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Protein

Nuclear pore complex protein Nup93

Gene

Nup93

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC (By similarity). During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (By similarity) (PubMed:26878725).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-MMU-191859 snRNP Assembly
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-3301854 Nuclear Pore Complex (NPC) Disassembly
R-MMU-3371453 Regulation of HSF1-mediated heat shock response
R-MMU-4551638 SUMOylation of chromatin organization proteins
R-MMU-4615885 SUMOylation of DNA replication proteins
R-MMU-5578749 Transcriptional regulation by small RNAs

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore complex protein Nup93
Alternative name(s):
93 kDa nucleoporin
CBP-interacting protein 4
Nucleoporin Nup93
Gene namesi
Name:Nup93
Synonyms:Cip4, Kiaa0095
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1919055 Nup93

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001247831 – 819Nuclear pore complex protein Nup93Add BLAST819

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphothreonineBy similarity1
Modified residuei52PhosphoserineBy similarity1
Modified residuei66PhosphoserineBy similarity1
Modified residuei72PhosphoserineBy similarity1
Modified residuei75PhosphoserineBy similarity1
Modified residuei80PhosphoserineBy similarity1
Modified residuei430PhosphoserineBy similarity1
Modified residuei767PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BJ71
PaxDbiQ8BJ71
PeptideAtlasiQ8BJ71
PRIDEiQ8BJ71

2D gel databases

REPRODUCTION-2DPAGEIPI00222307
IPI00410800

PTM databases

iPTMnetiQ8BJ71
PhosphoSitePlusiQ8BJ71
SwissPalmiQ8BJ71

Expressioni

Gene expression databases

BgeeiENSMUSG00000032939
CleanExiMM_NUP93
ExpressionAtlasiQ8BJ71 baseline and differential
GenevisibleiQ8BJ71 MM

Interactioni

Subunit structurei

Part of the nuclear pore complex (NPC). Component of the p62 complex, a complex composed of NUP62 and NUP54. Forms a complex with NUP35, NUP155, NUP205 and lamin B; the interaction with NUP35 is direct. Does not interact with TPR. Interacts with SMAD4 and IPO7; translocates SMAD4 to the nucleus through the NPC upon BMP7 stimulation resulting in activation of SMAD4 signaling.By similarity

Protein-protein interaction databases

BioGridi214942, 8 interactors
IntActiQ8BJ71, 3 interactors
MINTiQ8BJ71
STRINGi10090.ENSMUSP00000078878

Structurei

3D structure databases

ProteinModelPortaliQ8BJ71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2168 Eukaryota
ENOG410XPN3 LUCA
GeneTreeiENSGT00390000016353
HOGENOMiHOG000007350
HOVERGENiHBG052701
InParanoidiQ8BJ71
KOiK14309
OMAiIAFLFRM
OrthoDBiEOG091G02T1
PhylomeDBiQ8BJ71
TreeFamiTF315118

