Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8BIH0 (SP130_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone deacetylase complex subunit SAP130
Alternative name(s):
130 kDa Sin3-associated polypeptide
Sin3-associated polypeptide p130
Gene names
Name:Sap130
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1057 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes By similarity.

Subunit structure

Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2 By similarity. Interacts (released by dead or dying cells) with CLEC4E. Ref.3

Subcellular location

Nucleus By similarity.

Domain

The N-terminus may interact with a transcriptional coactivator By similarity.

The C-terminus may interact with HDAC-dependent and HDAC-independent corepressors By similarity.

Post-translational modification

Acetylated By similarity.

Sumoylated with SUMO1 By similarity.

Sequence similarities

Belongs to the SAP130 family.

Sequence caution

The sequence AAH66030.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8BIH0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8BIH0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-178: Missing.
Isoform 3 (identifier: Q8BIH0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     340-348: KTIFSTGTP → VRTVTPPEG
     349-1057: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10571057Histone deacetylase complex subunit SAP130
PRO_0000283737

Regions

Region845 – 1057213Interactions with SIN3A and HDAC1 By similarity
Compositional bias56 – 14388Pro-rich
Compositional bias208 – 2125Poly-Ala
Compositional bias718 – 845128Pro-rich

Amino acid modifications

Modified residue3291Phosphothreonine By similarity
Modified residue4161Phosphoserine By similarity
Modified residue8641Phosphoserine By similarity
Modified residue8651Phosphothreonine By similarity
Modified residue8841Phosphoserine By similarity

Natural variations

Alternative sequence1 – 178178Missing in isoform 2.
VSP_024357
Alternative sequence340 – 3489KTIFSTGTP → VRTVTPPEG in isoform 3.
VSP_024358
Alternative sequence349 – 1057709Missing in isoform 3.
VSP_024359

Experimental info

Sequence conflict5941Missing in BAC35469. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: 9D963F4CD53B971A

FASTA1,057111,228
        10         20         30         40         50         60 
MSSQQFPRLG TPSPGLSQPP SQIASSGSAG LINQVATVND EAGRDADVGT REHVGPSSSL 

        70         80         90        100        110        120 
PPREEKQEPV VVRPYPQVQM LPAHHAVASA TPVAVTAPPA HLTPAVPLSF SEGLMKPPPK 

       130        140        150        160        170        180 
PTMPSRPIAP APPSTMSLPP KVPGQVTVTM ESSIPQASAI PVATISGQQG HPSNLHHIMT 

       190        200        210        220        230        240 
TNVQMSIIRS NAPGPPLHIG ASHLPRGAAA AAVMSSSKVT TVLRPTSQLP NAATAQPAVQ 

       250        260        270        280        290        300 
HLIHQPIQSR PPVTTSSTIP PAVVATVSAT RAQSPVITTT AAHAADSTLS RPTLSIQHPP 

       310        320        330        340        350        360 
SAAISIQRPA QSRDVTTRIT LPSHPALGTP KQQLHTMAQK TIFSTGTPVA AATVAPILAT 

       370        380        390        400        410        420 
NTLPSTTTAG SVSHTQAPTS TIVTMTMPSH SSHATAVTTS NIPVAKVVPQ QITHTSPRIQ 

       430        440        450        460        470        480 
PDYPPERSSL IPISGHRASP NPVAMETRND NRPSVPVQFQ YFLPTYPPSA YPLAAHTYTP 

       490        500        510        520        530        540 
ITSSVSTIRQ YPVSAQAPNS TITAQTGVGV ASTVHLNPMQ LMTVDASHAR HIQGIQPAPI 

       550        560        570        580        590        600 
STQGIQPAPI GTSGIQPAPI GTPGIHSAAP INTQGLQPAA MANQQPQPEG KTSAVVLADG 

       610        620        630        640        650        660 
ATIVANPISN PFSAAPAATT VVQTHSQSAS TNTPAQGSSP RPSILRKKPA TDGMAVRKTL 

       670        680        690        700        710        720 
LPPQPPDVAT PRVESSMRSA SGSPRPAGAK PKSEVHVSIA TPVTVSLETI SNQNAEQPTV 

       730        740        750        760        770        780 
AVPPTAQQPP PTIPSMIAAA SPPSQPAIAL STIPGAVPVT PPITTIAATP TLSAPVGGTP 

       790        800        810        820        830        840 
STVLGPPVPE IKVKEEAEPV DITRPVSTVP PLATNTVSPS LALLASNLSM PPSDLPPGAS 

       850        860        870        880        890        900 
PRKKPRKQQH VISTEEGDMM ETNSTDDEKS AAKSLLVKAE KRKSPPKEYI DEEGVRYVPV 

       910        920        930        940        950        960 
RPRPPITLLR HYRNPWKAAY HHFQRYSDVR VKEEKKAMLQ EIANQKGVSC RAQGWKVHLC 

       970        980        990       1000       1010       1020 
AAQLLQLTNL EHDVYERLTN LQEGIIPKKK AATDDDLHRI NELIQGNMQR CKLVMDQISE 

      1030       1040       1050 
ARDSMLKVLD HKDRVLKLLN KNGTVKKVSK LKRKEKV 

« Hide

Isoform 2 [UniParc].

Checksum: F7AC76706F802240
Show »

FASTA87992,892
Isoform 3 [UniParc].

Checksum: C8FD4A7762B765FA
Show »

FASTA34835,934

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Strain: C57BL/6J.
Tissue: Eye and Spinal ganglion.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6.
Tissue: Brain.
[3]"Mincle is an ITAM-coupled activating receptor that senses damaged cells."
Yamasaki S., Ishikawa E., Sakuma M., Hara H., Ogata K., Saito T.
Nat. Immunol. 9:1179-1188(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CLEC4E.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK011978 mRNA. Translation: BAB27953.1.
AK053675 mRNA. Translation: BAC35469.1.
AK084078 mRNA. Translation: BAC39113.1.
BC063075 mRNA. Translation: AAH63075.1.
BC066030 mRNA. Translation: AAH66030.1. Different initiation.
RefSeqNP_766553.1. NM_172965.2.
XP_006526014.1. XM_006525951.1. [Q8BIH0-1]
XP_006526015.1. XM_006525952.1. [Q8BIH0-1]
XP_006526017.1. XM_006525954.1. [Q8BIH0-1]
UniGeneMm.194538.

3D structure databases

ProteinModelPortalQ8BIH0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid234593. 6 interactions.
IntActQ8BIH0. 2 interactions.
MINTMINT-4110764.

PTM databases

PhosphoSiteQ8BIH0.

Proteomic databases

MaxQBQ8BIH0.
PaxDbQ8BIH0.
PRIDEQ8BIH0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025109; ENSMUSP00000025109; ENSMUSG00000024260.
GeneID269003.
KEGGmmu:269003.
UCSCuc008eib.1. mouse. [Q8BIH0-1]
uc008eie.1. mouse. [Q8BIH0-2]

Organism-specific databases

CTD79595.
MGIMGI:1919782. Sap130.

Phylogenomic databases

eggNOGNOG12793.
GeneTreeENSGT00440000037733.
HOGENOMHOG000081804.
HOVERGENHBG106600.
InParanoidQ8BIH0.
PhylomeDBQ8BIH0.

Gene expression databases

BgeeQ8BIH0.
CleanExMM_SAP130.
GenevestigatorQ8BIH0.

Family and domain databases

InterProIPR024137. His_deAcase_cplx_SAP130.
[Graphical view]
PANTHERPTHR13497. PTHR13497. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSap130. mouse.
NextBio392636.
PROQ8BIH0.
SOURCESearch...

Entry information

Entry nameSP130_MOUSE
AccessionPrimary (citable) accession number: Q8BIH0
Secondary accession number(s): Q6NZP5 expand/collapse secondary AC list , Q6P553, Q8BID9, Q9CSU1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: June 11, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot