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Protein

RNA binding protein fox-1 homolog 3

Gene

Rbfox3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein that regulates alternative splicing events. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD).2 Publications

GO - Molecular functioni

  • DNA binding Source: MGI
  • mRNA binding Source: GO_Central
  • nucleotide binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA binding protein fox-1 homolog 3
Alternative name(s):
Fox-1 homolog C
Hexaribonucleotide-binding protein 3
Short name:
Fox-3
Neuronal nuclei
Short name:
NeuN
Gene namesi
Name:Rbfox3
Synonyms:D11Bwg0517e, Hrnbp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:106368. Rbfox3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • intracellular Source: MGI
  • neuronal cell body Source: MGI
  • nucleus Source: MGI
  • perikaryon Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374RNA binding protein fox-1 homolog 3PRO_0000349208Add
BLAST

Post-translational modificationi

Phosphorylated.1 Publication

Proteomic databases

MaxQBiQ8BIF2.
PaxDbiQ8BIF2.
PeptideAtlasiQ8BIF2.
PRIDEiQ8BIF2.

PTM databases

iPTMnetiQ8BIF2.

Expressioni

Tissue specificityi

Widely expressed in brain, regions including cerebral cortex, hippocampus, thalamus, caudate/putamen, cerebellum, as well as in the spinal cord (at protein level). Not expressed in all neuronal cells within a region, in cerebellum, expression is absent in Purkinje cells (at protein level). Expressed in the retina in the ganglion cells and some cells in the inner nuclear layer, but absent from the photoreceptor cells and most cells in the inner nuclear layer (at protein level).4 Publications

Developmental stagei

In the neural tube, expressed as early as embryonic day 9.5 (E9.5) and expression is confined to the nervous system. By embryonic day 12.5, can be found in the developing ventral horns and is also detected in the developing dorsal horns as well as in the dorsal root ganglion. Not detected in the ventricular zone, roof plate, floor plate or marginal zone (developing white matter). It is expressed from embryonic stage to adulthood.1 Publication

Inductioni

By retinoic acid. Expression is up-regulated in P19 cells during neural differentiation upon retinoic acid treatment (at the protein level).2 Publications

Gene expression databases

BgeeiQ8BIF2.
ExpressionAtlasiQ8BIF2. baseline and differential.
GenevisibleiQ8BIF2. MM.

Interactioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei100 – 1001Interaction with RNABy similarity
Sitei108 – 1081Interaction with RNABy similarity
Sitei109 – 1091Interaction with RNABy similarity
Sitei133 – 1331Interaction with RNABy similarity
Sitei138 – 1381Interaction with RNABy similarity
Sitei142 – 1421Interaction with RNABy similarity
Sitei166 – 1661Interaction with RNABy similarity
Sitei176 – 1761Interaction with RNABy similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
HIF1AQ166652EBI-4567146,EBI-447269From a different organism.
Hif1aQ612212EBI-4567146,EBI-298954

Protein-protein interaction databases

IntActiQ8BIF2. 4 interactions.
MINTiMINT-4110740.
STRINGi10090.ENSMUSP00000017576.

Structurei

3D structure databases

ProteinModelPortaliQ8BIF2.
SMRiQ8BIF2. Positions 95-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini99 – 17577RRMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 5855Pro-richAdd
BLAST
Compositional biasi242 – 29554Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0125. Eukaryota.
ENOG4111WJT. LUCA.
GeneTreeiENSGT00390000013767.
HOGENOMiHOG000230971.
HOVERGENiHBG000044.
InParanoidiQ8BIF2.
KOiK14946.
OMAiHTIGPTA.
OrthoDBiEOG7060R3.
PhylomeDBiQ8BIF2.
TreeFamiTF315942.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR025670. Fox-1_C_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR017325. RNA-bd_Fox-1.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF12414. Fox-1_C. 2 hits.
PF00076. RRM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037932. Ataxin_2_bd_A2BP. 1 hit.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BIF2-1) [UniParc]FASTAAdd to basket

Also known as: Fox3v1, Fox-3-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQPYPPAQY PPPPQNGIPA EYAPPPPHPT QDYSGQTPVP PEHGMTLYTP
60 70 80 90 100
AQTHPEQPGT EASTQPIAGT QTVPQADEAA QTDNQQLHPS DPTEKQQPKR
110 120 130 140 150
LHVSNIPFRF RDPDLRQMFG QFGKILDVEI IFNERGSKGF GFVTFETSSD
160 170 180 190 200
ADRAREKLNG TIVEGRKIEV NNATARVMTN KKPGNPYANG WKLNPVVGTV
210 220 230 240 250
YGPEFYAVTS FPYPTTGTAV AYRGAHLRGR GRAVYNTFRA APPPPPIPTY
260 270 280 290 300
GAALEQTLVK MPVPWAGLAP CPLPPQQTPE PAYPTSPAFP PLSCPFASRV
310 320 330 340 350
VYQDGFYGAE IYGGYAAYRY AQPAAATAAA YSDSYGRVYA AADPYHHTIG
360 370
PTATYSIGTM ASLCRGGYSR FTPY
Length:374
Mass (Da):40,610
Last modified:September 2, 2008 - v2
Checksum:iAC1454ADBCD2B810
GO
Isoform 2 (identifier: Q8BIF2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     361-374: Missing.

Show »
Length:360
Mass (Da):39,051
Checksum:i789CC518B9F6CC92
GO
Isoform 3 (identifier: Q8BIF2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-169: Missing.
     361-374: Missing.

Show »
Length:329
Mass (Da):35,638
Checksum:iBB7BA1021A5216D6
GO
Isoform 4 (identifier: Q8BIF2-4) [UniParc]FASTAAdd to basket

Also known as: Fox3v3

The sequence of this isoform differs from the canonical sequence as follows:
     253-299: Missing.
     361-374: Missing.

Show »
Length:313
Mass (Da):34,068
Checksum:i664AB23CC03D9B7A
GO
Isoform 5 (identifier: Q8BIF2-5) [UniParc]FASTAAdd to basket

Also known as: Fox3v2, Fox-3-S

The sequence of this isoform differs from the canonical sequence as follows:
     253-299: Missing.

Show »
Length:327
Mass (Da):35,628
Checksum:i2952868AD8C8E39A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti266 – 2661A → V in BAC37531 (PubMed:19713214).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei139 – 16931Missing in isoform 3. 1 PublicationVSP_035219Add
BLAST
Alternative sequencei253 – 29947Missing in isoform 4 and isoform 5. 1 PublicationVSP_043949Add
BLAST
Alternative sequencei361 – 37414Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsVSP_035220Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ958310 mRNA. Translation: ACY91937.1.
FJ958311 mRNA. Translation: ACY91938.1.
AK079086 mRNA. Translation: BAC37531.1.
AK160816 mRNA. Translation: BAE36031.1.
AL591514 Genomic DNA. No translation available.
AL591544 Genomic DNA. No translation available.
AL591075 Genomic DNA. Translation: CAM15761.1.
AL591075 Genomic DNA. Translation: CAM15760.1.
AL591075 Genomic DNA. Translation: CAM15762.1.
AL591075 Genomic DNA. Translation: CAX16099.1.
AL591075 Genomic DNA. Translation: CAX16100.1.
CH466558 Genomic DNA. Translation: EDL34674.1.
BC054403 mRNA. Translation: AAH54403.1.
CCDSiCCDS25705.1. [Q8BIF2-4]
CCDS25706.1. [Q8BIF2-1]
CCDS70358.1. [Q8BIF2-3]
CCDS70360.1. [Q8BIF2-2]
RefSeqiNP_001020102.2. NM_001024931.2. [Q8BIF2-4]
NP_001034256.1. NM_001039167.1. [Q8BIF2-1]
NP_001034257.1. NM_001039168.1.
NP_001272365.1. NM_001285436.1. [Q8BIF2-2]
NP_001272366.1. NM_001285437.1. [Q8BIF2-3]
NP_001272367.1. NM_001285438.1. [Q8BIF2-4]
XP_006533785.1. XM_006533722.2. [Q8BIF2-1]
XP_006533788.1. XM_006533725.2. [Q8BIF2-1]
XP_006533790.1. XM_006533727.2. [Q8BIF2-5]
XP_011247431.1. XM_011249129.1. [Q8BIF2-1]
UniGeneiMm.341103.

