Q8BIH0 (SP130_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone deacetylase complex subunit SAP130

Alternative name(s):
130 kDa Sin3-associated polypeptide
Sin3-associated polypeptide p130

Gene names

Name:

Sap130

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1057 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes By similarity.
Subunit structure	Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2 By similarity. Interacts (released by dead or dying cells) with CLEC4E. Ref.4
Subcellular location	Nucleus By similarity.
Domain	The N-terminus may interact with a transcriptional coactivator By similarity. The C-terminus may interact with HDAC-dependent and HDAC-independent corepressors By similarity.
Post-translational modification	Acetylated By similarity. Sumoylated with SUMO1 By similarity.
Sequence similarities	Belongs to the SAP130 family.
Sequence caution	The sequence AAH66030.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Molecular function	Repressor
PTM	Acetylation Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	histone H3 acetylation Inferred from electronic annotation. Source: Compara regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	STAGA complex Inferred from electronic annotation. Source: Compara
Molecular_function	histone acetyltransferase activity Inferred from electronic annotation. Source: Compara transcription coactivator activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8BIH0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8BIH0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-178: Missing.

Isoform 3 (identifier: Q8BIH0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     340-348: KTIFSTGTP → VRTVTPPEG
     349-1057: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1057	1057	Histone deacetylase complex subunit SAP130		PRO_0000283737
Regions
	Region	845 – 1057	213	Interactions with SIN3A and HDAC1 By similarity
	Compositional bias	56 – 143	88	Pro-rich
	Compositional bias	208 – 212	5	Poly-Ala
	Compositional bias	718 – 845	128	Pro-rich
Amino acid modifications
	Modified residue	329	1	Phosphothreonine By similarity
	Modified residue	416	1	Phosphoserine By similarity
	Modified residue	683	1	Phosphoserine Ref.3
	Modified residue	864	1	Phosphoserine By similarity
	Modified residue	865	1	Phosphothreonine By similarity
	Modified residue	884	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 178	178	Missing in isoform 2.		VSP_024357
	Alternative sequence	340 – 348	9	KTIFSTGTP → VRTVTPPEG in isoform 3.		VSP_024358
	Alternative sequence	349 – 1057	709	Missing in isoform 3.		VSP_024359
Experimental info
	Sequence conflict	594	1	Missing in BAC35469. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 3, 2007. Version 2. Checksum: 9D963F4CD53B971A	FASTA	1,057	111,228
