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Protein

Kazal-type serine protease inhibitor domain-containing protein 1

Gene

Kazald1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the proliferation of osteoblasts during bone formation and bone regeneration. Promotes matrix assembly.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Kazal-type serine protease inhibitor domain-containing protein 1
Alternative name(s):
Bone and odontoblast-expressed protein 1
Insulin-like growth factor-binding-related protein 10
Short name:
IGFBP-rP10
Short name:
IGFBP-related protein 10
Insulin-like growth factor-binding-related protein 4
Gene namesi
Name:Kazald1
Synonyms:Bono1, Igfbprp10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2147606 Kazald1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37Sequence analysisAdd BLAST37
ChainiPRO_000001507738 – 313Kazal-type serine protease inhibitor domain-containing protein 1Add BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi142 ↔ 175PROSITE-ProRule annotation
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi200 ↔ 260PROSITE-ProRule annotation
Glycosylationi284N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8BJ66
PRIDEiQ8BJ66

Expressioni

Tissue specificityi

Highly expressed in the spleen. Moderately expressed in the skin, lung and urinary bladder. Weakly expressed in the brain, tongue, esophagus, stomach, large intestine, liver and bone. Expressed in osteoblastic cells during bone regeneration. Expressed in secretory osteoblasts in the tooth.2 Publications

Developmental stagei

At E15 embryos, weakly expressed in osteoblasts within the distal area of the ossification center of the mid-shaft region of the ulna and the radius. At E16 embryos highly expressed in mandible, maxilla, frontal bone and ossification regions of the nasal septum. At E17 embryos expression is localized to developing mandibular and maxillar bones, the frontal bones and in the nasal capsule surrounding the nasopharynx. Expression throughout the developing mandibular bone is found at E15-E17 embryos. Present in periosteum of the humerus at E16.5 (at protein level).2 Publications

Inductioni

Up-regulated during the early phase of the bone regeneration. Up-regulated by BMP2 during osteoblast differentiation.1 Publication

Gene expression databases

BgeeiENSMUSG00000025213
CleanExiMM_KAZALD1
GenevisibleiQ8BJ66 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026234

Structurei

3D structure databases

ProteinModelPortaliQ8BJ66
SMRiQ8BJ66
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 131IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST76
Domaini127 – 177Kazal-likePROSITE-ProRule annotationAdd BLAST51
Domaini179 – 276Ig-like C2-typeAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi60 – 89Cys-richAdd BLAST30
Compositional biasi299 – 308Poly-Glu10

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410IEZ4 Eukaryota
ENOG410Y7A9 LUCA
GeneTreeiENSGT00530000063555
HOGENOMiHOG000261684
HOVERGENiHBG031621
InParanoidiQ8BJ66
OMAiGRCGEQL
OrthoDBiEOG091G0QK5
TreeFamiTF331645

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR000867 IGFBP-like
IPR011390 IGFBP_rP_mac25
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
PANTHERiPTHR14186 PTHR14186, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF00219 IGFBP, 1 hit
PF07648 Kazal_2, 1 hit
PIRSFiPIRSF018239 IGFBP_rP_mac25, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00280 KAZAL, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF48726 SSF48726, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS51465 KAZAL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BJ66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRVFTGLPA NYAAPTLALS LLLPLLLVVW TQLPVSARPS TGPDYLRRGW
60 70 80 90 100
LRLLAEGEGC APCRPEECAA PRGCLAGRVR DACGCCWECA NLEGQLCDLD
110 120 130 140 150
PSANFYGRCG EQLECRLDAG GDLSRGEVPE PLCVCRSQRP LCGSDGRTYA
160 170 180 190 200
QICRLQEAAR ARLDANLTVV HPGPCESEPQ ILSQPHNIWN VTGQDVIFGC
210 220 230 240 250
EVFAYPMASI EWRKDGLDIQ LPGDDPHISV QFRGGPQKFE VTGWLQIQAL
260 270 280 290 300
RPSDEGTYRC LARNALGQAE ASATLTVLTP EQLNATGFSQ LQSRSLFPEE
310
EEEAESEELG DYY
Length:313
Mass (Da):34,272
Last modified:July 27, 2011 - v2
Checksum:iDD1C117EBED4A0FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66 – 67EE → KK in BAC27075 (PubMed:16141072).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030678 mRNA Translation: BAC27075.1
CH466534 Genomic DNA Translation: EDL41948.1
BC115642 mRNA Translation: AAI15643.1
CCDSiCCDS29857.1
RefSeqiNP_849260.2, NM_178929.4
XP_006526629.1, XM_006526566.2
XP_006526630.1, XM_006526567.2
XP_006526631.1, XM_006526568.2
XP_017173531.1, XM_017318042.1
UniGeneiMm.24417

Genome annotation databases

EnsembliENSMUST00000026234; ENSMUSP00000026234; ENSMUSG00000025213
ENSMUST00000111948; ENSMUSP00000107579; ENSMUSG00000025213
GeneIDi107250
KEGGimmu:107250
UCSCiuc008hqs.2 mouse

Similar proteinsi

Entry informationi

Entry nameiKAZD1_MOUSE
AccessioniPrimary (citable) accession number: Q8BJ66
Secondary accession number(s): Q14BR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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