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Protein

F-box only protein 28

Gene

Fbxo28

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 28
Gene namesi
Name:Fbxo28
Synonyms:D1Ertd578e, Kiaa0483
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1261890. Fbxo28.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368F-box only protein 28PRO_0000307725Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei235 – 2351PhosphoserineBy similarity
Modified residuei242 – 2421PhosphoserineBy similarity
Modified residuei270 – 2701PhosphothreonineBy similarity
Modified residuei344 – 3441PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BIG4.
MaxQBiQ8BIG4.
PaxDbiQ8BIG4.
PRIDEiQ8BIG4.

PTM databases

PhosphoSiteiQ8BIG4.

Expressioni

Gene expression databases

BgeeiQ8BIG4.
CleanExiMM_FBXO28.
ExpressionAtlasiQ8BIG4. baseline and differential.
GenevisibleiQ8BIG4. MM.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

Protein-protein interaction databases

BioGridi212559. 1 interaction.
STRINGi10090.ENSMUSP00000054718.

Structurei

3D structure databases

ProteinModelPortaliQ8BIG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 10949F-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IJHM. Eukaryota.
ENOG410YPFN. LUCA.
GeneTreeiENSGT00390000002970.
HOGENOMiHOG000048043.
HOVERGENiHBG051573.
InParanoidiQ8BIG4.
KOiK10306.
OMAiPRQSKRL.
OrthoDBiEOG7W154M.
PhylomeDBiQ8BIG4.
TreeFamiTF324672.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BIG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAASEERMA EEGGGGHGDG GSCSAAGSAQ RQPPAPPSQA PPPGSQAPAA
60 70 80 90 100
PALAPDHLPQ NNTLVALPIV AIENILSFMS YDEISQLRLV CKRMDLVCQR
110 120 130 140 150
MLNQGFLKVE RFHNLCQKQV KAQLPRRESE RRNHSLARHA DILAAVETRL
160 170 180 190 200
SLLNMTFMKY VDSNLCCFIP GKVIDEIYRV LRYVNSTRAP QRAHEVLQEL
210 220 230 240 250
RDISSMAMEY FDEKIVPILK RKLPGSDVSG RLMGSPPVPG PSAALTTMQL
260 270 280 290 300
FSKQNPSRQE VTKLQQQVRT NGAGVTVLRR EISELRTKVQ EQQKQLQDQD
310 320 330 340 350
QKLLEQTQII GEQNARLAEL ERKLREVMES AVGTSSGSGQ SEESPRKRRK
360
ATEAIDSLRK SKRLRNRK
Length:368
Mass (Da):40,978
Last modified:March 1, 2003 - v1
Checksum:i4EA50210B5AFF175
GO

Sequence cautioni

The sequence AAH55458.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti356 – 3561D → N in BAC36929 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122295 mRNA. Translation: BAC65577.1.
AK076211 mRNA. Translation: BAC36256.1.
AK077653 mRNA. Translation: BAC36929.1.
AK162188 mRNA. Translation: BAE36778.1.
BC055458 mRNA. Translation: AAH55458.1. Different initiation.
BC094542 mRNA. Translation: AAH94542.1.
CCDSiCCDS15588.1.
RefSeqiNP_780336.1. NM_175127.2.
UniGeneiMm.30737.

Genome annotation databases

EnsembliENSMUST00000051431; ENSMUSP00000054718; ENSMUSG00000047539.
GeneIDi67948.
KEGGimmu:67948.
UCSCiuc007dyb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122295 mRNA. Translation: BAC65577.1.
AK076211 mRNA. Translation: BAC36256.1.
AK077653 mRNA. Translation: BAC36929.1.
AK162188 mRNA. Translation: BAE36778.1.
BC055458 mRNA. Translation: AAH55458.1. Different initiation.
BC094542 mRNA. Translation: AAH94542.1.
CCDSiCCDS15588.1.
RefSeqiNP_780336.1. NM_175127.2.
UniGeneiMm.30737.

3D structure databases

ProteinModelPortaliQ8BIG4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212559. 1 interaction.
STRINGi10090.ENSMUSP00000054718.

PTM databases

PhosphoSiteiQ8BIG4.

Proteomic databases

EPDiQ8BIG4.
MaxQBiQ8BIG4.
PaxDbiQ8BIG4.
PRIDEiQ8BIG4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051431; ENSMUSP00000054718; ENSMUSG00000047539.
GeneIDi67948.
KEGGimmu:67948.
UCSCiuc007dyb.1. mouse.

Organism-specific databases

CTDi23219.
MGIiMGI:1261890. Fbxo28.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IJHM. Eukaryota.
ENOG410YPFN. LUCA.
GeneTreeiENSGT00390000002970.
HOGENOMiHOG000048043.
HOVERGENiHBG051573.
InParanoidiQ8BIG4.
KOiK10306.
OMAiPRQSKRL.
OrthoDBiEOG7W154M.
PhylomeDBiQ8BIG4.
TreeFamiTF324672.

Miscellaneous databases

ChiTaRSiFbxo28. mouse.
NextBioi326046.
PROiQ8BIG4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BIG4.
CleanExiMM_FBXO28.
ExpressionAtlasiQ8BIG4. baseline and differential.
GenevisibleiQ8BIG4. MM.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Brain and Mammary tumor.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-344, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung.

Entry informationi

Entry nameiFBX28_MOUSE
AccessioniPrimary (citable) accession number: Q8BIG4
Secondary accession number(s): Q3TS97, Q7TMH9, Q8BIF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: March 16, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.