Genome annotation databases

EnsembliENSMUST00000017576; ENSMUSP00000017576; ENSMUSG00000025576. [Q8BIF2-1]
ENSMUST00000069343; ENSMUSP00000069598; ENSMUSG00000025576. [Q8BIF2-3]
ENSMUST00000103023; ENSMUSP00000099312; ENSMUSG00000025576. [Q8BIF2-4]
ENSMUST00000106278; ENSMUSP00000101885; ENSMUSG00000025576. [Q8BIF2-4]
ENSMUST00000117731; ENSMUSP00000113636; ENSMUSG00000025576. [Q8BIF2-2]
ENSMUST00000120061; ENSMUSP00000113987; ENSMUSG00000025576. [Q8BIF2-5]
GeneIDi52897.
KEGGimmu:52897.
UCSCiuc007mpl.1. mouse. [Q8BIF2-4]
uc007mpm.1. mouse. [Q8BIF2-5]
uc007mpn.1. mouse. [Q8BIF2-1]
uc007mpp.1. mouse. [Q8BIF2-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ958310 mRNA. Translation: ACY91937.1.
FJ958311 mRNA. Translation: ACY91938.1.
AK079086 mRNA. Translation: BAC37531.1.
AK160816 mRNA. Translation: BAE36031.1.
AL591514 Genomic DNA. No translation available.
AL591544 Genomic DNA. No translation available.
AL591075 Genomic DNA. Translation: CAM15761.1.
AL591075 Genomic DNA. Translation: CAM15760.1.
AL591075 Genomic DNA. Translation: CAM15762.1.
AL591075 Genomic DNA. Translation: CAX16099.1.
AL591075 Genomic DNA. Translation: CAX16100.1.
CH466558 Genomic DNA. Translation: EDL34674.1.
BC054403 mRNA. Translation: AAH54403.1.
CCDSiCCDS25705.1. [Q8BIF2-4]
CCDS25706.1. [Q8BIF2-1]
CCDS70358.1. [Q8BIF2-3]
CCDS70360.1. [Q8BIF2-2]
RefSeqiNP_001020102.2. NM_001024931.2. [Q8BIF2-4]
NP_001034256.1. NM_001039167.1. [Q8BIF2-1]
NP_001034257.1. NM_001039168.1.
NP_001272365.1. NM_001285436.1. [Q8BIF2-2]
NP_001272366.1. NM_001285437.1. [Q8BIF2-3]
NP_001272367.1. NM_001285438.1. [Q8BIF2-4]
XP_006533785.1. XM_006533722.2. [Q8BIF2-1]
XP_006533788.1. XM_006533725.2. [Q8BIF2-1]
XP_006533790.1. XM_006533727.2. [Q8BIF2-5]
XP_011247431.1. XM_011249129.1. [Q8BIF2-1]
UniGeneiMm.341103.

3D structure databases

ProteinModelPortaliQ8BIF2.
SMRiQ8BIF2. Positions 95-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BIF2. 4 interactions.
MINTiMINT-4110740.
STRINGi10090.ENSMUSP00000017576.

PTM databases

iPTMnetiQ8BIF2.

