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Protein

Catechol O-methyltransferase domain-containing protein 1

Gene

Comtd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Putative O-methyltransferase.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei108 – 1081S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei116 – 1161S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei134 – 1341S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei135 – 1351S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation
Binding sitei163 – 1631S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation
Binding sitei185 – 1851S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei187 – 1871S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei194 – 1941S-adenosyl-L-methioninePROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Catechol O-methyltransferase domain-containing protein 1 (EC:2.1.1.-)
Gene namesi
Name:Comtd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1916406. Comtd1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Catechol O-methyltransferase domain-containing protein 1PRO_0000233290Add
BLAST

Proteomic databases

EPDiQ8BIG7.
MaxQBiQ8BIG7.
PaxDbiQ8BIG7.
PeptideAtlasiQ8BIG7.
PRIDEiQ8BIG7.

PTM databases

iPTMnetiQ8BIG7.
PhosphoSiteiQ8BIG7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021773.
CleanExiMM_COMTD1.
ExpressionAtlasiQ8BIG7. baseline and differential.
GenevisibleiQ8BIG7. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000119330.

Structurei

3D structure databases

ProteinModelPortaliQ8BIG7.
SMRiQ8BIG7. Positions 46-262.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 1112S-adenosyl-L-methionine bindingPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1663. Eukaryota.
COG4122. LUCA.
GeneTreeiENSGT00390000004409.
HOGENOMiHOG000016839.
HOVERGENiHBG081259.
InParanoidiQ8BIG7.
OMAiIAGDNCF.
OrthoDBiEOG091G0JQB.
PhylomeDBiQ8BIG7.
TreeFamiTF312986.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002935. O-MeTrfase_3.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01596. Methyltransf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51682. SAM_OMT_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BIG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQPVPRLSI PAALALGSAA LGAAFATGLL LGKRWPPWGS RRQERLLPPE
60 70 80 90 100
DNPLWQYLLS RSMREHPALR SLRLLTLEQP QGDSMMTCEQ AQLLANLARL
110 120 130 140 150
IKAKKALDLG TFTGYSALAL ALALPEAGRV VTCEVDAEPP KLGRPMWKQA
160 170 180 190 200
EVEQKIDLRL QPALQTLDEL LAAGEAGTFD IAVVDADKEN CTAYYERCLQ
210 220 230 240 250
LLRPGGVLAV LRVLWRGEVL QPQPRNKTVE CVRNLNERIL RDARVYISLL
260
PLDDGLSLAF KI
Length:262
Mass (Da):28,961
Last modified:March 1, 2003 - v1
Checksum:i86D965CAF552BFD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010388 mRNA. Translation: CAJ18595.1.
AK054334 mRNA. Translation: BAC35735.1.
AY294423 Genomic DNA. Translation: AAQ01517.1.
BC049670 mRNA. Translation: AAH49670.1.
CCDSiCCDS26868.1.
RefSeqiNP_081241.1. NM_026965.2.
UniGeneiMm.11827.

Genome annotation databases

EnsembliENSMUST00000124549; ENSMUSP00000119330; ENSMUSG00000021773.
GeneIDi69156.
KEGGimmu:69156.
UCSCiuc007slt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010388 mRNA. Translation: CAJ18595.1.
AK054334 mRNA. Translation: BAC35735.1.
AY294423 Genomic DNA. Translation: AAQ01517.1.
BC049670 mRNA. Translation: AAH49670.1.
CCDSiCCDS26868.1.
RefSeqiNP_081241.1. NM_026965.2.
UniGeneiMm.11827.

3D structure databases

ProteinModelPortaliQ8BIG7.
SMRiQ8BIG7. Positions 46-262.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000119330.

PTM databases

iPTMnetiQ8BIG7.
PhosphoSiteiQ8BIG7.

Proteomic databases

EPDiQ8BIG7.
MaxQBiQ8BIG7.
PaxDbiQ8BIG7.
PeptideAtlasiQ8BIG7.
PRIDEiQ8BIG7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000124549; ENSMUSP00000119330; ENSMUSG00000021773.
GeneIDi69156.
KEGGimmu:69156.
UCSCiuc007slt.1. mouse.

Organism-specific databases

CTDi118881.
MGIiMGI:1916406. Comtd1.

Phylogenomic databases

eggNOGiKOG1663. Eukaryota.
COG4122. LUCA.
GeneTreeiENSGT00390000004409.
HOGENOMiHOG000016839.
HOVERGENiHBG081259.
InParanoidiQ8BIG7.
OMAiIAGDNCF.
OrthoDBiEOG091G0JQB.
PhylomeDBiQ8BIG7.
TreeFamiTF312986.

Miscellaneous databases

PROiQ8BIG7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021773.
CleanExiMM_COMTD1.
ExpressionAtlasiQ8BIG7. baseline and differential.
GenevisibleiQ8BIG7. MM.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002935. O-MeTrfase_3.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01596. Methyltransf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51682. SAM_OMT_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCMTD1_MOUSE
AccessioniPrimary (citable) accession number: Q8BIG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.