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Protein

Disks large-associated protein 2

Gene

Dlgap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.

GO - Biological processi

  1. cell-cell signaling Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Disks large-associated protein 2
Short name:
DAP-2
Alternative name(s):
PSD-95/SAP90-binding protein 2
SAP90/PSD-95-associated protein 2
Short name:
SAPAP2
Gene namesi
Name:Dlgap2
Synonyms:Dap2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2443181. Dlgap2.

Subcellular locationi

  1. Cell membrane By similarity; Peripheral membrane protein By similarity
  2. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity
  3. Cell junctionsynapse By similarity

  4. Note: Postsynaptic density of neuronal cells.By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. postsynaptic density Source: UniProtKB-SubCell
  3. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10591059Disks large-associated protein 2PRO_0000174292Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1012 – 10121Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BJ42.
PRIDEiQ8BJ42.

PTM databases

PhosphoSiteiQ8BJ42.

Expressioni

Tissue specificityi

Expressed in various brain areas.1 Publication

Gene expression databases

BgeeiQ8BJ42.
ExpressionAtlasiQ8BJ42. baseline and differential.
GenevestigatoriQ8BJ42.

Interactioni

Subunit structurei

Interacts with DLG4/PSD-95.By similarity

Protein-protein interaction databases

BioGridi232634. 1 interaction.
IntActiQ8BJ42. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8BJ42.
SMRiQ8BJ42. Positions 871-979.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAPAP family.Curated

Phylogenomic databases

eggNOGiNOG329647.
GeneTreeiENSGT00550000074473.
HOGENOMiHOG000015346.
HOVERGENiHBG018957.
InParanoidiQ8BJ42.
PhylomeDBiQ8BJ42.

Family and domain databases

InterProiIPR030525. DLGAP2.
IPR005026. SAPAP.
[Graphical view]
PANTHERiPTHR12353:SF3. PTHR12353:SF3. 1 hit.
PfamiPF03359. GKAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BJ42-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTAQVLPGI LQKHCCILPD RNTESQCTLC GEPEEEEGGD LAQPGLSFPG
60 70 80 90 100
PAEEDIDQQY SWSPTQHFNE ERYSPAPRNM KGLTGSRNQP QLCAGHTCGL
110 120 130 140 150
SPPDDCEHPH DHMHHGSDVR QPYLLSPAES CPMDHHRCSP RSSVHSECMM
160 170 180 190 200
MPVMLGDHVS SSTFPRMHYS SHYDTRDDCA MSHTSTKVNR IPANLLDQFE
210 220 230 240 250
KQLPLHRDGF HTLQYQRASA ATEQRNESPG RIRHLVHSVQ KLFTKSHSLE
260 270 280 290 300
GSSKSNINGT KSDSRVDDHH QSHLSKHSKR SKSKERKPES KHKSGMSSWW
310 320 330 340 350
SSDDNLDSDS TYRTPSVAHR HHMDHIPHCY PEALQSPFGD LSLKTSKSNN
360 370 380 390 400
DVKCSACEGL ALTPDTRYMK RSSWSTLTVS QAKEAYRKSS LNLDKPLVHP
410 420 430 440 450
EIKPSLRPCH YLQVPQDDWG AYPTGGKEEE IPCRRMRSGS YIKAMGDEES
460 470 480 490 500
GESDSSPKTS PTVAIRPEPL LKPIIQRPLG DHQTQSYLQA ATEVPVGHSL
510 520 530 540 550
NPSINYNSPK FRSRNQSYMR AVSTLSQASC VSQMSEAEVN GQFESVCESV
560 570 580 590 600
FSEVESQAMD ALDLPGCFRT RSHSYLRAIQ AGYSQDDECI PVMTSSNMTS
610 620 630 640 650
TIRSTAAVSY TNYKKTPPPV PPRTTSKPLI SVTAQSSTES TQDAYQDSRA
660 670 680 690 700
QRMSPWPQDS RGGLYNSMDS LDSNKAMNLA LETAAAQRHA ADTQSSSTRS
710 720 730 740 750
IDKAVLASKA EELLKSRCSS IGVQDSEFPD HQPYPRSDVE TATDSDTESR
760 770 780 790 800
GLREYHSVGV QVEDEKRHGR FKRSNSVTAA VQADLELEGF PGHVSMEDKG
810 820 830 840 850
LQFGSSFQRH SEPSTPTQYG ALRTVRTQGL FSYREDYRTQ VDTSTLPPPD
860 870 880 890 900
PWLEPSLDTV ETGRMSPCRR DGSWFLKLLH TETKRMEGWC KEMEREAEEN
910 920 930 940 950
DLLEDILGKI RSAVGSAQLL MSQKFQQFYW LCQQNMDPSA MPRPTSQDLA
960 970 980 990 1000
GYWDMLQLSV EDVSMKFDEL HQLKLNDWKI IESPERKEER KIPPPIPKKP
1010 1020 1030 1040 1050
PKGKFPITRE KSLDLPDRQR QEARRRLMAA KRAASFRQNS ATERADSIEI

YIPEAQTRL
Length:1,059
Mass (Da):119,074
Last modified:July 19, 2005 - v2
Checksum:i692A878032026054
GO
Isoform 2 (identifier: Q8BJ42-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     725-738: Missing.

Show »
Length:1,045
Mass (Da):117,402
Checksum:i5F0E7DD926B4C904
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti472 – 4721K → R in BAC27927 (PubMed:16141072).Curated
Sequence conflicti647 – 6471D → G in BAC27927 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei725 – 73814Missing in isoform 2. 1 PublicationVSP_014817Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032564 mRNA. Translation: BAC27927.1.
AY243847 mRNA. Translation: AAO89218.3.
CCDSiCCDS52492.1. [Q8BJ42-1]
RefSeqiNP_001139437.1. NM_001145965.1.
NP_766498.2. NM_172910.3. [Q8BJ42-1]
UniGeneiMm.404697.

Genome annotation databases

EnsembliENSMUST00000043279; ENSMUSP00000039647; ENSMUSG00000047495. [Q8BJ42-1]
ENSMUST00000133298; ENSMUSP00000119613; ENSMUSG00000047495. [Q8BJ42-1]
ENSMUST00000150247; ENSMUSP00000123104; ENSMUSG00000047495. [Q8BJ42-2]
GeneIDi244310.
KEGGimmu:244310.
UCSCiuc009kyy.2. mouse. [Q8BJ42-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032564 mRNA. Translation: BAC27927.1.
AY243847 mRNA. Translation: AAO89218.3.
CCDSiCCDS52492.1. [Q8BJ42-1]
RefSeqiNP_001139437.1. NM_001145965.1.
NP_766498.2. NM_172910.3. [Q8BJ42-1]
UniGeneiMm.404697.

3D structure databases

ProteinModelPortaliQ8BJ42.
SMRiQ8BJ42. Positions 871-979.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232634. 1 interaction.
IntActiQ8BJ42. 1 interaction.

PTM databases

PhosphoSiteiQ8BJ42.

Proteomic databases

PaxDbiQ8BJ42.
PRIDEiQ8BJ42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043279; ENSMUSP00000039647; ENSMUSG00000047495. [Q8BJ42-1]
ENSMUST00000133298; ENSMUSP00000119613; ENSMUSG00000047495. [Q8BJ42-1]
ENSMUST00000150247; ENSMUSP00000123104; ENSMUSG00000047495. [Q8BJ42-2]
GeneIDi244310.
KEGGimmu:244310.
UCSCiuc009kyy.2. mouse. [Q8BJ42-1]

Organism-specific databases

CTDi9228.
MGIiMGI:2443181. Dlgap2.

Phylogenomic databases

eggNOGiNOG329647.
GeneTreeiENSGT00550000074473.
HOGENOMiHOG000015346.
HOVERGENiHBG018957.
InParanoidiQ8BJ42.
PhylomeDBiQ8BJ42.

Miscellaneous databases

NextBioi386221.
PROiQ8BJ42.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BJ42.
ExpressionAtlasiQ8BJ42. baseline and differential.
GenevestigatoriQ8BJ42.

Family and domain databases

InterProiIPR030525. DLGAP2.
IPR005026. SAPAP.
[Graphical view]
PANTHERiPTHR12353:SF3. PTHR12353:SF3. 1 hit.
PfamiPF03359. GKAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Olfactory bulb.
  2. "Differential mRNA expression and protein localization of the SAP90/PSD-95-associated proteins (SAPAPs) in the nervous system of the mouse."
    Welch J.M., Wang D., Feng G.
    J. Comp. Neurol. 472:24-39(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 80-1059 (ISOFORM 2), TISSUE SPECIFICITY.
    Strain: ICR.
  3. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1012, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiDLGP2_MOUSE
AccessioniPrimary (citable) accession number: Q8BJ42
Secondary accession number(s): Q6XBF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: April 29, 2015
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.