Proteomic databases

MaxQBiQ8BIF2.
PaxDbiQ8BIF2.
PeptideAtlasiQ8BIF2.
PRIDEiQ8BIF2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017576; ENSMUSP00000017576; ENSMUSG00000025576. [Q8BIF2-1]
ENSMUST00000069343; ENSMUSP00000069598; ENSMUSG00000025576. [Q8BIF2-3]
ENSMUST00000103023; ENSMUSP00000099312; ENSMUSG00000025576. [Q8BIF2-4]
ENSMUST00000106278; ENSMUSP00000101885; ENSMUSG00000025576. [Q8BIF2-4]
ENSMUST00000117731; ENSMUSP00000113636; ENSMUSG00000025576. [Q8BIF2-2]
ENSMUST00000120061; ENSMUSP00000113987; ENSMUSG00000025576. [Q8BIF2-5]
GeneIDi52897.
KEGGimmu:52897.
UCSCiuc007mpl.1. mouse. [Q8BIF2-4]
uc007mpm.1. mouse. [Q8BIF2-5]
uc007mpn.1. mouse. [Q8BIF2-1]
uc007mpp.1. mouse. [Q8BIF2-3]

Organism-specific databases

CTDi146713.
MGIiMGI:106368. Rbfox3.

Phylogenomic databases

eggNOGiKOG0125. Eukaryota.
ENOG4111WJT. LUCA.
GeneTreeiENSGT00390000013767.
HOGENOMiHOG000230971.
HOVERGENiHBG000044.
InParanoidiQ8BIF2.
KOiK14946.
OMAiHTIGPTA.
OrthoDBiEOG7060R3.
PhylomeDBiQ8BIF2.
TreeFamiTF315942.

Miscellaneous databases

PROiQ8BIF2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BIF2.
ExpressionAtlasiQ8BIF2. baseline and differential.
GenevisibleiQ8BIF2. MM.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR025670. Fox-1_C_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR017325. RNA-bd_Fox-1.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF12414. Fox-1_C. 2 hits.
PF00076. RRM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037932. Ataxin_2_bd_A2BP. 1 hit.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of neuronal nuclei (NeuN) as Fox-3, a new member of the Fox-1 gene family of splicing factors."
    Kim K.K., Adelstein R.S., Kawamoto S.
    J. Biol. Chem. 284:31052-31061(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 5), PROTEIN SEQUENCE OF 139-153; 156-166 AND 320-360, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION BY RETINOIC ACID.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Diencephalon and Head.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Eye.
  6. "NeuN/Rbfox3 nuclear and cytoplasmic isoforms differentially regulate alternative splicing and nonsense-mediated decay of Rbfox2."
    Dredge B.K., Jensen K.B.
    PLoS ONE 6:E21585-E21585(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 102-135; 139-153; 192-201; 239-250 AND 319-337, FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY, INDUCTION BY RETINOIC ACID, IDENTIFICATION BY MASS SPECTROMETRY (ISOFORMS 1; 4 AND 5).
  7. "NeuN, a neuronal specific nuclear protein in vertebrates."
    Mullen R.J., Buck C.R., Smith A.M.
    Development 116:201-211(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  8. "Characterization of the neuronal marker NeuN as a multiply phosphorylated antigen with discrete subcellular localization."
    Lind D., Franken S., Kappler J., Jankowski J., Schilling K.
    J. Neurosci. Res. 79:295-302(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PHOSPHORYLATION.
  9. "Autoregulation of Fox protein expression to produce dominant negative splicing factors."
    Damianov A., Black D.L.
    RNA 16:405-416(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING.

Entry informationi

Entry nameiRFOX3_MOUSE
AccessioniPrimary (citable) accession number: Q8BIF2
Secondary accession number(s): A2A4W7
, A2A4W8, B7ZC12, B7ZC13, D1GI07, Q3TUE0, Q7TQI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: July 6, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Initial characterization was derived from usage of a monoclonal antibody (A60) directed to an unknown protein called NeuN (PubMed:15605376 and PubMed:1483388), but later identified as RBFOX3.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.