Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

F-box/LRR-repeat protein 14

Gene

Fbxl14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of some (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 14
Alternative name(s):
F-box and leucine-rich repeat protein 14
Gene namesi
Name:Fbxl14
Synonyms:Fbl14, Ppa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2141676 Fbxl14

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198621 – 400F-box/LRR-repeat protein 14Add BLAST400

Proteomic databases

PaxDbiQ8BID8
PRIDEiQ8BID8

PTM databases

iPTMnetiQ8BID8
PhosphoSitePlusiQ8BID8

Expressioni

Gene expression databases

BgeeiENSMUSG00000030019
CleanExiMM_FBXL14
GenevisibleiQ8BID8 MM

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) ubiquitin-protein ligase complex. Interacts with SKP1 and CUL1. Interacts with SNAI1; the interaction requires the phosphorylation of the two serine residues in the substrate destruction motif D-S-G-X(2,3,4)-S (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032094

Structurei

3D structure databases

ProteinModelPortaliQ8BID8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 48F-boxAdd BLAST47
Repeati144 – 163LRR 1Add BLAST20
Repeati170 – 191LRR 2Add BLAST22
Repeati203 – 225LRR 3Add BLAST23
Repeati229 – 250LRR 4Add BLAST22
Repeati254 – 275LRR 5Add BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 48Required for down-regulation of SNAI1By similarityAdd BLAST47

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IT1Z Eukaryota
ENOG410YK3H LUCA
GeneTreeiENSGT00760000119059
HOGENOMiHOG000007617
HOVERGENiHBG051674
InParanoidiQ8BID8
KOiK10280
OMAiSCWHVSD
OrthoDBiEOG091G08CA
PhylomeDBiQ8BID8
TreeFamiTF313434

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF13516 LRR_6, 5 hits
SMARTiView protein in SMART
SM00367 LRR_CC, 11 hits
SUPFAMiSSF81383 SSF81383, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BID8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METHISCLFP ELLAMIFGYL DVRDKGRAAQ VCTAWRDAAY HKSVWRGVEA
60 70 80 90 100
KLHLRRANPS LFPSLQARGI RRVQILSLRR SLSYVIQGMA NIESLNLSGC
110 120 130 140 150
YNLTDNGLGH AFVQEIGSLR ALNLSLCKQI TDSSLGRIAQ YLKGLEVLEL
160 170 180 190 200
GGCSNITNTG LLLIAWGLQR LKSLNLRSCR HLSDVGIGHL AGMTRSAAEG
210 220 230 240 250
CLGLEQLTLQ DCQKLTDLSL KHISRGLTGL RLLNLSFCGG ISDAGLLHLS
260 270 280 290 300
HMGSLRSLNL RSCDNISDTG IMHLAMGSLR LSGLDVSFCD KVGDQSLAYI
310 320 330 340 350
AQGLDGLKSL SLCSCHISDD GINRMVRQMH GLRTLNIGQC VRITDKGLEL
360 370 380 390 400
IAEHLSQLTG IDLYGCTRIT KRGLERITQL PCLKVLNLGL WQMTDSEKVR
Length:400
Mass (Da):43,864
Last modified:March 1, 2003 - v1
Checksum:iE0B297E4B4F83C22
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22V → F in AAH21329 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK084506 mRNA Translation: BAC39201.1
AK155154 mRNA Translation: BAE33081.1
BC006913 mRNA Translation: AAH06913.1
BC021329 mRNA Translation: AAH21329.1
AF467463 mRNA Translation: AAL75967.1
CCDSiCCDS20475.1
RefSeqiNP_598701.2, NM_133940.3
UniGeneiMm.125477

Genome annotation databases

EnsembliENSMUST00000032094; ENSMUSP00000032094; ENSMUSG00000030019
GeneIDi101358
KEGGimmu:101358
UCSCiuc009dmj.2 mouse

Similar proteinsi

Entry informationi

Entry nameiFXL14_MOUSE
AccessioniPrimary (citable) accession number: Q8BID8
Secondary accession number(s): Q3U2Q9
, Q8R5H7, Q8VDT7, Q922N5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health