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Protein

BTB/POZ domain-containing protein KCTD7

Gene

Kctd7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the control of excitability of cortical neurons.1 Publication

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD7
Gene namesi
Name:Kctd7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2442265. Kctd7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002514741 – 289BTB/POZ domain-containing protein KCTD7Add BLAST289

Proteomic databases

PaxDbiQ8BJK1.
PRIDEiQ8BJK1.

PTM databases

iPTMnetiQ8BJK1.
PhosphoSitePlusiQ8BJK1.

Expressioni

Tissue specificityi

High expression in brain, particularly in post-mitotic neurons. Expressed in the mitral cells of the olfactory bulbs, the hippocampus, the deep layers of the cerebral cortex and Purkinje cells of the cerebellum. Not detected in astrocytes or microglial cells. Also expressed in heart, liver, spleen and kidney.3 Publications

Gene expression databases

BgeeiENSMUSG00000034110.
ExpressionAtlasiQ8BJK1. baseline and differential.
GenevisibleiQ8BJK1. MM.

Interactioni

Subunit structurei

Interacts with CUL3.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ8BJK1.
SMRiQ8BJK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 141BTBAdd BLAST89

Sequence similaritiesi

Contains 1 BTB (POZ) domain.Curated

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000113201.
HOVERGENiHBG052220.
InParanoidiQ8BJK1.
OMAiHREAQYY.
OrthoDBiEOG091G0X03.
PhylomeDBiQ8BJK1.
TreeFamiTF315332.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BJK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVVTGREPD SRHSDGAMSS SEAEDDFLEP ATPTATQAGH GLPLLPQEFP
60 70 80 90 100
EVVPLNIGGA HFTTRLSTLR RYEDTMLAAM FSGRHYIPTD SEGRYFIDRD
110 120 130 140 150
GTHFGDVLNF LRSGDLPPRE HVRAVHKEAQ YYAIGPLLEQ LENMQPLKGE
160 170 180 190 200
KVRQAFLGLM PYYKDHLERI VEIARLRAVQ RKARFAKLKV CVFKEEMPIT
210 220 230 240 250
PYECPLLNSL RFERSESDGQ LFEHHCEVDV SFGPWEAVAD VYDLLHCLVT
260 270 280
DLSAQGLTVD HQCIGVCDKH LVNHYYCKRP IYEFKITWW
Length:289
Mass (Da):33,080
Last modified:March 1, 2003 - v1
Checksum:i64263FA2AD19FC2F
GO

Sequence cautioni

The sequence BAC26691 differs from that shown. Reason: Frameshift at position 236.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19S → C in BAE24427 (PubMed:16141072).Curated1
Sequence conflicti67S → C in BAE24427 (PubMed:16141072).Curated1
Sequence conflicti89 – 91TDS → HEA in AAH51544 (PubMed:15489334).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029942 mRNA. Translation: BAC26691.1. Frameshift.
AK083583 mRNA. Translation: BAC38959.1.
AK140606 mRNA. Translation: BAE24427.1.
CH466529 Genomic DNA. Translation: EDL19476.1.
BC051544 mRNA. Translation: AAH51544.1.
BC139070 mRNA. Translation: AAI39071.1.
BC141201 mRNA. Translation: AAI41202.1.
CCDSiCCDS19707.1.
RefSeqiNP_766097.1. NM_172509.3.
UniGeneiMm.55812.

Genome annotation databases

EnsembliENSMUST00000040616; ENSMUSP00000044568; ENSMUSG00000034110.
GeneIDi212919.
KEGGimmu:212919.
UCSCiuc008zue.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029942 mRNA. Translation: BAC26691.1. Frameshift.
AK083583 mRNA. Translation: BAC38959.1.
AK140606 mRNA. Translation: BAE24427.1.
CH466529 Genomic DNA. Translation: EDL19476.1.
BC051544 mRNA. Translation: AAH51544.1.
BC139070 mRNA. Translation: AAI39071.1.
BC141201 mRNA. Translation: AAI41202.1.
CCDSiCCDS19707.1.
RefSeqiNP_766097.1. NM_172509.3.
UniGeneiMm.55812.

3D structure databases

ProteinModelPortaliQ8BJK1.
SMRiQ8BJK1.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ8BJK1.
PhosphoSitePlusiQ8BJK1.

Proteomic databases

PaxDbiQ8BJK1.
PRIDEiQ8BJK1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040616; ENSMUSP00000044568; ENSMUSG00000034110.
GeneIDi212919.
KEGGimmu:212919.
UCSCiuc008zue.1. mouse.

Organism-specific databases

CTDi154881.
MGIiMGI:2442265. Kctd7.

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000113201.
HOVERGENiHBG052220.
InParanoidiQ8BJK1.
OMAiHREAQYY.
OrthoDBiEOG091G0X03.
PhylomeDBiQ8BJK1.
TreeFamiTF315332.

Miscellaneous databases

PROiQ8BJK1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034110.
ExpressionAtlasiQ8BJK1. baseline and differential.
GenevisibleiQ8BJK1. MM.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCTD7_MOUSE
AccessioniPrimary (citable) accession number: Q8BJK1
Secondary accession number(s): B2RSZ3
, Q3USA6, Q80WW8, Q8C0S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.