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Protein

Inter-alpha-trypsin inhibitor heavy chain H5

Gene

Itih5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May act as a tumor suppressor.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Inter-alpha-trypsin inhibitor heavy chain H5
Short name:
ITI heavy chain H5
Short name:
ITI-HC5
Short name:
Inter-alpha-inhibitor heavy chain 5
Gene namesi
Name:Itih5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1925751. Itih5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 952935Inter-alpha-trypsin inhibitor heavy chain H5PRO_0000331409Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence analysis
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence analysis
Glycosylationi136 – 1361N-linked (GlcNAc...)Sequence analysis
Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence analysis
Glycosylationi508 – 5081N-linked (GlcNAc...)Sequence analysis
Glycosylationi776 – 7761N-linked (GlcNAc...)Sequence analysis
Glycosylationi795 – 7951N-linked (GlcNAc...)Sequence analysis
Glycosylationi862 – 8621N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BJD1.
PaxDbiQ8BJD1.
PRIDEiQ8BJD1.

PTM databases

iPTMnetiQ8BJD1.
PhosphoSiteiQ8BJD1.

Expressioni

Gene expression databases

BgeeiQ8BJD1.
GenevisibleiQ8BJD1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026886.

Structurei

3D structure databases

ProteinModelPortaliQ8BJD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 161127VITPROSITE-ProRule annotationAdd
BLAST
Domaini295 – 478184VWFAPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 1312Poly-LeuAdd
BLAST

Sequence similaritiesi

Belongs to the ITIH family.Curated
Contains 1 VIT domain.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEJB. Eukaryota.
COG2304. LUCA.
GeneTreeiENSGT00550000074468.
HOGENOMiHOG000000680.
HOVERGENiHBG108012.
InParanoidiQ8BJD1.
OMAiLKTKPLM.
OrthoDBiEOG7CRTP5.
PhylomeDBiQ8BJD1.
TreeFamiTF328982.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR010600. ITI_HC_C.
IPR013694. VIT.
IPR002035. VWF_A.
[Graphical view]
PfamiPF06668. ITI_HC_C. 1 hit.
PF08487. VIT. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
SMARTiSM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BJD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLLGLCLG LPLFSESQEE ARSWDDTSEQ VVLRVPRQLR LLQRLKTKPL
60 70 80 90 100
MAEFSVKSTI ISRYAFTTVS CRMLNRASED QEAEFQMQIP ESAFITNFTM
110 120 130 140 150
LIGDSVYRGE ITQKDKKSSE SVKDKRNRTS DDNEENGSDM FKASLVIPSK
160 170 180 190 200
DKAAFFLSYE ELLQRRLGKY EHSISVRPQQ LVGRLTVEVD ILERSGITSL
210 220 230 240 250
EVLPLHNSRK KGSGKAEGDV GPPPSTLINQ NETFAKVIFK PTVVQQAKIA
260 270 280 290 300
QNGILGDFIV RYDVEREQNI GDIQVLNGYF VHYFAPKNLP PLPKNVVFVL
310 320 330 340 350
DISASMVGAK LQQTREALVT ILNDLRPQDR FNIIGFSNRI KMWKDHLLPV
360 370 380 390 400
TPDNIRNGKI YMYHLSPTGG TDINGALQAA IKLLNNYVAQ NDIEDRSVSL
410 420 430 440 450
IIFLTDGKPT FGETNTLKIL SNTKEATRGQ ICIFTVGIGD DVDFKLLEKL
460 470 480 490 500
SLENCGLTRR VHEEDKAGAQ LIGFYDEIRT PLLSDIRIDY PPDVVEHATK
510 520 530 540 550
TLFPNYFNGS EIVIAGKMVD KKFDQLHVEV TASNSKKFVI LKRDIPVEFR
560 570 580 590 600
KMGNDVSVTP GSARDGGKDL NHIERLWSYL TVKELLSSWR QSNSEQEKEQ
610 620 630 640 650
LRQKAQDLAL NYHFLTPFTS MKLRKPGLRT NQLEDTYGMS AATGPATVVQ
660 670 680 690 700
NLREAGKQPE PDLKKTYDPR IKISKTSVDG DPHFVVDFPL SKLTVCFNID
710 720 730 740 750
GEPGDILRLV SDHLNSGVTV NGELIGAPAP PNGHKKQRTY FRTITILINR
760 770 780 790 800
PERSYLEITP SRVILDGGDR LVLPCNQSVV VGSRGLEVSV SANANITVVI
810 820 830 840 850
QGNIAFVILI HLYKNPAPFQ RDHLGFYIAN SRGLSDNCHG LLGQFLNQDA
860 870 880 890 900
KLVGAPEEYG KNLSNQPFPR AEGMPEAILK VKGRRVPVVW KQRKIYNGQA
910 920 930 940 950
QVDCWFDRNN AAKLIDGVYK DYLASHPFDT ESALGLSTPR KPETDRPHEE

