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Protein

ARL14 effector protein

Gene

Arl14ep

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
ARL14 effector protein
Alternative name(s):
ARF7 effector protein
Gene namesi
Name:Arl14ep
Synonyms:Arf7ep
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1926020. Arl14ep.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276ARL14 effector proteinPRO_0000251893Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei182 – 1821PhosphoserineBy similarity
Modified residuei266 – 2661PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BIX3.
MaxQBiQ8BIX3.
PaxDbiQ8BIX3.
PeptideAtlasiQ8BIX3.
PRIDEiQ8BIX3.

PTM databases

iPTMnetiQ8BIX3.
PhosphoSiteiQ8BIX3.

Expressioni

Gene expression databases

BgeeiQ8BIX3.
CleanExiMM_2700007P21RIK.
GenevisibleiQ8BIX3. MM.

Interactioni

Subunit structurei

Interacts with ARL14 and MYO1E.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028536.

Structurei

3D structure databases

ProteinModelPortaliQ8BIX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi208 – 23629Cys-richAdd
BLAST

Phylogenomic databases

eggNOGiKOG4850. Eukaryota.
ENOG4111QTN. LUCA.
GeneTreeiENSGT00510000047210.
HOGENOMiHOG000232178.
HOVERGENiHBG055275.
InParanoidiQ8BIX3.
OMAiFANPGRQ.
OrthoDBiEOG7S4X8Z.
PhylomeDBiQ8BIX3.
TreeFamiTF333216.

Family and domain databases

InterProiIPR026515. ARF14EP.
IPR029264. ARF7EP_C.
[Graphical view]
PANTHERiPTHR23080:SF72. PTHR23080:SF72. 1 hit.
PfamiPF14949. ARF7EP_C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BIX3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPCSVGVQL RTTHDCHKTF YTRHTGFKTL KELSSNDMLL LQLRTGMTLS
60 70 80 90 100
GNNTICLHHV KIYIDRFEDL QKSCCDPFNI HKKLAKKNLH VIDLDDATFL
110 120 130 140 150
SAKFGRQLVP GWKLCPKCTQ IINGSVDVDS DDRQRRKPDS DGRTAKALRS
160 170 180 190 200
LQFTNPGKQT EFAPEGGKRE KRKLTKATSA ASDRQIIPAK SKVYDSQGLL
210 220 230 240 250
IFSGMDLCDC LDEDCLGCFY ACPTCGSTKC GAECRCDRKW LYEQIEIEGG
260 270
EIIHNKHAGK AYGLLSPCHP YDILQK
Length:276
Mass (Da):31,011
Last modified:March 1, 2003 - v1
Checksum:iFA117F0C09B97BAE
GO
Isoform 2 (identifier: Q8BIX3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-159: GRTAKALRSLQFTNPGKQ → VCIEAIVLSTVWDFRYME
     160-276: Missing.

Note: May be due to intron retention. No experimental confirmation available.
Show »
Length:159
Mass (Da):18,290
Checksum:iCF18583317B6AA5F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711Q → R in AAH54106 (PubMed:15489334).Curated
Sequence conflicti86 – 861K → R in BAB28102 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei142 – 15918GRTAK…NPGKQ → VCIEAIVLSTVWDFRYME in isoform 2. 1 PublicationVSP_020776Add
BLAST
Alternative sequencei160 – 276117Missing in isoform 2. 1 PublicationVSP_020777Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012215 mRNA. Translation: BAB28102.1.
AK076781 mRNA. Translation: BAC36478.1.
AK134965 mRNA. Translation: BAE22360.1.
BC054106 mRNA. Translation: AAH54106.1.
CCDSiCCDS16503.1. [Q8BIX3-1]
RefSeqiNP_001020273.1. NM_001025102.1. [Q8BIX3-1]
NP_776111.1. NM_173750.2. [Q8BIX3-1]
XP_006499149.1. XM_006499086.2. [Q8BIX3-1]
UniGeneiMm.381231.
Mm.453385.
Mm.470117.

Genome annotation databases

EnsembliENSMUST00000028536; ENSMUSP00000028536; ENSMUSG00000027122. [Q8BIX3-1]
ENSMUST00000093883; ENSMUSP00000091409; ENSMUSG00000027122. [Q8BIX3-1]
GeneIDi212772.
KEGGimmu:212772.
UCSCiuc008llq.1. mouse. [Q8BIX3-1]
uc008lls.1. mouse. [Q8BIX3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012215 mRNA. Translation: BAB28102.1.
AK076781 mRNA. Translation: BAC36478.1.
AK134965 mRNA. Translation: BAE22360.1.
BC054106 mRNA. Translation: AAH54106.1.
CCDSiCCDS16503.1. [Q8BIX3-1]
RefSeqiNP_001020273.1. NM_001025102.1. [Q8BIX3-1]
NP_776111.1. NM_173750.2. [Q8BIX3-1]
XP_006499149.1. XM_006499086.2. [Q8BIX3-1]
UniGeneiMm.381231.
Mm.453385.
Mm.470117.

3D structure databases

ProteinModelPortaliQ8BIX3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028536.

PTM databases

iPTMnetiQ8BIX3.
PhosphoSiteiQ8BIX3.

Proteomic databases

EPDiQ8BIX3.
MaxQBiQ8BIX3.
PaxDbiQ8BIX3.
PeptideAtlasiQ8BIX3.
PRIDEiQ8BIX3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028536; ENSMUSP00000028536; ENSMUSG00000027122. [Q8BIX3-1]
ENSMUST00000093883; ENSMUSP00000091409; ENSMUSG00000027122. [Q8BIX3-1]
GeneIDi212772.
KEGGimmu:212772.
UCSCiuc008llq.1. mouse. [Q8BIX3-1]
uc008lls.1. mouse. [Q8BIX3-2]

Organism-specific databases

CTDi120534.
MGIiMGI:1926020. Arl14ep.

Phylogenomic databases

eggNOGiKOG4850. Eukaryota.
ENOG4111QTN. LUCA.
GeneTreeiENSGT00510000047210.
HOGENOMiHOG000232178.
HOVERGENiHBG055275.
InParanoidiQ8BIX3.
OMAiFANPGRQ.
OrthoDBiEOG7S4X8Z.
PhylomeDBiQ8BIX3.
TreeFamiTF333216.

Miscellaneous databases

PROiQ8BIX3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BIX3.
CleanExiMM_2700007P21RIK.
GenevisibleiQ8BIX3. MM.

Family and domain databases

InterProiIPR026515. ARF14EP.
IPR029264. ARF7EP_C.
[Graphical view]
PANTHERiPTHR23080:SF72. PTHR23080:SF72. 1 hit.
PfamiPF14949. ARF7EP_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Embryo, Olfactory bulb and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: ICR.
    Tissue: Trophoblast stem cell.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-266, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiAL14E_MOUSE
AccessioniPrimary (citable) accession number: Q8BIX3
Secondary accession number(s): Q7TPE6, Q9CZS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.