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Protein

THAP domain-containing protein 3

Gene

Thap3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 8282THAP-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
THAP domain-containing protein 3
Gene namesi
Name:Thap3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1917126. Thap3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218THAP domain-containing protein 3PRO_0000068645Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei100 – 1001PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BJ25.
PRIDEiQ8BJ25.

Expressioni

Tissue specificityi

Highest levels in heart, liver and kidney. Lower levels in brain and lung.1 Publication

Gene expression databases

BgeeiENSMUSG00000039759.
ExpressionAtlasiQ8BJ25. baseline and differential.
GenevisibleiQ8BJ25. MM.

Interactioni

Subunit structurei

Component of a THAP1/THAP3-HCFC1-OGT complex that contains at least, either THAP1 or THAP3, HCFC1 and OGT. Interacts directly with OGT and HCFC1 (via its HBM) (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035240.

Structurei

3D structure databases

ProteinModelPortaliQ8BJ25.
SMRiQ8BJ25. Positions 1-82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi156 – 1594HCFC1-binding motif (HBM)By similarity

Sequence similaritiesi

Contains 1 THAP-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 8282THAP-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IRYI. Eukaryota.
ENOG410Y1BK. LUCA.
GeneTreeiENSGT00840000129785.
HOGENOMiHOG000231117.
HOVERGENiHBG100591.
InParanoidiQ8BJ25.
OMAiVLNIGRA.
OrthoDBiEOG091G034R.
PhylomeDBiQ8BJ25.
TreeFamiTF330127.

Family and domain databases

InterProiIPR026520. THAP3.
IPR006612. Znf_C2CH.
[Graphical view]
PANTHERiPTHR23080:SF64. PTHR23080:SF64. 2 hits.
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BJ25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKSCAARQC CNRYSSRRKQ LTFHRFPFSR PELLREWVLN IGRADFKPKQ
60 70 80 90 100
HTVICSEHFR PECFSAFGNR KNLKHNAVPT VFAFQNPTEV CPEVGAGGDS
110 120 130 140 150
SGRNMDTTLE ELQPPTPEGP VQQVLPDREA MEATEAAGLP ASPLGLKRPL
160 170 180 190 200
PGQPSDHSYA LSDLDTLKKK LFLTLKENKR LRKRLKAQRL LLRRTCGRLR
210
AYREGQPGPR ARRPAQGS
Length:218
Mass (Da):24,627
Last modified:March 1, 2003 - v1
Checksum:i5FD62D0594D6E715
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti157 – 1571H → R in BAC34401 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038184 mRNA. Translation: BAC29945.1.
AK050740 mRNA. Translation: BAC34401.1.
CCDSiCCDS18982.1.
RefSeqiNP_780361.2. NM_175152.4.
UniGeneiMm.226820.

Genome annotation databases

EnsembliENSMUST00000036680; ENSMUSP00000035240; ENSMUSG00000039759.
GeneIDi69876.
KEGGimmu:69876.
UCSCiuc008vyu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038184 mRNA. Translation: BAC29945.1.
AK050740 mRNA. Translation: BAC34401.1.
CCDSiCCDS18982.1.
RefSeqiNP_780361.2. NM_175152.4.
UniGeneiMm.226820.

3D structure databases

ProteinModelPortaliQ8BJ25.
SMRiQ8BJ25. Positions 1-82.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035240.

Proteomic databases

PaxDbiQ8BJ25.
PRIDEiQ8BJ25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036680; ENSMUSP00000035240; ENSMUSG00000039759.
GeneIDi69876.
KEGGimmu:69876.
UCSCiuc008vyu.2. mouse.

Organism-specific databases

CTDi90326.
MGIiMGI:1917126. Thap3.

Phylogenomic databases

eggNOGiENOG410IRYI. Eukaryota.
ENOG410Y1BK. LUCA.
GeneTreeiENSGT00840000129785.
HOGENOMiHOG000231117.
HOVERGENiHBG100591.
InParanoidiQ8BJ25.
OMAiVLNIGRA.
OrthoDBiEOG091G034R.
PhylomeDBiQ8BJ25.
TreeFamiTF330127.

Miscellaneous databases

ChiTaRSiThap3. mouse.
PROiQ8BJ25.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039759.
ExpressionAtlasiQ8BJ25. baseline and differential.
GenevisibleiQ8BJ25. MM.

Family and domain databases

InterProiIPR026520. THAP3.
IPR006612. Znf_C2CH.
[Graphical view]
PANTHERiPTHR23080:SF64. PTHR23080:SF64. 2 hits.
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHAP3_MOUSE
AccessioniPrimary (citable) accession number: Q8BJ25
Secondary accession number(s): Q8BII6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.