	10 20 30 40 50 60 MSSQQFPRLG TPSPGLSQPP SQIASSGSAG LINQVATVND EAGRDADVGT REHVGPSSSL 70 80 90 100 110 120 PPREEKQEPV VVRPYPQVQM LPAHHAVASA TPVAVTAPPA HLTPAVPLSF SEGLMKPPPK 130 140 150 160 170 180 PTMPSRPIAP APPSTMSLPP KVPGQVTVTM ESSIPQASAI PVATISGQQG HPSNLHHIMT 190 200 210 220 230 240 TNVQMSIIRS NAPGPPLHIG ASHLPRGAAA AAVMSSSKVT TVLRPTSQLP NAATAQPAVQ 250 260 270 280 290 300 HLIHQPIQSR PPVTTSSTIP PAVVATVSAT RAQSPVITTT AAHAADSTLS RPTLSIQHPP 310 320 330 340 350 360 SAAISIQRPA QSRDVTTRIT LPSHPALGTP KQQLHTMAQK TIFSTGTPVA AATVAPILAT 370 380 390 400 410 420 NTLPSTTTAG SVSHTQAPTS TIVTMTMPSH SSHATAVTTS NIPVAKVVPQ QITHTSPRIQ 430 440 450 460 470 480 PDYPPERSSL IPISGHRASP NPVAMETRND NRPSVPVQFQ YFLPTYPPSA YPLAAHTYTP 490 500 510 520 530 540 ITSSVSTIRQ YPVSAQAPNS TITAQTGVGV ASTVHLNPMQ LMTVDASHAR HIQGIQPAPI 550 560 570 580 590 600 STQGIQPAPI GTSGIQPAPI GTPGIHSAAP INTQGLQPAA MANQQPQPEG KTSAVVLADG 610 620 630 640 650 660 ATIVANPISN PFSAAPAATT VVQTHSQSAS TNTPAQGSSP RPSILRKKPA TDGMAVRKTL 670 680 690 700 710 720 LPPQPPDVAT PRVESSMRSA SGSPRPAGAK PKSEVHVSIA TPVTVSLETI SNQNAEQPTV 730 740 750 760 770 780 AVPPTAQQPP PTIPSMIAAA SPPSQPAIAL STIPGAVPVT PPITTIAATP TLSAPVGGTP 790 800 810 820 830 840 STVLGPPVPE IKVKEEAEPV DITRPVSTVP PLATNTVSPS LALLASNLSM PPSDLPPGAS 850 860 870 880 890 900 PRKKPRKQQH VISTEEGDMM ETNSTDDEKS AAKSLLVKAE KRKSPPKEYI DEEGVRYVPV 910 920 930 940 950 960 RPRPPITLLR HYRNPWKAAY HHFQRYSDVR VKEEKKAMLQ EIANQKGVSC RAQGWKVHLC 970 980 990 1000 1010 1020 AAQLLQLTNL EHDVYERLTN LQEGIIPKKK AATDDDLHRI NELIQGNMQR CKLVMDQISE 1030 1040 1050 ARDSMLKVLD HKDRVLKLLN KNGTVKKVSK LKRKEKV
	Isoform 2 [UniParc]. Checksum: F7AC76706F802240	FASTA	879	92,892
	10 20 30 40 50 60 MTTNVQMSII RSNAPGPPLH IGASHLPRGA AAAAVMSSSK VTTVLRPTSQ LPNAATAQPA 70 80 90 100 110 120 VQHLIHQPIQ SRPPVTTSST IPPAVVATVS ATRAQSPVIT TTAAHAADST LSRPTLSIQH 130 140 150 160 170 180 PPSAAISIQR PAQSRDVTTR ITLPSHPALG TPKQQLHTMA QKTIFSTGTP VAAATVAPIL 190 200 210 220 230 240 ATNTLPSTTT AGSVSHTQAP TSTIVTMTMP SHSSHATAVT TSNIPVAKVV PQQITHTSPR 250 260 270 280 290 300 IQPDYPPERS SLIPISGHRA SPNPVAMETR NDNRPSVPVQ FQYFLPTYPP SAYPLAAHTY 310 320 330 340 350 360 TPITSSVSTI RQYPVSAQAP NSTITAQTGV GVASTVHLNP MQLMTVDASH ARHIQGIQPA 370 380 390 400 410 420 PISTQGIQPA PIGTSGIQPA PIGTPGIHSA APINTQGLQP AAMANQQPQP EGKTSAVVLA 430 440 450 460 470 480 DGATIVANPI SNPFSAAPAA TTVVQTHSQS ASTNTPAQGS SPRPSILRKK PATDGMAVRK 490 500 510 520 530 540 TLLPPQPPDV ATPRVESSMR SASGSPRPAG AKPKSEVHVS IATPVTVSLE TISNQNAEQP 550 560 570 580 590 600 TVAVPPTAQQ PPPTIPSMIA AASPPSQPAI ALSTIPGAVP VTPPITTIAA TPTLSAPVGG 610 620 630 640 650 660 TPSTVLGPPV PEIKVKEEAE PVDITRPVST VPPLATNTVS PSLALLASNL SMPPSDLPPG 670 680 690 700 710 720 ASPRKKPRKQ QHVISTEEGD MMETNSTDDE KSAAKSLLVK AEKRKSPPKE YIDEEGVRYV 730 740 750 760 770 780 PVRPRPPITL LRHYRNPWKA AYHHFQRYSD VRVKEEKKAM LQEIANQKGV SCRAQGWKVH 790 800 810 820 830 840 LCAAQLLQLT NLEHDVYERL TNLQEGIIPK KKAATDDDLH RINELIQGNM QRCKLVMDQI 850 860 870 SEARDSMLKV LDHKDRVLKL LNKNGTVKKV SKLKRKEKV
