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Protein

Choline dehydrogenase, mitochondrial

Gene

Chdh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.

Cofactori

FADBy similarity

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route).
Proteins known to be involved in this subpathway in this organism are:
  1. Choline dehydrogenase, mitochondrial (Chdh)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route), the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei513Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi44 – 73FADBy similarityAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-MMU-6798163 Choline catabolism
UniPathwayiUPA00529; UER00385

Names & Taxonomyi

Protein namesi
Recommended name:
Choline dehydrogenase, mitochondrial (EC:1.1.99.1)
Short name:
CDH
Short name:
CHD
Gene namesi
Name:Chdh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1860776 Chdh

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Decreased testicular betaine and increased choline and phosphatidylcholine concentrations. Only one of eleven males was able to reproduce, impaired fertility was due to diminished sperm motility.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34MitochondrionBy similarityAdd BLAST34
ChainiPRO_000001233035 – 596Choline dehydrogenase, mitochondrialAdd BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei438N6-succinyllysineCombined sources1
Modified residuei486N6-acetyllysine; alternateCombined sources1
Modified residuei486N6-succinyllysine; alternateCombined sources1
Modified residuei498N6-acetyllysine; alternateCombined sources1
Modified residuei498N6-succinyllysine; alternateCombined sources1
Modified residuei582N6-acetyllysineCombined sources1

Post-translational modificationi

Acetylation of Lys-498 is observed in liver mitochondria from fasted mice but not from fed mice.

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8BJ64
PaxDbiQ8BJ64
PeptideAtlasiQ8BJ64
PRIDEiQ8BJ64

PTM databases

iPTMnetiQ8BJ64
PhosphoSitePlusiQ8BJ64
SwissPalmiQ8BJ64

Expressioni

Gene expression databases

BgeeiENSMUSG00000015970
CleanExiMM_CHDH
GenevisibleiQ8BJ64 MM

Interactioni

Protein-protein interaction databases

IntActiQ8BJ64, 2 interactors
MINTiQ8BJ64
STRINGi10090.ENSMUSP00000065542

Structurei

3D structure databases

ProteinModelPortaliQ8BJ64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1238 Eukaryota
COG2303 LUCA
GeneTreeiENSGT00530000063260
HOGENOMiHOG000139600
HOVERGENiHBG023639
InParanoidiQ8BJ64
KOiK00108
OMAiGWDYAHC
OrthoDBiEOG091G02M7
PhylomeDBiQ8BJ64
TreeFamiTF313911

Family and domain databases

Gene3Di3.50.50.60, 4 hits
4.10.450.10, 2 hits
InterProiView protein in InterPro
IPR011533 BetA
IPR036188 FAD/NAD-bd_sf
IPR027424 Glucose_Oxidase_domain_2
IPR012132 GMC_OxRdtase
IPR000172 GMC_OxRdtase_N
IPR007867 GMC_OxRtase_C
PfamiView protein in Pfam
PF05199 GMC_oxred_C, 1 hit
PF00732 GMC_oxred_N, 1 hit
PIRSFiPIRSF000137 Alcohol_oxidase, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR01810 betA, 1 hit
PROSITEiView protein in PROSITE
PS00623 GMC_OXRED_1, 1 hit
PS00624 GMC_OXRED_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BJ64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWQVLRGWRK GWQSPRGALA WAVQGQPCPP CSRAVASVGK DEYTFVVVGA
60 70 80 90 100
GSAGCVLASR LTEDPNHRVL LLEAGPKDLL MGSKRLQWKI HMPAALVSNL
110 120 130 140 150
CDDKYNWYYH TEPQPGMDSR VLYWPRGRVW GGSSSLNAMV YIRGHAEDYN
160 170 180 190 200
RWHREGAEGW DYAHCLPYFR KAQRHELGAN MYRGGDGPLH VSRGKTNHPL
210 220 230 240 250
HQAFLQAARQ AGYPFTEDMN GFQQEGFGWM DMTVHQGKRW STACAYLHPV
260 270 280 290 300
LSRPNLRAEV QTLVSRVLFE GTRAVGVEYI KDGQRHKAYV SREVILSGGA
310 320 330 340 350
INSPQLLMLS GVGNADDLRK LDIPVVCHLP GVGQNLQDHL EVYVQQACTQ
360 370 380 390 400
PITLHSAQKP LRKVCIGLEW LWSYTGDGAT AHLETGGFIR SRPGVPHPDI
410 420 430 440 450
QFHFLPSQVI DHGRKPTQQE AYQVHVGTMR ATSVGWLKLR SANPRDHPVI
460 470 480 490 500
HPNYLSTETD VEDFRQCVRL SREIFAQEAL APFRGKELQP GSHVQSDKEI
510 520 530 540 550
DAFVRAKADS AYHPSCTCKM GRSSDPTAVV DAQTKVIGVE NLRVVDASIM
560 570 580 590
PSVVSGNLNA PTVMIAEKAA DIIKGHPALE DKNVPVYKPQ TLDTQR
Length:596
Mass (Da):66,415
Last modified:March 1, 2003 - v1
Checksum:iD31F19A0E0DB9587
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4V → A in AAH39186 (PubMed:15489334).Curated1
Sequence conflicti12W → C in AAH39186 (PubMed:15489334).Curated1
Sequence conflicti24Q → R in AAH39186 (PubMed:15489334).Curated1
Sequence conflicti212G → A in BAE37601 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030900 mRNA Translation: BAC27176.1
AK164042 mRNA Translation: BAE37601.1
BC039186 mRNA Translation: AAH39186.1
CCDSiCCDS26892.1
RefSeqiNP_001129712.1, NM_001136240.1
NP_758468.2, NM_172264.2
NP_780552.1, NM_175343.5
UniGeneiMm.259916

Genome annotation databases

EnsembliENSMUST00000067620; ENSMUSP00000065542; ENSMUSG00000015970
ENSMUST00000118917; ENSMUSP00000112916; ENSMUSG00000015970
GeneIDi218865
KEGGimmu:218865
UCSCiuc007sup.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCHDH_MOUSE
AccessioniPrimary (citable) accession number: Q8BJ64
Secondary accession number(s): Q3TPY4, Q8CHT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health