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Protein

Nuclear pore complex protein Nup93

Gene

Nup93

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_272921. Regulation of HSF1-mediated heat shock response.
REACT_280637. Transcriptional regulation by small RNAs.
REACT_329153. Nuclear Pore Complex (NPC) Disassembly.
REACT_341634. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_360954. SUMOylation of DNA damage response and repair proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore complex protein Nup93
Alternative name(s):
93 kDa nucleoporin
CBP-interacting protein 4
Nucleoporin Nup93
Gene namesi
Name:Nup93
Synonyms:Cip4, Kiaa0095
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1919055. Nup93.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 819819Nuclear pore complex protein Nup93PRO_0000124783Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei52 – 521PhosphoserineBy similarity
Modified residuei72 – 721PhosphoserineBy similarity
Modified residuei75 – 751PhosphoserineBy similarity
Modified residuei80 – 801PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BJ71.
PaxDbiQ8BJ71.
PRIDEiQ8BJ71.

2D gel databases

REPRODUCTION-2DPAGEIPI00222307.
IPI00410800.

PTM databases

PhosphoSiteiQ8BJ71.

Expressioni

Gene expression databases

BgeeiQ8BJ71.
CleanExiMM_NUP93.
GenevisibleiQ8BJ71. MM.

Interactioni

Subunit structurei

Part of the nuclear pore complex (NPC). Component of the p62 complex, a complex composed of NUP62 and NUP54. Forms a complex with NUP53, NUP155, NUP205 and lamin B; the interaction with NUP53 is direct. Does not interact with TPR (By similarity).By similarity

Protein-protein interaction databases

BioGridi214942. 4 interactions.
IntActiQ8BJ71. 3 interactions.
MINTiMINT-4104375.
STRINGi10090.ENSMUSP00000078878.

Structurei

3D structure databases

ProteinModelPortaliQ8BJ71.
SMRiQ8BJ71. Positions 176-816.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG312233.
GeneTreeiENSGT00390000016353.
HOGENOMiHOG000007350.
HOVERGENiHBG052701.
InParanoidiQ8BJ71.
KOiK14309.
OMAiPHFPPLQ.
OrthoDBiEOG73JKTW.
PhylomeDBiQ8BJ71.
TreeFamiTF315118.

Family and domain databases

InterProiIPR007231. Nucleoporin_int_Nup93/Nic96.
[Graphical view]
PANTHERiPTHR11225. PTHR11225. 1 hit.
PfamiPF04097. Nic96. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BJ71-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTEGFGELL QQAEQLAAET EGISELPHVE RNLQEIQQAG ERLRSRTLTR
60 70 80 90 100
TSQETADVKA SVLLGSRGLD ISHISQRLES LSAATTFEPL EPVKDTDIQG
110 120 130 140 150
FLKNEKDNAL LSAIEESRKR TFGMAEEYHR ESMLVEWEQV KQRILHTLLA
160 170 180 190 200
SGEDALDFTQ ESEPSYIGDV NPPGRSSLDS IEMAYARQIY IYNEKIVSGH
210 220 230 240 250
LQPNLVDLCA SVAELDDKSI SDMWAMVKQM TDVVLTPATD ALKSRSSVEV
260 270 280 290 300
RMDFVKQALG YLEQSYKNYT LVTVFGNLHQ AQLGGVPGTY QLVRSFLNIK
310 320 330 340 350
LPAPSPGLQD GEVEGHPVWA LIYYCMRCGD LLAASQVVSR AQHQLGEFKT
360 370 380 390 400
WFQEYMNSKD RRLSPATENK LRLHYRRALR NNTDPYKRAV YCIIGRCDIT
410 420 430 440 450
DNQSEVADKT EDYLWLKLNQ VCFDDDGTSS PQDRLTLSQF QKQLLEDYGE
460 470 480 490 500
SHFTVNQQPF LYFQVLFLTA QFEAAIAFLF RMERLRCHAV HVALVLFELK
510 520 530 540 550
LLLKSSGQSA QLLSHEPGDP PCMRRLNFVR LLMLYTRKFE STDPREALQY
560 570 580 590 600
FYFLRDEKDS QGENMFLRCV SELVIESREF DMILGKLEND GSRKPGVIDK
610 620 630 640 650
FTSDTKPIIN KVASVAENKG LFEEAAKLYD LAKNADKVLE LMNKLLSPVV
660 670 680 690 700
PQISAPQSNK ERLKNMALSI AERYRAQGIS ANKFVDSTFY LLLDLITFFD
710 720 730 740 750
EYHSGHIDRA FDIIDRLKLV PLNQESVEER VAAFRNFSDE IRHNLSEVLL
760 770 780 790 800
ATMNILFTQF KRLKGTSPSS ATRPQRVIED RDSQLRSQAR ALITFAGMIP
810
YRTSGDTNAR LVQMEVLMN
Length:819
Mass (Da):93,281
Last modified:March 1, 2003 - v1
Checksum:i747EA591189DAFAF
GO
Isoform 2 (identifier: Q8BJ71-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Note: No experimental confirmation available.
Show »
Length:696
Mass (Da):79,675
Checksum:i853C96D4637D8586
GO

Sequence cautioni

The sequence BAC97865.2 differs from that shown. Reason: Frameshift at positions 418 and 784. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti116 – 1161E → K in CAD43733 (Ref. 5) Curated
Sequence conflicti463 – 4631F → Y in BAC32337 (PubMed:16141072).Curated
Sequence conflicti626 – 6261A → V in AAH23140 (PubMed:15489334).Curated
Sequence conflicti816 – 8194VLMN → LLSWEVH in BAC32337 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 123123Missing in isoform 2. 1 PublicationVSP_010089Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028864 mRNA. Translation: BAC26158.1.
AK045380 mRNA. Translation: BAC32337.1.
AK129055 Transcribed RNA. Translation: BAC97865.2. Frameshift.
AK167105 mRNA. Translation: BAE39254.1.
AK169693 mRNA. Translation: BAE41309.1.
BC023140 mRNA. Translation: AAH23140.1.
AJ505051 Other RNA. Translation: CAD43733.1.
CCDSiCCDS22540.1. [Q8BJ71-1]
RefSeqiNP_765998.1. NM_172410.2. [Q8BJ71-1]
XP_006531437.1. XM_006531374.2. [Q8BJ71-1]
XP_006531438.1. XM_006531375.2. [Q8BJ71-2]
XP_006531439.1. XM_006531376.2. [Q8BJ71-2]
UniGeneiMm.458170.

Genome annotation databases

EnsembliENSMUST00000079961; ENSMUSP00000078878; ENSMUSG00000032939. [Q8BJ71-1]
ENSMUST00000109547; ENSMUSP00000105174; ENSMUSG00000032939. [Q8BJ71-1]
GeneIDi71805.
KEGGimmu:71805.
UCSCiuc009mvz.1. mouse. [Q8BJ71-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028864 mRNA. Translation: BAC26158.1.
AK045380 mRNA. Translation: BAC32337.1.
AK129055 Transcribed RNA. Translation: BAC97865.2. Frameshift.
AK167105 mRNA. Translation: BAE39254.1.
AK169693 mRNA. Translation: BAE41309.1.
BC023140 mRNA. Translation: AAH23140.1.
AJ505051 Other RNA. Translation: CAD43733.1.
CCDSiCCDS22540.1. [Q8BJ71-1]
RefSeqiNP_765998.1. NM_172410.2. [Q8BJ71-1]
XP_006531437.1. XM_006531374.2. [Q8BJ71-1]
XP_006531438.1. XM_006531375.2. [Q8BJ71-2]
XP_006531439.1. XM_006531376.2. [Q8BJ71-2]
UniGeneiMm.458170.

3D structure databases

ProteinModelPortaliQ8BJ71.
SMRiQ8BJ71. Positions 176-816.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214942. 4 interactions.
IntActiQ8BJ71. 3 interactions.
MINTiMINT-4104375.
STRINGi10090.ENSMUSP00000078878.

PTM databases

PhosphoSiteiQ8BJ71.

2D gel databases

REPRODUCTION-2DPAGEIPI00222307.
IPI00410800.

Proteomic databases

MaxQBiQ8BJ71.
PaxDbiQ8BJ71.
PRIDEiQ8BJ71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079961; ENSMUSP00000078878; ENSMUSG00000032939. [Q8BJ71-1]
ENSMUST00000109547; ENSMUSP00000105174; ENSMUSG00000032939. [Q8BJ71-1]
GeneIDi71805.
KEGGimmu:71805.
UCSCiuc009mvz.1. mouse. [Q8BJ71-1]

Organism-specific databases

CTDi9688.
MGIiMGI:1919055. Nup93.
RougeiSearch...

Phylogenomic databases

eggNOGiNOG312233.
GeneTreeiENSGT00390000016353.
HOGENOMiHOG000007350.
HOVERGENiHBG052701.
InParanoidiQ8BJ71.
KOiK14309.
OMAiPHFPPLQ.
OrthoDBiEOG73JKTW.
PhylomeDBiQ8BJ71.
TreeFamiTF315118.

Enzyme and pathway databases

ReactomeiREACT_272921. Regulation of HSF1-mediated heat shock response.
REACT_280637. Transcriptional regulation by small RNAs.
REACT_329153. Nuclear Pore Complex (NPC) Disassembly.
REACT_341634. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_360954. SUMOylation of DNA damage response and repair proteins.

Miscellaneous databases

ChiTaRSiNup93. mouse.
NextBioi334568.
PROiQ8BJ71.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BJ71.
CleanExiMM_NUP93.
GenevisibleiQ8BJ71. MM.

Family and domain databases

InterProiIPR007231. Nucleoporin_int_Nup93/Nic96.
[Graphical view]
PANTHERiPTHR11225. PTHR11225. 1 hit.
PfamiPF04097. Nic96. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Brain, Skin and Thymus.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryonic tail.
  3. Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Mammary tumor.
  5. "Diverse nuclear proteins compete with SRC1 for interaction with CREB binding protein."
    Heery D.M., Harries J.C., Kindle K.B., Viskaduraki M., Matsuda S., Sheppard H.M., Davis A.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 1-163 (ISOFORM 1).

Entry informationi

Entry nameiNUP93_MOUSE
AccessioniPrimary (citable) accession number: Q8BJ71
Secondary accession number(s): Q3TED9
, Q8BIK7, Q8K1R4, Q8R592
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2003
Last modified: June 24, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.