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Q8BIH0

- SP130_MOUSE

UniProt

Q8BIH0 - SP130_MOUSE

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Protein
Histone deacetylase complex subunit SAP130
Gene
Sap130
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes By similarity.

GO - Molecular functioni

  1. histone acetyltransferase activity Source: Ensembl
  2. protein binding Source: UniProtKB
  3. transcription coactivator activity Source: Ensembl

GO - Biological processi

  1. histone H3 acetylation Source: Ensembl
  2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_226917. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase complex subunit SAP130
Alternative name(s):
130 kDa Sin3-associated polypeptide
Sin3-associated polypeptide p130
Gene namesi
Name:Sap130
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1919782. Sap130.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. STAGA complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10571057Histone deacetylase complex subunit SAP130
PRO_0000283737Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei329 – 3291Phosphothreonine By similarity
Modified residuei416 – 4161Phosphoserine By similarity
Modified residuei864 – 8641Phosphoserine By similarity
Modified residuei865 – 8651Phosphothreonine By similarity
Modified residuei884 – 8841Phosphoserine By similarity

Post-translational modificationi

Acetylated By similarity.
Sumoylated with SUMO1 By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8BIH0.
PaxDbiQ8BIH0.
PRIDEiQ8BIH0.

PTM databases

PhosphoSiteiQ8BIH0.

Expressioni

Gene expression databases

BgeeiQ8BIH0.
CleanExiMM_SAP130.
GenevestigatoriQ8BIH0.

Interactioni

Subunit structurei

Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2 By similarity. Interacts (released by dead or dying cells) with CLEC4E.1 Publication

Protein-protein interaction databases

BioGridi234593. 6 interactions.
IntActiQ8BIH0. 2 interactions.
MINTiMINT-4110764.

Structurei

3D structure databases

ProteinModelPortaliQ8BIH0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni845 – 1057213Interactions with SIN3A and HDAC1 By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi56 – 14388Pro-rich
Add
BLAST
Compositional biasi208 – 2125Poly-Ala
Compositional biasi718 – 845128Pro-rich
Add
BLAST

Domaini

The N-terminus may interact with a transcriptional coactivator By similarity.
The C-terminus may interact with HDAC-dependent and HDAC-independent corepressors By similarity.

Sequence similaritiesi

Belongs to the SAP130 family.

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00440000037733.
HOGENOMiHOG000081804.
HOVERGENiHBG106600.
InParanoidiQ8BIH0.
PhylomeDBiQ8BIH0.

Family and domain databases

InterProiIPR024137. His_deAcase_cplx_SAP130.
[Graphical view]
PANTHERiPTHR13497. PTHR13497. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8BIH0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSSQQFPRLG TPSPGLSQPP SQIASSGSAG LINQVATVND EAGRDADVGT     50
REHVGPSSSL PPREEKQEPV VVRPYPQVQM LPAHHAVASA TPVAVTAPPA 100
HLTPAVPLSF SEGLMKPPPK PTMPSRPIAP APPSTMSLPP KVPGQVTVTM 150
ESSIPQASAI PVATISGQQG HPSNLHHIMT TNVQMSIIRS NAPGPPLHIG 200
ASHLPRGAAA AAVMSSSKVT TVLRPTSQLP NAATAQPAVQ HLIHQPIQSR 250
PPVTTSSTIP PAVVATVSAT RAQSPVITTT AAHAADSTLS RPTLSIQHPP 300
SAAISIQRPA QSRDVTTRIT LPSHPALGTP KQQLHTMAQK TIFSTGTPVA 350
AATVAPILAT NTLPSTTTAG SVSHTQAPTS TIVTMTMPSH SSHATAVTTS 400
NIPVAKVVPQ QITHTSPRIQ PDYPPERSSL IPISGHRASP NPVAMETRND 450
NRPSVPVQFQ YFLPTYPPSA YPLAAHTYTP ITSSVSTIRQ YPVSAQAPNS 500
TITAQTGVGV ASTVHLNPMQ LMTVDASHAR HIQGIQPAPI STQGIQPAPI 550
GTSGIQPAPI GTPGIHSAAP INTQGLQPAA MANQQPQPEG KTSAVVLADG 600
ATIVANPISN PFSAAPAATT VVQTHSQSAS TNTPAQGSSP RPSILRKKPA 650
TDGMAVRKTL LPPQPPDVAT PRVESSMRSA SGSPRPAGAK PKSEVHVSIA 700
TPVTVSLETI SNQNAEQPTV AVPPTAQQPP PTIPSMIAAA SPPSQPAIAL 750
STIPGAVPVT PPITTIAATP TLSAPVGGTP STVLGPPVPE IKVKEEAEPV 800
DITRPVSTVP PLATNTVSPS LALLASNLSM PPSDLPPGAS PRKKPRKQQH 850
VISTEEGDMM ETNSTDDEKS AAKSLLVKAE KRKSPPKEYI DEEGVRYVPV 900
RPRPPITLLR HYRNPWKAAY HHFQRYSDVR VKEEKKAMLQ EIANQKGVSC 950
RAQGWKVHLC AAQLLQLTNL EHDVYERLTN LQEGIIPKKK AATDDDLHRI 1000
NELIQGNMQR CKLVMDQISE ARDSMLKVLD HKDRVLKLLN KNGTVKKVSK 1050
LKRKEKV 1057
Length:1,057
Mass (Da):111,228
Last modified:April 3, 2007 - v2
Checksum:i9D963F4CD53B971A
GO
Isoform 2 (identifier: Q8BIH0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-178: Missing.

