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Q8BJ71

- NUP93_MOUSE

UniProt

Q8BJ71 - NUP93_MOUSE

Protein

Nuclear pore complex protein Nup93

Gene

Nup93

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC By similarity.By similarity

    GO - Molecular functioni

    1. structural constituent of nuclear pore Source: UniProtKB

    GO - Biological processi

    1. mRNA transport Source: UniProtKB-KW
    2. nuclear pore complex assembly Source: UniProtKB
    3. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    mRNA transport, Protein transport, Translocation, Transport

    Enzyme and pathway databases

    ReactomeiREACT_196650. Nuclear Pore Complex (NPC) Disassembly.
    REACT_204192. Regulation of Glucokinase by Glucokinase Regulatory Protein.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear pore complex protein Nup93
    Alternative name(s):
    93 kDa nucleoporin
    CBP-interacting protein 4
    Nucleoporin Nup93
    Gene namesi
    Name:Nup93
    Synonyms:Cip4, Kiaa0095
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1919055. Nup93.

    Subcellular locationi

    Nucleus membrane By similarity; Peripheral membrane protein By similarity. Nucleusnuclear pore complex By similarity
    Note: Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore.By similarity

    GO - Cellular componenti

    1. nuclear membrane Source: UniProtKB
    2. nuclear periphery Source: UniProtKB
    3. nuclear pore Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Nuclear pore complex, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 819819Nuclear pore complex protein Nup93PRO_0000124783Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei52 – 521PhosphoserineBy similarity
    Modified residuei72 – 721PhosphoserineBy similarity
    Modified residuei75 – 751PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8BJ71.
    PaxDbiQ8BJ71.
    PRIDEiQ8BJ71.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00222307.
    IPI00410800.

    PTM databases

    PhosphoSiteiQ8BJ71.

    Expressioni

    Gene expression databases

    BgeeiQ8BJ71.
    CleanExiMM_NUP93.
    GenevestigatoriQ8BJ71.

    Interactioni

    Subunit structurei

    Part of the nuclear pore complex (NPC). Component of the p62 complex, a complex composed of NUP62 and NUP54. Forms a complex with NUP53, NUP155, NUP205 and lamin B; the interaction with NUP53 is direct. Does not interact with TPR By similarity.By similarity

    Protein-protein interaction databases

    BioGridi214942. 3 interactions.
    IntActiQ8BJ71. 3 interactions.
    MINTiMINT-4104375.
    STRINGi10090.ENSMUSP00000078878.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BJ71.
    SMRiQ8BJ71. Positions 252-814.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG312233.
    GeneTreeiENSGT00390000016353.
    HOGENOMiHOG000007350.
    HOVERGENiHBG052701.
    InParanoidiQ8BJ71.
    KOiK14309.
    OMAiKFEITDP.
    OrthoDBiEOG73JKTW.
    PhylomeDBiQ8BJ71.
    TreeFamiTF315118.

    Family and domain databases

    InterProiIPR007231. Nucleoporin_int_Nup93/Nic96.
    [Graphical view]
    PANTHERiPTHR11225. PTHR11225. 1 hit.
    PfamiPF04097. Nic96. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8BJ71-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDTEGFGELL QQAEQLAAET EGISELPHVE RNLQEIQQAG ERLRSRTLTR    50
    TSQETADVKA SVLLGSRGLD ISHISQRLES LSAATTFEPL EPVKDTDIQG 100
    FLKNEKDNAL LSAIEESRKR TFGMAEEYHR ESMLVEWEQV KQRILHTLLA 150
    SGEDALDFTQ ESEPSYIGDV NPPGRSSLDS IEMAYARQIY IYNEKIVSGH 200
    LQPNLVDLCA SVAELDDKSI SDMWAMVKQM TDVVLTPATD ALKSRSSVEV 250
    RMDFVKQALG YLEQSYKNYT LVTVFGNLHQ AQLGGVPGTY QLVRSFLNIK 300
    LPAPSPGLQD GEVEGHPVWA LIYYCMRCGD LLAASQVVSR AQHQLGEFKT 350
    WFQEYMNSKD RRLSPATENK LRLHYRRALR NNTDPYKRAV YCIIGRCDIT 400
    DNQSEVADKT EDYLWLKLNQ VCFDDDGTSS PQDRLTLSQF QKQLLEDYGE 450
    SHFTVNQQPF LYFQVLFLTA QFEAAIAFLF RMERLRCHAV HVALVLFELK 500
    LLLKSSGQSA QLLSHEPGDP PCMRRLNFVR LLMLYTRKFE STDPREALQY 550
    FYFLRDEKDS QGENMFLRCV SELVIESREF DMILGKLEND GSRKPGVIDK 600
    FTSDTKPIIN KVASVAENKG LFEEAAKLYD LAKNADKVLE LMNKLLSPVV 650
    PQISAPQSNK ERLKNMALSI AERYRAQGIS ANKFVDSTFY LLLDLITFFD 700
    EYHSGHIDRA FDIIDRLKLV PLNQESVEER VAAFRNFSDE IRHNLSEVLL 750
    ATMNILFTQF KRLKGTSPSS ATRPQRVIED RDSQLRSQAR ALITFAGMIP 800
    YRTSGDTNAR LVQMEVLMN 819
    Length:819
    Mass (Da):93,281
    Last modified:March 1, 2003 - v1
    Checksum:i747EA591189DAFAF
    GO
    Isoform 2 (identifier: Q8BJ71-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-123: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:696
    Mass (Da):79,675
    Checksum:i853C96D4637D8586
    GO

