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Q8BIH0

- SP130_MOUSE

UniProt

Q8BIH0 - SP130_MOUSE

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Protein

Histone deacetylase complex subunit SAP130

Gene

Sap130

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity).By similarity

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_226917. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase complex subunit SAP130
Alternative name(s):
130 kDa Sin3-associated polypeptide
Sin3-associated polypeptide p130
Gene namesi
Name:Sap130
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1919782. Sap130.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10571057Histone deacetylase complex subunit SAP130PRO_0000283737Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei329 – 3291PhosphothreonineBy similarity
Modified residuei416 – 4161PhosphoserineBy similarity
Modified residuei864 – 8641PhosphoserineBy similarity
Modified residuei865 – 8651PhosphothreonineBy similarity
Modified residuei884 – 8841PhosphoserineBy similarity

Post-translational modificationi

Acetylated.By similarity
Sumoylated with SUMO1.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8BIH0.
PaxDbiQ8BIH0.
PRIDEiQ8BIH0.

PTM databases

PhosphoSiteiQ8BIH0.

Expressioni

Gene expression databases

BgeeiQ8BIH0.
CleanExiMM_SAP130.
ExpressionAtlasiQ8BIH0. baseline and differential.
GenevestigatoriQ8BIH0.

Interactioni

Subunit structurei

Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2 (By similarity). Interacts (released by dead or dying cells) with CLEC4E.By similarity1 Publication

Protein-protein interaction databases

BioGridi234593. 6 interactions.
IntActiQ8BIH0. 2 interactions.
MINTiMINT-4110764.

Structurei

3D structure databases

ProteinModelPortaliQ8BIH0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni845 – 1057213Interactions with SIN3A and HDAC1By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi56 – 14388Pro-richAdd
BLAST
Compositional biasi208 – 2125Poly-Ala
Compositional biasi718 – 845128Pro-richAdd
BLAST

Domaini

The N-terminus may interact with a transcriptional coactivator.By similarity
The C-terminus may interact with HDAC-dependent and HDAC-independent corepressors.By similarity

Sequence similaritiesi

Belongs to the SAP130 family.Curated

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00440000037733.
HOGENOMiHOG000081804.
HOVERGENiHBG106600.
InParanoidiQ8BIH0.
PhylomeDBiQ8BIH0.

Family and domain databases

InterProiIPR024137. His_deAcase_cplx_SAP130.
[Graphical view]
PANTHERiPTHR13497. PTHR13497. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8BIH0) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSQQFPRLG TPSPGLSQPP SQIASSGSAG LINQVATVND EAGRDADVGT
60 70 80 90 100
REHVGPSSSL PPREEKQEPV VVRPYPQVQM LPAHHAVASA TPVAVTAPPA
110 120 130 140 150
HLTPAVPLSF SEGLMKPPPK PTMPSRPIAP APPSTMSLPP KVPGQVTVTM
160 170 180 190 200
ESSIPQASAI PVATISGQQG HPSNLHHIMT TNVQMSIIRS NAPGPPLHIG
210 220 230 240 250
ASHLPRGAAA AAVMSSSKVT TVLRPTSQLP NAATAQPAVQ HLIHQPIQSR
260 270 280 290 300
PPVTTSSTIP PAVVATVSAT RAQSPVITTT AAHAADSTLS RPTLSIQHPP
310 320 330 340 350
SAAISIQRPA QSRDVTTRIT LPSHPALGTP KQQLHTMAQK TIFSTGTPVA
360 370 380 390 400
AATVAPILAT NTLPSTTTAG SVSHTQAPTS TIVTMTMPSH SSHATAVTTS
410 420 430 440 450
NIPVAKVVPQ QITHTSPRIQ PDYPPERSSL IPISGHRASP NPVAMETRND
460 470 480 490 500
NRPSVPVQFQ YFLPTYPPSA YPLAAHTYTP ITSSVSTIRQ YPVSAQAPNS
510 520 530 540 550
TITAQTGVGV ASTVHLNPMQ LMTVDASHAR HIQGIQPAPI STQGIQPAPI
560 570 580 590 600
GTSGIQPAPI GTPGIHSAAP INTQGLQPAA MANQQPQPEG KTSAVVLADG
610 620 630 640 650
ATIVANPISN PFSAAPAATT VVQTHSQSAS TNTPAQGSSP RPSILRKKPA
660 670 680 690 700
TDGMAVRKTL LPPQPPDVAT PRVESSMRSA SGSPRPAGAK PKSEVHVSIA
710 720 730 740 750
TPVTVSLETI SNQNAEQPTV AVPPTAQQPP PTIPSMIAAA SPPSQPAIAL
760 770 780 790 800
STIPGAVPVT PPITTIAATP TLSAPVGGTP STVLGPPVPE IKVKEEAEPV
810 820 830 840 850
DITRPVSTVP PLATNTVSPS LALLASNLSM PPSDLPPGAS PRKKPRKQQH
860 870 880 890 900
VISTEEGDMM ETNSTDDEKS AAKSLLVKAE KRKSPPKEYI DEEGVRYVPV
910 920 930 940 950
RPRPPITLLR HYRNPWKAAY HHFQRYSDVR VKEEKKAMLQ EIANQKGVSC
960 970 980 990 1000
RAQGWKVHLC AAQLLQLTNL EHDVYERLTN LQEGIIPKKK AATDDDLHRI
1010 1020 1030 1040 1050
NELIQGNMQR CKLVMDQISE ARDSMLKVLD HKDRVLKLLN KNGTVKKVSK

LKRKEKV
Length:1,057
Mass (Da):111,228
Last modified:April 3, 2007 - v2
Checksum:i9D963F4CD53B971A
GO
Isoform 2 (identifier: Q8BIH0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-178: Missing.

