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Q8BJ71 (NUP93_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nuclear pore complex protein Nup93
Alternative name(s):
93 kDa nucleoporin
CBP-interacting protein 4
Nucleoporin Nup93
Gene names
Name:Nup93
Synonyms:Cip4, Kiaa0095
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length819 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC By similarity.

Subunit structure

Part of the nuclear pore complex (NPC). Component of the p62 complex, a complex composed of NUP62 and NUP54. Forms a complex with NUP53, NUP155, NUP205 and lamin B; the interaction with NUP53 is direct. Does not interact with TPR By similarity.

Subcellular location

Nucleus membrane; Peripheral membrane protein By similarity. Nucleusnuclear pore complex By similarity. Note: Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore By similarity.

Sequence similarities

Belongs to the nucleoporin interacting component (NIC) family.

Sequence caution

The sequence BAC97865.2 differs from that shown. Reason: Frameshift at positions 418 and 784.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8BJ71-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8BJ71-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 819819Nuclear pore complex protein Nup93
PRO_0000124783

Amino acid modifications

Modified residue521Phosphoserine By similarity
Modified residue721Phosphoserine By similarity
Modified residue751Phosphoserine By similarity

Natural variations

Alternative sequence1 – 123123Missing in isoform 2.
VSP_010089

Experimental info

Sequence conflict1161E → K in CAD43733. Ref.5
Sequence conflict4631F → Y in BAC32337. Ref.1
Sequence conflict6261A → V in AAH23140. Ref.4
Sequence conflict816 – 8194VLMN → LLSWEVH in BAC32337. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 747EA591189DAFAF

FASTA81993,281
        10         20         30         40         50         60 
MDTEGFGELL QQAEQLAAET EGISELPHVE RNLQEIQQAG ERLRSRTLTR TSQETADVKA 

        70         80         90        100        110        120 
SVLLGSRGLD ISHISQRLES LSAATTFEPL EPVKDTDIQG FLKNEKDNAL LSAIEESRKR 

       130        140        150        160        170        180 
TFGMAEEYHR ESMLVEWEQV KQRILHTLLA SGEDALDFTQ ESEPSYIGDV NPPGRSSLDS 

       190        200        210        220        230        240 
IEMAYARQIY IYNEKIVSGH LQPNLVDLCA SVAELDDKSI SDMWAMVKQM TDVVLTPATD 

       250        260        270        280        290        300 
ALKSRSSVEV RMDFVKQALG YLEQSYKNYT LVTVFGNLHQ AQLGGVPGTY QLVRSFLNIK 

       310        320        330        340        350        360 
LPAPSPGLQD GEVEGHPVWA LIYYCMRCGD LLAASQVVSR AQHQLGEFKT WFQEYMNSKD 

       370        380        390        400        410        420 
RRLSPATENK LRLHYRRALR NNTDPYKRAV YCIIGRCDIT DNQSEVADKT EDYLWLKLNQ 

       430        440        450        460        470        480 
VCFDDDGTSS PQDRLTLSQF QKQLLEDYGE SHFTVNQQPF LYFQVLFLTA QFEAAIAFLF 

       490        500        510        520        530        540 
RMERLRCHAV HVALVLFELK LLLKSSGQSA QLLSHEPGDP PCMRRLNFVR LLMLYTRKFE 

       550        560        570        580        590        600 
STDPREALQY FYFLRDEKDS QGENMFLRCV SELVIESREF DMILGKLEND GSRKPGVIDK 

       610        620        630        640        650        660 
FTSDTKPIIN KVASVAENKG LFEEAAKLYD LAKNADKVLE LMNKLLSPVV PQISAPQSNK 

       670        680        690        700        710        720 
ERLKNMALSI AERYRAQGIS ANKFVDSTFY LLLDLITFFD EYHSGHIDRA FDIIDRLKLV 

       730        740        750        760        770        780 
PLNQESVEER VAAFRNFSDE IRHNLSEVLL ATMNILFTQF KRLKGTSPSS ATRPQRVIED 

       790        800        810 
RDSQLRSQAR ALITFAGMIP YRTSGDTNAR LVQMEVLMN 

« Hide

Isoform 2 [UniParc].

Checksum: 853C96D4637D8586
Show »

FASTA69679,675

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J and NOD.
Tissue: Brain, Skin and Thymus.
[2]"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Embryonic tail.
[3]Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H.
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Mammary tumor.
[5]"Diverse nuclear proteins compete with SRC1 for interaction with CREB binding protein."
Heery D.M., Harries J.C., Kindle K.B., Viskaduraki M., Matsuda S., Sheppard H.M., Davis A.
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE OF 1-163 (ISOFORM 1).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK028864 mRNA. Translation: BAC26158.1.
AK045380 mRNA. Translation: BAC32337.1.
AK129055 Transcribed RNA. Translation: BAC97865.2. Frameshift.
AK167105 mRNA. Translation: BAE39254.1.
AK169693 mRNA. Translation: BAE41309.1.
BC023140 mRNA. Translation: AAH23140.1.
AJ505051 Other RNA. Translation: CAD43733.1.
CCDSCCDS22540.1. [Q8BJ71-1]
RefSeqNP_765998.1. NM_172410.2. [Q8BJ71-1]
XP_006531437.1. XM_006531374.1. [Q8BJ71-1]
XP_006531438.1. XM_006531375.1. [Q8BJ71-2]
XP_006531439.1. XM_006531376.1. [Q8BJ71-2]
UniGeneMm.458170.

3D structure databases

ProteinModelPortalQ8BJ71.
SMRQ8BJ71. Positions 252-814.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid214942. 3 interactions.
IntActQ8BJ71. 3 interactions.
MINTMINT-4104375.
STRING10090.ENSMUSP00000078878.

PTM databases

PhosphoSiteQ8BJ71.

2D gel databases

REPRODUCTION-2DPAGEIPI00222307.
IPI00410800.

Proteomic databases

MaxQBQ8BJ71.
PaxDbQ8BJ71.
PRIDEQ8BJ71.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000079961; ENSMUSP00000078878; ENSMUSG00000032939. [Q8BJ71-1]
ENSMUST00000109547; ENSMUSP00000105174; ENSMUSG00000032939. [Q8BJ71-1]
GeneID71805.
KEGGmmu:71805.
UCSCuc009mvz.1. mouse. [Q8BJ71-1]

Organism-specific databases

CTD9688.
MGIMGI:1919055. Nup93.
RougeSearch...

Phylogenomic databases

eggNOGNOG312233.
GeneTreeENSGT00390000016353.
HOGENOMHOG000007350.
HOVERGENHBG052701.
InParanoidQ8BJ71.
KOK14309.
OMAKFEITDP.
OrthoDBEOG73JKTW.
PhylomeDBQ8BJ71.
TreeFamTF315118.

Gene expression databases

BgeeQ8BJ71.
CleanExMM_NUP93.
GenevestigatorQ8BJ71.

Family and domain databases

InterProIPR007231. Nucleoporin_int_Nup93/Nic96.
[Graphical view]
PANTHERPTHR11225. PTHR11225. 1 hit.
PfamPF04097. Nic96. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNUP93. mouse.
NextBio334568.
PROQ8BJ71.
SOURCESearch...

Entry information

Entry nameNUP93_MOUSE
AccessionPrimary (citable) accession number: Q8BJ71
Secondary accession number(s): Q3TED9 expand/collapse secondary AC list , Q8BIK7, Q8K1R4, Q8R592
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot