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Protein

F-box only protein 30

Gene

Fbxo30

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri49 – 110TRAF-typePROSITE-ProRule annotationAdd BLAST62

GO - Molecular functioni

Keywordsi

Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 30
Alternative name(s):
Muscle ubiquitin ligase of SCF complex in atrophy-1
Short name:
MUSA1
Gene namesi
Name:Fbxo30
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1919115 Fbxo30

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199191 – 746F-box only protein 30Add BLAST746

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei383PhosphoserineBy similarity1

Post-translational modificationi

Auto-ubiquitinated.1 Publication
May be neddylated. Neddylation may be required for E3 ligase activity, since it was observed only after purification with o-phenanthroline (PubMed:24076600).1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8BJL1
MaxQBiQ8BJL1
PaxDbiQ8BJL1
PeptideAtlasiQ8BJL1
PRIDEiQ8BJL1

PTM databases

iPTMnetiQ8BJL1
PhosphoSitePlusiQ8BJL1

Expressioni

Inductioni

Up-regulated in denervated muscles (at protein level), with highest expression levels around 14 days following denervation. Negatively regulated by the bone morphogenetic protein (BMP) pathway.1 Publication

Gene expression databases

BgeeiENSMUSG00000047648
CleanExiMM_FBXO30
GenevisibleiQ8BJL1 MM

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1, CUL1 and RBX1/ROC1.1 Publication

Protein-protein interaction databases

BioGridi214990, 1 interactor
MINTiQ8BJL1
STRINGi10090.ENSMUSP00000068230

Structurei

3D structure databases

ProteinModelPortaliQ8BJL1
SMRiQ8BJL1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini611 – 659F-boxPROSITE-ProRule annotationAdd BLAST49

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri49 – 110TRAF-typePROSITE-ProRule annotationAdd BLAST62

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IH36 Eukaryota
ENOG410XQPH LUCA
GeneTreeiENSGT00410000025582
HOGENOMiHOG000059618
HOVERGENiHBG051574
InParanoidiQ8BJL1
KOiK10307
OMAiIGCPLVC
OrthoDBiEOG091G06SE
PhylomeDBiQ8BJL1
TreeFamiTF343227

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR031890 Fbxo30/Fbxo40
IPR008974 TRAF-like
IPR013083 Znf_RING/FYVE/PHD
IPR001293 Znf_TRAF
PANTHERiPTHR15933 PTHR15933, 1 hit
PfamiView protein in Pfam
PF15966 F-box_4, 1 hit
PF15965 zf-TRAF_2, 1 hit
SUPFAMiSSF49599 SSF49599, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
PS50145 ZF_TRAF, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BJL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEEVQQHSH CMNCVSRRCM TRPEPGVSCD LIGCPLVCGA VFHSCKADEH
60 70 80 90 100
RLLCPFERVA CLNRNFGCPF TLARNKVAEH LEMCPASVVC CTMEWNRWPV
110 120 130 140 150
SYSDRKSYES LSRDVDEVAQ LDMALALQDQ RMLLESLKVA TMMSKATDKI
160 170 180 190 200
SEPREQISVK SSVQEIPRTN GLVSVDEESY GALYQATVET TRSLAAALDI
210 220 230 240 250
LNSATRDIGM LNTSLHATAN EMDEENNKES FQDKNLKDQD HLDEGEIGAV
260 270 280 290 300
GGVDYSGTSQ NAQAEQNGSS DLLCDLNPSS NGTSALCNGF PLEKMCIQVK
310 320 330 340 350
GQDQNFHGDS TESNITNGDC VEADGTSEPS SSLVVPEQLR EISPFSALPD
360 370 380 390 400
STFQQILMPD EDDEKDLCWK KVDLGDLKDV NGSPFSHAPS FKFLSNSWYI
410 420 430 440 450
PKEDKAVDTS DLEVAEDPMG LQGIDLITAA LLFCLGDSPG GRGISDSRMT
460 470 480 490 500
DVYHVDFGTQ TFSLPSAILA TNTMVGEIAS ASACDHANPQ LSNPSPFQTL
510 520 530 540 550
GLDLVLECVA RYQPKQRSMF TFVCGQLFRR KEFSSHFKNV HGDIHAGLNG
560 570 580 590 600
WMEQRCPLAY YGCTYSQRRF CPSTQGAKII HDRHLRSFGV QPCVSTVLEE
610 620 630 640 650
PSRNCVLGLR SDHLSSLPFE VLQHIAGFLD GFSLCQLACV SRLMRDVCGS
660 670 680 690 700
LLQSRGMVIL QWGKKKYPEG NSSWQIKEKV WRFSTAFCSV NDWKFADILS
710 720 730 740
MADHLKNCSY NVIEKREEAI PLPCMCVTRE LTKEGRSLRS VLKPVL
Length:746
Mass (Da):82,687
Last modified:July 27, 2011 - v2
Checksum:iFD88404AFC9560D0
GO

Sequence cautioni

The sequence AAH37691 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87S → G in BAB24551 (PubMed:16141072).Curated1
Sequence conflicti140A → P in BAC38931 (PubMed:16141072).Curated1
Sequence conflicti296C → G in BAB24551 (PubMed:16141072).Curated1
Sequence conflicti431L → S in BAB24551 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006369 mRNA Translation: BAB24551.1
AK083479 mRNA Translation: BAC38931.1
AK135274 mRNA Translation: BAE22469.1
CH466562 Genomic DNA Translation: EDL03517.1
BC037691 mRNA Translation: AAH37691.1 Different initiation.
CCDSiCCDS23697.1
RefSeqiNP_001161769.1, NM_001168297.1
NP_082244.2, NM_027968.3
XP_006512922.1, XM_006512859.3
UniGeneiMm.276229

Genome annotation databases

EnsembliENSMUST00000070300; ENSMUSP00000068230; ENSMUSG00000047648
ENSMUST00000129456; ENSMUSP00000117687; ENSMUSG00000047648
GeneIDi71865
KEGGimmu:71865
UCSCiuc007ejt.2 mouse

Similar proteinsi

Entry informationi

Entry nameiFBX30_MOUSE
AccessioniPrimary (citable) accession number: Q8BJL1
Secondary accession number(s): Q3UXU4, Q8CI21, Q9D9X5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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