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Protein

F-box/LRR-repeat protein 14

Gene

Fbxl14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of some (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 14
Alternative name(s):
F-box and leucine-rich repeat protein 14
Gene namesi
Name:Fbxl14
Synonyms:Fbl14, Ppa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2141676. Fbxl14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198621 – 400F-box/LRR-repeat protein 14Add BLAST400

Proteomic databases

PaxDbiQ8BID8.
PRIDEiQ8BID8.

PTM databases

iPTMnetiQ8BID8.
PhosphoSitePlusiQ8BID8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030019.
CleanExiMM_FBXL14.
GenevisibleiQ8BID8. MM.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) ubiquitin-protein ligase complex. Interacts with SKP1 and CUL1. Interacts with SNAI1; the interaction requires the phosphorylation of the two serine residues in the substrate destruction motif D-S-G-X(2,3,4)-S (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032094.

Structurei

3D structure databases

ProteinModelPortaliQ8BID8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 48F-boxAdd BLAST47
Repeati144 – 163LRR 1Add BLAST20
Repeati170 – 191LRR 2Add BLAST22
Repeati203 – 225LRR 3Add BLAST23
Repeati229 – 250LRR 4Add BLAST22
Repeati254 – 275LRR 5Add BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 48Required for down-regulation of SNAI1By similarityAdd BLAST47

Sequence similaritiesi

Contains 1 F-box domain.Curated
Contains 5 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IT1Z. Eukaryota.
ENOG410YK3H. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000007617.
HOVERGENiHBG051674.
InParanoidiQ8BID8.
KOiK10280.
OMAiKHLARMP.
OrthoDBiEOG091G08CA.
PhylomeDBiQ8BID8.
TreeFamiTF313434.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF13516. LRR_6. 5 hits.
[Graphical view]
SMARTiSM00367. LRR_CC. 11 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BID8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METHISCLFP ELLAMIFGYL DVRDKGRAAQ VCTAWRDAAY HKSVWRGVEA
60 70 80 90 100
KLHLRRANPS LFPSLQARGI RRVQILSLRR SLSYVIQGMA NIESLNLSGC
110 120 130 140 150
YNLTDNGLGH AFVQEIGSLR ALNLSLCKQI TDSSLGRIAQ YLKGLEVLEL
160 170 180 190 200
GGCSNITNTG LLLIAWGLQR LKSLNLRSCR HLSDVGIGHL AGMTRSAAEG
210 220 230 240 250
CLGLEQLTLQ DCQKLTDLSL KHISRGLTGL RLLNLSFCGG ISDAGLLHLS
260 270 280 290 300
HMGSLRSLNL RSCDNISDTG IMHLAMGSLR LSGLDVSFCD KVGDQSLAYI
310 320 330 340 350
AQGLDGLKSL SLCSCHISDD GINRMVRQMH GLRTLNIGQC VRITDKGLEL
360 370 380 390 400
IAEHLSQLTG IDLYGCTRIT KRGLERITQL PCLKVLNLGL WQMTDSEKVR
Length:400
Mass (Da):43,864
Last modified:March 1, 2003 - v1
Checksum:iE0B297E4B4F83C22
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22V → F in AAH21329 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK084506 mRNA. Translation: BAC39201.1.
AK155154 mRNA. Translation: BAE33081.1.
BC006913 mRNA. Translation: AAH06913.1.
BC021329 mRNA. Translation: AAH21329.1.
AF467463 mRNA. Translation: AAL75967.1.
CCDSiCCDS20475.1.
RefSeqiNP_598701.2. NM_133940.3.
UniGeneiMm.125477.

Genome annotation databases

EnsembliENSMUST00000032094; ENSMUSP00000032094; ENSMUSG00000030019.
GeneIDi101358.
KEGGimmu:101358.
UCSCiuc009dmj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK084506 mRNA. Translation: BAC39201.1.
AK155154 mRNA. Translation: BAE33081.1.
BC006913 mRNA. Translation: AAH06913.1.
BC021329 mRNA. Translation: AAH21329.1.
AF467463 mRNA. Translation: AAL75967.1.
CCDSiCCDS20475.1.
RefSeqiNP_598701.2. NM_133940.3.
UniGeneiMm.125477.

3D structure databases

ProteinModelPortaliQ8BID8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032094.

PTM databases

iPTMnetiQ8BID8.
PhosphoSitePlusiQ8BID8.

Proteomic databases

PaxDbiQ8BID8.
PRIDEiQ8BID8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032094; ENSMUSP00000032094; ENSMUSG00000030019.
GeneIDi101358.
KEGGimmu:101358.
UCSCiuc009dmj.2. mouse.

Organism-specific databases

CTDi144699.
MGIiMGI:2141676. Fbxl14.

Phylogenomic databases

eggNOGiENOG410IT1Z. Eukaryota.
ENOG410YK3H. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000007617.
HOVERGENiHBG051674.
InParanoidiQ8BID8.
KOiK10280.
OMAiKHLARMP.
OrthoDBiEOG091G08CA.
PhylomeDBiQ8BID8.
TreeFamiTF313434.

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiQ8BID8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030019.
CleanExiMM_FBXL14.
GenevisibleiQ8BID8. MM.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF13516. LRR_6. 5 hits.
[Graphical view]
SMARTiSM00367. LRR_CC. 11 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFXL14_MOUSE
AccessioniPrimary (citable) accession number: Q8BID8
Secondary accession number(s): Q3U2Q9
, Q8R5H7, Q8VDT7, Q922N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.