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Protein

Charged multivesicular body protein 2b

Gene

Chmp2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1632852 Macroautophagy
R-MMU-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Names & Taxonomyi

Protein namesi
Recommended name:
Charged multivesicular body protein 2b
Alternative name(s):
Chromatin-modifying protein 2b
Short name:
CHMP2b
Gene namesi
Name:Chmp2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1916192 Chmp2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002114702 – 213Charged multivesicular body protein 2bAdd BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei199PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8BJF9
MaxQBiQ8BJF9
PaxDbiQ8BJF9
PeptideAtlasiQ8BJF9
PRIDEiQ8BJF9

PTM databases

iPTMnetiQ8BJF9
PhosphoSitePlusiQ8BJF9

Expressioni

Tissue specificityi

In brain, it is expressed in all neuronal populations with a relatively enhanced expression in the hippocampus, frontal and temporal lobes and in both granule and Purkinje cells of the cerebellum. Not expressed in astrocytes or oligodendrocytes.1 Publication

Gene expression databases

BgeeiENSMUSG00000004843
CleanExiMM_CHMP2B
GenevisibleiQ8BJF9 MM

Interactioni

Subunit structurei

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. Interacts with CHMP2A. Interacts with VPS4A. Interacts with VPS4B; the interaction is direct (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8BJF9, 1 interactor
MINTiQ8BJF9
STRINGi10090.ENSMUSP00000004965

Structurei

3D structure databases

ProteinModelPortaliQ8BJF9
SMRiQ8BJF9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili25 – 55Sequence analysisAdd BLAST31

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi201 – 211MIT-interacting motifAdd BLAST11

Sequence similaritiesi

Belongs to the SNF7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3231 Eukaryota
ENOG4111QA0 LUCA
GeneTreeiENSGT00550000074737
HOGENOMiHOG000177218
HOVERGENiHBG102628
InParanoidiQ8BJF9
KOiK12192
OMAiENMKMGM
OrthoDBiEOG091G0S04
PhylomeDBiQ8BJF9
TreeFamiTF314163

Family and domain databases

InterProiView protein in InterPro
IPR005024 Snf7_fam
PfamiView protein in Pfam
PF03357 Snf7, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BJF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLFKKKTV DDVIKEQNRE LRGTQRAIIR DRAALEKQEK QLELEIKKMA
60 70 80 90 100
KIGNKEACRV LAKQLVHLRK QKTRTFAVSS KVTSMSTQTK VMNSQMKMAG
110 120 130 140 150
AMSTTAKTMQ AVNKKMDPQK TLQTMQNFQK ENMKMEMTEE MINDTLDDIF
160 170 180 190 200
DGSDDEEESQ DIVNQVLDEI GIEISGKMAK APSAARSLPS ASTSKATISD
210
EEIERQLKAL GVD
Length:213
Mass (Da):23,935
Last modified:March 1, 2003 - v1
Checksum:iAC5B40ED59E4489B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti131E → D in BAB23339 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004506 mRNA Translation: BAB23339.1
AK084111 mRNA Translation: BAC39118.1
BC042626 mRNA Translation: AAH42626.1
BC055809 mRNA Translation: AAH55809.1
CCDSiCCDS28269.1
RefSeqiNP_081155.1, NM_026879.2
UniGeneiMm.432944

Genome annotation databases

EnsembliENSMUST00000004965; ENSMUSP00000004965; ENSMUSG00000004843
GeneIDi68942
KEGGimmu:68942
UCSCiuc007zqj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCHM2B_MOUSE
AccessioniPrimary (citable) accession number: Q8BJF9
Secondary accession number(s): Q80UZ4, Q9CT65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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