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Protein

Proton-associated sugar transporter A

Gene

Slc45a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Mediates glucose uptake along the pH gradient.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Proton-associated sugar transporter A
Short name:
PAST-A
Alternative name(s):
Deleted in neuroblastoma 5 protein homolog
Short name:
DNb-5 homolog
Solute carrier family 45 member 1
Gene namesi
Name:Slc45a1
Synonyms:Dnb5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2653235. Slc45a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Transmembranei536 – 556HelicalSequence analysisAdd BLAST21
Transmembranei576 – 596HelicalSequence analysisAdd BLAST21
Transmembranei606 – 626HelicalSequence analysisAdd BLAST21
Transmembranei630 – 650HelicalSequence analysisAdd BLAST21
Transmembranei688 – 708HelicalSequence analysisAdd BLAST21
Transmembranei710 – 730HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001225151 – 751Proton-associated sugar transporter AAdd BLAST751

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei500PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BIV7.
PRIDEiQ8BIV7.

PTM databases

iPTMnetiQ8BIV7.
PhosphoSitePlusiQ8BIV7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039838.
CleanExiMM_SLC45A1.
ExpressionAtlasiQ8BIV7. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036774.

Structurei

3D structure databases

ProteinModelPortaliQ8BIV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0637. Eukaryota.
ENOG410Y28T. LUCA.
GeneTreeiENSGT00390000018882.
HOGENOMiHOG000231090.
HOVERGENiHBG053518.
InParanoidiQ8BIV7.
KOiK15378.
OMAiPKYGSFI.
OrthoDBiEOG091G05H5.
PhylomeDBiQ8BIV7.
TreeFamiTF325412.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8BIV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPPASSTPP GEAVIPSVAP QDFWRSPISS YSGSVTGHIS HRANNFKRHP
60 70 80 90 100
KRRKYIRPSP PPPPNTPCPI ELVDFGDLHP QRSFWELLFN GCILFGIEFS
110 120 130 140 150
YAMETAYVTP VLLQMGLPDQ LYSLVWFISP ILGFLLQPLL GAWSDRCTSR
160 170 180 190 200
FGRRRPFILV LAIGALLGLS LLLNGRDIGM ALADTATNHK WGILLTVCGV
210 220 230 240 250
VLMDFSADSA DNPSHAYMMD VCGPVDQDRG LNIHALMAGL GGGFGYVVGG
260 270 280 290 300
IHWDKTSFGR ALGGQLRVIY VFTAITLSVT TVLTLISIPE RPLRPLGEKR
310 320 330 340 350
TAMKSPSLPL PPSPPVLLEE GAGDALPSTT ATSLYASFSS PISPPSPLTP
360 370 380 390 400
KYGSFISRDS SLTGINEFAS SFGTSNIDSV LIDCFTAGHD NYLALPSSVP
410 420 430 440 450
RQAISVSFPR APDGFYCQER GLERREGPLT LGSDGDVLRV GSLDTSKPRA
460 470 480 490 500
SGILKRPQTL ALPDVAGGNG PETSRRRNVT FSQQVANILL NGVKYESELT
510 520 530 540 550
GSSEQSEQPL SLRHLCSTIY NMPKALRNLC VNHFLGWLSF EGMLLFYTDF
560 570 580 590 600
MGEVVFQGDP KAPHTSEAYQ KYNSGVTMGC WGMCIYAFSA AFYSAILEKL
610 620 630 640 650
EECLSVRTLY FIAYLAFGLG TGLATLSRNL YVVLSLCTTY GILFSTLCTL
660 670 680 690 700
PYSLLCDYYQ SKKFAGSSAD GTRRGMGVDI SLLSCQYFLA QILVSLVLGP
710 720 730 740 750
LTSAVGSANG VMYFSSLVSF LGCLYSSLCV TYEIPSVDAA DEERQPLLLN

V
Length:751
Mass (Da):81,474
Last modified:May 16, 2006 - v3
Checksum:i129F390E154F6BBD
GO

Sequence cautioni

The sequence AK082651 differs from that shown. Reason: Frameshift at position 217.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti287S → R in BAE34311 (PubMed:16141072).Curated1
Sequence conflicti433S → L in BAE34311 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK082651 mRNA. No translation available.
AK158002 mRNA. Translation: BAE34311.1.
CCDSiCCDS18973.1.
RefSeqiNP_776135.2. NM_173774.3.
UniGeneiMm.29280.

Genome annotation databases

EnsembliENSMUST00000037827; ENSMUSP00000036774; ENSMUSG00000039838.
GeneIDi242773.
KEGGimmu:242773.
UCSCiuc008vxt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK082651 mRNA. No translation available.
AK158002 mRNA. Translation: BAE34311.1.
CCDSiCCDS18973.1.
RefSeqiNP_776135.2. NM_173774.3.
UniGeneiMm.29280.

3D structure databases

ProteinModelPortaliQ8BIV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036774.

PTM databases

iPTMnetiQ8BIV7.
PhosphoSitePlusiQ8BIV7.

Proteomic databases

PaxDbiQ8BIV7.
PRIDEiQ8BIV7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037827; ENSMUSP00000036774; ENSMUSG00000039838.
GeneIDi242773.
KEGGimmu:242773.
UCSCiuc008vxt.1. mouse.

Organism-specific databases

CTDi50651.
MGIiMGI:2653235. Slc45a1.

Phylogenomic databases

eggNOGiKOG0637. Eukaryota.
ENOG410Y28T. LUCA.
GeneTreeiENSGT00390000018882.
HOGENOMiHOG000231090.
HOVERGENiHBG053518.
InParanoidiQ8BIV7.
KOiK15378.
OMAiPKYGSFI.
OrthoDBiEOG091G05H5.
PhylomeDBiQ8BIV7.
TreeFamiTF325412.

Miscellaneous databases

PROiQ8BIV7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039838.
CleanExiMM_SLC45A1.
ExpressionAtlasiQ8BIV7. baseline and differential.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiS45A1_MOUSE
AccessioniPrimary (citable) accession number: Q8BIV7
Secondary accession number(s): Q3TZ98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: May 16, 2006
Last modified: November 2, 2016
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.