Show »
Length:879
Mass (Da):92,892
Checksum:iF7AC76706F802240
GO
Isoform 3 (identifier: Q8BIH0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-348: KTIFSTGTP → VRTVTPPEG
     349-1057: Missing.

Show »
Length:348
Mass (Da):35,934
Checksum:iC8FD4A7762B765FA
GO

Sequence cautioni

The sequence AAH66030.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 178178Missing in isoform 2.
VSP_024357Add
BLAST
Alternative sequencei340 – 3489KTIFSTGTP → VRTVTPPEG in isoform 3.
VSP_024358
Alternative sequencei349 – 1057709Missing in isoform 3.
VSP_024359Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti594 – 5941Missing in BAC35469. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK011978 mRNA. Translation: BAB27953.1.
AK053675 mRNA. Translation: BAC35469.1.
AK084078 mRNA. Translation: BAC39113.1.
BC063075 mRNA. Translation: AAH63075.1.
BC066030 mRNA. Translation: AAH66030.1. Different initiation.
RefSeqiNP_766553.1. NM_172965.2.
XP_006526014.1. XM_006525951.1. [Q8BIH0-1]
XP_006526015.1. XM_006525952.1. [Q8BIH0-1]
XP_006526017.1. XM_006525954.1. [Q8BIH0-1]
UniGeneiMm.194538.

Genome annotation databases

EnsembliENSMUST00000025109; ENSMUSP00000025109; ENSMUSG00000024260.
GeneIDi269003.
KEGGimmu:269003.
UCSCiuc008eib.1. mouse. [Q8BIH0-1]
uc008eie.1. mouse. [Q8BIH0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK011978 mRNA. Translation: BAB27953.1 .
AK053675 mRNA. Translation: BAC35469.1 .
AK084078 mRNA. Translation: BAC39113.1 .
BC063075 mRNA. Translation: AAH63075.1 .
BC066030 mRNA. Translation: AAH66030.1 . Different initiation.
RefSeqi NP_766553.1. NM_172965.2.
XP_006526014.1. XM_006525951.1. [Q8BIH0-1 ]
XP_006526015.1. XM_006525952.1. [Q8BIH0-1 ]
XP_006526017.1. XM_006525954.1. [Q8BIH0-1 ]
UniGenei Mm.194538.

3D structure databases

ProteinModelPortali Q8BIH0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 234593. 6 interactions.
IntActi Q8BIH0. 2 interactions.
MINTi MINT-4110764.

PTM databases

PhosphoSitei Q8BIH0.

Proteomic databases

MaxQBi Q8BIH0.
PaxDbi Q8BIH0.
PRIDEi Q8BIH0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025109 ; ENSMUSP00000025109 ; ENSMUSG00000024260 .
GeneIDi 269003.
KEGGi mmu:269003.
UCSCi uc008eib.1. mouse. [Q8BIH0-1 ]
uc008eie.1. mouse. [Q8BIH0-2 ]

Organism-specific databases

CTDi 79595.
MGIi MGI:1919782. Sap130.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00440000037733.
HOGENOMi HOG000081804.
HOVERGENi HBG106600.
InParanoidi Q8BIH0.
PhylomeDBi Q8BIH0.

Enzyme and pathway databases

Reactomei REACT_226917. HATs acetylate histones.

Miscellaneous databases

ChiTaRSi Sap130. mouse.
NextBioi 392636.
PROi Q8BIH0.
SOURCEi Search...

Gene expression databases

Bgeei Q8BIH0.
CleanExi MM_SAP130.
Genevestigatori Q8BIH0.

Family and domain databases

InterProi IPR024137. His_deAcase_cplx_SAP130.
[Graphical view ]
PANTHERi PTHR13497. PTHR13497. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Strain: C57BL/6J.
    Tissue: Eye and Spinal ganglion.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6.
    Tissue: Brain.
  3. "Mincle is an ITAM-coupled activating receptor that senses damaged cells."
    Yamasaki S., Ishikawa E., Sakuma M., Hara H., Ogata K., Saito T.
    Nat. Immunol. 9:1179-1188(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CLEC4E.

Entry informationi

Entry nameiSP130_MOUSE
AccessioniPrimary (citable) accession number: Q8BIH0
Secondary accession number(s): Q6NZP5
, Q6P553, Q8BID9, Q9CSU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 3, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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