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Protein

Smad nuclear-interacting protein 1

Gene

Snip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRNA-mediated gene silencing

Names & Taxonomyi

Protein namesi
Recommended name:
Smad nuclear-interacting protein 1
Gene namesi
Name:Snip1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2156003. Snip1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000720101 – 383Smad nuclear-interacting protein 1Add BLAST383

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineCombined sources1
Cross-linki28Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity
Cross-linki28Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki28Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei33PhosphoserineBy similarity1
Modified residuei48PhosphoserineCombined sources1
Modified residuei50PhosphoserineCombined sources1
Modified residuei91PhosphoserineBy similarity1
Cross-linki100Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei145PhosphoserineBy similarity1
Modified residuei381PhosphoserineBy similarity1

Post-translational modificationi

Degraded by the proteasome upon binding to the SMAD1/OAZ1/PSMB4 complex.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8BIZ6.
MaxQBiQ8BIZ6.
PaxDbiQ8BIZ6.
PeptideAtlasiQ8BIZ6.
PRIDEiQ8BIZ6.

PTM databases

iPTMnetiQ8BIZ6.
PhosphoSitePlusiQ8BIZ6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000050213.
CleanExiMM_SNIP1.
GenevisibleiQ8BIZ6. MM.

Interactioni

Subunit structurei

Binds SMAD4 and CREBBP/EP300. Binds the SMAD1/OAZ1/PSMB4 complex. Interacts with DROSHA and SMARCA4. Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8BIZ6. 1 interactor.
STRINGi10090.ENSMUSP00000060721.

Structurei

3D structure databases

ProteinModelPortaliQ8BIZ6.
SMRiQ8BIZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini268 – 331FHAPROSITE-ProRule annotationAdd BLAST64

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili153 – 194Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 180Arg-richAdd BLAST119
Compositional biasi374 – 377Poly-Glu4

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1882. Eukaryota.
ENOG4111F4H. LUCA.
GeneTreeiENSGT00730000110659.
HOGENOMiHOG000264922.
HOVERGENiHBG056615.
InParanoidiQ8BIZ6.
KOiK13108.
OMAiLKYHEPA.
OrthoDBiEOG091G0M70.
PhylomeDBiQ8BIZ6.
TreeFamiTF312797.

Family and domain databases

InterProiView protein in InterPro
IPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
PfamiView protein in Pfam
PF00498. FHA. 1 hit.
SMARTiView protein in SMART
SM00240. FHA. 1 hit.
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiView protein in PROSITE
PS50006. FHA_DOMAIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BIZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAGKSERER SGRRRHRSGD ALTTVVVKQE RLSPEPVAHR RPDAPAASLS
60 70 80 90 100
PPAAEPGHSG HRGSRARSPA KKKSKSSGRR SKSPRTKRSQ SPHYPMVKVK
110 120 130 140 150
QEREDHPRRG REDRQHREPS EQEHRRARNS ERDRHRGHSR QGRSSDERPV
160 170 180 190 200
SGQDRDRDSQ NLQAQEEERD FHNARRREHR QQNESAGSEA QEVIPRPAGN
210 220 230 240 250
RSKEVPVKEK PSFELSGALL EDTNTFRGVV IKYSEPPEAR IPKKRWRLYP
260 270 280 290 300
FKNDEVLPVM YIHRQSAYLL GRHRRIADIP IDHPSCSKQH AVFQYRLVEY
310 320 330 340 350
TRADGTVGRR VKPYIIDLGS GNGTFLNNKR IEPQRYYELK EKDVLKFGFS
360 370 380
SREYVLLHES SDTSELDRKE DEDDEEEEMV SDS
Length:383
Mass (Da):44,415
Last modified:March 1, 2003 - v1
Checksum:i0ADD646D4CB952BE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti223T → P in BAC33680 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK040571 mRNA. Translation: BAE20582.1.
AK049254 mRNA. Translation: BAC33638.1.
AK049318 mRNA. Translation: BAC33680.1.
AK132768 mRNA. Translation: BAE21347.1.
AK143801 mRNA. Translation: BAE25543.1.
BC064067 mRNA. Translation: AAH64067.1.
CCDSiCCDS18636.1.
RefSeqiNP_780455.2. NM_175246.4.
UniGeneiMm.22548.

Genome annotation databases

EnsembliENSMUST00000052183; ENSMUSP00000060721; ENSMUSG00000050213.
GeneIDi76793.
KEGGimmu:76793.
UCSCiuc008urq.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSNIP1_MOUSE
AccessioniPrimary (citable) accession number: Q8BIZ6
Secondary accession number(s): Q3V106, Q8BIZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: March 1, 2003
Last modified: June 7, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot