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Q8BIH0

- SP130_MOUSE

UniProt

Q8BIH0 - SP130_MOUSE

Protein

Histone deacetylase complex subunit SAP130

Gene

Sap130

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes By similarity.By similarity

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: Ensembl
    2. protein binding Source: UniProtKB
    3. transcription coactivator activity Source: Ensembl

    GO - Biological processi

    1. histone H3 acetylation Source: Ensembl
    2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_226917. HATs acetylate histones.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylase complex subunit SAP130
    Alternative name(s):
    130 kDa Sin3-associated polypeptide
    Sin3-associated polypeptide p130
    Gene namesi
    Name:Sap130
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:1919782. Sap130.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. STAGA complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10571057Histone deacetylase complex subunit SAP130PRO_0000283737Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei329 – 3291PhosphothreonineBy similarity
    Modified residuei416 – 4161PhosphoserineBy similarity
    Modified residuei864 – 8641PhosphoserineBy similarity
    Modified residuei865 – 8651PhosphothreonineBy similarity
    Modified residuei884 – 8841PhosphoserineBy similarity

    Post-translational modificationi

    Acetylated.By similarity
    Sumoylated with SUMO1.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ8BIH0.
    PaxDbiQ8BIH0.
    PRIDEiQ8BIH0.

    PTM databases

    PhosphoSiteiQ8BIH0.

    Expressioni

    Gene expression databases

    BgeeiQ8BIH0.
    CleanExiMM_SAP130.
    GenevestigatoriQ8BIH0.

    Interactioni

    Subunit structurei

    Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2 By similarity. Interacts (released by dead or dying cells) with CLEC4E.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi234593. 6 interactions.
    IntActiQ8BIH0. 2 interactions.
    MINTiMINT-4110764.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BIH0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni845 – 1057213Interactions with SIN3A and HDAC1By similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi56 – 14388Pro-richAdd
    BLAST
    Compositional biasi208 – 2125Poly-Ala
    Compositional biasi718 – 845128Pro-richAdd
    BLAST

    Domaini

    The N-terminus may interact with a transcriptional coactivator.By similarity
    The C-terminus may interact with HDAC-dependent and HDAC-independent corepressors.By similarity

    Sequence similaritiesi

    Belongs to the SAP130 family.Curated

    Phylogenomic databases

    eggNOGiNOG12793.
    GeneTreeiENSGT00440000037733.
    HOGENOMiHOG000081804.
    HOVERGENiHBG106600.
    InParanoidiQ8BIH0.
    PhylomeDBiQ8BIH0.

    Family and domain databases

    InterProiIPR024137. His_deAcase_cplx_SAP130.
    [Graphical view]
    PANTHERiPTHR13497. PTHR13497. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8BIH0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSQQFPRLG TPSPGLSQPP SQIASSGSAG LINQVATVND EAGRDADVGT     50
    REHVGPSSSL PPREEKQEPV VVRPYPQVQM LPAHHAVASA TPVAVTAPPA 100
    HLTPAVPLSF SEGLMKPPPK PTMPSRPIAP APPSTMSLPP KVPGQVTVTM 150
    ESSIPQASAI PVATISGQQG HPSNLHHIMT TNVQMSIIRS NAPGPPLHIG 200
    ASHLPRGAAA AAVMSSSKVT TVLRPTSQLP NAATAQPAVQ HLIHQPIQSR 250
    PPVTTSSTIP PAVVATVSAT RAQSPVITTT AAHAADSTLS RPTLSIQHPP 300
    SAAISIQRPA QSRDVTTRIT LPSHPALGTP KQQLHTMAQK TIFSTGTPVA 350
    AATVAPILAT NTLPSTTTAG SVSHTQAPTS TIVTMTMPSH SSHATAVTTS 400
    NIPVAKVVPQ QITHTSPRIQ PDYPPERSSL IPISGHRASP NPVAMETRND 450
    NRPSVPVQFQ YFLPTYPPSA YPLAAHTYTP ITSSVSTIRQ YPVSAQAPNS 500
    TITAQTGVGV ASTVHLNPMQ LMTVDASHAR HIQGIQPAPI STQGIQPAPI 550
    GTSGIQPAPI GTPGIHSAAP INTQGLQPAA MANQQPQPEG KTSAVVLADG 600
    ATIVANPISN PFSAAPAATT VVQTHSQSAS TNTPAQGSSP RPSILRKKPA 650
    TDGMAVRKTL LPPQPPDVAT PRVESSMRSA SGSPRPAGAK PKSEVHVSIA 700
    TPVTVSLETI SNQNAEQPTV AVPPTAQQPP PTIPSMIAAA SPPSQPAIAL 750
    STIPGAVPVT PPITTIAATP TLSAPVGGTP STVLGPPVPE IKVKEEAEPV 800
    DITRPVSTVP PLATNTVSPS LALLASNLSM PPSDLPPGAS PRKKPRKQQH 850
    VISTEEGDMM ETNSTDDEKS AAKSLLVKAE KRKSPPKEYI DEEGVRYVPV 900
    RPRPPITLLR HYRNPWKAAY HHFQRYSDVR VKEEKKAMLQ EIANQKGVSC 950
    RAQGWKVHLC AAQLLQLTNL EHDVYERLTN LQEGIIPKKK AATDDDLHRI 1000
    NELIQGNMQR CKLVMDQISE ARDSMLKVLD HKDRVLKLLN KNGTVKKVSK 1050
    LKRKEKV 1057
    Length:1,057
    Mass (Da):111,228
    Last modified:April 3, 2007 - v2
    Checksum:i9D963F4CD53B971A
    GO
    Isoform 2 (identifier: Q8BIH0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-178: Missing.

