Q8BJ71 (NUP93_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear pore complex protein Nup93

Alternative name(s):
93 kDa nucleoporin
CBP-interacting protein 4
Nucleoporin Nup93

Gene names

Name:	Nup93
Synonyms:	Cip4, Kiaa0095

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	819 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC By similarity.
Subunit structure	Part of the nuclear pore complex (NPC). Component of the p62 complex, a complex composed of NUP62 and NUP54. Forms a complex with NUP53, NUP155, NUP205 and lamin B; the interaction with NUP53 is direct. Does not interact with TPR By similarity.
Subcellular location	Nucleus membrane; Peripheral membrane protein By similarity. Nucleus › nuclear pore complex By similarity. Note: Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore By similarity.
Sequence similarities	Belongs to the nucleoporin interacting component (NIC) family.
Sequence caution	The sequence BAC97865.2 differs from that shown. Reason: Frameshift at positions 418 and 784.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport mRNA transport
Cellular component	Membrane Nuclear pore complex Nucleus
Coding sequence diversity	Alternative splicing
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mRNA transport Inferred from electronic annotation. Source: UniProtKB-KW nuclear pore complex assembly Inferred from sequence or structural similarity. Source: UniProtKB protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nuclear membrane Inferred from sequence or structural similarity. Source: UniProtKB nuclear periphery Inferred from sequence or structural similarity. Source: UniProtKB nuclear pore Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	structural constituent of nuclear pore Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8BJ71-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8BJ71-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 819	819	Nuclear pore complex protein Nup93		PRO_0000124783
Amino acid modifications
	Modified residue	52	1	Phosphoserine By similarity
	Modified residue	72	1	Phosphoserine By similarity
	Modified residue	75	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 123	123	Missing in isoform 2.		VSP_010089
Experimental info
	Sequence conflict	116	1	E → K in CAD43733. Ref.5
	Sequence conflict	463	1	F → Y in BAC32337. Ref.1
	Sequence conflict	626	1	A → V in AAH23140. Ref.4
	Sequence conflict	816 – 819	4	VLMN → LLSWEVH in BAC32337. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 747EA591189DAFAF	FASTA	819	93,281
	10 20 30 40 50 60 MDTEGFGELL QQAEQLAAET EGISELPHVE RNLQEIQQAG ERLRSRTLTR TSQETADVKA 70 80 90 100 110 120 SVLLGSRGLD ISHISQRLES LSAATTFEPL EPVKDTDIQG FLKNEKDNAL LSAIEESRKR 130 140 150 160 170 180 TFGMAEEYHR ESMLVEWEQV KQRILHTLLA SGEDALDFTQ ESEPSYIGDV NPPGRSSLDS 190 200 210 220 230 240 IEMAYARQIY IYNEKIVSGH LQPNLVDLCA SVAELDDKSI SDMWAMVKQM TDVVLTPATD 250 260 270 280 290 300 ALKSRSSVEV RMDFVKQALG YLEQSYKNYT LVTVFGNLHQ AQLGGVPGTY QLVRSFLNIK 310 320 330 340 350 360 LPAPSPGLQD GEVEGHPVWA LIYYCMRCGD LLAASQVVSR AQHQLGEFKT WFQEYMNSKD 370 380 390 400 410 420 RRLSPATENK LRLHYRRALR NNTDPYKRAV YCIIGRCDIT DNQSEVADKT EDYLWLKLNQ 430 440 450 460 470 480 VCFDDDGTSS PQDRLTLSQF QKQLLEDYGE SHFTVNQQPF LYFQVLFLTA QFEAAIAFLF 490 500 510 520 530 540 RMERLRCHAV HVALVLFELK LLLKSSGQSA QLLSHEPGDP PCMRRLNFVR LLMLYTRKFE 550 560 570 580 590 600 STDPREALQY FYFLRDEKDS QGENMFLRCV SELVIESREF DMILGKLEND GSRKPGVIDK 610 620 630 640 650 660 FTSDTKPIIN KVASVAENKG LFEEAAKLYD LAKNADKVLE LMNKLLSPVV PQISAPQSNK 670 680 690 700 710 720 ERLKNMALSI AERYRAQGIS ANKFVDSTFY LLLDLITFFD EYHSGHIDRA FDIIDRLKLV 730 740 750 760 770 780 PLNQESVEER VAAFRNFSDE IRHNLSEVLL ATMNILFTQF KRLKGTSPSS ATRPQRVIED 790 800 810 RDSQLRSQAR ALITFAGMIP YRTSGDTNAR LVQMEVLMN
