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Q8BIF0

- C99L2_MOUSE

UniProt

Q8BIF0 - C99L2_MOUSE

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Protein

CD99 antigen-like protein 2

Gene
Cd99l2, Mic2l1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Homophilic adhesion molecule, but these interactions may not be required for cell aggregation.3 Publications

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
CD99 antigen-like protein 2
Alternative name(s):
MIC2-like protein 1
CD_antigen: CD99
Gene namesi
Name:Cd99l2
Synonyms:Mic2l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:2177151. Cd99l2.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein; Extracellular side By similarity. Cell junction
Note: Concentrated at cell-cell contacts in cultured endothelial cells.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 161136Extracellular Reviewed predictionAdd
BLAST
Transmembranei162 – 18221Helical; Reviewed predictionAdd
BLAST
Topological domaini183 – 23755Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 237212CD99 antigen-like protein 2PRO_0000340093Add
BLAST

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BIF0.
PaxDbiQ8BIF0.
PRIDEiQ8BIF0.

PTM databases

PhosphoSiteiQ8BIF0.

Expressioni

Tissue specificityi

Highly expressed in the nervous system, including brain, dentate nucleus of hippocampus, granular and Purkinje cells of cerebellum, brain stem nucleus and choroid plexus. Expressed in peripheral blood T- and B-cells and neutrophils (at protein level). Almost undetectable in bone marrow-derived neutrophils (at protein level). Also expressed in thymocytes (at protein level) with higher expression in cortical thymocytes than in medullary thymocytes. Expressed at high levels in testis (mostly in germ cells and Sertoli cells) and ovary (mostly in granulosa cells). Expressed in lung, heart, kidney and liver (at protein level); however, expression in heart, kidney and liver seems restricted to endothelial cells (at protein level). Highly expressed in endothelial cells and to a lower level in vascular smooth muscle cells (at protein level). Low expression in spleen.3 Publications

Developmental stagei

At 12.5 dpc, expressed in most tissues, especially in the nervous system, including the cerebral cortex, cerebellum, spinal cord and ganglion. There is no change in expression pattern from 12.5 dpc to neonatal day 1. Highly expressed in the subventricular zone and cortical plate of fetal brain and in the dorsal root ganglion of the peripheral nervous system. Except in the nervous system, expression in adult tissues is weaker than in fetal ones.

Gene expression databases

ArrayExpressiQ8BIF0.
BgeeiQ8BIF0.
GenevestigatoriQ8BIF0.

Interactioni

Protein-protein interaction databases

IntActiQ8BIF0. 1 interaction.
MINTiMINT-4119087.
STRINGi10090.ENSMUSP00000042606.

Structurei

3D structure databases

ProteinModelPortaliQ8BIF0.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi74 – 774Poly-Thr
Compositional biasi142 – 1476Poly-Gly
Compositional biasi229 – 2357Poly-Pro

Sequence similaritiesi

Belongs to the CD99 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42091.
GeneTreeiENSGT00530000063944.
HOGENOMiHOG000233665.
HOVERGENiHBG067989.
InParanoidiQ8BIF0.
OMAiKYSTLHT.
OrthoDBiEOG77WWG1.
PhylomeDBiQ8BIF0.
TreeFamiTF332323.

Family and domain databases

InterProiIPR022078. CD99L2.
[Graphical view]
PfamiPF12301. CD99L2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8BIF0-1) [UniParc]FASTAAdd to Basket

Also known as: Long isoform

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVARLTAFLV CLVFSLATLV QRGYGDTDGF NLEDALKETS SVKQRWDHFS    50
TTTRRPVTTR APANPAERWD HVATTTTRRP GTTRAPSNPM ELDGFDLEDA 100
LDDRNDLDGP KKPSAGEAGG WSDKDLEDIV EGGGYKPDKN KGGGGYGSND 150
DPGSGISTET GTIAGVASAL AMALIGAVSS YISYQQKKFC FSIQQGLNAD 200
YVKGENLEAV VCEEPQVTYS KQETQSAEPP PPEPPRI 237
Length:237
Mass (Da):25,463
Last modified:March 1, 2003 - v1
Checksum:i6876EB515DFA426A
GO
Isoform 2 (identifier: Q8BIF0-2) [UniParc]FASTAAdd to Basket

Also known as: Short isoform

The sequence of this isoform differs from the canonical sequence as follows:
     49-71: Missing.

Note: Seems to be the major transcript.

Show »
Length:214
Mass (Da):22,813
Checksum:i660931CD66220AFA
GO

Sequence cautioni

The sequence CAM25451.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei49 – 7123Missing in isoform 2. VSP_034186Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY078163 mRNA. Translation: AAL86615.1.
EF516990 mRNA. Translation: ABP73253.1.
AK080225 mRNA. Translation: BAC37853.1.
AK166275 mRNA. Translation: BAE38674.1.
AL833776, AL772294 Genomic DNA. Translation: CAM25449.1.
AL833776, AL772294 Genomic DNA. Translation: CAM25450.1.
AL833776, AL772294 Genomic DNA. Translation: CAM25451.1. Sequence problems.
BC031736 mRNA. Translation: AAH31736.1.
CCDSiCCDS30179.1. [Q8BIF0-2]
CCDS57761.1. [Q8BIF0-1]
RefSeqiNP_001186278.1. NM_001199349.1. [Q8BIF0-1]
NP_612182.1. NM_138309.3. [Q8BIF0-2]
UniGeneiMm.283879.
Mm.397118.