    Sequence cautioni

    The sequence BAC97865.2 differs from that shown. Reason: Frameshift at positions 418 and 784.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti116 – 1161E → K in CAD43733. 1 PublicationCurated
    Sequence conflicti463 – 4631F → Y in BAC32337. (PubMed:16141072)Curated
    Sequence conflicti626 – 6261A → V in AAH23140. (PubMed:15489334)Curated
    Sequence conflicti816 – 8194VLMN → LLSWEVH in BAC32337. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 123123Missing in isoform 2. 1 PublicationVSP_010089Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK028864 mRNA. Translation: BAC26158.1.
    AK045380 mRNA. Translation: BAC32337.1.
    AK129055 Transcribed RNA. Translation: BAC97865.2. Frameshift.
    AK167105 mRNA. Translation: BAE39254.1.
    AK169693 mRNA. Translation: BAE41309.1.
    BC023140 mRNA. Translation: AAH23140.1.
    AJ505051 Other RNA. Translation: CAD43733.1.
    CCDSiCCDS22540.1. [Q8BJ71-1]
    RefSeqiNP_765998.1. NM_172410.2. [Q8BJ71-1]
    XP_006531437.1. XM_006531374.1. [Q8BJ71-1]
    XP_006531438.1. XM_006531375.1. [Q8BJ71-2]
    XP_006531439.1. XM_006531376.1. [Q8BJ71-2]
    UniGeneiMm.458170.

    Genome annotation databases

    EnsembliENSMUST00000079961; ENSMUSP00000078878; ENSMUSG00000032939. [Q8BJ71-1]
    ENSMUST00000109547; ENSMUSP00000105174; ENSMUSG00000032939. [Q8BJ71-1]
    GeneIDi71805.
    KEGGimmu:71805.
    UCSCiuc009mvz.1. mouse. [Q8BJ71-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK028864 mRNA. Translation: BAC26158.1 .
    AK045380 mRNA. Translation: BAC32337.1 .
    AK129055 Transcribed RNA. Translation: BAC97865.2 . Frameshift.
    AK167105 mRNA. Translation: BAE39254.1 .
    AK169693 mRNA. Translation: BAE41309.1 .
    BC023140 mRNA. Translation: AAH23140.1 .
    AJ505051 Other RNA. Translation: CAD43733.1 .
    CCDSi CCDS22540.1. [Q8BJ71-1 ]
    RefSeqi NP_765998.1. NM_172410.2. [Q8BJ71-1 ]
    XP_006531437.1. XM_006531374.1. [Q8BJ71-1 ]
    XP_006531438.1. XM_006531375.1. [Q8BJ71-2 ]
    XP_006531439.1. XM_006531376.1. [Q8BJ71-2 ]
    UniGenei Mm.458170.

    3D structure databases

    ProteinModelPortali Q8BJ71.
    SMRi Q8BJ71. Positions 252-814.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 214942. 3 interactions.
    IntActi Q8BJ71. 3 interactions.
    MINTi MINT-4104375.
    STRINGi 10090.ENSMUSP00000078878.

    PTM databases

    PhosphoSitei Q8BJ71.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00222307.
    IPI00410800.

    Proteomic databases

    MaxQBi Q8BJ71.
    PaxDbi Q8BJ71.
    PRIDEi Q8BJ71.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000079961 ; ENSMUSP00000078878 ; ENSMUSG00000032939 . [Q8BJ71-1 ]
    ENSMUST00000109547 ; ENSMUSP00000105174 ; ENSMUSG00000032939 . [Q8BJ71-1 ]
    GeneIDi 71805.
    KEGGi mmu:71805.
    UCSCi uc009mvz.1. mouse. [Q8BJ71-1 ]

    Organism-specific databases

    CTDi 9688.
    MGIi MGI:1919055. Nup93.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG312233.
    GeneTreei ENSGT00390000016353.
    HOGENOMi HOG000007350.
    HOVERGENi HBG052701.
    InParanoidi Q8BJ71.
    KOi K14309.
    OMAi KFEITDP.
    OrthoDBi EOG73JKTW.
    PhylomeDBi Q8BJ71.
    TreeFami TF315118.

    Enzyme and pathway databases

    Reactomei REACT_196650. Nuclear Pore Complex (NPC) Disassembly.
    REACT_204192. Regulation of Glucokinase by Glucokinase Regulatory Protein.

    Miscellaneous databases

    ChiTaRSi NUP93. mouse.
    NextBioi 334568.
    PROi Q8BJ71.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BJ71.
    CleanExi MM_NUP93.
    Genevestigatori Q8BJ71.

    Family and domain databases

    InterProi IPR007231. Nucleoporin_int_Nup93/Nic96.
    [Graphical view ]
    PANTHERi PTHR11225. PTHR11225. 1 hit.
    Pfami PF04097. Nic96. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J and NOD.
      Tissue: Brain, Skin and Thymus.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Embryonic tail.
    3. Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H.
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Mammary tumor.
    5. "Diverse nuclear proteins compete with SRC1 for interaction with CREB binding protein."
      Heery D.M., Harries J.C., Kindle K.B., Viskaduraki M., Matsuda S., Sheppard H.M., Davis A.
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 1-163 (ISOFORM 1).

    Entry informationi

    Entry nameiNUP93_MOUSE
    AccessioniPrimary (citable) accession number: Q8BJ71
    Secondary accession number(s): Q3TED9
    , Q8BIK7, Q8K1R4, Q8R592
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3