Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8BJ42 (DLGP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Disks large-associated protein 2

Short name=DAP-2
Alternative name(s):
PSD-95/SAP90-binding protein 2
SAP90/PSD-95-associated protein 2
Short name=SAPAP2
Gene names
Name:Dlgap2
Synonyms:Dap2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1059 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.

Subunit structure

Interacts with DLG4/PSD-95 By similarity.

Subcellular location

Cell membrane; Peripheral membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Cell junctionsynapse By similarity. Note: Postsynaptic density of neuronal cells By similarity.

Tissue specificity

Expressed in various brain areas. Ref.2

Sequence similarities

Belongs to the SAPAP family.

Ontologies

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8BJ42-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8BJ42-2)

The sequence of this isoform differs from the canonical sequence as follows:
     725-738: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10591059Disks large-associated protein 2
PRO_0000174292

Amino acid modifications

Modified residue10121Phosphoserine Ref.3

Natural variations

Alternative sequence725 – 73814Missing in isoform 2.
VSP_014817

Experimental info

Sequence conflict4721K → R in BAC27927. Ref.1
Sequence conflict6471D → G in BAC27927. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 19, 2005. Version 2.
Checksum: 692A878032026054

FASTA1,059119,074
        10         20         30         40         50         60 
MGTAQVLPGI LQKHCCILPD RNTESQCTLC GEPEEEEGGD LAQPGLSFPG PAEEDIDQQY 

        70         80         90        100        110        120 
SWSPTQHFNE ERYSPAPRNM KGLTGSRNQP QLCAGHTCGL SPPDDCEHPH DHMHHGSDVR 

       130        140        150        160        170        180 
QPYLLSPAES CPMDHHRCSP RSSVHSECMM MPVMLGDHVS SSTFPRMHYS SHYDTRDDCA 

       190        200        210        220        230        240 
MSHTSTKVNR IPANLLDQFE KQLPLHRDGF HTLQYQRASA ATEQRNESPG RIRHLVHSVQ 

       250        260        270        280        290        300 
KLFTKSHSLE GSSKSNINGT KSDSRVDDHH QSHLSKHSKR SKSKERKPES KHKSGMSSWW 

       310        320        330        340        350        360 
SSDDNLDSDS TYRTPSVAHR HHMDHIPHCY PEALQSPFGD LSLKTSKSNN DVKCSACEGL 

       370        380        390        400        410        420 
ALTPDTRYMK RSSWSTLTVS QAKEAYRKSS LNLDKPLVHP EIKPSLRPCH YLQVPQDDWG 

       430        440        450        460        470        480 
AYPTGGKEEE IPCRRMRSGS YIKAMGDEES GESDSSPKTS PTVAIRPEPL LKPIIQRPLG 

       490        500        510        520        530        540 
DHQTQSYLQA ATEVPVGHSL NPSINYNSPK FRSRNQSYMR AVSTLSQASC VSQMSEAEVN 

       550        560        570        580        590        600 
GQFESVCESV FSEVESQAMD ALDLPGCFRT RSHSYLRAIQ AGYSQDDECI PVMTSSNMTS 

       610        620        630        640        650        660 
TIRSTAAVSY TNYKKTPPPV PPRTTSKPLI SVTAQSSTES TQDAYQDSRA QRMSPWPQDS 

       670        680        690        700        710        720 
RGGLYNSMDS LDSNKAMNLA LETAAAQRHA ADTQSSSTRS IDKAVLASKA EELLKSRCSS 

       730        740        750        760        770        780 
IGVQDSEFPD HQPYPRSDVE TATDSDTESR GLREYHSVGV QVEDEKRHGR FKRSNSVTAA 

       790        800        810        820        830        840 
VQADLELEGF PGHVSMEDKG LQFGSSFQRH SEPSTPTQYG ALRTVRTQGL FSYREDYRTQ 

       850        860        870        880        890        900 
VDTSTLPPPD PWLEPSLDTV ETGRMSPCRR DGSWFLKLLH TETKRMEGWC KEMEREAEEN 

       910        920        930        940        950        960 
DLLEDILGKI RSAVGSAQLL MSQKFQQFYW LCQQNMDPSA MPRPTSQDLA GYWDMLQLSV 

       970        980        990       1000       1010       1020 
EDVSMKFDEL HQLKLNDWKI IESPERKEER KIPPPIPKKP PKGKFPITRE KSLDLPDRQR 

      1030       1040       1050 
QEARRRLMAA KRAASFRQNS ATERADSIEI YIPEAQTRL 

« Hide

Isoform 2 [UniParc].

Checksum: 5F0E7DD926B4C904
Show »

FASTA1,045117,402

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Olfactory bulb.
[2]"Differential mRNA expression and protein localization of the SAP90/PSD-95-associated proteins (SAPAPs) in the nervous system of the mouse."
Welch J.M., Wang D., Feng G.
J. Comp. Neurol. 472:24-39(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 80-1059 (ISOFORM 2), TISSUE SPECIFICITY.
Strain: ICR.
[3]"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1012, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK032564 mRNA. Translation: BAC27927.1.
AY243847 mRNA. Translation: AAO89218.3.
CCDSCCDS52492.1. [Q8BJ42-1]
RefSeqNP_001139437.1. NM_001145965.1.
NP_766498.2. NM_172910.3. [Q8BJ42-1]
UniGeneMm.404697.

3D structure databases

ProteinModelPortalQ8BJ42.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid232634. 1 interaction.
IntActQ8BJ42. 1 interaction.

PTM databases

PhosphoSiteQ8BJ42.

Proteomic databases

PaxDbQ8BJ42.
PRIDEQ8BJ42.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000043279; ENSMUSP00000039647; ENSMUSG00000047495. [Q8BJ42-1]
ENSMUST00000133298; ENSMUSP00000119613; ENSMUSG00000047495. [Q8BJ42-1]
ENSMUST00000150247; ENSMUSP00000123104; ENSMUSG00000047495. [Q8BJ42-2]
GeneID244310.
KEGGmmu:244310.
UCSCuc009kyy.2. mouse. [Q8BJ42-1]

Organism-specific databases

CTD9228.
MGIMGI:2443181. Dlgap2.

Phylogenomic databases

eggNOGNOG329647.
GeneTreeENSGT00550000074473.
HOGENOMHOG000015346.
HOVERGENHBG018957.
InParanoidQ8BJ42.
PhylomeDBQ8BJ42.

Gene expression databases

BgeeQ8BJ42.
GenevestigatorQ8BJ42.

Family and domain databases

InterProIPR005026. GKAP.
[Graphical view]
PfamPF03359. GKAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio386221.
PROQ8BJ42.
SOURCESearch...

Entry information

Entry nameDLGP2_MOUSE
AccessionPrimary (citable) accession number: Q8BJ42
Secondary accession number(s): Q6XBF3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: July 9, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot