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Protein

Zinc finger protein 2

Gene

Znf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri169 – 191C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 2
Alternative name(s):
Zinc finger protein 661
Short name:
Zfp-661
Gene namesi
Name:Znf2
Synonyms:Zfp661
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1919430. Zfp661.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002740501 – 427Zinc finger protein 2Add BLAST427

Proteomic databases

PaxDbiQ8BIQ3.
PRIDEiQ8BIQ3.

PTM databases

iPTMnetiQ8BIQ3.
PhosphoSitePlusiQ8BIQ3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034800.
CleanExiMM_ZFP661.
GenevisibleiQ8BIQ3. MM.

Interactioni

Protein-protein interaction databases

BioGridi215203. 1 interactor.
STRINGi10090.ENSMUSP00000076637.

Structurei

3D structure databases

ProteinModelPortaliQ8BIQ3.
SMRiQ8BIQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 85KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri169 – 191C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00900000140937.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8BIQ3.
KOiK09228.
OMAiSPYECSV.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8BIQ3.
TreeFamiTF340946.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 5 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.

Sequencei

Sequence statusi: Complete.

Q8BIQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVSPPTRC QALVTFEDVA VTFTDDEWKR LVPVQRALYK AVMLENYESI
60 70 80 90 100
ISLGLPVPRP DVILQFKRRG EPWIRGFHGS EEKTWPESVS LDLETKPETL
110 120 130 140 150
DASRGTLREI HRKQSSLCPK REIQTLTGGP EPEKESPKAR TCKKPLSLDK
160 170 180 190 200
GLHQMSAPSK KALTKHQDQE CSECGKTFFD HSSLIRHQRT HTGEKPYDCP
210 220 230 240 250
ECGKAFSHRS SLSRHLMFHT GESPYECDAC GKAFFDRSSL TVHQRIHTGE
260 270 280 290 300
KPFKCNDCGK AFFDRSSLTR HQRIHTGESP YECQQCGKAF SQKSILTRHL
310 320 330 340 350
LTHTGRKPYE CRDCGKAFYG VTSLNRHQKV HTEEPRYQCS ECGKAFFDRS
360 370 380 390 400
SLTQHQKIHT GDKPYECGEC GKAFSQRCRL TRHQRVHTGE KPFECSVCGK
410 420
EFSSKSSIIQ HQRRYAKQGI DRGGSMS
Length:427
Mass (Da):48,640
Last modified:March 1, 2003 - v1
Checksum:iAC70BD8A1D246F58
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62V → A in AAH52876 (PubMed:15489334).Curated1
Sequence conflicti95T → A in AAH52876 (PubMed:15489334).Curated1
Sequence conflicti249G → E in AAH52876 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033122 mRNA. Translation: BAC28161.1.
BC052876 mRNA. Translation: AAH52876.1.
CCDSiCCDS16705.1.
RefSeqiNP_001104499.1. NM_001111029.1.
NP_082417.3. NM_028141.3.
XP_006500290.1. XM_006500227.2.
XP_011238090.1. XM_011239788.2.
UniGeneiMm.46715.

Genome annotation databases

EnsembliENSMUST00000077422; ENSMUSP00000076637; ENSMUSG00000034800.
ENSMUST00000110366; ENSMUSP00000105995; ENSMUSG00000034800.
ENSMUST00000110368; ENSMUSP00000105997; ENSMUSG00000034800.
ENSMUST00000164551; ENSMUSP00000132820; ENSMUSG00000034800.
GeneIDi72180.
KEGGimmu:72180.
UCSCiuc008mfq.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiZNF2_MOUSE
AccessioniPrimary (citable) accession number: Q8BIQ3
Secondary accession number(s): Q7TPW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 1, 2003
Last modified: November 22, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families