMUSP00000024870; ENSMUSG00000024069.
GeneIDi210148.
KEGGimmu:210148.
UCSCiuc008dob.2. mouse.

Organism-specific databases

CTDi55676.
MGIiMGI:2386741. Slc30a6.

Phylogenomic databases

eggNOGiKOG1484. Eukaryota.
COG1230. LUCA.
GeneTreeiENSGT00630000089781.
HOGENOMiHOG000060341.
HOVERGENiHBG106400.
InParanoidiQ8BJM5.
KOiK14693.
PhylomeDBiQ8BJM5.

Enzyme and pathway databases

ReactomeiR-MMU-264876. Insulin processing.
R-MMU-435368. Zinc efflux and compartmentalization by the SLC30 family.

Miscellaneous databases

NextBioi372890.
PROiQ8BJM5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BJM5.
ExpressionAtlasiQ8BJM5. baseline and differential.
GenevisibleiQ8BJM5. MM.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 2 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Functional characterization of a novel mammalian zinc transporter, ZnT6."
    Huang L., Kirschke C.P., Gitschier J.
    J. Biol. Chem. 277:26389-26395(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
  2. "Cloning of new mammalian zinc transporter-like genes."
    Zhu W., Mager S.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Eye, Kidney and Mammary tumor.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen.

Entry informationi

Entry nameiZNT6_MOUSE
AccessioniPrimary (citable) accession number: Q8BJM5
Secondary accession number(s): Q3UB35
, Q6NVE0, Q8K4H6, Q8R4Z2, Q99JQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Seems to have lost most of the histidine residues in the loop between the fourth and fifth transmembrane regions and appears to exert transport function by forming complexes with ZNT5.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.