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Protein

Sodium-dependent neutral amino acid transporter SLC6A17

Gene

Slc6a17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent neutral amino acid transporter SLC6A17
Alternative name(s):
Sodium-dependent neurotransmitter transporter NTT4
Solute carrier family 6 member 17
Gene namesi
Name:Slc6a17
Synonyms:Ntt4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2442535. Slc6a17.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 68CytoplasmicSequence analysisAdd BLAST68
Transmembranei69 – 89Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini90 – 96ExtracellularSequence analysis7
Transmembranei97 – 116Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini117 – 140CytoplasmicSequence analysisAdd BLAST24
Transmembranei141 – 161Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini162 – 224ExtracellularSequence analysisAdd BLAST63
Transmembranei225 – 243Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini244 – 251CytoplasmicSequence analysis8
Transmembranei252 – 269Helical; Name=5Sequence analysisAdd BLAST18
Topological domaini270 – 304ExtracellularSequence analysisAdd BLAST35
Transmembranei305 – 322Helical; Name=6Sequence analysisAdd BLAST18
Topological domaini323 – 333CytoplasmicSequence analysisAdd BLAST11
Transmembranei334 – 355Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini356 – 451ExtracellularSequence analysisAdd BLAST96
Transmembranei452 – 471Helical; Name=8Sequence analysisAdd BLAST20
Topological domaini472 – 494CytoplasmicSequence analysisAdd BLAST23
Transmembranei495 – 513Helical; Name=9Sequence analysisAdd BLAST19
Topological domaini514 – 528ExtracellularSequence analysisAdd BLAST15
Transmembranei529 – 549Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini550 – 569CytoplasmicSequence analysisAdd BLAST20
Transmembranei570 – 591Helical; Name=11Sequence analysisAdd BLAST22
Topological domaini592 – 618ExtracellularSequence analysisAdd BLAST27
Transmembranei619 – 641Helical; Name=12Sequence analysisAdd BLAST23
Topological domaini642 – 727CytoplasmicSequence analysisAdd BLAST86

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002148041 – 727Sodium-dependent neutral amino acid transporter SLC6A17Add BLAST727

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineCombined sources1
Modified residuei20PhosphoserineCombined sources1
Glycosylationi186N-linked (GlcNAc...)Sequence analysis1
Modified residuei377PhosphotyrosineCombined sources1
Glycosylationi393N-linked (GlcNAc...)Sequence analysis1
Modified residuei665PhosphoserineCombined sources1
Modified residuei701PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8BJI1.
PaxDbiQ8BJI1.
PeptideAtlasiQ8BJI1.
PRIDEiQ8BJI1.

PTM databases

iPTMnetiQ8BJI1.
PhosphoSitePlusiQ8BJI1.

Expressioni

Tissue specificityi

Expressed in the brain. The strongest expression levels in embryonic, postnatal, and adult stages are found in both cortical and hippocampal tissues.1 Publication

Developmental stagei

Expressed during embryonic brain development and the highest levels are observed postnatally.1 Publication

Gene expression databases

BgeeiENSMUSG00000027894.
ExpressionAtlasiQ8BJI1. baseline and differential.
GenevisibleiQ8BJI1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029499.

