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Protein

ARL14 effector protein

Gene

Arl14ep

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
ARL14 effector protein
Alternative name(s):
ARF7 effector protein
Gene namesi
Name:Arl14ep
Synonyms:Arf7ep
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1926020. Arl14ep.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002518931 – 276ARL14 effector proteinAdd BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei182PhosphoserineBy similarity1
Modified residuei266PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8BIX3.
PaxDbiQ8BIX3.
PeptideAtlasiQ8BIX3.
PRIDEiQ8BIX3.

PTM databases

iPTMnetiQ8BIX3.
PhosphoSitePlusiQ8BIX3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027122.
CleanExiMM_2700007P21RIK.
GenevisibleiQ8BIX3. MM.

Interactioni

Subunit structurei

Interacts with ARL14 and MYO1E.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028536.

Structurei

3D structure databases

ProteinModelPortaliQ8BIX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi208 – 236Cys-richAdd BLAST29

Phylogenomic databases

eggNOGiKOG4850. Eukaryota.
ENOG4111QTN. LUCA.
GeneTreeiENSGT00510000047210.
HOGENOMiHOG000232178.
HOVERGENiHBG055275.
InParanoidiQ8BIX3.
OMAiQFANPGR.
OrthoDBiEOG091G0X7Y.
PhylomeDBiQ8BIX3.
TreeFamiTF333216.

Family and domain databases

InterProiView protein in InterPro
IPR029264. ARF7EP_C.
IPR026515. ARL14EP.
PANTHERiPTHR23080:SF91. PTHR23080:SF91. 1 hit.
PfamiView protein in Pfam
PF14949. ARF7EP_C. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BIX3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPCSVGVQL RTTHDCHKTF YTRHTGFKTL KELSSNDMLL LQLRTGMTLS
60 70 80 90 100
GNNTICLHHV KIYIDRFEDL QKSCCDPFNI HKKLAKKNLH VIDLDDATFL
110 120 130 140 150
SAKFGRQLVP GWKLCPKCTQ IINGSVDVDS DDRQRRKPDS DGRTAKALRS
160 170 180 190 200
LQFTNPGKQT EFAPEGGKRE KRKLTKATSA ASDRQIIPAK SKVYDSQGLL
210 220 230 240 250
IFSGMDLCDC LDEDCLGCFY ACPTCGSTKC GAECRCDRKW LYEQIEIEGG
260 270
EIIHNKHAGK AYGLLSPCHP YDILQK
Length:276
Mass (Da):31,011
Last modified:March 1, 2003 - v1
Checksum:iFA117F0C09B97BAE
GO
Isoform 2 (identifier: Q8BIX3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-159: GRTAKALRSLQFTNPGKQ → VCIEAIVLSTVWDFRYME
     160-276: Missing.

Note: May be due to intron retention. No experimental confirmation available.
Show »
Length:159
Mass (Da):18,290
Checksum:iCF18583317B6AA5F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71Q → R in AAH54106 (PubMed:15489334).Curated1
Sequence conflicti86K → R in BAB28102 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020776142 – 159GRTAK…NPGKQ → VCIEAIVLSTVWDFRYME in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_020777160 – 276Missing in isoform 2. 1 PublicationAdd BLAST117

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012215 mRNA. Translation: BAB28102.1.
AK076781 mRNA. Translation: BAC36478.1.
AK134965 mRNA. Translation: BAE22360.1.
BC054106 mRNA. Translation: AAH54106.1.
CCDSiCCDS16503.1. [Q8BIX3-1]
RefSeqiNP_001020273.1. NM_001025102.1. [Q8BIX3-1]
NP_776111.1. NM_173750.2. [Q8BIX3-1]
XP_006499149.1. XM_006499086.3. [Q8BIX3-1]
UniGeneiMm.381231.
Mm.453385.
Mm.470117.

Genome annotation databases

EnsembliENSMUST00000028536; ENSMUSP00000028536; ENSMUSG00000027122. [Q8BIX3-1]
ENSMUST00000093883; ENSMUSP00000091409; ENSMUSG00000027122. [Q8BIX3-1]
GeneIDi212772.
KEGGimmu:212772.
UCSCiuc008llq.1. mouse. [Q8BIX3-1]
uc008lls.1. mouse. [Q8BIX3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAL14E_MOUSE
AccessioniPrimary (citable) accession number: Q8BIX3
Secondary accession number(s): Q7TPE6, Q9CZS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: August 30, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot