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Protein

POU domain, class 6, transcription factor 2

Gene

Pou6f2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3' (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi607 – 666HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 6, transcription factor 2
Gene namesi
Name:Pou6f2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2443631 Pou6f2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007631 – 691POU domain, class 6, transcription factor 2Add BLAST691

Proteomic databases

PaxDbiQ8BJI4
PRIDEiQ8BJI4

PTM databases

PhosphoSitePlusiQ8BJI4

Expressioni

Tissue specificityi

Expressed in kidney, heart, muscle, spleen and ovary, but not in lung.1 Publication

Developmental stagei

At 18 dpc, expressed in kidney, adrenal gland, heart, stomach, muscle and eye, but not in lung and skin.1 Publication

Gene expression databases

CleanExiMM_POU6F2

Interactioni

Protein-protein interaction databases

BioGridi229987, 1 interactor
STRINGi10090.ENSMUSP00000114173

Structurei

3D structure databases

ProteinModelPortaliQ8BJI4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini476 – 586POU-specificPROSITE-ProRule annotationAdd BLAST111

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi159 – 426Gln-richAdd BLAST268
Compositional biasi199 – 293Pro-richAdd BLAST95
Compositional biasi440 – 461Ser-richAdd BLAST22

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG3802 Eukaryota
ENOG410XQ7X LUCA
HOVERGENiHBG008230
InParanoidiQ8BJI4
KOiK09368
PhylomeDBiQ8BJI4

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR033056 POU6F2
IPR000327 POU_dom
PANTHERiPTHR11636:SF68 PTHR11636:SF68, 1 hit
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00157 Pou, 2 hits
PRINTSiPR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 2 hits
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BJI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAGQVSKPL LSVRSEMNAE LRGEDKAATS DSELNEPLLA PAESNDSEDT
60 70 80 90 100
PSKLFGARGN TVLPDPGTPD QHQACQTHPT FPVGPQPLLT AQQLASAVAG
110 120 130 140 150
VMPGGPPALN QPILIPFNMA GQLGGQQGLV LTLPTANLTN IQGLVAAAAA
160 170 180 190 200
GGIMTLPLQN LQATSSLNSQ LQQLQQLQLQ QQQQQQQQQQ QQQQQQQQPP
210 220 230 240 250
PPPTSQHPQP ASQAPPQSQP TPPHQPPPAS QQLPAPPAQL EQATQPQQHQ
260 270 280 290 300
PHSHPQNQTQ NQPSPTQQSS SPPQKPSPSP GHSLPSPLTP PNPLQLVNNP
310 320 330 340 350
LASQAAAAAA AMGSIASSQA FGNALSSLQG VTGQLVTNAQ GQIIGTIPLM
360 370 380 390 400
PNPGPSSQAA SGTQGLQVQP ITPQLLTNAQ GQIIATVIGN QILPVINTQG
410 420 430 440 450
ITLSPIKPGQ QLHQSSQTSV GQAGTQGNLL HLAHGQAATS HSPVRQASSS
460 470 480 490 500
SSSSSSSSAL SVGQLVSNPQ TAAGEVDGVN LEEIREFAKA FKIRRLSLGL
510 520 530 540 550
TQTQVGQALS ATEGPAYSQS AICRHTILRS HFFLPQEAQE NTIASSLTAK
560 570 580 590 600
LNPGLLYPAR FEKLDITPKS AQKIKPVLER WMAEAEARHR AGMQNLTEFI
610 620 630 640 650
GSEPSKKRKR RTSFTPQALE ILNAHFEKNT HPSGQEMTEI AEKLNYDREV
660 670 680 690
VRVWFCNKRQ ALKNTIKRLK QHEPTSAAPL EPLADSPEEN C
Length:691
Mass (Da):73,309
Last modified:March 1, 2003 - v1
Checksum:i501A64262721A70D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK083772 mRNA Translation: BAC39017.1
RefSeqiNP_778171.2, NM_175006.2
UniGeneiMm.352263

Genome annotation databases

GeneIDi218030
KEGGimmu:218030
UCSCiuc007poh.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPO6F2_MOUSE
AccessioniPrimary (citable) accession number: Q8BJI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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