Structurei

3D structure databases

ProteinModelPortaliQ8BJI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000119044.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ8BJI1.
KOiK05048.
OMAiMEMYNVI.
OrthoDBiEOG091G08PX.
PhylomeDBiQ8BJI1.
TreeFamiTF352709.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 2 hits.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BJI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKNSKVTQR EHSNEHVTES VADLLALEEP VDYKQSVLNV AGETGGKQKV
60 70 80 90 100
AEEELDTEDR PAWNSKLQYI LAQIGFSVGL GNIWRFPYLC QKNGGGAYLV
110 120 130 140 150
PYLVLLIIIG IPLFFLELAV GQRIRRGSIG VWHYVCPRLG GIGFSSCIVC
160 170 180 190 200
LFVGLYYNVI IGWSVFYFFK SFQYPLPWSE CPVIRNGTVA VVEPECEKSS
210 220 230 240 250
ATTYFWYREA LDISNSISES GGLNWKMTLC LLVAWSIVGM AVVKGIQSSG
260 270 280 290 300
KVMYFSSLFP YVVLACFLVR GLLLRGAVDG ILHMFTPKLD KMLDPQVWRE
310 320 330 340 350
AATQVFFALG LGFGGVIAFS SYNKQDNNCH FDAALVSFIN FFTSVLATLV
360 370 380 390 400
VFAVLGFKAN IMNEKCVVEN AEKILGYLNS NVLSRDLIPP HVNFSHLTTK
410 420 430 440 450
DYSEMYSVIM TVKEKQFPAL GLDPCLLEDE LDKSVQGTGL AFIAFTEAMT
460 470 480 490 500
HFPASPFWSV MFFLMLINLG LGSMIGTMAG ITTPIIDTFK VPKEMFTVGC
510 520 530 540 550
CVFAFFVGLL FVQRSGNYFV TMFDDYSATL PLTVIVILEN IAVAWIYGTK
560 570 580 590 600
KFMQELTEML GFQPYRFYFY MWKFVSPLCM AVLTTASIIQ LGVSPPGYSA
610 620 630 640 650
WIKEEAAERY LYFPNWAMAL LITLIAVATL PIPVVFILRH FHLLSDGSNT
660 670 680 690 700
LSVSYKKGRM MKDISNLEEN DETRFILSKV PSEAPSPMPT HRSYLGPGST
710 720
SPLDNSNNPN GRYGSGYLLA STPESEL
Length:727
Mass (Da):81,071
Last modified:March 1, 2003 - v1
Checksum:i0EAA2B192E77D7FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti434 – 436Missing in AAN75010 (Ref. 1) Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY155578 mRNA. Translation: AAN75010.1.
AK083807 mRNA. Translation: BAC39024.1.
AK032262 mRNA. Translation: BAC27785.1.
BC141148 mRNA. Translation: AAI41149.1.
BC171962 mRNA. Translation: AAI71962.1.
CCDSiCCDS79998.1.
PIRiC46027.
RefSeqiNP_001280618.1. NM_001293689.1.
NP_758475.1. NM_172271.2.
XP_006501469.1. XM_006501406.2.
XP_006501470.1. XM_006501407.2.
UniGeneiMm.212867.

Genome annotation databases

EnsembliENSMUST00000169449; ENSMUSP00000129379; ENSMUSG00000027894.
GeneIDi229706.
KEGGimmu:229706.
UCSCiuc008qxb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY155578 mRNA. Translation: AAN75010.1.
AK083807 mRNA. Translation: BAC39024.1.
AK032262 mRNA. Translation: BAC27785.1.
BC141148 mRNA. Translation: AAI41149.1.
BC171962 mRNA. Translation: AAI71962.1.
CCDSiCCDS79998.1.
PIRiC46027.
RefSeqiNP_001280618.1. NM_001293689.1.
NP_758475.1. NM_172271.2.
XP_006501469.1. XM_006501406.2.
XP_006501470.1. XM_006501407.2.
UniGeneiMm.212867.

3D structure databases

ProteinModelPortaliQ8BJI1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029499.

PTM databases

iPTMnetiQ8BJI1.
PhosphoSitePlusiQ8BJI1.

Proteomic databases

MaxQBiQ8BJI1.
PaxDbiQ8BJI1.
PeptideAtlasiQ8BJI1.
PRIDEiQ8BJI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000169449; ENSMUSP00000129379; ENSMUSG00000027894.
GeneIDi229706.
KEGGimmu:229706.
UCSCiuc008qxb.1. mouse.

Organism-specific databases

CTDi388662.
MGIiMGI:2442535. Slc6a17.

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000119044.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ8BJI1.
KOiK05048.
OMAiMEMYNVI.
OrthoDBiEOG091G08PX.
PhylomeDBiQ8BJI1.
TreeFamiTF352709.

Miscellaneous databases

ChiTaRSiSlc6a17. mouse.
PROiQ8BJI1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027894.
ExpressionAtlasiQ8BJI1. baseline and differential.
GenevisibleiQ8BJI1. MM.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 2 hits.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS6A17_MOUSE
AccessioniPrimary (citable) accession number: Q8BJI1
Secondary accession number(s): B2RUH5, Q8C057, Q8CGQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.