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Q8BJ42

- DLGP2_MOUSE

UniProt

Q8BJ42 - DLGP2_MOUSE

Protein

Disks large-associated protein 2

Gene

Dlgap2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.

    GO - Biological processi

    1. cell-cell signaling Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Disks large-associated protein 2
    Short name:
    DAP-2
    Alternative name(s):
    PSD-95/SAP90-binding protein 2
    SAP90/PSD-95-associated protein 2
    Short name:
    SAPAP2
    Gene namesi
    Name:Dlgap2
    Synonyms:Dap2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:2443181. Dlgap2.

    Subcellular locationi

    Cell membrane By similarity; Peripheral membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Cell junctionsynapse By similarity
    Note: Postsynaptic density of neuronal cells.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. postsynaptic density Source: UniProtKB-SubCell
    3. postsynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10591059Disks large-associated protein 2PRO_0000174292Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1012 – 10121Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8BJ42.
    PRIDEiQ8BJ42.

    PTM databases

    PhosphoSiteiQ8BJ42.

    Expressioni

    Tissue specificityi

    Expressed in various brain areas.1 Publication

    Gene expression databases

    BgeeiQ8BJ42.
    GenevestigatoriQ8BJ42.

    Interactioni

    Subunit structurei

    Interacts with DLG4/PSD-95.By similarity

    Protein-protein interaction databases

    BioGridi232634. 1 interaction.
    IntActiQ8BJ42. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BJ42.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SAPAP family.Curated

    Phylogenomic databases

    eggNOGiNOG329647.
    GeneTreeiENSGT00550000074473.
    HOGENOMiHOG000015346.
    HOVERGENiHBG018957.
    InParanoidiQ8BJ42.
    PhylomeDBiQ8BJ42.

    Family and domain databases

    InterProiIPR005026. GKAP.
    [Graphical view]
    PfamiPF03359. GKAP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8BJ42-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGTAQVLPGI LQKHCCILPD RNTESQCTLC GEPEEEEGGD LAQPGLSFPG     50
    PAEEDIDQQY SWSPTQHFNE ERYSPAPRNM KGLTGSRNQP QLCAGHTCGL 100
    SPPDDCEHPH DHMHHGSDVR QPYLLSPAES CPMDHHRCSP RSSVHSECMM 150
    MPVMLGDHVS SSTFPRMHYS SHYDTRDDCA MSHTSTKVNR IPANLLDQFE 200
    KQLPLHRDGF HTLQYQRASA ATEQRNESPG RIRHLVHSVQ KLFTKSHSLE 250
    GSSKSNINGT KSDSRVDDHH QSHLSKHSKR SKSKERKPES KHKSGMSSWW 300
    SSDDNLDSDS TYRTPSVAHR HHMDHIPHCY PEALQSPFGD LSLKTSKSNN 350
    DVKCSACEGL ALTPDTRYMK RSSWSTLTVS QAKEAYRKSS LNLDKPLVHP 400
    EIKPSLRPCH YLQVPQDDWG AYPTGGKEEE IPCRRMRSGS YIKAMGDEES 450
    GESDSSPKTS PTVAIRPEPL LKPIIQRPLG DHQTQSYLQA ATEVPVGHSL 500
    NPSINYNSPK FRSRNQSYMR AVSTLSQASC VSQMSEAEVN GQFESVCESV 550
    FSEVESQAMD ALDLPGCFRT RSHSYLRAIQ AGYSQDDECI PVMTSSNMTS 600
    TIRSTAAVSY TNYKKTPPPV PPRTTSKPLI SVTAQSSTES TQDAYQDSRA 650
    QRMSPWPQDS RGGLYNSMDS LDSNKAMNLA LETAAAQRHA ADTQSSSTRS 700
    IDKAVLASKA EELLKSRCSS IGVQDSEFPD HQPYPRSDVE TATDSDTESR 750
    GLREYHSVGV QVEDEKRHGR FKRSNSVTAA VQADLELEGF PGHVSMEDKG 800
    LQFGSSFQRH SEPSTPTQYG ALRTVRTQGL FSYREDYRTQ VDTSTLPPPD 850
    PWLEPSLDTV ETGRMSPCRR DGSWFLKLLH TETKRMEGWC KEMEREAEEN 900
    DLLEDILGKI RSAVGSAQLL MSQKFQQFYW LCQQNMDPSA MPRPTSQDLA 950
    GYWDMLQLSV EDVSMKFDEL HQLKLNDWKI IESPERKEER KIPPPIPKKP 1000
    PKGKFPITRE KSLDLPDRQR QEARRRLMAA KRAASFRQNS ATERADSIEI 1050
    YIPEAQTRL 1059
    Length:1,059
    Mass (Da):119,074
    Last modified:July 19, 2005 - v2
    Checksum:i692A878032026054
    GO
    Isoform 2 (identifier: Q8BJ42-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         725-738: Missing.