	Isoform 2 [UniParc]. Checksum: 853C96D4637D8586	FASTA	696	79,675
	10 20 30 40 50 60 MAEEYHRESM LVEWEQVKQR ILHTLLASGE DALDFTQESE PSYIGDVNPP GRSSLDSIEM 70 80 90 100 110 120 AYARQIYIYN EKIVSGHLQP NLVDLCASVA ELDDKSISDM WAMVKQMTDV VLTPATDALK 130 140 150 160 170 180 SRSSVEVRMD FVKQALGYLE QSYKNYTLVT VFGNLHQAQL GGVPGTYQLV RSFLNIKLPA 190 200 210 220 230 240 PSPGLQDGEV EGHPVWALIY YCMRCGDLLA ASQVVSRAQH QLGEFKTWFQ EYMNSKDRRL 250 260 270 280 290 300 SPATENKLRL HYRRALRNNT DPYKRAVYCI IGRCDITDNQ SEVADKTEDY LWLKLNQVCF 310 320 330 340 350 360 DDDGTSSPQD RLTLSQFQKQ LLEDYGESHF TVNQQPFLYF QVLFLTAQFE AAIAFLFRME 370 380 390 400 410 420 RLRCHAVHVA LVLFELKLLL KSSGQSAQLL SHEPGDPPCM RRLNFVRLLM LYTRKFESTD 430 440 450 460 470 480 PREALQYFYF LRDEKDSQGE NMFLRCVSEL VIESREFDMI LGKLENDGSR KPGVIDKFTS 490 500 510 520 530 540 DTKPIINKVA SVAENKGLFE EAAKLYDLAK NADKVLELMN KLLSPVVPQI SAPQSNKERL 550 560 570 580 590 600 KNMALSIAER YRAQGISANK FVDSTFYLLL DLITFFDEYH SGHIDRAFDI IDRLKLVPLN 610 620 630 640 650 660 QESVEERVAA FRNFSDEIRH NLSEVLLATM NILFTQFKRL KGTSPSSATR PQRVIEDRDS 670 680 690 QLRSQARALI TFAGMIPYRT SGDTNARLVQ MEVLMN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: C57BL/6J and NOD. Tissue: Brain, Skin and Thymus.
[2]	"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H. DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Embryonic tail.
[3]	Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H. Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Mammary tumor.
[5]	"Diverse nuclear proteins compete with SRC1 for interaction with CREB binding protein." Heery D.M., Harries J.C., Kindle K.B., Viskaduraki M., Matsuda S., Sheppard H.M., Davis A. Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 1-163 (ISOFORM 1).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK028864 mRNA. Translation: BAC26158.1. AK045380 mRNA. Translation: BAC32337.1. AK129055 Transcribed RNA. Translation: BAC97865.2. Frameshift. AK167105 mRNA. Translation: BAE39254.1. AK169693 mRNA. Translation: BAE41309.1. BC023140 mRNA. Translation: AAH23140.1. AJ505051 Other RNA. Translation: CAD43733.1.
IPI	IPI00222307. IPI00410800.
RefSeq	NP_765998.1. NM_172410.2.
UniGene	Mm.458170.
3D structure databases
ProteinModelPortal	Q8BJ71.
SMR	Q8BJ71. Positions 177-816.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8BJ71. 2 interactions.
STRING	10090.ENSMUSP00000078878.
PTM databases
PhosphoSite	Q8BJ71.
2D gel databases
REPRODUCTION-2DPAGE	IPI00222307. IPI00410800.
Proteomic databases
PaxDb	Q8BJ71.
PRIDE	Q8BJ71.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000079961; ENSMUSP00000078878; ENSMUSG00000032939. ENSMUST00000109547; ENSMUSP00000105174; ENSMUSG00000032939.
GeneID	71805.
KEGG	mmu:71805.
UCSC	uc009mvz.1. mouse. uc009mwb.1. mouse.
Organism-specific databases
CTD	9688.
MGI	MGI:1919055. Nup93.
Rouge	Search...
Phylogenomic databases
eggNOG	NOG312233.
GeneTree	ENSGT00390000016353.
HOGENOM	HOG000007350.
HOVERGEN	HBG052701.
InParanoid	Q8BJ71.
KO	K14309.
OMA	IAFLFRM.
OrthoDB	EOG4BRWK4.
Gene expression databases
Bgee	Q8BJ71.
CleanEx	MM_NUP93.
Genevestigator	Q8BJ71.
GermOnline	ENSMUSG00000032939. Mus musculus.
Family and domain databases
InterPro	IPR007231. Nucleoporin_int_Nup93/Nic96. [Graphical view]
PANTHER	PTHR11225. PTHR11225. 1 hit.
Pfam	PF04097. Nic96. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NUP93. mouse.
NextBio	334568.
SOURCE	Search...

Entry information

Entry name

NUP93_MOUSE

Accession

Primary (citable) accession number: Q8BJ71
Secondary accession number(s): Q3TED9 , Q8BIK7, Q8K1R4, Q8R592

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program