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Protein

THAP domain-containing protein 3

Gene

Thap3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 82THAP-typePROSITE-ProRule annotationAdd BLAST82

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
THAP domain-containing protein 3
Gene namesi
Name:Thap3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1917126 Thap3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686451 – 218THAP domain-containing protein 3Add BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei100PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BJ25
PRIDEiQ8BJ25

Expressioni

Tissue specificityi

Highest levels in heart, liver and kidney. Lower levels in brain and lung.1 Publication

Gene expression databases

BgeeiENSMUSG00000039759
ExpressionAtlasiQ8BJ25 baseline and differential
GenevisibleiQ8BJ25 MM

Interactioni

Subunit structurei

Component of a THAP1/THAP3-HCFC1-OGT complex that contains at least, either THAP1 or THAP3, HCFC1 and OGT. Interacts directly with OGT and HCFC1 (via its HBM) (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035240

Structurei

3D structure databases

ProteinModelPortaliQ8BJ25
SMRiQ8BJ25
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi156 – 159HCFC1-binding motif (HBM)By similarity4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 82THAP-typePROSITE-ProRule annotationAdd BLAST82

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IRYI Eukaryota
ENOG410Y1BK LUCA
GeneTreeiENSGT00840000129785
HOGENOMiHOG000231117
HOVERGENiHBG100591
InParanoidiQ8BJ25
OMAiVLNIGRA
OrthoDBiEOG091G034R
PhylomeDBiQ8BJ25
TreeFamiTF330127

Family and domain databases

Gene3Di3.30.40.180, 1 hit
InterProiView protein in InterPro
IPR026520 THAP3
IPR006612 THAP_Znf
IPR038441 THAP_Znf_sf
PANTHERiPTHR23080:SF64 PTHR23080:SF64, 2 hits
PfamiView protein in Pfam
PF05485 THAP, 1 hit
SMARTiView protein in SMART
SM00692 DM3, 1 hit
SM00980 THAP, 1 hit
PROSITEiView protein in PROSITE
PS50950 ZF_THAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BJ25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKSCAARQC CNRYSSRRKQ LTFHRFPFSR PELLREWVLN IGRADFKPKQ
60 70 80 90 100
HTVICSEHFR PECFSAFGNR KNLKHNAVPT VFAFQNPTEV CPEVGAGGDS
110 120 130 140 150
SGRNMDTTLE ELQPPTPEGP VQQVLPDREA MEATEAAGLP ASPLGLKRPL
160 170 180 190 200
PGQPSDHSYA LSDLDTLKKK LFLTLKENKR LRKRLKAQRL LLRRTCGRLR
210
AYREGQPGPR ARRPAQGS
Length:218
Mass (Da):24,627
Last modified:March 1, 2003 - v1
Checksum:i5FD62D0594D6E715
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti157H → R in BAC34401 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038184 mRNA Translation: BAC29945.1
AK050740 mRNA Translation: BAC34401.1
CCDSiCCDS18982.1
RefSeqiNP_780361.2, NM_175152.4
UniGeneiMm.226820

Genome annotation databases

EnsembliENSMUST00000036680; ENSMUSP00000035240; ENSMUSG00000039759
GeneIDi69876
KEGGimmu:69876
UCSCiuc008vyu.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTHAP3_MOUSE
AccessioniPrimary (citable) accession number: Q8BJ25
Secondary accession number(s): Q8BII6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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