    Show »
    Length:1,045
    Mass (Da):117,402
    Checksum:i5F0E7DD926B4C904
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti472 – 4721K → R in BAC27927. (PubMed:16141072)Curated
    Sequence conflicti647 – 6471D → G in BAC27927. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei725 – 73814Missing in isoform 2. 1 PublicationVSP_014817Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK032564 mRNA. Translation: BAC27927.1.
    AY243847 mRNA. Translation: AAO89218.3.
    CCDSiCCDS52492.1. [Q8BJ42-1]
    RefSeqiNP_001139437.1. NM_001145965.1.
    NP_766498.2. NM_172910.3. [Q8BJ42-1]
    UniGeneiMm.404697.

    Genome annotation databases

    EnsembliENSMUST00000043279; ENSMUSP00000039647; ENSMUSG00000047495. [Q8BJ42-1]
    ENSMUST00000133298; ENSMUSP00000119613; ENSMUSG00000047495. [Q8BJ42-1]
    ENSMUST00000150247; ENSMUSP00000123104; ENSMUSG00000047495. [Q8BJ42-2]
    GeneIDi244310.
    KEGGimmu:244310.
    UCSCiuc009kyy.2. mouse. [Q8BJ42-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK032564 mRNA. Translation: BAC27927.1 .
    AY243847 mRNA. Translation: AAO89218.3 .
    CCDSi CCDS52492.1. [Q8BJ42-1 ]
    RefSeqi NP_001139437.1. NM_001145965.1.
    NP_766498.2. NM_172910.3. [Q8BJ42-1 ]
    UniGenei Mm.404697.

    3D structure databases

    ProteinModelPortali Q8BJ42.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 232634. 1 interaction.
    IntActi Q8BJ42. 1 interaction.

    PTM databases

    PhosphoSitei Q8BJ42.

    Proteomic databases

    PaxDbi Q8BJ42.
    PRIDEi Q8BJ42.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000043279 ; ENSMUSP00000039647 ; ENSMUSG00000047495 . [Q8BJ42-1 ]
    ENSMUST00000133298 ; ENSMUSP00000119613 ; ENSMUSG00000047495 . [Q8BJ42-1 ]
    ENSMUST00000150247 ; ENSMUSP00000123104 ; ENSMUSG00000047495 . [Q8BJ42-2 ]
    GeneIDi 244310.
    KEGGi mmu:244310.
    UCSCi uc009kyy.2. mouse. [Q8BJ42-1 ]

    Organism-specific databases

    CTDi 9228.
    MGIi MGI:2443181. Dlgap2.

    Phylogenomic databases

    eggNOGi NOG329647.
    GeneTreei ENSGT00550000074473.
    HOGENOMi HOG000015346.
    HOVERGENi HBG018957.
    InParanoidi Q8BJ42.
    PhylomeDBi Q8BJ42.

    Miscellaneous databases

    NextBioi 386221.
    PROi Q8BJ42.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BJ42.
    Genevestigatori Q8BJ42.

    Family and domain databases

    InterProi IPR005026. GKAP.
    [Graphical view ]
    Pfami PF03359. GKAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Olfactory bulb.
    2. "Differential mRNA expression and protein localization of the SAP90/PSD-95-associated proteins (SAPAPs) in the nervous system of the mouse."
      Welch J.M., Wang D., Feng G.
      J. Comp. Neurol. 472:24-39(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 80-1059 (ISOFORM 2), TISSUE SPECIFICITY.
      Strain: ICR.
    3. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1012, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.

    Entry informationi

    Entry nameiDLGP2_MOUSE
    AccessioniPrimary (citable) accession number: Q8BJ42
    Secondary accession number(s): Q6XBF3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3