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Protein

Zinc finger CCCH domain-containing protein 14

Gene

Zc3h14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri595 – 62026C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri621 – 64020C3H1-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri641 – 65616C3H1-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri681 – 69818C3H1-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri700 – 71819C3H1-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 14
Gene namesi
Name:Zc3h14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1919824. Zc3h14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Zinc finger CCCH domain-containing protein 14PRO_0000331313Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei85 – 851PhosphoserineCombined sources
Cross-linki175 – 175Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei240 – 2401PhosphoserineBy similarity
Modified residuei309 – 3091PhosphoserineCombined sources
Modified residuei327 – 3271PhosphoserineBy similarity
Modified residuei343 – 3431PhosphoserineBy similarity
Modified residuei357 – 3571N6-acetyllysineBy similarity
Modified residuei390 – 3901PhosphoserineBy similarity
Modified residuei409 – 4091PhosphoserineBy similarity
Cross-linki413 – 413Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei498 – 4981PhosphoserineBy similarity
Modified residuei515 – 5151PhosphoserineCombined sources
Modified residuei527 – 5271PhosphoserineCombined sources
Modified residuei620 – 6201PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8BJ05.
MaxQBiQ8BJ05.
PaxDbiQ8BJ05.
PeptideAtlasiQ8BJ05.
PRIDEiQ8BJ05.

PTM databases

iPTMnetiQ8BJ05.
PhosphoSiteiQ8BJ05.

Expressioni

Tissue specificityi

Expressed in kidney, liver, muscle, heart brain and testes.1 Publication

Gene expression databases

BgeeiENSMUSG00000021012.
GenevisibleiQ8BJ05. MM.

Interactioni

Protein-protein interaction databases

BioGridi217572. 1 interaction.
IntActiQ8BJ05. 2 interactions.
MINTiMINT-4127881.
STRINGi10090.ENSMUSP00000105732.

Structurei

3D structure databases

ProteinModelPortaliQ8BJ05.
SMRiQ8BJ05. Positions 598-657, 679-716.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZC3H14 family.Curated
Contains 5 C3H1-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri595 – 62026C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri621 – 64020C3H1-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri641 – 65616C3H1-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri681 – 69818C3H1-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri700 – 71819C3H1-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG3702. Eukaryota.
ENOG410YE77. LUCA.
GeneTreeiENSGT00440000038430.
HOVERGENiHBG108760.
InParanoidiQ8BJ05.
OMAiFNHDGEE.
OrthoDBiEOG091G0234.
PhylomeDBiQ8BJ05.
TreeFamiTF329509.

Family and domain databases

InterProiIPR000571. Znf_CCCH.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 3 hits.
[Graphical view]
PROSITEiPS50103. ZF_C3H1. 3 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BJ05-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIGTEISRK IRSAIKGKLQ ELGAYVDEEL PDYIMVMVAN KKSQDQMTED
60 70 80 90 100
LSLFLGNNTI RFTVWLHGVL DKLRSVTTEP SSLKSPDASI FDSHVPSNKS
110 120 130 140 150
SFSRGDERRH EAAVPPLAVS SSRPEKRDSR VSTSSQEQKS TNVRHSYDDG
160 170 180 190 200
ASTRLMSTVK PLREPAPSED VIDIKPEPDD LIDEDLNFVQ ENPLSQKKPT
210 220 230 240 250
VTLTYGSSRP SIEIYRPPAS RNADTGTHLN RLQLHPQQSS AHAAKQLDVQ
260 270 280 290 300
SSQVSEAGRL CEPPVLSSVE DTYSPFFRNN LDKMSIEDEN FRKRKLPVVS
310 320 330 340 350
SVVKVKRFSH DGEEEEEDED YGTRIGSLSS SVSVPAKPER RPSLPPSKQA
360 370 380 390 400
NKNLILKAIS EAQESVTKTT NYSAVPQKQT LPVAPRTRTS QEELLAEMVQ
410 420 430 440 450
GQNRAPRISP PVKEEEAKGD NTGKSQGTQQ RQLLSRLQID PVMVETMEMS
460 470 480 490 500
QDYYDMESMV HADTRSFILK KPKLSEEIVV TPNQDSGMKT ADALRVLSGH
510 520 530 540 550
LMQTRDLVQP DKPASPKFIV TLDGVPSPPG YMSDQEEEMC FEGMKPVNQT
560 570 580 590 600
SASNKGLRGL LHPQQLHLLS RQLEDPDGSF SNAEMTDLSV AQKPEKLLER
610 620 630 640 650
CKYWPACKNG DECVYHHPIS PCKAFPNCKF AEKCLFVHPN CKYDTKCTKA
660 670 680 690 700
DCPFTHMSRR ASILTPKPVS SPAPSSNGQL CRYFPACKKM ECPFYHPKHC
710 720 730
RFNTQCTRPD CTFYHPTITV PPRHALKWIR PQSSE
Length:735
Mass (Da):82,409
Last modified:March 1, 2003 - v1
Checksum:i550696563E7E87C3
GO
Isoform 2 (identifier: Q8BJ05-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     427-582: Missing.

Show »
Length:579
Mass (Da):64,937
Checksum:i71F35EE73B829234
GO
Isoform 3 (identifier: Q8BJ05-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     452-582: Missing.

Show »
Length:604
Mass (Da):67,839
Checksum:iBA1E05A017712FAE
GO
Isoform 4 (identifier: Q8BJ05-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-295: Missing.
     296-426: LPVVSSVVKV...AKGDNTGKSQ → MKMSSRFSSP...LIGFLTEVEK
     452-582: Missing.

Show »
Length:309
Mass (Da):35,073
Checksum:i054E426908EA5224
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271D → H in BAC34134 (PubMed:16141072).Curated
Sequence conflicti665 – 6651T → A in BAE36101 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 295295Missing in isoform 4. 1 PublicationVSP_033177Add
BLAST
Alternative sequencei296 – 426131LPVVS…TGKSQ → MKMSSRFSSPSLPVFLSPEP ADLGSLTSASCSLNELGNIS YLLRKIATDINEMKGMKAAI LTVEANLFDLNVRVSQNEAK ISSLEVKMNEYLTSTSECNR QLEDFQERLEFESQSETTDA NLIGFLTEVEK in isoform 4. 1 PublicationVSP_033178Add
BLAST
Alternative sequencei427 – 582156Missing in isoform 2. 2 PublicationsVSP_033179Add
BLAST
Alternative sequencei452 – 582131Missing in isoform 3 and isoform 4. 2 PublicationsVSP_033180Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006009 mRNA. Translation: BAB24364.1.
AK048046 mRNA. Translation: BAC33222.1.
AK050226 mRNA. Translation: BAC34134.1.
AK160937 mRNA. Translation: BAE36101.1.
BC021797 mRNA. Translation: AAH21797.1.
BC024824 mRNA. Translation: AAH24824.1.
BC024856 mRNA. Translation: AAH24856.1.
BC026610 mRNA. Translation: AAH26610.1.
CCDSiCCDS26099.1. [Q8BJ05-3]
CCDS26100.1. [Q8BJ05-1]
CCDS49138.1. [Q8BJ05-2]
CCDS49139.1. [Q8BJ05-4]
RefSeqiNP_001008506.2. NM_001008506.2. [Q8BJ05-3]
NP_001153579.1. NM_001160107.1. [Q8BJ05-2]
NP_001153580.1. NM_001160108.1. [Q8BJ05-4]
NP_083610.2. NM_029334.2. [Q8BJ05-1]
UniGeneiMm.25549.

Genome annotation databases

EnsembliENSMUST00000021399; ENSMUSP00000021399; ENSMUSG00000021012. [Q8BJ05-4]
ENSMUST00000057000; ENSMUSP00000055879; ENSMUSG00000021012. [Q8BJ05-2]
ENSMUST00000110104; ENSMUSP00000105731; ENSMUSG00000021012. [Q8BJ05-3]
ENSMUST00000110105; ENSMUSP00000105732; ENSMUSG00000021012. [Q8BJ05-1]
GeneIDi75553.
KEGGimmu:75553.
UCSCiuc007org.1. mouse. [Q8BJ05-1]
uc007orh.1. mouse. [Q8BJ05-3]
uc007ori.1. mouse. [Q8BJ05-2]
uc007orl.2. mouse. [Q8BJ05-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006009 mRNA. Translation: BAB24364.1.
AK048046 mRNA. Translation: BAC33222.1.
AK050226 mRNA. Translation: BAC34134.1.
AK160937 mRNA. Translation: BAE36101.1.
BC021797 mRNA. Translation: AAH21797.1.
BC024824 mRNA. Translation: AAH24824.1.
BC024856 mRNA. Translation: AAH24856.1.
BC026610 mRNA. Translation: AAH26610.1.
CCDSiCCDS26099.1. [Q8BJ05-3]
CCDS26100.1. [Q8BJ05-1]
CCDS49138.1. [Q8BJ05-2]
CCDS49139.1. [Q8BJ05-4]
RefSeqiNP_001008506.2. NM_001008506.2. [Q8BJ05-3]
NP_001153579.1. NM_001160107.1. [Q8BJ05-2]
NP_001153580.1. NM_001160108.1. [Q8BJ05-4]
NP_083610.2. NM_029334.2. [Q8BJ05-1]
UniGeneiMm.25549.

3D structure databases

ProteinModelPortaliQ8BJ05.
SMRiQ8BJ05. Positions 598-657, 679-716.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217572. 1 interaction.
IntActiQ8BJ05. 2 interactions.
MINTiMINT-4127881.
STRINGi10090.ENSMUSP00000105732.

PTM databases

iPTMnetiQ8BJ05.
PhosphoSiteiQ8BJ05.

Proteomic databases

EPDiQ8BJ05.
MaxQBiQ8BJ05.
PaxDbiQ8BJ05.
PeptideAtlasiQ8BJ05.
PRIDEiQ8BJ05.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021399; ENSMUSP00000021399; ENSMUSG00000021012. [Q8BJ05-4]
ENSMUST00000057000; ENSMUSP00000055879; ENSMUSG00000021012. [Q8BJ05-2]
ENSMUST00000110104; ENSMUSP00000105731; ENSMUSG00000021012. [Q8BJ05-3]
ENSMUST00000110105; ENSMUSP00000105732; ENSMUSG00000021012. [Q8BJ05-1]
GeneIDi75553.
KEGGimmu:75553.
UCSCiuc007org.1. mouse. [Q8BJ05-1]
uc007orh.1. mouse. [Q8BJ05-3]
uc007ori.1. mouse. [Q8BJ05-2]
uc007orl.2. mouse. [Q8BJ05-4]

Organism-specific databases

CTDi79882.
MGIiMGI:1919824. Zc3h14.

Phylogenomic databases

eggNOGiKOG3702. Eukaryota.
ENOG410YE77. LUCA.
GeneTreeiENSGT00440000038430.
HOVERGENiHBG108760.
InParanoidiQ8BJ05.
OMAiFNHDGEE.
OrthoDBiEOG091G0234.
PhylomeDBiQ8BJ05.
TreeFamiTF329509.

Miscellaneous databases

ChiTaRSiZc3h14. mouse.
PROiQ8BJ05.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021012.
GenevisibleiQ8BJ05. MM.

Family and domain databases

InterProiIPR000571. Znf_CCCH.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 3 hits.
[Graphical view]
PROSITEiPS50103. ZF_C3H1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZC3HE_MOUSE
AccessioniPrimary (citable) accession number: Q8BJ05
Secondary accession number(s): A0PJE7
, A1A4A9, Q3TU70, Q8BIY8, Q8R3Q8, Q8R3R2, Q9DAA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.