    Show »
    Length:879
    Mass (Da):92,892
    Checksum:iF7AC76706F802240
    GO
    Isoform 3 (identifier: Q8BIH0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         340-348: KTIFSTGTP → VRTVTPPEG
         349-1057: Missing.

    Show »
    Length:348
    Mass (Da):35,934
    Checksum:iC8FD4A7762B765FA
    GO

    Sequence cautioni

    The sequence AAH66030.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti594 – 5941Missing in BAC35469. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 178178Missing in isoform 2. 1 PublicationVSP_024357Add
    BLAST
    Alternative sequencei340 – 3489KTIFSTGTP → VRTVTPPEG in isoform 3. 1 PublicationVSP_024358
    Alternative sequencei349 – 1057709Missing in isoform 3. 1 PublicationVSP_024359Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK011978 mRNA. Translation: BAB27953.1.
    AK053675 mRNA. Translation: BAC35469.1.
    AK084078 mRNA. Translation: BAC39113.1.
    BC063075 mRNA. Translation: AAH63075.1.
    BC066030 mRNA. Translation: AAH66030.1. Different initiation.
    RefSeqiNP_766553.1. NM_172965.2.
    XP_006526014.1. XM_006525951.1. [Q8BIH0-1]
    XP_006526015.1. XM_006525952.1. [Q8BIH0-1]
    XP_006526017.1. XM_006525954.1. [Q8BIH0-1]
    UniGeneiMm.194538.

    Genome annotation databases

    EnsembliENSMUST00000025109; ENSMUSP00000025109; ENSMUSG00000024260.
    GeneIDi269003.
    KEGGimmu:269003.
    UCSCiuc008eib.1. mouse. [Q8BIH0-1]
    uc008eie.1. mouse. [Q8BIH0-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK011978 mRNA. Translation: BAB27953.1 .
    AK053675 mRNA. Translation: BAC35469.1 .
    AK084078 mRNA. Translation: BAC39113.1 .
    BC063075 mRNA. Translation: AAH63075.1 .
    BC066030 mRNA. Translation: AAH66030.1 . Different initiation.
    RefSeqi NP_766553.1. NM_172965.2.
    XP_006526014.1. XM_006525951.1. [Q8BIH0-1 ]
    XP_006526015.1. XM_006525952.1. [Q8BIH0-1 ]
    XP_006526017.1. XM_006525954.1. [Q8BIH0-1 ]
    UniGenei Mm.194538.

    3D structure databases

    ProteinModelPortali Q8BIH0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 234593. 6 interactions.
    IntActi Q8BIH0. 2 interactions.
    MINTi MINT-4110764.

    PTM databases

    PhosphoSitei Q8BIH0.

    Proteomic databases

    MaxQBi Q8BIH0.
    PaxDbi Q8BIH0.
    PRIDEi Q8BIH0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025109 ; ENSMUSP00000025109 ; ENSMUSG00000024260 .
    GeneIDi 269003.
    KEGGi mmu:269003.
    UCSCi uc008eib.1. mouse. [Q8BIH0-1 ]
    uc008eie.1. mouse. [Q8BIH0-2 ]

    Organism-specific databases

    CTDi 79595.
    MGIi MGI:1919782. Sap130.

    Phylogenomic databases

    eggNOGi NOG12793.
    GeneTreei ENSGT00440000037733.
    HOGENOMi HOG000081804.
    HOVERGENi HBG106600.
    InParanoidi Q8BIH0.
    PhylomeDBi Q8BIH0.

    Enzyme and pathway databases

    Reactomei REACT_226917. HATs acetylate histones.

    Miscellaneous databases

    ChiTaRSi Sap130. mouse.
    NextBioi 392636.
    PROi Q8BIH0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BIH0.
    CleanExi MM_SAP130.
    Genevestigatori Q8BIH0.

    Family and domain databases

    InterProi IPR024137. His_deAcase_cplx_SAP130.
    [Graphical view ]
    PANTHERi PTHR13497. PTHR13497. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Strain: C57BL/6J.
      Tissue: Eye and Spinal ganglion.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6.
      Tissue: Brain.
    3. "Mincle is an ITAM-coupled activating receptor that senses damaged cells."
      Yamasaki S., Ishikawa E., Sakuma M., Hara H., Ogata K., Saito T.
      Nat. Immunol. 9:1179-1188(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CLEC4E.

    Entry informationi

    Entry nameiSP130_MOUSE
    AccessioniPrimary (citable) accession number: Q8BIH0
    Secondary accession number(s): Q6NZP5
    , Q6P553, Q8BID9, Q9CSU1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3