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Protein

Sodium-dependent neutral amino acid transporter SLC6A17

Gene

Slc6a17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent neutral amino acid transporter SLC6A17
Alternative name(s):
Sodium-dependent neurotransmitter transporter NTT4
Solute carrier family 6 member 17
Gene namesi
Name:Slc6a17
Synonyms:Ntt4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2442535. Slc6a17.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6868CytoplasmicSequence analysisAdd
BLAST
Transmembranei69 – 8921Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini90 – 967ExtracellularSequence analysis
Transmembranei97 – 11620Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini117 – 14024CytoplasmicSequence analysisAdd
BLAST
Transmembranei141 – 16121Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini162 – 22463ExtracellularSequence analysisAdd
BLAST
Transmembranei225 – 24319Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini244 – 2518CytoplasmicSequence analysis
Transmembranei252 – 26918Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini270 – 30435ExtracellularSequence analysisAdd
BLAST
Transmembranei305 – 32218Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini323 – 33311CytoplasmicSequence analysisAdd
BLAST
Transmembranei334 – 35522Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini356 – 45196ExtracellularSequence analysisAdd
BLAST
Transmembranei452 – 47120Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini472 – 49423CytoplasmicSequence analysisAdd
BLAST
Transmembranei495 – 51319Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini514 – 52815ExtracellularSequence analysisAdd
BLAST
Transmembranei529 – 54921Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini550 – 56920CytoplasmicSequence analysisAdd
BLAST
Transmembranei570 – 59122Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini592 – 61827ExtracellularSequence analysisAdd
BLAST
Transmembranei619 – 64123Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini642 – 72786CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 727727Sodium-dependent neutral amino acid transporter SLC6A17PRO_0000214804Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131PhosphoserineCombined sources
Modified residuei20 – 201PhosphoserineCombined sources
Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence analysis
Modified residuei377 – 3771PhosphotyrosineCombined sources
Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence analysis
Modified residuei665 – 6651PhosphoserineCombined sources
Modified residuei701 – 7011PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8BJI1.
PaxDbiQ8BJI1.
PRIDEiQ8BJI1.

PTM databases

iPTMnetiQ8BJI1.
PhosphoSiteiQ8BJI1.

Expressioni

Tissue specificityi

Expressed in the brain. The strongest expression levels in embryonic, postnatal, and adult stages are found in both cortical and hippocampal tissues.1 Publication

Developmental stagei

Expressed during embryonic brain development and the highest levels are observed postnatally.1 Publication

Gene expression databases

BgeeiQ8BJI1.
ExpressionAtlasiQ8BJI1. baseline and differential.
GenevisibleiQ8BJI1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029499.

Structurei

3D structure databases

ProteinModelPortaliQ8BJI1.
SMRiQ8BJI1. Positions 58-645.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000119044.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ8BJI1.
KOiK05048.
OMAiMEMYNVI.
OrthoDBiEOG793B71.
PhylomeDBiQ8BJI1.
TreeFamiTF352709.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 2 hits.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BJI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKNSKVTQR EHSNEHVTES VADLLALEEP VDYKQSVLNV AGETGGKQKV
60 70 80 90 100
AEEELDTEDR PAWNSKLQYI LAQIGFSVGL GNIWRFPYLC QKNGGGAYLV
110 120 130 140 150
PYLVLLIIIG IPLFFLELAV GQRIRRGSIG VWHYVCPRLG GIGFSSCIVC
160 170 180 190 200
LFVGLYYNVI IGWSVFYFFK SFQYPLPWSE CPVIRNGTVA VVEPECEKSS
210 220 230 240 250
ATTYFWYREA LDISNSISES GGLNWKMTLC LLVAWSIVGM AVVKGIQSSG
260 270 280 290 300
KVMYFSSLFP YVVLACFLVR GLLLRGAVDG ILHMFTPKLD KMLDPQVWRE
310 320 330 340 350
AATQVFFALG LGFGGVIAFS SYNKQDNNCH FDAALVSFIN FFTSVLATLV
360 370 380 390 400
VFAVLGFKAN IMNEKCVVEN AEKILGYLNS NVLSRDLIPP HVNFSHLTTK
410 420 430 440 450
DYSEMYSVIM TVKEKQFPAL GLDPCLLEDE LDKSVQGTGL AFIAFTEAMT
460 470 480 490 500
HFPASPFWSV MFFLMLINLG LGSMIGTMAG ITTPIIDTFK VPKEMFTVGC
510 520 530 540 550
CVFAFFVGLL FVQRSGNYFV TMFDDYSATL PLTVIVILEN IAVAWIYGTK
560 570 580 590 600
KFMQELTEML GFQPYRFYFY MWKFVSPLCM AVLTTASIIQ LGVSPPGYSA
610 620 630 640 650
WIKEEAAERY LYFPNWAMAL LITLIAVATL PIPVVFILRH FHLLSDGSNT
660 670 680 690 700
LSVSYKKGRM MKDISNLEEN DETRFILSKV PSEAPSPMPT HRSYLGPGST
710 720
SPLDNSNNPN GRYGSGYLLA STPESEL
Length:727
Mass (Da):81,071
Last modified:March 1, 2003 - v1
Checksum:i0EAA2B192E77D7FA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti434 – 4363Missing in AAN75010 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY155578 mRNA. Translation: AAN75010.1.
AK083807 mRNA. Translation: BAC39024.1.
AK032262 mRNA. Translation: BAC27785.1.
BC141148 mRNA. Translation: AAI41149.1.
BC171962 mRNA. Translation: AAI71962.1.
CCDSiCCDS79998.1.
PIRiC46027.
RefSeqiNP_001280618.1. NM_001293689.1.
NP_758475.1. NM_172271.2.
XP_006501469.1. XM_006501406.1.
XP_006501470.1. XM_006501407.1.
UniGeneiMm.212867.

Genome annotation databases

EnsembliENSMUST00000169449; ENSMUSP00000129379; ENSMUSG00000027894.
GeneIDi229706.
KEGGimmu:229706.
UCSCiuc008qxb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY155578 mRNA. Translation: AAN75010.1.
AK083807 mRNA. Translation: BAC39024.1.
AK032262 mRNA. Translation: BAC27785.1.
BC141148 mRNA. Translation: AAI41149.1.
BC171962 mRNA. Translation: AAI71962.1.
CCDSiCCDS79998.1.
PIRiC46027.
RefSeqiNP_001280618.1. NM_001293689.1.
NP_758475.1. NM_172271.2.
XP_006501469.1. XM_006501406.1.
XP_006501470.1. XM_006501407.1.
UniGeneiMm.212867.

3D structure databases

ProteinModelPortaliQ8BJI1.
SMRiQ8BJI1. Positions 58-645.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029499.

PTM databases

iPTMnetiQ8BJI1.
PhosphoSiteiQ8BJI1.

Proteomic databases

MaxQBiQ8BJI1.
PaxDbiQ8BJI1.
PRIDEiQ8BJI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000169449; ENSMUSP00000129379; ENSMUSG00000027894.
GeneIDi229706.
KEGGimmu:229706.
UCSCiuc008qxb.1. mouse.

Organism-specific databases

CTDi388662.
MGIiMGI:2442535. Slc6a17.

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000119044.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ8BJI1.
KOiK05048.
OMAiMEMYNVI.
OrthoDBiEOG793B71.
PhylomeDBiQ8BJI1.
TreeFamiTF352709.

Miscellaneous databases

ChiTaRSiSlc6a17. mouse.
PROiQ8BJI1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BJI1.
ExpressionAtlasiQ8BJI1. baseline and differential.
GenevisibleiQ8BJI1. MM.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 2 hits.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sodium and chloride dependent mouse orphan neurotransmitter transporter NTT4 cDNA."
    Liu Q.-R., Uhl G.R.
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Olfactory bulb and Spinal ganglion.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  5. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-377, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13; SER-20 AND SER-665, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  7. Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiS6A17_MOUSE
AccessioniPrimary (citable) accession number: Q8BJI1
Secondary accession number(s): B2RUH5, Q8C057, Q8CGQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.