SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8BJ42

- DLGP2_MOUSE

UniProt

Q8BJ42 - DLGP2_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Disks large-associated protein 2

Gene
Dlgap2, Dap2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.

GO - Biological processi

  1. cell-cell signaling Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Disks large-associated protein 2
Short name:
DAP-2
Alternative name(s):
PSD-95/SAP90-binding protein 2
SAP90/PSD-95-associated protein 2
Short name:
SAPAP2
Gene namesi
Name:Dlgap2
Synonyms:Dap2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:2443181. Dlgap2.

Subcellular locationi

Cell membrane; Peripheral membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Cell junctionsynapse By similarity
Note: Postsynaptic density of neuronal cells By similarity.

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. postsynaptic density Source: UniProtKB-SubCell
  3. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10591059Disks large-associated protein 2PRO_0000174292Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1012 – 10121Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BJ42.
PRIDEiQ8BJ42.

PTM databases

PhosphoSiteiQ8BJ42.

Expressioni

Tissue specificityi

Expressed in various brain areas.1 Publication

Gene expression databases

BgeeiQ8BJ42.
GenevestigatoriQ8BJ42.

Interactioni

Subunit structurei

Interacts with DLG4/PSD-95 By similarity.

Protein-protein interaction databases

BioGridi232634. 1 interaction.
IntActiQ8BJ42. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8BJ42.

Family & Domainsi

Sequence similaritiesi

Belongs to the SAPAP family.

Phylogenomic databases

eggNOGiNOG329647.
GeneTreeiENSGT00550000074473.
HOGENOMiHOG000015346.
HOVERGENiHBG018957.
InParanoidiQ8BJ42.
PhylomeDBiQ8BJ42.

Family and domain databases

InterProiIPR005026. GKAP.
[Graphical view]
PfamiPF03359. GKAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8BJ42-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGTAQVLPGI LQKHCCILPD RNTESQCTLC GEPEEEEGGD LAQPGLSFPG     50
PAEEDIDQQY SWSPTQHFNE ERYSPAPRNM KGLTGSRNQP QLCAGHTCGL 100
SPPDDCEHPH DHMHHGSDVR QPYLLSPAES CPMDHHRCSP RSSVHSECMM 150
MPVMLGDHVS SSTFPRMHYS SHYDTRDDCA MSHTSTKVNR IPANLLDQFE 200
KQLPLHRDGF HTLQYQRASA ATEQRNESPG RIRHLVHSVQ KLFTKSHSLE 250
GSSKSNINGT KSDSRVDDHH QSHLSKHSKR SKSKERKPES KHKSGMSSWW 300
SSDDNLDSDS TYRTPSVAHR HHMDHIPHCY PEALQSPFGD LSLKTSKSNN 350
DVKCSACEGL ALTPDTRYMK RSSWSTLTVS QAKEAYRKSS LNLDKPLVHP 400
EIKPSLRPCH YLQVPQDDWG AYPTGGKEEE IPCRRMRSGS YIKAMGDEES 450
GESDSSPKTS PTVAIRPEPL LKPIIQRPLG DHQTQSYLQA ATEVPVGHSL 500
NPSINYNSPK FRSRNQSYMR AVSTLSQASC VSQMSEAEVN GQFESVCESV 550
FSEVESQAMD ALDLPGCFRT RSHSYLRAIQ AGYSQDDECI PVMTSSNMTS 600
TIRSTAAVSY TNYKKTPPPV PPRTTSKPLI SVTAQSSTES TQDAYQDSRA 650
QRMSPWPQDS RGGLYNSMDS LDSNKAMNLA LETAAAQRHA ADTQSSSTRS 700
IDKAVLASKA EELLKSRCSS IGVQDSEFPD HQPYPRSDVE TATDSDTESR 750
GLREYHSVGV QVEDEKRHGR FKRSNSVTAA VQADLELEGF PGHVSMEDKG 800
LQFGSSFQRH SEPSTPTQYG ALRTVRTQGL FSYREDYRTQ VDTSTLPPPD 850
PWLEPSLDTV ETGRMSPCRR DGSWFLKLLH TETKRMEGWC KEMEREAEEN 900
DLLEDILGKI RSAVGSAQLL MSQKFQQFYW LCQQNMDPSA MPRPTSQDLA 950
GYWDMLQLSV EDVSMKFDEL HQLKLNDWKI IESPERKEER KIPPPIPKKP 1000
PKGKFPITRE KSLDLPDRQR QEARRRLMAA KRAASFRQNS ATERADSIEI 1050
YIPEAQTRL 1059
Length:1,059
Mass (Da):119,074
Last modified:July 19, 2005 - v2
Checksum:i692A878032026054
GO
Isoform 2 (identifier: Q8BJ42-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     725-738: Missing.

