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Protein

Ran-binding protein 6

Gene

Ranbp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function in nuclear protein import as nuclear transport receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Ran-binding protein 6
Short name:
RanBP6
Gene namesi
Name:Ranbp6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2683212. Ranbp6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 11051104Ran-binding protein 6PRO_0000120780Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei835 – 8351PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8BIV3.
PaxDbiQ8BIV3.
PRIDEiQ8BIV3.

PTM databases

iPTMnetiQ8BIV3.
PhosphoSiteiQ8BIV3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000074909.
CleanExiMM_RANBP6.
ExpressionAtlasiQ8BIV3. baseline and differential.
GenevisibleiQ8BIV3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100503.

Structurei

3D structure databases

ProteinModelPortaliQ8BIV3.
SMRiQ8BIV3. Positions 177-629.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati219 – 25739HEAT 1Add
BLAST
Repeati361 – 39939HEAT 2Add
BLAST
Repeati402 – 44039HEAT 3Add
BLAST
Repeati444 – 48340HEAT 4Add
BLAST
Repeati866 – 90540HEAT 5Add
BLAST
Repeati908 – 94639HEAT 6Add
BLAST
Repeati949 – 98739HEAT 7Add
BLAST

Sequence similaritiesi

Belongs to the importin beta family.Curated
Contains 7 HEAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2171. Eukaryota.
ENOG410XQAJ. LUCA.
GeneTreeiENSGT00550000074773.
HOGENOMiHOG000209725.
HOVERGENiHBG006156.
InParanoidiQ8BIV3.
OMAiFGTQERH.
OrthoDBiEOG091G011X.
PhylomeDBiQ8BIV3.
TreeFamiTF300344.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
[Graphical view]
PfamiPF02985. HEAT. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BIV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAGSAGLP ATVSEKQEFY QLLKNLINPS CMVRRQAEEV YENIPGLCKT
60 70 80 90 100
TFLLDAVRNR RAGYEVRQMA AALLRRLLSS GFEEVYPNLP PEVQRDVKIE
110 120 130 140 150
LILAVKLETH ASMRKKLCDI FAVLARNLID ESGTNHWPEG LKFLIDSIHS
160 170 180 190 200
KNVVLWEVAL HVFWHFPGIF GNQDRHDLDI IKRLLDQCIQ DQEHPAIRTL
210 220 230 240 250
SARAAATFVL ANENNIALFK DFADLLPGIL QAVNDSCYQD DDSVLESLVE
260 270 280 290 300
IADTVPKYLG PYLEDTLQLS LKLCGDSRLS NLQRQLALEV IVTLSETATP
310 320 330 340 350
MLKKHTNIIA QAVPHILAMM VDLQDDDDWV NADEMEEDDF DSNAVAAESA
360 370 380 390 400
LDRLACGLGG KVVLPMTKEH IMQMLQSPDW KCRHAGLMAL SAIGEGCHQQ
410 420 430 440 450
MEPILDETVN SVLLFLQDPH PRVRAAACTT LGQMATDFAP SFQKKFHEIV
460 470 480 490 500
ITALLRTMEN QGNQRVQSHA ASALVIFIED CPKSLLILYL ENMVKSLHSI
510 520 530 540 550
LVIKLQELIR NGTKLALEQL VTTIASVADA IEESFIPYYD IFMPSLKHVV
560 570 580 590 600
ELAVQKELKL LRGKTIECIS HVGLAVGKEK FMQDASNVMQ LLLKTQSDLN
610 620 630 640 650
NMEDDDPQTS YMVSAWARMC KILGKDFEQY LPLVIEPLIK TASAKPDVAL
660 670 680 690 700
LDTQDVENMS DDDGWQFVNL GDQQSFGIKT SGLEAKATAC QMLVYYAKEL
710 720 730 740 750
REGFVEYTEQ VVKMMVPLLK FYFHDNVRVA AAEAMPFLLE CARIRGSEYL
760 770 780 790 800
SQMWQFICDP LIKAIGTEPD TDVLSEIMNS FAKSIEVMGD GCLNDEHLEE
810 820 830 840 850
LGGILKAKLE GHFKNQELRQ VKRQEENYDQ QVEMSLQDED ECDVYILTKV
860 870 880 890 900
SDILHSLFST YKEKILPWFE QLLPLIVNLI CSSRPWPDRQ WGLCIFDDII
910 920 930 940 950
EHCSPTSFKY VEYFRWPMLL NMRDNNPEVR QAAAYGLGVM AQFGGDDYRS
960 970 980 990 1000
LCSEAVPLLV KVIKCANSKT KKNVIATENC ISAIGKILKF KPNCVNVDEV
1010 1020 1030 1040 1050
LPHWLSWLPL HEDKEEAIQT LNFLCDLIES NHPVVIGPNN SNLPKIISII
1060 1070 1080 1090 1100
AEGKINETIS HEDPCAKRLA NVVRQIQTSE ELWLECTSQL DDEQQEALHE

LLSFA
Length:1,105
Mass (Da):124,587
Last modified:January 9, 2007 - v3
Checksum:iA79A4D2F0BEB4578
GO

Sequence cautioni

The sequence BAC38756 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE36329 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1105 – 11051A → CLKQFNTIYHKSSYNVS in BAE36329 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120159 Genomic DNA. No translation available.
AK083089 mRNA. Translation: BAC38756.1. Different initiation.
AK161331 mRNA. Translation: BAE36329.1. Different initiation.
CCDSiCCDS37954.1.
RefSeqiNP_808389.2. NM_177721.4.
UniGeneiMm.125503.

Genome annotation databases

EnsembliENSMUST00000099525; ENSMUSP00000100503; ENSMUSG00000074909.
GeneIDi240614.
KEGGimmu:240614.
UCSCiuc008heb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120159 Genomic DNA. No translation available.
AK083089 mRNA. Translation: BAC38756.1. Different initiation.
AK161331 mRNA. Translation: BAE36329.1. Different initiation.
CCDSiCCDS37954.1.
RefSeqiNP_808389.2. NM_177721.4.
UniGeneiMm.125503.

3D structure databases

ProteinModelPortaliQ8BIV3.
SMRiQ8BIV3. Positions 177-629.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100503.

PTM databases

iPTMnetiQ8BIV3.
PhosphoSiteiQ8BIV3.

Proteomic databases

MaxQBiQ8BIV3.
PaxDbiQ8BIV3.
PRIDEiQ8BIV3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099525; ENSMUSP00000100503; ENSMUSG00000074909.
GeneIDi240614.
KEGGimmu:240614.
UCSCiuc008heb.2. mouse.

Organism-specific databases

CTDi26953.
MGIiMGI:2683212. Ranbp6.

Phylogenomic databases

eggNOGiKOG2171. Eukaryota.
ENOG410XQAJ. LUCA.
GeneTreeiENSGT00550000074773.
HOGENOMiHOG000209725.
HOVERGENiHBG006156.
InParanoidiQ8BIV3.
OMAiFGTQERH.
OrthoDBiEOG091G011X.
PhylomeDBiQ8BIV3.
TreeFamiTF300344.

Miscellaneous databases

PROiQ8BIV3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074909.
CleanExiMM_RANBP6.
ExpressionAtlasiQ8BIV3. baseline and differential.
GenevisibleiQ8BIV3. MM.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
[Graphical view]
PfamiPF02985. HEAT. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiRNBP6_MOUSE
AccessioniPrimary (citable) accession number: Q8BIV3
Secondary accession number(s): Q3TTJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 9, 2007
Last modified: September 7, 2016
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.