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Protein

Cytochrome c oxidase assembly protein COX15 homolog

Gene

Cox15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the biosynthesis of heme A.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-189451 Heme biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly protein COX15 homolog
Gene namesi
Name:Cox15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1920112 Cox15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei157 – 174HelicalSequence analysisAdd BLAST18
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21
Transmembranei360 – 380HelicalSequence analysisAdd BLAST21
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839321 – 413Cytochrome c oxidase assembly protein COX15 homologAdd BLAST413

Proteomic databases

PaxDbiQ8BJ03
PeptideAtlasiQ8BJ03
PRIDEiQ8BJ03

PTM databases

PhosphoSitePlusiQ8BJ03

Expressioni

Gene expression databases

BgeeiENSMUSG00000040018
GenevisibleiQ8BJ03 MM

Interactioni

Protein-protein interaction databases

BioGridi230478, 1 interactor
STRINGi10090.ENSMUSP00000041820

Structurei

3D structure databases

SMRiQ8BJ03
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COX15/CtaA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2725 Eukaryota
COG1612 LUCA
GeneTreeiENSGT00390000002223
HOGENOMiHOG000214943
HOVERGENiHBG051086
InParanoidiQ8BJ03
KOiK02259
OMAiAGLIYNT
OrthoDBiEOG091G08NN
PhylomeDBiQ8BJ03
TreeFamiTF105073

Family and domain databases

HAMAPiMF_01665 HemeA_synth_type2, 1 hit
InterProiView protein in InterPro
IPR003780 COX15/CtaA_fam
IPR023754 HemeA_Synthase_type2
IPR009003 Peptidase_S1_PA
PANTHERiPTHR23289 PTHR23289, 1 hit
PfamiView protein in Pfam
PF02628 COX15-CtaA, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BJ03-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQRLLLPSLR ALTGSRNVGL LVPRVASRTQ CGSSCGSQRP LRPGQYSTIT
60 70 80 90 100
EVALQSGKGT VSLPSRAAER AVGRWLLVCS GTVAGAVILG GVTRLTESGL
110 120 130 140 150
SMVDWHLIKE MKPPTSQEEW EAEFQKYQQF PEFKILNHDM TLAEFKFIWY
160 170 180 190 200
MEYSHRMWGR AVGLAYILPA AYFWRKGWLN RGMKGRVLAL CGLVCFQGLL
210 220 230 240 250
GWYMVKSGLE EKPESYDIPR VSQYRLAAHL GSALVLYCAS LWTSLSLLLP
260 270 280 290 300
QHKLPETRQL LWLRRFAGGT AGLVFLTALS GAFVAGLDAG LVYNSFPKMG
310 320 330 340 350
ESWIPEDLLT FSPVLKNVFE NPTMVQFDHR LLGVTSVTAI TVLYFLSRRI
360 370 380 390 400
PLPRRTKMAA VTLLALAYAQ VALGISTLLM YVPTPLAATH QSGSLALLSG
410
ALWLMNELRR VPK
Length:413
Mass (Da):45,853
Last modified:March 1, 2003 - v1
Checksum:i089D0EA76078C1EA
GO
Isoform 2 (identifier: Q8BJ03-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     391-413: QSGSLALLSGALWLMNELRRVPK → THTHTP

Note: No experimental confirmation available.
Show »
Length:396
Mass (Da):44,006
Checksum:i68109E82CC4E268E
GO

Sequence cautioni

The sequence AAH21498 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011282391 – 413QSGSL…RRVPK → THTHTP in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048099 mRNA Translation: BAC33241.1
AK141631 mRNA Translation: BAE24776.1
BC011509 mRNA Translation: AAH11509.1
BC021498 mRNA Translation: AAH21498.1 Different initiation.
CCDSiCCDS29836.1 [Q8BJ03-1]
RefSeqiNP_659123.2, NM_144874.4 [Q8BJ03-1]
UniGeneiMm.248237

Genome annotation databases

EnsembliENSMUST00000045562; ENSMUSP00000041820; ENSMUSG00000040018 [Q8BJ03-1]
GeneIDi226139
KEGGimmu:226139
UCSCiuc008hot.2 mouse [Q8BJ03-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCOX15_MOUSE
AccessioniPrimary (citable) accession number: Q8BJ03
Secondary accession number(s): Q3URB2, Q8VDN0, Q921K5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health