Family and domain databases

InterProiView protein in InterPro
IPR007231 Nucleoporin_int_Nup93/Nic96
PANTHERiPTHR11225 PTHR11225, 1 hit
PfamiView protein in Pfam
PF04097 Nic96, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BJ71-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTEGFGELL QQAEQLAAET EGISELPHVE RNLQEIQQAG ERLRSRTLTR
60 70 80 90 100
TSQETADVKA SVLLGSRGLD ISHISQRLES LSAATTFEPL EPVKDTDIQG
110 120 130 140 150
FLKNEKDNAL LSAIEESRKR TFGMAEEYHR ESMLVEWEQV KQRILHTLLA
160 170 180 190 200
SGEDALDFTQ ESEPSYIGDV NPPGRSSLDS IEMAYARQIY IYNEKIVSGH
210 220 230 240 250
LQPNLVDLCA SVAELDDKSI SDMWAMVKQM TDVVLTPATD ALKSRSSVEV
260 270 280 290 300
RMDFVKQALG YLEQSYKNYT LVTVFGNLHQ AQLGGVPGTY QLVRSFLNIK
310 320 330 340 350
LPAPSPGLQD GEVEGHPVWA LIYYCMRCGD LLAASQVVSR AQHQLGEFKT
360 370 380 390 400
WFQEYMNSKD RRLSPATENK LRLHYRRALR NNTDPYKRAV YCIIGRCDIT
410 420 430 440 450
DNQSEVADKT EDYLWLKLNQ VCFDDDGTSS PQDRLTLSQF QKQLLEDYGE
460 470 480 490 500
SHFTVNQQPF LYFQVLFLTA QFEAAIAFLF RMERLRCHAV HVALVLFELK
510 520 530 540 550
LLLKSSGQSA QLLSHEPGDP PCMRRLNFVR LLMLYTRKFE STDPREALQY
560 570 580 590 600
FYFLRDEKDS QGENMFLRCV SELVIESREF DMILGKLEND GSRKPGVIDK
610 620 630 640 650
FTSDTKPIIN KVASVAENKG LFEEAAKLYD LAKNADKVLE LMNKLLSPVV
660 670 680 690 700
PQISAPQSNK ERLKNMALSI AERYRAQGIS ANKFVDSTFY LLLDLITFFD
710 720 730 740 750
EYHSGHIDRA FDIIDRLKLV PLNQESVEER VAAFRNFSDE IRHNLSEVLL
760 770 780 790 800
ATMNILFTQF KRLKGTSPSS ATRPQRVIED RDSQLRSQAR ALITFAGMIP
810
YRTSGDTNAR LVQMEVLMN
Length:819
Mass (Da):93,281
Last modified:March 1, 2003 - v1
Checksum:i747EA591189DAFAF
GO
Isoform 2 (identifier: Q8BJ71-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Note: No experimental confirmation available.
Show »
Length:696
Mass (Da):79,675
Checksum:i853C96D4637D8586
GO

Sequence cautioni

The sequence BAC97865 differs from that shown. Reason: Frameshift at positions 418 and 784.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116E → K in CAD43733 (Ref. 5) Curated1
Sequence conflicti463F → Y in BAC32337 (PubMed:16141072).Curated1
Sequence conflicti626A → V in AAH23140 (PubMed:15489334).Curated1
Sequence conflicti816 – 819VLMN → LLSWEVH in BAC32337 (PubMed:16141072).Curated4

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0100891 – 123Missing in isoform 2. 1 PublicationAdd BLAST123

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028864 mRNA Translation: BAC26158.1
AK045380 mRNA Translation: BAC32337.1
AK129055 Transcribed RNA Translation: BAC97865.2 Frameshift.
AK167105 mRNA Translation: BAE39254.1
AK169693 mRNA Translation: BAE41309.1
BC023140 mRNA Translation: AAH23140.1
AJ505051 Other RNA Translation: CAD43733.1
CCDSiCCDS22540.1 [Q8BJ71-1]
RefSeqiNP_765998.1, NM_172410.2 [Q8BJ71-1]
XP_006531437.1, XM_006531374.3
XP_006531438.1, XM_006531375.3
XP_006531439.1, XM_006531376.2 [Q8BJ71-2]
UniGeneiMm.458170

Genome annotation databases

EnsembliENSMUST00000079961; ENSMUSP00000078878; ENSMUSG00000032939 [Q8BJ71-1]
ENSMUST00000109547; ENSMUSP00000105174; ENSMUSG00000032939 [Q8BJ71-1]
ENSMUST00000212824; ENSMUSP00000148700; ENSMUSG00000032939 [Q8BJ71-1]
GeneIDi71805
KEGGimmu:71805
UCSCiuc009mvz.1 mouse [Q8BJ71-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNUP93_MOUSE
AccessioniPrimary (citable) accession number: Q8BJ71
Secondary accession number(s): Q3TED9
, Q8BIK7, Q8K1R4, Q8R592
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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