	Isoform 3 [UniParc]. Checksum: C8FD4A7762B765FA	FASTA	348	35,934
	10 20 30 40 50 60 MSSQQFPRLG TPSPGLSQPP SQIASSGSAG LINQVATVND EAGRDADVGT REHVGPSSSL 70 80 90 100 110 120 PPREEKQEPV VVRPYPQVQM LPAHHAVASA TPVAVTAPPA HLTPAVPLSF SEGLMKPPPK 130 140 150 160 170 180 PTMPSRPIAP APPSTMSLPP KVPGQVTVTM ESSIPQASAI PVATISGQQG HPSNLHHIMT 190 200 210 220 230 240 TNVQMSIIRS NAPGPPLHIG ASHLPRGAAA AAVMSSSKVT TVLRPTSQLP NAATAQPAVQ 250 260 270 280 290 300 HLIHQPIQSR PPVTTSSTIP PAVVATVSAT RAQSPVITTT AAHAADSTLS RPTLSIQHPP 310 320 330 340 SAAISIQRPA QSRDVTTRIT LPSHPALGTP KQQLHTMAQV RTVTPPEG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Strain: C57BL/6J. Tissue: Eye and Spinal ganglion.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: C57BL/6. Tissue: Brain.
[3]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-683, MASS SPECTROMETRY. Tissue: Melanoma.
[4]	"Mincle is an ITAM-coupled activating receptor that senses damaged cells." Yamasaki S., Ishikawa E., Sakuma M., Hara H., Ogata K., Saito T. Nat. Immunol. 9:1179-1188(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CLEC4E.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK011978 mRNA. Translation: BAB27953.1. AK053675 mRNA. Translation: BAC35469.1. AK084078 mRNA. Translation: BAC39113.1. BC063075 mRNA. Translation: AAH63075.1. BC066030 mRNA. Translation: AAH66030.1. Different initiation.
IPI	IPI00454138. IPI00844747. IPI00844759.
RefSeq	NP_766553.1. NM_172965.2.
UniGene	Mm.194538.
3D structure databases
ProteinModelPortal	Q8BIH0.
ModBase	Search...
PTM databases
PhosphoSite	Q8BIH0.
Proteomic databases
PaxDb	Q8BIH0.
PRIDE	Q8BIH0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000025109; ENSMUSP00000025109; ENSMUSG00000024260.
GeneID	269003.
KEGG	mmu:269003.
UCSC	uc008eib.1. mouse. uc008eic.1. mouse.
Organism-specific databases
CTD	79595.
MGI	MGI:1919782. Sap130.
Phylogenomic databases
eggNOG	NOG12793.
GeneTree	ENSGT00440000037733.
HOGENOM	HOG000081804.
HOVERGEN	HBG106600.
InParanoid	Q8BIH0.
OrthoDB	EOG49W2GD.
Gene expression databases
Bgee	Q8BIH0.
CleanEx	MM_SAP130.
Genevestigator	Q8BIH0.
Family and domain databases
InterPro	IPR024137. His_deAcase_cplx_SAP130. [Graphical view]
PANTHER	PTHR13497. PTHR13497. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	Sap130. mouse.
NextBio	392636.
SOURCE	Search...

Entry information

Entry name

SP130_MOUSE

Accession

Primary (citable) accession number: Q8BIH0
Secondary accession number(s): Q6NZP5 , Q6P553, Q8BID9, Q9CSU1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	April 3, 2007
Last modified:	April 3, 2013
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program