Genome annotation databases

EnsembliENSMUST00000037391; ENSMUSP00000042606; ENSMUSG00000035776. [Q8BIF0-1]
ENSMUST00000080035; ENSMUSP00000078944; ENSMUSG00000035776. [Q8BIF0-2]
GeneIDi171486.
KEGGimmu:171486.
UCSCiuc009tjz.2. mouse. [Q8BIF0-2]
uc009tka.2. mouse. [Q8BIF0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY078163 mRNA. Translation: AAL86615.1 .
EF516990 mRNA. Translation: ABP73253.1 .
AK080225 mRNA. Translation: BAC37853.1 .
AK166275 mRNA. Translation: BAE38674.1 .
AL833776 , AL772294 Genomic DNA. Translation: CAM25449.1 .
AL833776 , AL772294 Genomic DNA. Translation: CAM25450.1 .
AL833776 , AL772294 Genomic DNA. Translation: CAM25451.1 . Sequence problems.
BC031736 mRNA. Translation: AAH31736.1 .
CCDSi CCDS30179.1. [Q8BIF0-2 ]
CCDS57761.1. [Q8BIF0-1 ]
RefSeqi NP_001186278.1. NM_001199349.1. [Q8BIF0-1 ]
NP_612182.1. NM_138309.3. [Q8BIF0-2 ]
UniGenei Mm.283879.
Mm.397118.

3D structure databases

ProteinModelPortali Q8BIF0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8BIF0. 1 interaction.
MINTi MINT-4119087.
STRINGi 10090.ENSMUSP00000042606.

PTM databases

PhosphoSitei Q8BIF0.

Proteomic databases

MaxQBi Q8BIF0.
PaxDbi Q8BIF0.
PRIDEi Q8BIF0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037391 ; ENSMUSP00000042606 ; ENSMUSG00000035776 . [Q8BIF0-1 ]
ENSMUST00000080035 ; ENSMUSP00000078944 ; ENSMUSG00000035776 . [Q8BIF0-2 ]
GeneIDi 171486.
KEGGi mmu:171486.
UCSCi uc009tjz.2. mouse. [Q8BIF0-2 ]
uc009tka.2. mouse. [Q8BIF0-1 ]

Organism-specific databases

CTDi 83692.
MGIi MGI:2177151. Cd99l2.

Phylogenomic databases

eggNOGi NOG42091.
GeneTreei ENSGT00530000063944.
HOGENOMi HOG000233665.
HOVERGENi HBG067989.
InParanoidi Q8BIF0.
OMAi KYSTLHT.
OrthoDBi EOG77WWG1.
PhylomeDBi Q8BIF0.
TreeFami TF332323.

Miscellaneous databases

NextBioi 371011.
PROi Q8BIF0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BIF0.
Bgeei Q8BIF0.
Genevestigatori Q8BIF0.

Family and domain databases

InterProi IPR022078. CD99L2.
[Graphical view ]
Pfami PF12301. CD99L2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, genomic organization, alternative transcripts and expression analysis of CD99L2, a novel paralog of human CD99, and identification of evolutionary conserved motifs."
    Suh Y.H., Shin Y.K., Kook M.-C., Oh K.I., Park W.S., Kim S.H., Lee I.-S., Park H.J., Huh T.-L., Park S.H.
    Gene 307:63-76(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
  2. "The murine CD99-related molecule CD99-like 2 (CD99L2) is an adhesion molecule involved in the inflammatory response."
    Schenkel A.R., Dufour E.M., Chew T.W., Sorg E., Muller W.A.
    Cell Commun. Adhes. 14:227-237(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Thymus.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Aorta and Mammary gland.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  6. "A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivo."
    Bixel M.G., Petri B., Khandoga A.G., Khandoga A., Wolburg-Buchholz K., Wolburg H., Marz S., Krombach F., Vestweber D.
    Blood 109:5327-5336(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION.
  7. "CD99 and CD99L2 act at the same site as, but independently of, PECAM-1 during leukocyte diapedesis."
    Bixel M.G., Li H., Petri B., Khandoga A.G., Khandoga A., Zarbock A., Wolburg-Buchholz K., Wolburg H., Sorokin L., Zeuschner D., Maerz S., Butz S., Krombach F., Vestweber D.
    Blood 116:1172-1184(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiC99L2_MOUSE
AccessioniPrimary (citable) accession number: Q8BIF0
Secondary accession number(s): A2AP77, Q8R447
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi