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Protein

CD99 antigen-like protein 2

Gene

Cd99l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Homophilic adhesion molecule, but these interactions may not be required for cell aggregation.3 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
CD99 antigen-like protein 2
Alternative name(s):
MIC2-like protein 1
CD_antigen: CD99
Gene namesi
Name:Cd99l2
Synonyms:Mic2l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2177151. Cd99l2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 161ExtracellularSequence analysisAdd BLAST136
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 237CytoplasmicSequence analysisAdd BLAST55

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000034009326 – 237CD99 antigen-like protein 2Add BLAST212

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8BIF0.
PeptideAtlasiQ8BIF0.
PRIDEiQ8BIF0.

PTM databases

iPTMnetiQ8BIF0.
PhosphoSitePlusiQ8BIF0.

Expressioni

Tissue specificityi

Highly expressed in the nervous system, including brain, dentate nucleus of hippocampus, granular and Purkinje cells of cerebellum, brain stem nucleus and choroid plexus. Expressed in peripheral blood T- and B-cells and neutrophils (at protein level). Almost undetectable in bone marrow-derived neutrophils (at protein level). Also expressed in thymocytes (at protein level) with higher expression in cortical thymocytes than in medullary thymocytes. Expressed at high levels in testis (mostly in germ cells and Sertoli cells) and ovary (mostly in granulosa cells). Expressed in lung, heart, kidney and liver (at protein level); however, expression in heart, kidney and liver seems restricted to endothelial cells (at protein level). Highly expressed in endothelial cells and to a lower level in vascular smooth muscle cells (at protein level). Low expression in spleen.3 Publications

Developmental stagei

At 12.5 dpc, expressed in most tissues, especially in the nervous system, including the cerebral cortex, cerebellum, spinal cord and ganglion. There is no change in expression pattern from 12.5 dpc to neonatal day 1. Highly expressed in the subventricular zone and cortical plate of fetal brain and in the dorsal root ganglion of the peripheral nervous system. Except in the nervous system, expression in adult tissues is weaker than in fetal ones.

Gene expression databases

BgeeiENSMUSG00000035776.
ExpressionAtlasiQ8BIF0. baseline and differential.
GenevisibleiQ8BIF0. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8BIF0. 1 interactor.
MINTiMINT-4119087.

Structurei

3D structure databases

ProteinModelPortaliQ8BIF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi74 – 77Poly-Thr4
Compositional biasi142 – 147Poly-Gly6
Compositional biasi229 – 235Poly-Pro7

Sequence similaritiesi

Belongs to the CD99 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J1MW. Eukaryota.
ENOG410YNQK. LUCA.
GeneTreeiENSGT00530000063944.
HOGENOMiHOG000233665.
HOVERGENiHBG067989.
InParanoidiQ8BIF0.
OMAiKYSTLHT.
OrthoDBiEOG091G0YLT.
PhylomeDBiQ8BIF0.
TreeFamiTF332323.

Family and domain databases

InterProiIPR022078. CD99L2.
[Graphical view]
PfamiPF12301. CD99L2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BIF0-1) [UniParc]FASTAAdd to basket
Also known as: Long isoform

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVARLTAFLV CLVFSLATLV QRGYGDTDGF NLEDALKETS SVKQRWDHFS
60 70 80 90 100
TTTRRPVTTR APANPAERWD HVATTTTRRP GTTRAPSNPM ELDGFDLEDA
110 120 130 140 150
LDDRNDLDGP KKPSAGEAGG WSDKDLEDIV EGGGYKPDKN KGGGGYGSND
160 170 180 190 200
DPGSGISTET GTIAGVASAL AMALIGAVSS YISYQQKKFC FSIQQGLNAD
210 220 230
YVKGENLEAV VCEEPQVTYS KQETQSAEPP PPEPPRI
Length:237
Mass (Da):25,463
Last modified:March 1, 2003 - v1
Checksum:i6876EB515DFA426A
GO
Isoform 2 (identifier: Q8BIF0-2) [UniParc]FASTAAdd to basket
Also known as: Short isoform

The sequence of this isoform differs from the canonical sequence as follows:
     49-71: Missing.

Note: Seems to be the major transcript.
Show »
Length:214
Mass (Da):22,813
Checksum:i660931CD66220AFA
GO

Sequence cautioni

The sequence CAM25451 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03418649 – 71Missing in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078163 mRNA. Translation: AAL86615.1.
EF516990 mRNA. Translation: ABP73253.1.
AK080225 mRNA. Translation: BAC37853.1.
AK166275 mRNA. Translation: BAE38674.1.
AL833776, AL772294 Genomic DNA. Translation: CAM25449.1.
AL833776, AL772294 Genomic DNA. Translation: CAM25450.1.
AL833776, AL772294 Genomic DNA. Translation: CAM25451.1. Sequence problems.
BC031736 mRNA. Translation: AAH31736.1.
CCDSiCCDS30179.1. [Q8BIF0-2]
CCDS57761.1. [Q8BIF0-1]
RefSeqiNP_001186278.1. NM_001199349.1. [Q8BIF0-1]
NP_612182.1. NM_138309.3. [Q8BIF0-2]
UniGeneiMm.283879.
Mm.397118.

Genome annotation databases

EnsembliENSMUST00000037391; ENSMUSP00000042606; ENSMUSG00000035776. [Q8BIF0-1]
ENSMUST00000080035; ENSMUSP00000078944; ENSMUSG00000035776. [Q8BIF0-2]
GeneIDi171486.
KEGGimmu:171486.
UCSCiuc009tjz.2. mouse. [Q8BIF0-2]
uc009tka.2. mouse. [Q8BIF0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078163 mRNA. Translation: AAL86615.1.
EF516990 mRNA. Translation: ABP73253.1.
AK080225 mRNA. Translation: BAC37853.1.
AK166275 mRNA. Translation: BAE38674.1.
AL833776, AL772294 Genomic DNA. Translation: CAM25449.1.
AL833776, AL772294 Genomic DNA. Translation: CAM25450.1.
AL833776, AL772294 Genomic DNA. Translation: CAM25451.1. Sequence problems.
BC031736 mRNA. Translation: AAH31736.1.
CCDSiCCDS30179.1. [Q8BIF0-2]
CCDS57761.1. [Q8BIF0-1]
RefSeqiNP_001186278.1. NM_001199349.1. [Q8BIF0-1]
NP_612182.1. NM_138309.3. [Q8BIF0-2]
UniGeneiMm.283879.
Mm.397118.

3D structure databases

ProteinModelPortaliQ8BIF0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BIF0. 1 interactor.
MINTiMINT-4119087.

PTM databases

iPTMnetiQ8BIF0.
PhosphoSitePlusiQ8BIF0.

Proteomic databases

PaxDbiQ8BIF0.
PeptideAtlasiQ8BIF0.
PRIDEiQ8BIF0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037391; ENSMUSP00000042606; ENSMUSG00000035776. [Q8BIF0-1]
ENSMUST00000080035; ENSMUSP00000078944; ENSMUSG00000035776. [Q8BIF0-2]
GeneIDi171486.
KEGGimmu:171486.
UCSCiuc009tjz.2. mouse. [Q8BIF0-2]
uc009tka.2. mouse. [Q8BIF0-1]

Organism-specific databases

CTDi83692.
MGIiMGI:2177151. Cd99l2.

Phylogenomic databases

eggNOGiENOG410J1MW. Eukaryota.
ENOG410YNQK. LUCA.
GeneTreeiENSGT00530000063944.
HOGENOMiHOG000233665.
HOVERGENiHBG067989.
InParanoidiQ8BIF0.
OMAiKYSTLHT.
OrthoDBiEOG091G0YLT.
PhylomeDBiQ8BIF0.
TreeFamiTF332323.

Miscellaneous databases

PROiQ8BIF0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035776.
ExpressionAtlasiQ8BIF0. baseline and differential.
GenevisibleiQ8BIF0. MM.

Family and domain databases

InterProiIPR022078. CD99L2.
[Graphical view]
PfamiPF12301. CD99L2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC99L2_MOUSE
AccessioniPrimary (citable) accession number: Q8BIF0
Secondary accession number(s): A2AP77, Q8R447
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.