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Protein

Cytochrome c oxidase assembly protein COX15 homolog

Gene

Cox15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the biosynthesis of heme A.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-189451. Heme biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly protein COX15 homolog
Gene namesi
Name:Cox15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1920112. Cox15.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei72 – 9221HelicalSequence analysisAdd
BLAST
Transmembranei157 – 17418HelicalSequence analysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence analysisAdd
BLAST
Transmembranei230 – 25021HelicalSequence analysisAdd
BLAST
Transmembranei272 – 29221HelicalSequence analysisAdd
BLAST
Transmembranei360 – 38021HelicalSequence analysisAdd
BLAST
Transmembranei385 – 40521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytochrome complex Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413Cytochrome c oxidase assembly protein COX15 homologPRO_0000183932Add
BLAST

Proteomic databases

EPDiQ8BJ03.
MaxQBiQ8BJ03.
PaxDbiQ8BJ03.
PRIDEiQ8BJ03.

PTM databases

PhosphoSiteiQ8BJ03.

Expressioni

Gene expression databases

BgeeiQ8BJ03.
GenevisibleiQ8BJ03. MM.

Interactioni

Protein-protein interaction databases

BioGridi230478. 1 interaction.
STRINGi10090.ENSMUSP00000041820.

Family & Domainsi

Sequence similaritiesi

Belongs to the COX15/CtaA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2725. Eukaryota.
COG1612. LUCA.
GeneTreeiENSGT00390000002223.
HOGENOMiHOG000214943.
HOVERGENiHBG051086.
InParanoidiQ8BJ03.
KOiK02259.
OMAiTALIYIV.
OrthoDBiEOG7X9G74.
PhylomeDBiQ8BJ03.
TreeFamiTF105073.

Family and domain databases

HAMAPiMF_01665. HemeA_synth_type2.
InterProiIPR003780. COX15/CtaA_fam.
IPR023754. HemeA_Synthase_type2.
IPR009003. Peptidase_S1_PA.
[Graphical view]
PfamiPF02628. COX15-CtaA. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BJ03-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQRLLLPSLR ALTGSRNVGL LVPRVASRTQ CGSSCGSQRP LRPGQYSTIT
60 70 80 90 100
EVALQSGKGT VSLPSRAAER AVGRWLLVCS GTVAGAVILG GVTRLTESGL
110 120 130 140 150
SMVDWHLIKE MKPPTSQEEW EAEFQKYQQF PEFKILNHDM TLAEFKFIWY
160 170 180 190 200
MEYSHRMWGR AVGLAYILPA AYFWRKGWLN RGMKGRVLAL CGLVCFQGLL
210 220 230 240 250
GWYMVKSGLE EKPESYDIPR VSQYRLAAHL GSALVLYCAS LWTSLSLLLP
260 270 280 290 300
QHKLPETRQL LWLRRFAGGT AGLVFLTALS GAFVAGLDAG LVYNSFPKMG
310 320 330 340 350
ESWIPEDLLT FSPVLKNVFE NPTMVQFDHR LLGVTSVTAI TVLYFLSRRI
360 370 380 390 400
PLPRRTKMAA VTLLALAYAQ VALGISTLLM YVPTPLAATH QSGSLALLSG
410
ALWLMNELRR VPK
Length:413
Mass (Da):45,853
Last modified:March 1, 2003 - v1
Checksum:i089D0EA76078C1EA
GO
Isoform 2 (identifier: Q8BJ03-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     391-413: QSGSLALLSGALWLMNELRRVPK → THTHTP

Note: No experimental confirmation available.
Show »
Length:396
Mass (Da):44,006
Checksum:i68109E82CC4E268E
GO

Sequence cautioni

The sequence AAH21498.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei391 – 41323QSGSL…RRVPK → THTHTP in isoform 2. 1 PublicationVSP_011282Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048099 mRNA. Translation: BAC33241.1.
AK141631 mRNA. Translation: BAE24776.1.
BC011509 mRNA. Translation: AAH11509.1.
BC021498 mRNA. Translation: AAH21498.1. Different initiation.
CCDSiCCDS29836.1. [Q8BJ03-1]
RefSeqiNP_659123.2. NM_144874.4. [Q8BJ03-1]
UniGeneiMm.248237.

Genome annotation databases

EnsembliENSMUST00000045562; ENSMUSP00000041820; ENSMUSG00000040018. [Q8BJ03-1]
GeneIDi226139.
KEGGimmu:226139.
UCSCiuc008hot.2. mouse. [Q8BJ03-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048099 mRNA. Translation: BAC33241.1.
AK141631 mRNA. Translation: BAE24776.1.
BC011509 mRNA. Translation: AAH11509.1.
BC021498 mRNA. Translation: AAH21498.1. Different initiation.
CCDSiCCDS29836.1. [Q8BJ03-1]
RefSeqiNP_659123.2. NM_144874.4. [Q8BJ03-1]
UniGeneiMm.248237.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230478. 1 interaction.
STRINGi10090.ENSMUSP00000041820.

PTM databases

PhosphoSiteiQ8BJ03.

Proteomic databases

EPDiQ8BJ03.
MaxQBiQ8BJ03.
PaxDbiQ8BJ03.
PRIDEiQ8BJ03.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045562; ENSMUSP00000041820; ENSMUSG00000040018. [Q8BJ03-1]
GeneIDi226139.
KEGGimmu:226139.
UCSCiuc008hot.2. mouse. [Q8BJ03-1]

Organism-specific databases

CTDi1355.
MGIiMGI:1920112. Cox15.

Phylogenomic databases

eggNOGiKOG2725. Eukaryota.
COG1612. LUCA.
GeneTreeiENSGT00390000002223.
HOGENOMiHOG000214943.
HOVERGENiHBG051086.
InParanoidiQ8BJ03.
KOiK02259.
OMAiTALIYIV.
OrthoDBiEOG7X9G74.
PhylomeDBiQ8BJ03.
TreeFamiTF105073.

Enzyme and pathway databases

ReactomeiR-MMU-189451. Heme biosynthesis.

Miscellaneous databases

ChiTaRSiCox15. mouse.
NextBioi378016.
PROiQ8BJ03.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BJ03.
GenevisibleiQ8BJ03. MM.

Family and domain databases

HAMAPiMF_01665. HemeA_synth_type2.
InterProiIPR003780. COX15/CtaA_fam.
IPR023754. HemeA_Synthase_type2.
IPR009003. Peptidase_S1_PA.
[Graphical view]
PfamiPF02628. COX15-CtaA. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Head and Hippocampus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen and Testis.

Entry informationi

Entry nameiCOX15_MOUSE
AccessioniPrimary (citable) accession number: Q8BJ03
Secondary accession number(s): Q3URB2, Q8VDN0, Q921K5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.