SV
Length:952
Mass (Da):106,749
Last modified:March 1, 2003 - v1
Checksum:i38168BCBFDF758AE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161E → K in BAE24467 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK140756 mRNA. Translation: BAE24467.1.
AK087428 mRNA. Translation: BAC39871.1.
AK134707 mRNA. Translation: BAE22250.1.
AL772367, AL953853 Genomic DNA. Translation: CAM13913.1.
AL953853, AL772367 Genomic DNA. Translation: CAM26660.1.
BC043314 mRNA. Translation: AAH43314.2.
BC062196 mRNA. Translation: AAH62196.1.
CCDSiCCDS15678.1.
RefSeqiNP_766059.1. NM_172471.2.
UniGeneiMm.313876.

Genome annotation databases

EnsembliENSMUST00000026886; ENSMUSP00000026886; ENSMUSG00000025780.
GeneIDi209378.
KEGGimmu:209378.
UCSCiuc008ihr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK140756 mRNA. Translation: BAE24467.1.
AK087428 mRNA. Translation: BAC39871.1.
AK134707 mRNA. Translation: BAE22250.1.
AL772367, AL953853 Genomic DNA. Translation: CAM13913.1.
AL953853, AL772367 Genomic DNA. Translation: CAM26660.1.
BC043314 mRNA. Translation: AAH43314.2.
BC062196 mRNA. Translation: AAH62196.1.
CCDSiCCDS15678.1.
RefSeqiNP_766059.1. NM_172471.2.
UniGeneiMm.313876.

3D structure databases

ProteinModelPortaliQ8BJD1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026886.

PTM databases

iPTMnetiQ8BJD1.
PhosphoSiteiQ8BJD1.

Proteomic databases

MaxQBiQ8BJD1.
PaxDbiQ8BJD1.
PRIDEiQ8BJD1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026886; ENSMUSP00000026886; ENSMUSG00000025780.
GeneIDi209378.
KEGGimmu:209378.
UCSCiuc008ihr.1. mouse.

Organism-specific databases

CTDi80760.
MGIiMGI:1925751. Itih5.

Phylogenomic databases

eggNOGiENOG410IEJB. Eukaryota.
COG2304. LUCA.
GeneTreeiENSGT00550000074468.
HOGENOMiHOG000000680.
HOVERGENiHBG108012.
InParanoidiQ8BJD1.
OMAiLKTKPLM.
OrthoDBiEOG7CRTP5.
PhylomeDBiQ8BJD1.
TreeFamiTF328982.

Miscellaneous databases

ChiTaRSiItih5. mouse.
PROiQ8BJD1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BJD1.
GenevisibleiQ8BJD1. MM.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR010600. ITI_HC_C.
IPR013694. VIT.
IPR002035. VWF_A.
[Graphical view]
PfamiPF06668. ITI_HC_C. 1 hit.
PF08487. VIT. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
SMARTiSM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye, Head and Medulla oblongata.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiITIH5_MOUSE
AccessioniPrimary (citable) accession number: Q8BJD1
Secondary accession number(s): Q3US68, Q80VG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.