Show »
Length:879
Mass (Da):92,892
Checksum:iF7AC76706F802240
GO
Isoform 3 (identifier: Q8BIH0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-348: KTIFSTGTP → VRTVTPPEG
     349-1057: Missing.

Show »
Length:348
Mass (Da):35,934
Checksum:iC8FD4A7762B765FA
GO

Sequence cautioni

The sequence AAH66030.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti594 – 5941Missing in BAC35469. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 178178Missing in isoform 2. 1 PublicationVSP_024357Add
BLAST
Alternative sequencei340 – 3489KTIFSTGTP → VRTVTPPEG in isoform 3. 1 PublicationVSP_024358
Alternative sequencei349 – 1057709Missing in isoform 3. 1 PublicationVSP_024359Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK011978 mRNA. Translation: BAB27953.1.
AK053675 mRNA. Translation: BAC35469.1.
AK084078 mRNA. Translation: BAC39113.1.
BC063075 mRNA. Translation: AAH63075.1.
BC066030 mRNA. Translation: AAH66030.1. Different initiation.
RefSeqiNP_766553.1. NM_172965.2.
XP_006526014.1. XM_006525951.1. [Q8BIH0-1]
XP_006526015.1. XM_006525952.1. [Q8BIH0-1]
XP_006526017.1. XM_006525954.1. [Q8BIH0-1]
UniGeneiMm.194538.

Genome annotation databases

EnsembliENSMUST00000025109; ENSMUSP00000025109; ENSMUSG00000024260.
GeneIDi269003.
KEGGimmu:269003.
UCSCiuc008eib.1. mouse. [Q8BIH0-1]
uc008eie.1. mouse. [Q8BIH0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK011978 mRNA. Translation: BAB27953.1 .
AK053675 mRNA. Translation: BAC35469.1 .
AK084078 mRNA. Translation: BAC39113.1 .
BC063075 mRNA. Translation: AAH63075.1 .
BC066030 mRNA. Translation: AAH66030.1 . Different initiation.
RefSeqi NP_766553.1. NM_172965.2.
XP_006526014.1. XM_006525951.1. [Q8BIH0-1 ]
XP_006526015.1. XM_006525952.1. [Q8BIH0-1 ]
XP_006526017.1. XM_006525954.1. [Q8BIH0-1 ]
UniGenei Mm.194538.

3D structure databases

ProteinModelPortali Q8BIH0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 234593. 6 interactions.
IntActi Q8BIH0. 2 interactions.
MINTi MINT-4110764.

PTM databases

PhosphoSitei Q8BIH0.

Proteomic databases

MaxQBi Q8BIH0.
PaxDbi Q8BIH0.
PRIDEi Q8BIH0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025109 ; ENSMUSP00000025109 ; ENSMUSG00000024260 .
GeneIDi 269003.
KEGGi mmu:269003.
UCSCi uc008eib.1. mouse. [Q8BIH0-1 ]
uc008eie.1. mouse. [Q8BIH0-2 ]

Organism-specific databases

CTDi 79595.
MGIi MGI:1919782. Sap130.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00440000037733.
HOGENOMi HOG000081804.
HOVERGENi HBG106600.
InParanoidi Q8BIH0.
PhylomeDBi Q8BIH0.

Enzyme and pathway databases

Reactomei REACT_226917. HATs acetylate histones.

Miscellaneous databases

ChiTaRSi Sap130. mouse.
NextBioi 392636.
PROi Q8BIH0.
SOURCEi Search...

Gene expression databases

Bgeei Q8BIH0.
CleanExi MM_SAP130.
ExpressionAtlasi Q8BIH0. baseline and differential.
Genevestigatori Q8BIH0.

Family and domain databases

InterProi IPR024137. His_deAcase_cplx_SAP130.
[Graphical view ]
PANTHERi PTHR13497. PTHR13497. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Strain: C57BL/6J.
    Tissue: Eye and Spinal ganglion.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6.
    Tissue: Brain.
  3. "Mincle is an ITAM-coupled activating receptor that senses damaged cells."
    Yamasaki S., Ishikawa E., Sakuma M., Hara H., Ogata K., Saito T.
    Nat. Immunol. 9:1179-1188(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CLEC4E.

Entry informationi

Entry nameiSP130_MOUSE
AccessioniPrimary (citable) accession number: Q8BIH0
Secondary accession number(s): Q6NZP5
, Q6P553, Q8BID9, Q9CSU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: October 29, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3