Show »
Length:1,045
Mass (Da):117,402
Checksum:i5F0E7DD926B4C904
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei725 – 73814Missing in isoform 2. VSP_014817Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti472 – 4721K → R in BAC27927. 1 Publication
Sequence conflicti647 – 6471D → G in BAC27927. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK032564 mRNA. Translation: BAC27927.1.
AY243847 mRNA. Translation: AAO89218.3.
CCDSiCCDS52492.1. [Q8BJ42-1]
RefSeqiNP_001139437.1. NM_001145965.1.
NP_766498.2. NM_172910.3. [Q8BJ42-1]
UniGeneiMm.404697.

Genome annotation databases

EnsembliENSMUST00000043279; ENSMUSP00000039647; ENSMUSG00000047495. [Q8BJ42-1]
ENSMUST00000133298; ENSMUSP00000119613; ENSMUSG00000047495. [Q8BJ42-1]
ENSMUST00000150247; ENSMUSP00000123104; ENSMUSG00000047495. [Q8BJ42-2]
GeneIDi244310.
KEGGimmu:244310.
UCSCiuc009kyy.2. mouse. [Q8BJ42-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK032564 mRNA. Translation: BAC27927.1 .
AY243847 mRNA. Translation: AAO89218.3 .
CCDSi CCDS52492.1. [Q8BJ42-1 ]
RefSeqi NP_001139437.1. NM_001145965.1.
NP_766498.2. NM_172910.3. [Q8BJ42-1 ]
UniGenei Mm.404697.

3D structure databases

ProteinModelPortali Q8BJ42.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 232634. 1 interaction.
IntActi Q8BJ42. 1 interaction.

PTM databases

PhosphoSitei Q8BJ42.

Proteomic databases

PaxDbi Q8BJ42.
PRIDEi Q8BJ42.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000043279 ; ENSMUSP00000039647 ; ENSMUSG00000047495 . [Q8BJ42-1 ]
ENSMUST00000133298 ; ENSMUSP00000119613 ; ENSMUSG00000047495 . [Q8BJ42-1 ]
ENSMUST00000150247 ; ENSMUSP00000123104 ; ENSMUSG00000047495 . [Q8BJ42-2 ]
GeneIDi 244310.
KEGGi mmu:244310.
UCSCi uc009kyy.2. mouse. [Q8BJ42-1 ]

Organism-specific databases

CTDi 9228.
MGIi MGI:2443181. Dlgap2.

Phylogenomic databases

eggNOGi NOG329647.
GeneTreei ENSGT00550000074473.
HOGENOMi HOG000015346.
HOVERGENi HBG018957.
InParanoidi Q8BJ42.
PhylomeDBi Q8BJ42.

Miscellaneous databases

NextBioi 386221.
PROi Q8BJ42.
SOURCEi Search...

Gene expression databases

Bgeei Q8BJ42.
Genevestigatori Q8BJ42.

Family and domain databases

InterProi IPR005026. GKAP.
[Graphical view ]
Pfami PF03359. GKAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Olfactory bulb.
  2. "Differential mRNA expression and protein localization of the SAP90/PSD-95-associated proteins (SAPAPs) in the nervous system of the mouse."
    Welch J.M., Wang D., Feng G.
    J. Comp. Neurol. 472:24-39(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 80-1059 (ISOFORM 2), TISSUE SPECIFICITY.
    Strain: ICR.
  3. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1012, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiDLGP2_MOUSE
AccessioniPrimary (citable) accession number: Q8BJ42
Secondary accession number(s): Q6XBF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: July 9, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi