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Protein

Zinc finger CCCH domain-containing protein 14

Gene

Zc3h14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri595 – 620C3H1-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri621 – 640C3H1-type 2PROSITE-ProRule annotationAdd BLAST20
Zinc fingeri641 – 656C3H1-type 3PROSITE-ProRule annotationAdd BLAST16
Zinc fingeri681 – 698C3H1-type 4PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri700 – 718C3H1-type 5PROSITE-ProRule annotationAdd BLAST19

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 14
Gene namesi
Name:Zc3h14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1919824 Zc3h14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003313131 – 735Zinc finger CCCH domain-containing protein 14Add BLAST735

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei85PhosphoserineCombined sources1
Cross-linki99Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki139Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki175Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki198Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei240PhosphoserineBy similarity1
Cross-linki245Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki283Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki295Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei309PhosphoserineCombined sources1
Modified residuei327PhosphoserineBy similarity1
Modified residuei343PhosphoserineBy similarity1
Modified residuei357N6-acetyllysine; alternateBy similarity1
Cross-linki357Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki378Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei390PhosphoserineBy similarity1
Modified residuei409PhosphoserineBy similarity1
Cross-linki413Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki489Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei498PhosphoserineBy similarity1
Modified residuei515PhosphoserineCombined sources1
Modified residuei527PhosphoserineCombined sources1
Modified residuei620PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8BJ05
PaxDbiQ8BJ05
PeptideAtlasiQ8BJ05
PRIDEiQ8BJ05

PTM databases

iPTMnetiQ8BJ05
PhosphoSitePlusiQ8BJ05

Expressioni

Tissue specificityi

Expressed in hippocampal pyramidal neurons (at protein level) (PubMed:21734151).Expressed in kidney, liver, muscle, heart brain and testes (PubMed:19303045). Expressed in hippocampal pyramidal neurons (PubMed:21734151).1 Publication

Gene expression databases

BgeeiENSMUSG00000021012
ExpressionAtlasiQ8BJ05 baseline and differential
GenevisibleiQ8BJ05 MM

Interactioni

Subunit structurei

Interacts with HOOK2. Interacts with ZFC3H1 in a RNase-sensitive manner.By similarity

Protein-protein interaction databases

BioGridi217572, 1 interactor
IntActiQ8BJ05, 2 interactors
MINTiQ8BJ05
STRINGi10090.ENSMUSP00000105732

Structurei

3D structure databases

ProteinModelPortaliQ8BJ05
SMRiQ8BJ05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZC3H14 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri595 – 620C3H1-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri621 – 640C3H1-type 2PROSITE-ProRule annotationAdd BLAST20
Zinc fingeri641 – 656C3H1-type 3PROSITE-ProRule annotationAdd BLAST16
Zinc fingeri681 – 698C3H1-type 4PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri700 – 718C3H1-type 5PROSITE-ProRule annotationAdd BLAST19

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG3702 Eukaryota
ENOG410YE77 LUCA
GeneTreeiENSGT00440000038430
HOVERGENiHBG108760
InParanoidiQ8BJ05
OMAiFNHDGEE
OrthoDBiEOG091G0234
PhylomeDBiQ8BJ05
TreeFamiTF329509

Family and domain databases

InterProiView protein in InterPro
IPR000571 Znf_CCCH
SMARTiView protein in SMART
SM00356 ZnF_C3H1, 3 hits
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 3 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BJ05-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIGTEISRK IRSAIKGKLQ ELGAYVDEEL PDYIMVMVAN KKSQDQMTED
60 70 80 90 100
LSLFLGNNTI RFTVWLHGVL DKLRSVTTEP SSLKSPDASI FDSHVPSNKS
110 120 130 140 150
SFSRGDERRH EAAVPPLAVS SSRPEKRDSR VSTSSQEQKS TNVRHSYDDG
160 170 180 190 200
ASTRLMSTVK PLREPAPSED VIDIKPEPDD LIDEDLNFVQ ENPLSQKKPT
210 220 230 240 250
VTLTYGSSRP SIEIYRPPAS RNADTGTHLN RLQLHPQQSS AHAAKQLDVQ
260 270 280 290 300
SSQVSEAGRL CEPPVLSSVE DTYSPFFRNN LDKMSIEDEN FRKRKLPVVS
310 320 330 340 350
SVVKVKRFSH DGEEEEEDED YGTRIGSLSS SVSVPAKPER RPSLPPSKQA
360 370 380 390 400
NKNLILKAIS EAQESVTKTT NYSAVPQKQT LPVAPRTRTS QEELLAEMVQ
410 420 430 440 450
GQNRAPRISP PVKEEEAKGD NTGKSQGTQQ RQLLSRLQID PVMVETMEMS
460 470 480 490 500
QDYYDMESMV HADTRSFILK KPKLSEEIVV TPNQDSGMKT ADALRVLSGH
510 520 530 540 550
LMQTRDLVQP DKPASPKFIV TLDGVPSPPG YMSDQEEEMC FEGMKPVNQT
560 570 580 590 600
SASNKGLRGL LHPQQLHLLS RQLEDPDGSF SNAEMTDLSV AQKPEKLLER
610 620 630 640 650
CKYWPACKNG DECVYHHPIS PCKAFPNCKF AEKCLFVHPN CKYDTKCTKA
660 670 680 690 700
DCPFTHMSRR ASILTPKPVS SPAPSSNGQL CRYFPACKKM ECPFYHPKHC
710 720 730
RFNTQCTRPD CTFYHPTITV PPRHALKWIR PQSSE
Length:735
Mass (Da):82,409
Last modified:March 1, 2003 - v1
Checksum:i550696563E7E87C3
GO
Isoform 2 (identifier: Q8BJ05-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     427-582: Missing.

Show »
Length:579
Mass (Da):64,937
Checksum:i71F35EE73B829234
GO
Isoform 3 (identifier: Q8BJ05-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     452-582: Missing.

Show »
Length:604
Mass (Da):67,839
Checksum:iBA1E05A017712FAE
GO
Isoform 4 (identifier: Q8BJ05-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-295: Missing.
     296-426: LPVVSSVVKV...AKGDNTGKSQ → MKMSSRFSSP...LIGFLTEVEK
     452-582: Missing.

Show »
Length:309
Mass (Da):35,073
Checksum:i054E426908EA5224
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27D → H in BAC34134 (PubMed:16141072).Curated1
Sequence conflicti665T → A in BAE36101 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0331771 – 295Missing in isoform 4. 1 PublicationAdd BLAST295
Alternative sequenceiVSP_033178296 – 426LPVVS…TGKSQ → MKMSSRFSSPSLPVFLSPEP ADLGSLTSASCSLNELGNIS YLLRKIATDINEMKGMKAAI LTVEANLFDLNVRVSQNEAK ISSLEVKMNEYLTSTSECNR QLEDFQERLEFESQSETTDA NLIGFLTEVEK in isoform 4. 1 PublicationAdd BLAST131
Alternative sequenceiVSP_033179427 – 582Missing in isoform 2. 2 PublicationsAdd BLAST156
Alternative sequenceiVSP_033180452 – 582Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST131

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006009 mRNA Translation: BAB24364.1
AK048046 mRNA Translation: BAC33222.1
AK050226 mRNA Translation: BAC34134.1
AK160937 mRNA Translation: BAE36101.1
BC021797 mRNA Translation: AAH21797.1
BC024824 mRNA Translation: AAH24824.1
BC024856 mRNA Translation: AAH24856.1
BC026610 mRNA Translation: AAH26610.1
CCDSiCCDS26099.1 [Q8BJ05-3]
CCDS26100.1 [Q8BJ05-1]
CCDS49138.1 [Q8BJ05-2]
CCDS49139.1 [Q8BJ05-4]
RefSeqiNP_001008506.2, NM_001008506.2 [Q8BJ05-3]
NP_001153579.1, NM_001160107.1 [Q8BJ05-2]
NP_001153580.1, NM_001160108.1 [Q8BJ05-4]
NP_083610.2, NM_029334.2 [Q8BJ05-1]
UniGeneiMm.25549

Genome annotation databases

EnsembliENSMUST00000021399; ENSMUSP00000021399; ENSMUSG00000021012 [Q8BJ05-4]
ENSMUST00000057000; ENSMUSP00000055879; ENSMUSG00000021012 [Q8BJ05-2]
ENSMUST00000110104; ENSMUSP00000105731; ENSMUSG00000021012 [Q8BJ05-3]
ENSMUST00000110105; ENSMUSP00000105732; ENSMUSG00000021012 [Q8BJ05-1]
GeneIDi75553
KEGGimmu:75553
UCSCiuc007org.1 mouse [Q8BJ05-1]
uc007orh.1 mouse [Q8BJ05-3]
uc007ori.1 mouse [Q8BJ05-2]
uc007orl.2 mouse [Q8BJ05-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZC3HE_MOUSE
AccessioniPrimary (citable) accession number: Q8BJ05
Secondary accession number(s): A0PJE7
, A1A4A9, Q3TU70, Q8BIY8, Q8R3Q8, Q8R3R2, Q9DAA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2003
Last modified: June 20, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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